Protein and platelet interactions with polymer surfaces.

Abstract

An attempt is made to develop an understanding of the basic mechanism governing the interaction of the major blood proteins and cells with polymer surfaces with a focus on thermodynamic approach. It is believed that such investigations may be helpful to provide a rational for the design of suitable cardiovascular prosthetic materials and to choose materials in such a way that adsorption of certain proteins eg. 'fibrinogen' is thermodynamically unfavourable compared to adsorption of other proteins eg. 'albumin'.