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New luminescent materials based on amphiphilic complexes of lanthanides with 4-(octadecyloxy)pyridine-2,6-dicarboxylic acid 基于4-（十八烷基氧基）吡啶-2,6-二羧酸镧系两亲性配合物的新型发光材料
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5083-2
F. A. Kolokolov, A. N. Morozov, R. V. Khatymov, G. I. Buravchenko, D. I. Kuznetsov, N. Yu. Spitsyn, A. E. Shchekotikhin, O. A. Raitman
{"title":"New luminescent materials based on amphiphilic complexes of lanthanides with 4-(octadecyloxy)pyridine-2,6-dicarboxylic acid","authors":"F. A. Kolokolov,&nbsp;A. N. Morozov,&nbsp;R. V. Khatymov,&nbsp;G. I. Buravchenko,&nbsp;D. I. Kuznetsov,&nbsp;N. Yu. Spitsyn,&nbsp;A. E. Shchekotikhin,&nbsp;O. A. Raitman","doi":"10.1007/s11172-026-5083-2","DOIUrl":"10.1007/s11172-026-5083-2","url":null,"abstract":"<div><p>Efficiently luminescing in the visible region complexes of 4-(octadecyloxy)pyridine-2,6-dicarboxylic acid with europium(<span>iii</span>), terbium(<span>iii</span>), samarium(<span>iii</span>), thulium(<span>iii</span>) and gadolinium(<span>iii</span>) were synthesized. Analysis of the luminescence spectra revealed that the emission intensity of the terbium complex significantly exceeds the luminescence intensity of other lanthanides in the visible region. Langmuir monolayers were for the first time formed on the surface of an aqueous subphase using the terbium complex. The obtained data indicate that these complexes hold promise as materials for the development of molecular photonics and optoelectronic devices.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 8","pages":"2367 - 2373"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-pot microfluidic synthesis of α-(1→5)-linked d-arabinofuranose trisaccharide bearing a Janus aglycone from 3-O-benzoyl-β-d-arabinofuranose 1,2,5-orthobenzoate 以3- o -苯甲酰-β-d-阿拉伯糖铀糖1,2,5-邻苯甲酸酯为原料，一锅微流控合成含Janus糖苷元的α-(1→5)-连接d-阿拉伯糖铀糖三糖
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5078-z
I. V. Myachin, A. I. Zinin, A. O. Chizhov, N. G. Kolotyrkina, O. G. Malyshev, L. O. Kononov
{"title":"One-pot microfluidic synthesis of α-(1→5)-linked d-arabinofuranose trisaccharide bearing a Janus aglycone from 3-O-benzoyl-β-d-arabinofuranose 1,2,5-orthobenzoate","authors":"I. V. Myachin,&nbsp;A. I. Zinin,&nbsp;A. O. Chizhov,&nbsp;N. G. Kolotyrkina,&nbsp;O. G. Malyshev,&nbsp;L. O. Kononov","doi":"10.1007/s11172-026-5078-z","DOIUrl":"10.1007/s11172-026-5078-z","url":null,"abstract":"<div><p>A one-step method for the synthesis of α-(1→5)-linked oligomers of <span>d</span>-arabinofuranose with a Janus aglycone was studied <i>via</i> the ring-opening of 3-<i>O</i>-benzoylated <span>d</span>-arabinofuranose 1,2,5-orthobenzoate with 4-(3-chloropropoxy)phenol (CPP-OH) in the presence of SnCl<sub>4</sub>. The reaction was optimized in a continuous flow reactor, which opens prospects for scaling the process. It was shown that the isolation of products up to the undecasaccharide is possible. Using this process, it is possible to synthesize the trisaccharide CPP glycoside in 10–17% yield, which is competitive compared to the results of alternative multistep approaches. Analysis of the structure of the by-products enabled refinement of the reaction mechanism.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 7","pages":"2306 - 2322"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linker effect on the exchange and dipolar coupling in TEMPO-based radicals and diradicals 连结体效应对tempo基自由基和双自由基交换和偶极耦合的影响
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5066-3
D. A. Kuznetsov, A. M. Zakirov, A. V. Medved’ko, A. R. Melnikov, E. G. Bagryanskaya, S. Z. Vatsadze
