American journal of obstetrics and gynecology最新文献

{"title":"AJOG GR Table of Contents","authors":"","doi":"10.1016/S0002-9378(25)00324-2","DOIUrl":"10.1016/S0002-9378(25)00324-2","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"233 1","pages":"Page A8"},"PeriodicalIF":8.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for readers","authors":"","doi":"10.1016/S0002-9378(25)00322-9","DOIUrl":"10.1016/S0002-9378(25)00322-9","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"233 1","pages":"Page A6"},"PeriodicalIF":8.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 AJOG Top Reviewers","authors":"","doi":"10.1016/S0002-9378(25)00392-8","DOIUrl":"10.1016/S0002-9378(25)00392-8","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"233 1","pages":"Page A9"},"PeriodicalIF":8.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AJOG MFM Table of Contents","authors":"","doi":"10.1016/S0002-9378(25)00323-0","DOIUrl":"10.1016/S0002-9378(25)00323-0","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"233 1","pages":"Page A7"},"PeriodicalIF":8.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of breast cancer history on decision-making for ovarian cancer risk-reducing surgery in the TUBA-WISP-II study.","authors":"T A Gootzen,M P Steenbeek,M M H J van Gelder,M H D van Bommel,J N H Timmer-Bonte,C M Kets,R Nitecki Wilke,E M Swisher,B M Norquist,K H Lu,,R P M G Hermens,J A de Hullu","doi":"10.1016/j.ajog.2025.06.024","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.06.024","url":null,"abstract":"BACKGROUNDFemale BRCA1/2 pathogenic variant carriers have an increased risk of breast and ovarian cancer. In the TUBA-WISP II study, women choose between standard risk-reducing salpingo-oophorectomy or risk-reducing salpingectomy with delayed oophorectomy to prevent ovarian cancer. At inclusion, a significant proportion of the enrolled women had a history of breast cancer, which could impact decision-making.OBJECTIVEThis study aimed to describe decision-making regarding type and timing of risk-reducing surgery among women with versus without a history of breast cancer.STUDY DESIGNPremenopausal BRCA1/2 pathogenic variant carriers completed web-based questionnaires on their personal histories and preferred risk-reducing strategy. Differences in type and timing of first risk-reducing surgery in women with versus without a history of breast cancer were assessed. A multivariable analysis was conducted to examine personal, environmental, and breast cancer related characteristics associated with the choice for risk-reducing salpingo-oophorectomy among women with a history of breast cancer.RESULTSWe included 1676 women, of whom 222 (13.2%) had a history of breast cancer. Of those, 77.0% chose RRS/DO, compared to 78.0% in the non- history of breast cancer group (p=0.73). Individuals with breast cancer before their BRCA1/2 diagnosis had their first surgery median 2 years later than women who were diagnosed simultaneously or had their BRCA1/2 diagnosis first. Women diagnosed with breast cancer within the guideline age range for completing risk-reducing salpingo-oophorectomy (35-40 BRCA1, 40-45 BRCA2) more often chose risk-reducing salpingo-oophorectomy than women before the guideline age range, odds ratio 6.2 (95%CI 1.9-19.9).CONCLUSIONA history of breast cancer was not associated with preference for a specific risk-reducing strategy. Women diagnosed with breast cancer in the guideline age range more often chose risk-reducing salpingo-oophorectomy than women diagnosed before the guideline age range.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"5 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of vaginal birth after induction of labor with maternal circulating RNA transcripts","authors":"Wenjing DING PhD, Stephen Siu Chung CHIM PhD, Karen Ka Wing WONG MSc, Elaine Yee Ling KO BSc, Claire Yik Lok CHUNG PhD, Joyce Ka Yu TSE PhD, Ting Fung CHAN PhD, Chi Chiu WANG PhD, Tak Yeung LEUNG MD","doi":"10.1016/j.ajog.2025.06.023","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.06.023","url":null,"abstract":"Induction of labor is commonly performed in pregnancies for clinical benefits, but 25%-30% of inductions eventually fail and require cesarean delivery. So far, there is no biomarker for the prediction of successful vaginal birth after induction of labor, and clinical prediction remains unsatisfactory.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"13 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing use of a uterine manipulator for laparoscopic hysterectomy: a cadaveric study of distances to the pelvic ureter","authors":"Evelyn T. Pan MD, Briana M. Belmonte MD, Clifford Y. Wai MD, Sunil Balgobin","doi":"10.1016/j.ajog.2025.06.022","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.06.022","url":null,"abstract":"Uterine manipulator use may mitigate the risk of ureteral injury during laparoscopic hysterectomy by distancing the ureters, particularly for critical steps such as uterine artery ligation and colpotomy. However, evidence to reliably support this spatial effect is lacking, and more data is needed to inform optimal manipulator position and technique.