American journal of obstetrics and gynecology最新文献

{"title":"The effect of aspirin on the risk of preeclampsia based on the Fetal Medicine Foundation first-trimester risk","authors":"Emmanuel Bujold MD, MSc , Daniel L. Rolnik MD, PhD , Liona Poon MD , Argyro Syngelaki PhD , David Wright PhD , Kypros H. Nicolaides MD","doi":"10.1016/j.ajog.2025.10.032","DOIUrl":"10.1016/j.ajog.2025.10.032","url":null,"abstract":"<div><h3>Background</h3><div>Aspirin reduces the risk of delivery with preterm preeclampsia among high-risk women, and such risk can be estimated in the first trimester of pregnancy using the Fetal Medicine Foundation algorithm by combining maternal factors with mean arterial pressure, uterine artery pulsatility index, and serum placental growth factor. It is unclear whether the initial risk influences the effect of aspirin.</div></div><div><h3>Objective</h3><div>This study aimed to estimate the effect of aspirin on preeclampsia according to first-trimester risk.</div></div><div><h3>Study Design</h3><div>This was a post hoc secondary analysis of the Aspirin for Evidence-Based Preeclampsia Prevention trial, which randomized participants with a first-trimester risk of preeclampsia with delivery before 37 weeks of gestation (preterm preeclampsia) of ≥1 in 100 (or 1%), based on the Fetal Medicine Foundation algorithm, to receive aspirin 150 mg or placebo daily from 11 to 14 weeks to 36 weeks of gestation. The rates of preeclampsia, preterm preeclampsia, and early preeclampsia (with delivery before 34 weeks of gestation) were calculated according to the initial Fetal Medicine Foundation risk. Among participants with high compliance (≥90% of tablets prescribed) based on regular tablet counts, the effect of aspirin was estimated according to the initial Fetal Medicine Foundation risk. Relative risks with 95% confidence intervals were calculated.</div></div><div><h3>Results</h3><div>Of 822 participants in the placebo group, those with an initial Fetal Medicine Foundation risk of ≥1 in 20 (or >5%) had an overall rate of preeclampsia (21.7%), preterm preeclampsia (8.4%), and early preeclampsia (6.4%) significantly greater than those with an initial risk of <1 in 20 (8.1%, 2.9%, and 0.3%, respectively; all with <em>P</em><.01). Of 1143 participants with high compliance randomized to aspirin or placebo, aspirin was associated with a reduction in preeclampsia at any gestation (relative risk, 0.64 [95% confidence interval, 0.44–0.93]), preterm preeclampsia (relative risk, 0.24 [95% confidence interval, 0.09–0.63]), and early preeclampsia (estimated relative risk, 0.06 [95% confidence interval, 0.01–0.96]) compared with placebo. Subgroup analyses enabled the identification of a differential response according to the initial Fetal Medicine Foundation risk. Among participants with an initial risk of ≥1 in 20, an absence (0.0%) of delivery with preeclampsia up to 35 weeks of gestation was observed in those randomized to aspirin compared with 6.1% in those randomized to placebo (estimated relative risk, 0.06 [95% confidence interval, 0.01–0.94]). In addition, it was observed that aspirin did not reduce significantly the preterm preeclampsia in this subgroup (relative risk, 0.47 [95% confidence interval, 0.17–1.34]). In contrast, when the initial risk was <1 in 20, aspirin was associated with an absence of delivery with preeclampsia up to 37 weeks of ges","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Pages 770-778"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female stress urinary incontinence: erbium-doped yttrium aluminum garnet laser","authors":"Barry O’Reilly MD, Christian Phillips MD, Volker Viereck MD","doi":"10.1016/j.ajog.2025.09.014","DOIUrl":"10.1016/j.ajog.2025.09.014","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e96"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter removals after cesarean deliveries","authors":"David M. Haas MD, Krista Wagner RN, Maryann Chimhanda MD","doi":"10.1016/j.ajog.2025.09.023","DOIUrl":"10.1016/j.ajog.2025.09.023","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e100"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating reproductive psychiatry in contraceptive counseling","authors":"Kaleigh Wingate MS, Rajah Darwish BS, Marina Zakhary BS","doi":"10.1016/j.ajog.2025.10.019","DOIUrl":"10.1016/j.ajog.2025.10.019","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e113"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doxycycline vs levofloxacin combined with tinidazole for treating chronic endometritis (reply to letter to the editor)","authors":"Yue Liu (MM), Zijun Zhao BD, Dacheng Qu PhD","doi":"10.1016/j.ajog.2025.10.041","DOIUrl":"10.1016/j.ajog.2025.10.041","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e122"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145434548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deepening the analysis of pelvic examination barriers: unanswered questions on patient bias, setting variability, and gender equity","authors":"Xinru Wang MMED","doi":"10.1016/j.ajog.2025.12.013","DOIUrl":"10.1016/j.ajog.2025.12.013","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e125"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying site variability, gender differences, and patient perspectives in pelvic examination training","authors":"Michelle L. Shui MD, Monica L. Lypson MD, MHPE, Said S. Saab MD, MEd, MPhil","doi":"10.1016/j.ajog.2025.12.014","DOIUrl":"10.1016/j.ajog.2025.12.014","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e126"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing clinical translatability of histology-specific ovarian cancer natural history models","authors":"Ruijie Meng","doi":"10.1016/j.ajog.2025.09.007","DOIUrl":"10.1016/j.ajog.2025.09.007","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e103"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering the role of episiotomy during instrumental delivery in nulliparous women","authors":"Yajing Liu MM, Bingqing Jia MM, Yunxiang Feng MM","doi":"10.1016/j.ajog.2025.09.025","DOIUrl":"10.1016/j.ajog.2025.09.025","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Page e109"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussing the implementation of a restrictive use of episiotomy in operative vaginal delivery in nulliparous women (reply to letter to the editor)","authors":"Bertrand Gachon MD, PhD, Yoann Foucher PhD, Xavier Fritel MD, PhD","doi":"10.1016/j.ajog.2025.09.026","DOIUrl":"10.1016/j.ajog.2025.09.026","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"234 3","pages":"Pages e110-e111"},"PeriodicalIF":8.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}