{"title":"Linker effect on the exchange and dipolar coupling in TEMPO-based radicals and diradicals","authors":"D. A. Kuznetsov,&nbsp;A. M. Zakirov,&nbsp;A. V. Medved’ko,&nbsp;A. R. Melnikov,&nbsp;E. G. Bagryanskaya,&nbsp;S. Z. Vatsadze","doi":"10.1007/s11172-026-5066-3","DOIUrl":"10.1007/s11172-026-5066-3","url":null,"abstract":"<div><p>TEMPO-based mono- and diradicals were studied by EPR spectroscopy in liquid (300 K) and frozen (80 K) solutions. Quantum chemical calculations of various conformations of the diradicals were performed. The hyperfine coupling constants and exchange constants of the diradicals were obtained by comparing the experimental and simulated EPR spectra. The strength of dipole-dipole interaction between the unpaired electrons in the diradicals was evaluated using the average distance between the radical centers. The X-band electron spin relaxation times were measured. It was concluded that diradicals can be used as polarizing agents for dynamic nuclear polarization.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 7","pages":"2177 - 2184"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-pot domino cyclization of chiral pinane amino alcohols with ethyl 4,4,4-trifluoroacetoacetate and acetone 手性蒎烷氨基醇与4,4,4-三氟乙酸乙酯和丙酮的一锅多米诺骨牌环化
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5068-1
M. V. Goryaeva, S. O. Kushch, Ya. V. Burgart, E. V. Shchegolkov, M. A. Ezhikova, M. I. Kodess, P. A. Slepukhin, A. A. Tumashov, L. L. Frolova, P. V. Gribkov, D. V. Sudarikov, A. V. Kutchin, V. I. Saloutin
{"title":"One-pot domino cyclization of chiral pinane amino alcohols with ethyl 4,4,4-trifluoroacetoacetate and acetone","authors":"M. V. Goryaeva,&nbsp;S. O. Kushch,&nbsp;Ya. V. Burgart,&nbsp;E. V. Shchegolkov,&nbsp;M. A. Ezhikova,&nbsp;M. I. Kodess,&nbsp;P. A. Slepukhin,&nbsp;A. A. Tumashov,&nbsp;L. L. Frolova,&nbsp;P. V. Gribkov,&nbsp;D. V. Sudarikov,&nbsp;A. V. Kutchin,&nbsp;V. I. Saloutin","doi":"10.1007/s11172-026-5068-1","DOIUrl":"10.1007/s11172-026-5068-1","url":null,"abstract":"<div><p>The three-component domino reaction of ethyl 4,4,4-trifluoroacetoacetate and acetone with (1<i>S</i>,2<i>S</i>,3<i>R</i>,4<i>S</i>,5<i>S</i>)-2-amino-4,6,6-trimethylbicyclo[3.1.1]heptan-3-ol affords (3<i>S</i>/R,4a<i>S</i>/<i>R</i>,5a<i>R</i>,6<i>S</i>,7<i>S</i>,9<i>S</i>,9a<i>S</i>)-3-hydroxy-4a,6,8,8-tetramethyl-3-(trifluoromethyl)-decahydro-1<i>H</i>-7,9-methanobenzo[4,5]oxazolo[3,2-<i>a</i>]pyridin-1-one as three enantiomerically pure diastereomers differing in the positions of the substituents at the C(3) and C(4a) stereocenters, whereas a similar reaction with (1<i>S</i>,2<i>R</i>,3<i>S</i>,5<i>R</i>)-2-aminomethyl-6,6-dimethylbicyclo[3.1.1]heptan-3-ol produces two atropisomers of (<i>R</i>)-5-hydroxy-3-({[(1<i>S</i>,2<i>R</i>,3<i>S</i>,5<i>R</i>)-3-hydroxy-6,6-dimethylbicyclo[3.1.1]heptan-2-yl]methyl}amino)-5-(trifluoromethyl)cyclohex-2-en-1-one, which differ in the configuration about the C—N bond. The structures of the new compounds were established by IR spectroscopy, <sup>1</sup>H, <sup>19</sup>F, and <sup>13</sup>C NMR spectroscopy, including 2D NMR experiments, and X-ray diffraction.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 7","pages":"2192 - 2206"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reaction of 1-aryl-1-chlorocyclopropanes with azoles in the KOH—DMSO system: a convenient synthetic route to 1-(2-arylcyclopropyl)azoles KOH-DMSO体系中1-芳基-1-氯环丙烷与唑的反应：1-（2-芳基环丙基）唑的便捷合成途径
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5070-7
V. D. Gvozdev, M. P. Egorov
{"title":"Reaction of 1-aryl-1-chlorocyclopropanes with azoles in the KOH—DMSO system: a convenient synthetic route to 1-(2-arylcyclopropyl)azoles","authors":"V. D. Gvozdev,&nbsp;M. P. Egorov","doi":"10.1007/s11172-026-5070-7","DOIUrl":"10.1007/s11172-026-5070-7","url":null,"abstract":"<div><p>Reaction of 1-aryl-1-chlorocyclopropanes with pyrazole, imidazole, and their C-methyl-substituted derivatives in the KOH—DMSO system at 80–100 °C affords corresponding 1-(2-arylcyclopropyl)azoles in yields of up to 84%. The process is highly stereoselective and in most cases gives exclusively isomers of the final products with <i>trans</i>-arrangement of the azolyl and adjacent aryl fragments. The results obtained suggest that the title transformation proceeds by the elimination—addition mechanism <i>via</i> the intermediate formation of 1-arylcyclopropenes.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 7","pages":"2219 - 2232"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Derivatives of 1,2,4-thiadiazole with an NO-generating moiety 含no生成基团的1,2,4-噻二唑衍生物