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"14 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A low maternal sFlt-1 before 11 weeks is associated with a greater risk of early preeclampsia.","authors":"Emmanuel Bujold,Charlotte K Ekelund,Berit Woetmann Pedersen,Line Rode","doi":"10.1016/j.ajog.2025.06.019","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.06.019","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"6 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Analysis of cerebral palsy subtypes by intrapartum cardiotocography and postnatal neuroimaging\".","authors":"Shoichi Magawa,Masahiro Nakao,Yukiko Nanba,Mitsutoshi Iwashita,Tomoaki Ikeda","doi":"10.1016/j.ajog.2025.06.021","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.06.021","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"22 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late preterm PROM (>33 weeks): the risk of intra-amniotic inflammation and fetal inflammation is influenced by the cervical microbial ecosystem and cervical inflammation.","authors":"Marian Kacerovsky, Filip Vrbacky, Jana Matulova, Radka Bolehovska, Rudolf Kukla, Ladislava Pavlikova, Magdalena Holeckova, Marek Lubusky, Ivana Musilova, Bo Jacobsson, Antonin Libra","doi":"10.1016/j.ajog.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.06.017","url":null,"abstract":"<p><strong>Background: </strong>Approximately 25-30% of pregnancies with late preterm prelabor rupture of membranes (PROM) are complicated by the development of fetal inflammatory response syndrome (FIRS), which is characterized by elevated levels of interleukin-6 in fetal blood. FIRS represents a serious condition that can induce temporary or persistent changes in multiple essential fetal organs. Most importantly, FIRS may impact infant neurodevelopment and increase the risk of neuropsychiatric disorders.</p><p><strong>Objective: </strong>To characterize the cervical microbial ecosystem and cervical fluid interleukin-6 levels in late preterm PROM with respect to i) intra-amniotic inflammation and/or microbial invasion of the amniotic cavity, and ii) the development of FIRS.</p><p><strong>Study design: </strong>This retrospective cohort study included women with singleton pregnancies complicated by late preterm PROM, in whom amniocentesis was performed at admission to assess intra-amniotic environment. Cervical fluid samples were collected using Dacron swabs upon admission. The samples were used for DNA isolation with sequencing of 16S rRNA gene and analysis of interleukin-6 levels. The cervical microbiota was classified based on the relative abundance of Lactobacillus species. Interleukin-6 levels in cervical fluid were measured using electrochemiluminescence. FIRS was defined as the concentration of interleukin-6 > 11.0 pg/mL in umbilical cord blood.</p><p><strong>Results: </strong>A total of 114 women with late preterm PROM were included in this study. In total, 378 microbial taxa were identified in the cervical samples. Dominant abundance (≥50%) of L. iners and the depletion (<50%) of L. spp. were the most prevalent cervical ecosystems in women with intra-amniotic infection [63% (5/8)] and microbial invasion of the amniotic cavity without inflammation [82% (9/11)], respectively. Women whose fetuses developed FIRS had a lower prevalence of L. crispatus dominant cervical microbiota [2% (1/42) vs. 43% (31/72); p < 0.0001] and higher prevalences of L. iners dominant [38% (16/42) vs. 19% (14/92); p = 0.05] and L. spp. depleted cervical microbiotas [55% (23/42) vs. 32% (23/72); p = 0.02], compared to those whose fetuses did not develop FIRS. In the group of women with amniotic fluid negative for inflammation and microorganisms, FIRS was associated with a lower prevalence of L. crispatus dominant microbiota [0% (0/25) vs. 46% (29/63); p < 0.0001] and a higher prevalence of L. iners dominant microbiota [44% (11/25) vs. 20% (13/63); p = 0.04]. Cervical IL-6 levels were highest in women with intra-amniotic infection. The presence of FIRS was associated with elevated IL-6 levels.</p><p><strong>Conclusion: </strong>Intra-amniotic and fetal inflammatory complications were influenced by the cervical microbial ecosystem and local inflammation. The absence of a high relative abundance of L. crispatus in the cervical microbial ecosystem was associated with an","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}