Biomaterials, medical devices, and artificial organs最新文献_第4页

Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex. 聚氯乙烯-焦内酮-棉酚配合物的生育控制研究。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118817

Z W Gu, Y Jiang, X D Feng

引用次数: 3

Specific removal of digoxin by hemoperfusion through agarose polyacrolein microsphere polyacrolein microsphere beads-antidigoxin antibodies (APAMB-AD). 琼脂糖聚丙烯醛微球-抗地高辛抗体(APAMB-AD)血液灌注特异性去除地高辛。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118819

S Margel, L Marcus, H Savin, M Offarim, A Mashiah

{"title":"Specific removal of digoxin by hemoperfusion through agarose polyacrolein microsphere polyacrolein microsphere beads-antidigoxin antibodies (APAMB-AD).","authors":"S Margel, L Marcus, H Savin, M Offarim, A Mashiah","doi":"10.3109/10731198409118819","DOIUrl":"https://doi.org/10.3109/10731198409118819","url":null,"abstract":"The efficacy of a new, biocompatible, specific immunosorbent for hemoperfusive removal of digoxin is described. The sorbent contains antidigoxin antibodies covalently bound to polyacrolein microspheres, 0.2 mu diam. Thousands of microspheres are matrix-encapsulated in crosslinked agarose to form beads of 500 to 800 mu diam. Digoxin intoxicated dogs showed heart block, ventricular and atrial tachycardia and extended runs of PVCs. During hemoperfusion the abnormal ECG abated; at 2 h of hemoperfusion the ECG tracings returned to normal. Up to 25% of the total digoxin burden was removed. The numbers of the blood cells and the content of a battery of relevant soluble components of the blood remained constant. Dogs were alive and well after the hemoperfusion. Non hemoperfused dogs, which received antiarrythmic agents, did not survive the intoxication. This is the first report of a practical hemoperfusive system for the specific removal of digoxin from whole blood.","PeriodicalId":75597,"journal":{"name":"Biomaterials, medical devices, and artificial organs","volume":"12 1-2","pages":"25-36"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198409118819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17589127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Problems in the development of materials that are compatible with blood. 与血液相容的材料开发中的问题。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118838

L Vroman

引用次数: 18

Protein and platelet interaction with polymer surfaces--a comment. 蛋白质和血小板与聚合物表面的相互作用——评论。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118835

C P Sharma

引用次数: 1

Vein harvesting by long blunt and blind dissection. A standardized technique in the dog. 通过长钝和盲目的解剖获取静脉。狗的标准化技术。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118821

H Ben-Simhon, N Sheiner, J Borzone, R Guidoin

引用次数: 0

Tissue reaction to a failed Bion hip prosthesis in a dog. 狗的Bion髋关节假体失败后的组织反应。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118818

S D Cook, R C Anderson, H G French, R J Haddad

引用次数: 1

Electrode-biologic tissue interreactions at interfaces--a review. 电极-生物组织界面相互作用综述。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118831

P N Sawyer

引用次数: 15

Protein and platelet interactions with polymer surfaces. 蛋白质和血小板与聚合物表面的相互作用。

Biomaterials, medical devices, and artificial organs Pub Date : 1984-01-01 DOI: 10.3109/10731198409118834

D R Absolom, W Zingg, C J Van Oss, A W Neumann

引用次数: 11

Thrombogenicity and the interaction of proteins, platelets and white cells. 血栓形成性和蛋白质、血小板和白细胞的相互作用。

Biomaterials, medical devices, and artificial organs Pub Date : 1983-01-01 DOI: 10.3109/10731198309118795