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5104-1
I. V. Serkov, E. V. Fomina-Ageeva, V. V. Bezuglov, A. N. Proshin
{"title":"Derivatives of 1,2,4-thiadiazole with an NO-generating moiety","authors":"I. V. Serkov,&nbsp;E. V. Fomina-Ageeva,&nbsp;V. V. Bezuglov,&nbsp;A. N. Proshin","doi":"10.1007/s11172-026-5104-1","DOIUrl":"10.1007/s11172-026-5104-1","url":null,"abstract":"<div><p>The synthesis of 1,2,4-thiadiazole derivatives containing a nitroxy or hydroxylimino group as a NO-generating moiety was developed based on the condensation of thiadiazole derivatives containing a keto group with nitroethanolamine and hydroxylamine. The generation of nitric oxide by the synthesized compounds was demonstrated, with the compounds containing a nitroxy group being the most active.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 8","pages":"2572 - 2577"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Push-pull hydrazonocyclopentadiene chromophores containing a vinyl π-spacer: synthesis, optical, and nonlinear optical properties 含乙烯基π间隔剂的推拉式腙环戊二烯发色团：合成、光学及非线性光学性质
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5080-5
K. P. Trainov, A. N. Sheremetyeva, A. Yu. Belyy, D. N. Platonov, S. A. Paveliev
{"title":"Push-pull hydrazonocyclopentadiene chromophores containing a vinyl π-spacer: synthesis, optical, and nonlinear optical properties","authors":"K. P. Trainov,&nbsp;A. N. Sheremetyeva,&nbsp;A. Yu. Belyy,&nbsp;D. N. Platonov,&nbsp;S. A. Paveliev","doi":"10.1007/s11172-026-5080-5","DOIUrl":"10.1007/s11172-026-5080-5","url":null,"abstract":"<div><p>Tetramethyl 5-(2-{4-[(dimethoxyphosphoryl)methyl]phenyl}hydrazono)cyclopenta-1,3-diene-1,2,3,4-tetracarboxylate was synthesized for the first time by a modified decarboxylating azo coupling reaction. This made it possible to synthesize four new chromophores based on the hydrazonocyclopentadiene acceptor fragment connected to four different donors <i>via</i> a stilbene linker. The structures of the chromophores were determined using UV—Vis electronic spectroscopy, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, and high-resolution mass spectrometry data. The dipole moment (μ) and the nonlinear optical (NLO) properties, namely, the average linear polarizability &lt;α&gt; and the first- and second-order hyperpolarizabilities (β<sub>tot</sub> and γ<sub>tot</sub>, respectively) were investigated theoretically using density functional theory calculations at the B3LYP(D4)/def2-TZVPP//r<sup>2</sup>SCAN-3c level. The calculations predicted high &lt;α&gt; and β<sub>tot</sub> values for all compounds. The maximum β<sub>tot</sub> value equal to 391699 a.u. was obtained for (<i>E</i>)-tetramethyl 5-(2-{4-[4-(diethylamino)-styryl]phenyl}hydrazono)cyclopenta-1,3-diene-1,2,3,4-tetracarboxylate. The high NLO responses of the synthesized compounds and the possibility to modulate them by varying the acidity of the environment allows one to consider the title systems as high-performance materials for advanced NLO applications.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 8","pages":"2341 - 2350"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intramolecular [4+2] cycloaddition of unsaturated ammonium salts in the synthesis of fused isoindolinium derivatives and evaluation of their biological activity 不饱和铵盐分子内[4+2]环加成合成融合异吲哚衍生物及其生物活性评价
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5095-y
L. V. Ayrapetyan, E. O. Chukhadzhyan, H. S. Mkrtchyan, H. R. Gevorgyan, I. S. Danielyan, A. S. Agaronyan, R. E. Muradyan, H. G. Arakelyan, M. Yu. Dangyan, L. E. Nersesyan
