1,8-重氮杂环[5.4.0]十一-7-烯存在下(E)-1,5-二苯基戊-1-en-4- n-3 -1苯基腙杂环化动力学

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-08-16 DOI:10.1007/s11172-025-4688-1

D. A. Shkolnikov, I. S. Odin, D. M. Gusev, M. Yu. Ovchinnikov, S. A. Grabovskii, A. A. Golovanov

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引用次数: 0

摘要

研究了1,8-重氮杂环[5.4.0]十一-7-烯存在下(E)-1,5-二苯基戊-1-en-4- n-3 -1苯基腙在373.15 ~ 407.15 K范围内的乙二醇环化动力学。反应产物为(E)-1,2-二苯基-4-苯基- 1h -吡唑，收率为99%。使用催化剂可以在保持产物收率的情况下缩短反应时间。考虑了反应物与催化剂之间形成络合物的机理以及质子从反应物向催化剂的转移，从而降低了环化的激活势垒。

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Kinetics of the heterocyclization of (E)-1,5-diphenylpent-1-en-4-yn-3-one phenylhydrazone in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene

The kinetics of the cyclization of (E)-1,5-diphenylpent-1-en-4-yn-3-one phenylhydrazone in ethylene glycol in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene at temperatures ranging from 373.15 to 407.15 K was studied. The reaction product is (E)-1,2-diphenyl-4-styryl-1H-pyrazole in a yield of 99%. The use of catalysis allows one to shorten the reaction time with retaining the yield of the product. The mechanism of the formation of a complex between the reactant and catalyst and the proton transfer from the reactant to the catalyst, which decreases the activation barrier for cyclization, is considered.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.