American journal of obstetrics and gynecology最新文献

{"title":"Clarifying the complex relationship between obesity and post-treatment CIN3+: Evidence gaps and clinical research priorities (Reply to Letter-to-the-Editor).","authors":"Megan A Clarke,Nicolas Wentzensen","doi":"10.1016/j.ajog.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.09.004","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"21 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Clinical Translatability of Histology-Specific Ovarian Cancer Natural History Models (Letter-to-the-Editor).","authors":"Ruijie Meng","doi":"10.1016/j.ajog.2025.09.007","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.09.007","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"53 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Priming during Vaginoscopic Hysteroscopy Using Lower Doses of Vaginal Misoprostol (Reply to Letter-to-the-Editor).","authors":"Dilip Kumar Maurya,Raju Govindegowdanadoddi Puttaswamy,Anish Keepanasseril","doi":"10.1016/j.ajog.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.09.009","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"36 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a Natural History Model to Benchmark Progress in Managing Ovarian Cancer (Reply to Letter-to-the-Editor).","authors":"Larissa A Meyer,Sayaka Ishizawa,Iakovos Toumazis","doi":"10.1016/j.ajog.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.09.006","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"9 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Two Vaginal Misoprostol Dosing Regimens for Cervical Priming in Vaginoscopic Hysteroscopy (Letter to the Editor).","authors":"Mei Zhao,Xiaolan Liu,Fuhua Zhou","doi":"10.1016/j.ajog.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.09.008","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"55 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine in Systemic Lupus Erythematosus, Anti-SSA/SSB, and Antiphospholipid Antibody-Positive Pregnancies.","authors":"Zeinab Saleh,Emily C Somers,Vivian C Romero,Wendy Marder","doi":"10.1016/j.ajog.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.09.002","url":null,"abstract":"Pregnancies in patients with systemic lupus erythematosus (SLE) and those positive for anti-SSA/SSB or antiphospholipid antibodies carry a heightened risk of adverse pregnancy outcomes (APOs), including preeclampsia, preterm birth, and congenital heart block. Among available therapies, hydroxychloroquine (HCQ) plays a pivotal role due to its immunomodulatory and antithrombotic properties, which may help improve pregnancy outcomes. Emerging evidence supports HCQ's role in reducing SLE flares, as well as lowering the recurrence risk of congenital heart block in anti-SSA/SSB-positive pregnancies. Additionally, in patients with antiphospholipid antibodies, HCQ may serve as an adjunctive therapy to mitigate obstetric complications, particularly in refractory cases. Despite early concerns about teratogenicity, large cohort studies and international guidelines affirm HCQ's safety at standard doses (≤400 mg/day), with no consistent association with congenital malformations. Recent research suggests that subtherapeutic HCQ blood levels during pregnancy may correlate with higher maternal disease activity and adverse pregnancy outcomes ,though their primary utility currently lies in identifying nonadherence. Given the heightened risk of pregnancy complications in this population, a clear understanding of HCQ's essential role is crucial for both patients and their multidisciplinary care teams. This review provides up-to-date information on HCQ in pregnancy to help guide clinical decision-making.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"308 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New tools required to optimize timing of antenatal corticosteroids in early-onset fetal growth restriction (Reply to Letter-to-the-editor).","authors":"Mette van de Meent,A Titia Lely,Judith Kooiman","doi":"10.1016/j.ajog.2025.08.093","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.08.093","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"35 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing antenatal corticosteroids administration in early fetal growth restriction: still more work to do (Letter-to-the-Editor).","authors":"Giovanni Morganelli,Stefania Fieni,Andrea Dall'Asta","doi":"10.1016/j.ajog.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.09.003","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"35 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery after Low-Impact Laparoscopic Hysterectomy: A Randomized Controlled Clinical Trial.","authors":"Karim Bouattour,Christine Louis-Sylvestre,Richard Berry,Yael Levy-Zauberman,Jean-Marc Lacombe,Marlène Cherruault,Olivier Montandrau,Marc Beaussier","doi":"10.1016/j.ajog.2025.08.090","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.08.090","url":null,"abstract":"BACKGROUNDLow-impact laparoscopy (LIL), a surgical protocol using mini-laparoscopic instruments and low-and-stable pneumoperitoneal pressure, was developed as a minimally invasive approach to mitigate local and systemic effects of laparoscopy. However, its real clinical impact is still poorly documented.OBJECTIVETo evaluate LIL impact on the postoperative recovery quality 6 hours after laparoscopic hysterectomy (henceforth 6H postsurgery) compared to conventional laparoscopy.STUDY DESIGNSingle-center, double-blinded, randomized controlled trial, conducted between December 2019 and August 2023, evaluating different approaches for outpatient laparoscopic hysterectomies. Sixty-eight adult patients scheduled for outpatient laparoscopic hysterectomy were included and randomized into 2 groups: LIL with mini-trocars and low peritoneal pressure or conventional laparoscopy with standard-size trocars and higher peritoneal insufflation pressure. The primary outcome was recovery quality 6H postsurgery, assessed with the multidimensional Postoperative Quality of Recovery Scale (PQRS). Secondary outcomes were: Analgesia Nociception Index-guided intraoperative remifentanil administration, intraoperative pain stimulation, postoperative pain intensity, opioid use, surgeon-assessed surgical conditions, adverse events, time to discharge and patient satisfaction.RESULTSTwo homogeneous groups were obtained. Protocol deviations attributable to surgical difficulties requiring larger instruments and higher pneumoperitoneal pressures to complete the intervention occurred in 6 LIL-group patients. Recovery quality 6H postsurgery was comparable for the LIL and conventional groups (respectively, 10/34 (29%) and 8/34 (24%) of patients recovered their preoperative PQRS values, p=0.58). The LIL group had lower intraoperative pain stimulation, with less remifentanil consumption. Postoperative pain intensity at rest and coughing, and morphine-requirement, adverse event, same-day-discharge and patient-satisfaction rates did not differ between the 2 groups. Surgical conditions were deemed poorer in the LIL group.CONCLUSIONDespite slightly less intraoperative pain stimulation, attesting to its minimally invasive nature, LIL did not appear to improve 6H-postsurgery recovery compared to conventional laparoscopy. Surgical conditions were rated poorer for the LIL group. LIL does not seem to provide any clinical benefit.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"27 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous uterine rupture at 23 weeks' gestation after prior myomectomy.","authors":"Daniel L Kuhr,Sunidhi Singh,Nicola F Tavella,Henri M Rosenberg,Angela Bianco","doi":"10.1016/j.ajog.2025.08.089","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.08.089","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"8 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}