M. S. Kuzmina, N. E. Astakhova, D. A. Vasilenko, K. N. Sedenkova, Yu. K. Grishin, Yu. A. Gracheva, E. R. Milaeva, E. B. Averina
{"title":"异恶唑系列康布他汀A4新型类似物的合成及抗增殖活性研究","authors":"M. S. Kuzmina, N. E. Astakhova, D. A. Vasilenko, K. N. Sedenkova, Yu. K. Grishin, Yu. A. Gracheva, E. R. Milaeva, E. B. Averina","doi":"10.1007/s11172-025-4702-7","DOIUrl":null,"url":null,"abstract":"<div><p>A series of novel analogs of well-known antitumor agent combretastatin A4 of the isoxazole series were obtained. The target compounds were synthesized using sulfonylation reaction of 4-amino-5-methyl-3-(trimethoxyphenyl)isoxazole. Antiproliferative activity of the obtained isoxazole derivatives against four cancer cell lines (HCT116, PC3, A2780, A2780cis) was investigated.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 7","pages":"2184 - 2189"},"PeriodicalIF":1.7000,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and investigation of antiproliferative activity of novel analogs of combretastatin A4 of isoxazole series\",\"authors\":\"M. S. Kuzmina, N. E. Astakhova, D. A. Vasilenko, K. N. Sedenkova, Yu. K. Grishin, Yu. A. Gracheva, E. R. Milaeva, E. B. Averina\",\"doi\":\"10.1007/s11172-025-4702-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A series of novel analogs of well-known antitumor agent combretastatin A4 of the isoxazole series were obtained. The target compounds were synthesized using sulfonylation reaction of 4-amino-5-methyl-3-(trimethoxyphenyl)isoxazole. Antiproliferative activity of the obtained isoxazole derivatives against four cancer cell lines (HCT116, PC3, A2780, A2780cis) was investigated.</p></div>\",\"PeriodicalId\":756,\"journal\":{\"name\":\"Russian Chemical Bulletin\",\"volume\":\"74 7\",\"pages\":\"2184 - 2189\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Chemical Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11172-025-4702-7\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11172-025-4702-7","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis and investigation of antiproliferative activity of novel analogs of combretastatin A4 of isoxazole series
A series of novel analogs of well-known antitumor agent combretastatin A4 of the isoxazole series were obtained. The target compounds were synthesized using sulfonylation reaction of 4-amino-5-methyl-3-(trimethoxyphenyl)isoxazole. Antiproliferative activity of the obtained isoxazole derivatives against four cancer cell lines (HCT116, PC3, A2780, A2780cis) was investigated.
期刊介绍:
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.