{"title":"Intramolecular [4+2] cycloaddition of unsaturated ammonium salts in the synthesis of fused isoindolinium derivatives and evaluation of their biological activity","authors":"L. V. Ayrapetyan,&nbsp;E. O. Chukhadzhyan,&nbsp;H. S. Mkrtchyan,&nbsp;H. R. Gevorgyan,&nbsp;I. S. Danielyan,&nbsp;A. S. Agaronyan,&nbsp;R. E. Muradyan,&nbsp;H. G. Arakelyan,&nbsp;M. Yu. Dangyan,&nbsp;L. E. Nersesyan","doi":"10.1007/s11172-026-5095-y","DOIUrl":"10.1007/s11172-026-5095-y","url":null,"abstract":"<div><p>A base-catalyzed intramolecular [4+2]-cycloaddition of unsaturated ammonium salts containing a 1-allyl-3-α-naphthylprop-2-ynyl moiety to 3-phenylallyl bromide and 3-phenylpropargyl bromide was implemented. This approach enables the efficient construction of new fused isoindolinium derivatives, which are of interest as promising biologically active compounds.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 8","pages":"2471 - 2479"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetic model of the glutamate neuron-astrocytic system: N-acetylaspartylglutamate and glutamate carboxypeptidase 谷氨酸神经元-星形细胞系统的动力学模型：n-乙酰天冬氨酸和谷氨酸羧肽酶
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5108-x
S. D. Varfolomeev, V. I. Bykov, S. B. Tsybenova
{"title":"Kinetic model of the glutamate neuron-astrocytic system: N-acetylaspartylglutamate and glutamate carboxypeptidase","authors":"S. D. Varfolomeev,&nbsp;V. I. Bykov,&nbsp;S. B. Tsybenova","doi":"10.1007/s11172-026-5108-x","DOIUrl":"10.1007/s11172-026-5108-x","url":null,"abstract":"<div><p>The kinetic model of excitatory synapse functioning with glutamate and <i>N</i>-acetylaspartylglutamate (NAAG) as neurotransmitters in a three-component system regarding neuroglial astrocytic cells and glutamate carboxypeptidase (GCPII) enzyme has been developed. The biphasic nature of the process providing excitation amplification within the modeling framework is shown. The role of excitatory synapse intensity was studied. The role of NAAG for enhancing neuronal connectivity and accomplishing cognitive function was shown. The mechanism of cognition control by influencing on the efficiency of mGluR3 metabotropic receptor functioning is discussed. The role of GCPII inhibition as a method of improving cognitive functions is studied. Dynamic features of the glutamatergic system behavior in neurodegenerative diseases (Alzheimer’s disease, dementia), schizophrenia, traumatic brain injury, and epilepsy were analyzed. The positive role of GCPII inhibition with the NAAG level increase as an efficient approach to neuropathology treatment is shown.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 8","pages":"2612 - 2624"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted synthesis of antimicrobial agents based on a trifluoromethyl-containing 4-(sulfonylaryl)hydrazinylideneisoxazole skeleton 基于含三氟甲基4-（磺酰基）肼基苯并恶唑骨架的抗菌剂的靶向合成
IF 1.6 4区 化学
Russian Chemical Bulletin Pub Date : 2026-10-17 DOI: 10.1007/s11172-026-5106-z
N. A. Elkina, O. E. Melnikov, E. V. Shchegolkov, Ya. V. Burgart, N. A. Gerasimova, N. P. Evstigneeva, V. I. Saloutin
{"title":"Targeted synthesis of antimicrobial agents based on a trifluoromethyl-containing 4-(sulfonylaryl)hydrazinylideneisoxazole skeleton","authors":"N. A. Elkina,&nbsp;O. E. Melnikov,&nbsp;E. V. Shchegolkov,&nbsp;Ya. V. Burgart,&nbsp;N. A. Gerasimova,&nbsp;N. P. Evstigneeva,&nbsp;V. I. Saloutin","doi":"10.1007/s11172-026-5106-z","DOIUrl":"10.1007/s11172-026-5106-z","url":null,"abstract":"<div><p>The cyclization of trifluoromethyl-containing 2-sulfonylarylhydrazinylidene-1,3-dicarbonyl compounds with hydroxylamine hydrochloride proceeds <i>via</i> different regioselective pathways: 4-sulfonylarylhydrazinylidene-5-hydroxy-5-trifluoromethylisoxazolines were obtained from 1,3-diketones, while 4-sulfonylarylhydrazinylidene-3-trifluoromethylisoxazol-5-ones were obtained from 3-oxoesters. The study of their antimicrobial activity revealed that sulfonamide-containing isoxazolines exhibit pronounced selective activity against <i>Neisseria gonorrhoeae</i>, including a ceftriaxone-resistant clinical isolate, combined with moderate antifungal activity against the dermatophyte strains <i>Trichophyton rubrum, Epidermophyton floccosum</i>, and <i>Microsporum canis</i>. Based on molecular docking results, we propose a mechanism for the antigonococcal effect of these isoxazolines as inhibitors of bacterial cell wall synthesis.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"75 8","pages":"2586 - 2598"},"PeriodicalIF":1.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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