J Long, S DeSantis, E Shors, M Uszler, C Wuest, S Klein, R White

{"title":"Thrombogenicity and the interaction of proteins, platelets and white cells.","authors":"J Long, S DeSantis, E Shors, M Uszler, C Wuest, S Klein, R White","doi":"10.3109/10731198309118795","DOIUrl":"https://doi.org/10.3109/10731198309118795","url":null,"abstract":"Radioactive labeled protein and platelet studies suggest that an ideal vascular surface absorbs albumin and prevents platelet adherence and aggregation. This study examines the interaction of serum and plasma proteins, white cells, and platelets in the thrombotic response to small internal diameter vascular prostheses. Thirty-seven replamineform silicone rubber vascular prostheses, 4 mm internal diameter and 6 cm length, had 5% aspirin and 5% theophylline by weight dispersed in a luminal coating (D); the remaining 37 control (C) prostheses had an identical silicone rubber coating without drugs. Scanning electron and darkfield microscopy confirmed similar surface topography in C and D grafts. One C and one D graft were studied in parallel using a modified canine arteriovenous fistula. Consistently, D prosthesis had increased bleeding through the graft wall. The 7 serum and 8 plasma experiments demonstrated greater accumulation on the D prostheses, the greatest deposition occurring within the first 30 minutes. In 8 platelet experiments, D grafts accumulated more radioactivity at both the 5 and 30 minute intervals. Six mononuclear and 8 PMN experiments had less accumulation on the D grafts at 15 minutes and no consistent difference at 60 minutes. Elution of C and D Grafts demonstrated significant drug levels in only the D grafts at the beginning of the experiments and after 15 minutes of exposure of blood. We conclude: (1) aspirin and theophylline have an effect on the initial interaction of plasma proteins, platelets and white cells in the thrombogenic response, (2) the effect diminishes as time released drug levels decrease.","PeriodicalId":75597,"journal":{"name":"Biomaterials, medical devices, and artificial organs","volume":"11 1","pages":"63-72"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198309118795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17671926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Cardiac and sinoaortic reflexes during aortic constriction in awake calves. 清醒小牛主动脉收缩时的心脏和窦主动脉反射。

Biomaterials, medical devices, and artificial organs Pub Date : 1983-01-01 DOI: 10.3109/10731198309118805

J E Chimoskey, B A Breuhaus, S W Ely

{"title":"Cardiac and sinoaortic reflexes during aortic constriction in awake calves.","authors":"J E Chimoskey, B A Breuhaus, S W Ely","doi":"10.3109/10731198309118805","DOIUrl":"https://doi.org/10.3109/10731198309118805","url":null,"abstract":"The hemodynamic responses to increased afterload of the left ventricle were studied in conscious calves before and during cooling of the cervical vagus nerves bilaterally. The calves were chronically instrumented to measure (or derive) heart rate, stroke volume, cardiac output, iliac, superior mesenteric and renal flows and resistances, mean aortic, right atrial, pulmonary artery, and left atrial pressures, the systemic and pulmonary pressure gradients, and total systemic and total pulmonary resistances. The calves were also instrumented to produce reversible partial constriction of the ascending aorta and for cooling of the cervical vagus nerves. The hemodynamic responses to increased afterload were characterized before and during bilateral cervical vagus nerve cooling to 6-7 degrees C. Aortic constriction causes stroke volume, cardiac output and aortic pulse pressure to decrease. Left atrial pressure and total peripheral resistance increase. Mean aortic pressure is constant during aortic constriction alone, despite a continued decrease in pulse pressure, due to a balance between sinoaortic reflexes which attempt to increase arterial pressure in response to the decreased pulse pressure and cardiopulmonary reflexes which attempt to decrease arterial pressure in response to the increased left atrial and cardiopulmonary pressures. Vagal cooling removes cardiopulmonary reflex modulation of the sinoaortic reflexes. During aortic constriction and vagal cooling, the carotid sinus reflex, acting alone, causes large increases in renal and total peripheral resistance and mean aortic pressure.","PeriodicalId":75597,"journal":{"name":"Biomaterials, medical devices, and artificial organs","volume":"11 2-3","pages":"175-95"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198309118805","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17721829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1