Marisa R Imbroane, Felicia LeMoine, Christopher T Nau
{"title":"Expanded Discussion of Limitations for Impact of Glucagon-like peptide-1 Receptor Agonist Use Association with Decreased Risk of Adverse Obstetrical Outcomes.","authors":"Marisa R Imbroane, Felicia LeMoine, Christopher T Nau","doi":"10.1016/j.ajog.2025.05.029","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.05.029","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral antihypertensive treatment during pregnancy: can individualized treatment improve maternal and perinatal outcomes?","authors":"R J Hup, A T Lely, M Depmann","doi":"10.1016/j.ajog.2025.05.025","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.05.025","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annick Bogaerts, Hanne VAN Uytsel, Lieveke Ameye, Yael Winter Shafran, Yves Jacquemyn, Caroline VAN Holsbeke, Roland Devlieger
{"title":"Interpregnancy and pregnancy lifestyle intervention (INTER-ACT): a randomized controlled trial.","authors":"Annick Bogaerts, Hanne VAN Uytsel, Lieveke Ameye, Yael Winter Shafran, Yves Jacquemyn, Caroline VAN Holsbeke, Roland Devlieger","doi":"10.1016/j.ajog.2025.05.041","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.05.041","url":null,"abstract":"<p><strong>Background: </strong>Lifestyle interventions prior to conception hold potential to reduce pregnancy-related complications, although this has been constrained due to challenges in reaching preconception women.</p><p><strong>Objectives: </strong>We aim to study the effectiveness of the INTER-ACT lifestyle intervention spanning through the interpregnancy and subsequent pregnancy periods in women with a history of excessive GWG on reducing pregnancy complications.</p><p><strong>Study design: </strong>The Interpregnancy Coaching for a Healthy Future (INTER-ACT) study is a prospective, multicenter randomized controlled trial.</p><p><strong>Methods: </strong>Participants were recruited within six weeks after a previous pregnancy from a combination of primary and secondary healthcare facilities across six Flemish hospitals in Belgium. The INTER-ACT intervention involved face-to-face coaching sessions and an E-Health application aimed at promoting healthy behaviors, including nutrition, physical activity, and mental wellbeing. The primary outcome was a composite of pregnancy complications including pregnancy-induced hypertension, gestational diabetes, cesarean section, and large for gestational age infants. To identify a significant difference between the intervention and control group in the incidence of composite outcome, with a statistical power of 80% and significance level of 0.05, 250 women with subsequent delivery in each group needed to be recruited.</p><p><strong>Results: </strong>Participants were recruited from May 2017 through April 2019. Out of 8897 women with excessive GWG, 1450 were randomized. 390 subsequently experienced singleton pregnancy, with 193 in the intervention group and 197 in usual care. Baseline socio-demographics were generally comparable between groups. The lifestyle intervention did not significantly reduce the composite outcome (OR 1.29, 95% CI 0.85 to 1.96, p=0.23) or secondary outcomes. In a post hoc sub-analysis, we found that adherence to follow-up during the subsequent pregnancy was associated with a reduced risk of the composite outcome in both study arms (intervention group: OR 0.50, 95% CI 0.26 to 0.98, p=0.04; control group OR 0.48, 95% CI 0.26 to 0.90, p=0.02), suggesting a potential benefit of continued engagement regardless of allocation.</p><p><strong>Conclusions: </strong>The INTER-ACT intervention did not result in a lower composite outcome rate in women with previous excessive gestational weight gain. However, adherence during pregnancy was key, halving risks in both study arms. Future trials should focus on improving adherence and exploring the impact of lifestyle interventions on pregnancy outcomes in women across diverse BMI ranges, particularly in the preconception and interpregnancy periods.</p>","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incorporating Metabolic Health Into Postpartum Hemorrhage Risk Assessment.","authors":"Isabelle Attali, Diane Korb, Catherine Deneux-Tharaux","doi":"10.1016/j.ajog.2025.05.035","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.05.035","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Signal capture in intrapartum electronic fetal monitoring.","authors":"Jennifer A McCoy, William G LA Cava","doi":"10.1016/j.ajog.2025.05.027","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.05.027","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intrapartum electronic fetal monitoring: the importance of accurate signal capture to harness the potential of deep learning.","authors":"Daniel J Kiely","doi":"10.1016/j.ajog.2025.05.026","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.05.026","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reevaluating the Link Between Birthweight and Postpartum Hemorrhage: The Overlooked Role of Gestational Diabetes in India.","authors":"Nidhi Basavaraj","doi":"10.1016/j.ajog.2025.05.032","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.05.032","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}