Allergy, Asthma & Immunology Research最新文献

{"title":"Unmet Needs of Patients With Chronic Urticaria: A Survey in Korea.","authors":"Joonhong Min, Young Her, Ki Won Moon, Ji In Park, Sunmi Kim, Eun-Hee Cho, Kyu-Hyoung Lim, Jae-Woo Kwon","doi":"10.4168/aair.2023.15.6.837","DOIUrl":"10.4168/aair.2023.15.6.837","url":null,"abstract":"<p><p>Chronic urticaria (CU) is a common problem with a high disease burden that has a significant negative impact on quality of life. Many patients are undertreated, and awareness of management strategies is low among clinicians. The present study aimed to improve understanding of CU from the patients' perspective, including the disease burden and current healthcare system use. Adult patients who presented to our referral hospital for CU treatment completed self-report questionnaires about demographics, clinical characteristics of CU, the impact of CU on daily life, unmet needs, and the history of medical service usage. This self-report survey included 127 participants (females, 57.0%; mean age, 42.0 ± 13.6 years; mean CU duration, 1.8 ± 3.4 years); 51.6% reported frequent discomfort with CU in daily life, including 44.1% of those who reported a good response to medication. More than half of the respondents reported a depressed mood and anxiety. Although 46.4% of the respondents reported that urticaria completely disappeared while on medication, only 10% were satisfied with the CU management provided by primary care hospitals. The principal cause of dissatisfaction was that they did not know the cause of CU (68.4% of patients). In total, 55% of the patients visited 2 or more hospitals before presenting to our referral hospital and 6.3% had tried folk remedies. In conclusion, most patients report that CU is not adequately controlled. Therefore, in addition to appropriate medication, information on the cause of CU, long-term treatment plan, medication safety, and expected prognosis is required to meet patients' needs.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"837-845"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Ciliary Dyskinesia: A More Prevalent Disease Than Previously Believed?","authors":"Kyung Won Kim","doi":"10.4168/aair.2023.15.6.699","DOIUrl":"10.4168/aair.2023.15.6.699","url":null,"abstract":"","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"699-701"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Hum j 6, a Major Allergen From <i>Humulus japonicus</i> Pollen, the Primary Cause of Weed Pollinosis in East Asia.","authors":"Kyoung Yong Jeong, Minkyu Sang, Yong Seok Lee, Gabriele Gadermaier, Fatima Ferreira, Jung-Won Park","doi":"10.4168/aair.2023.15.6.767","DOIUrl":"10.4168/aair.2023.15.6.767","url":null,"abstract":"<p><strong>Purpose: </strong><i>Humulus japonicus</i> (<i>HJ</i>) is one of the most important causes of weed pollinosis in East Asia. The 10 kDa protein with pI 10 in 2-dimensional gel has been recognized as the representative major allergen of <i>HJ</i>, but its major allergens have not been characterized. This study aimed to characterize the major allergen of <i>HJ</i>.</p><p><strong>Methods: </strong>A major allergen in Japanese hop was detected by proteome analysis; it was purified to homogeneity and its sequence was obtained by transcriptome analysis. The recombinant proteins were produced in <i>Escherichia coli</i> and <i>Pichia</i> expression systems, and their immunoglobulin E (IgE) reactivities were compared to those of the natural counterpart. We also analyzed post-translational modifications such as glycosylation and phosphorylation.</p><p><strong>Results: </strong>Pectin methylesterase inhibitor, Hum j 6, was found to be the major allergen of <i>HJ</i>, and <i>in silico</i> signal peptide prediction corresponds to a 15.1 kDa protein with a theoretical pI of 8.28. Natural Hum j 6 was recognized by IgE antibodies from 86.4% (19/22) of <i>HJ</i> pollinosis patients, whereas the recombinant proteins did not show strong IgE reactivity. No glycosylation was detected, while at least 15 phosphorylated amino acids, possibly causing the pI and molecular weight shift, were detected by tandem mass spectrometry analysis.</p><p><strong>Conclusions: </strong>Hum j 6 was identified as the representative major allergen of <i>HJ</i> and seems to be modified significantly after translation. These findings are useful for the development of component-resolved diagnosis and immunotherapy.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"767-778"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study.","authors":"Mengru Zhang, Alyn H Morice, Fengli Si, Li Zhang, Qiang Chen, Shengyuan Wang, Yiqing Zhu, Xianghuai Xu, Li Yu, Zhongmin Qiu","doi":"10.4168/aair.2023.15.6.795","DOIUrl":"10.4168/aair.2023.15.6.795","url":null,"abstract":"<p><strong>Purpose: </strong>Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifestations, and long-term outcomes on a large series of consecutive RCC/UCC patients, providing a guideline-led real-world clinical experience.</p><p><strong>Methods: </strong>Retrospective baseline information was obtained from Clinical Research Database (January 2016 to May 2021). At least 6 months after the last clinic visit, included subjects were prospectively followed up.</p><p><strong>Results: </strong>Three hundred and sixty-nine RCC and UCC patients (199 females, 53.9%) were analyzed. The median cough duration was 24.0 (12.0-72.0) months. Laryngeal symptoms were reported in 95.9% of the patients. The common triggers for coughing were talking (74.9%), pungent odors (47.3%), eating (45.5%), and cold air (42.8%). RCC was considered in 38.2%, and the remainder of 228 patients had UCC, with an equal sex distribution (<i>P</i> = 0.66). Among the 141 RCCs, 90.8% (128) had refractory reflux cough, which was more responsive to current treatments (<i>P</i> < 0.01). Although most features and test results between RCC and UCC were similar, UCC was more commonly inappropriately treated (<i>P</i> < 0.01). Nineteen (7.7-41.1) months after the final clinic visit, 31.2% still coughed persistently, while 68.8% reported cough improvement or remission. RCC reported more favorable treatment outcomes (including cough improvement, control, and spontaneous remission) than UCC (<i>P</i> < 0.01). Coughs with long duration before the initial cough clinic visit (<i>P</i> < 0.01), frequent urinary incontinence (<i>P</i> < 0.01), and being sensitive to \"talking\" (<i>P</i> < 0.01) or \"cold air\" (<i>P</i> < 0.01) were less likely to be solved.</p><p><strong>Conclusions: </strong>The current treatments only improve cough symptoms in two-thirds of patients. Clinical indicators for treatment failure were those coughing for long duration and being sensitive to \"talking\" or \"cold air.\"</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"795-811"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Sublingual Immunotherapy using a Combination of Dermatophagoides Pteronyssinus and Blomia Tropicalis Extracts in Patients with Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial","authors":"Macedo Priscilla Rios Cordeiro, Moraes Priscila, Arruda Luisa Karla, Castro Fábio Fernandes Morato, Kalil Jorge, Santos Galvão Clóvis Eduardo","doi":"10.29328/journal.aaai.1001033","DOIUrl":"https://doi.org/10.29328/journal.aaai.1001033","url":null,"abstract":"The aim of this study was to evaluate the safety and efficacy of sublingual immunotherapy (SLIT) with extracts of Dermatophagoides pteronyssinus and Blomia tropicalis in patients with moderate/severe persistent allergic rhinitis (AR). Methods: This was a double-blind, randomized, placebo-controlled trial of SLIT for the treatment of house dust mite-induced AR. A total of 65 patients, aged between 12 and 60 years, were treated for 12 months and randomized into two groups: SLIT and placebo. The SLIT group received a combination of extracts containing Dermatophagoides pteronyssinus and Blomia tropicalis allergens. All had their sensitization confirmed by skin prick test or serum-specific IgE. Total Nasal Symptom Score, RQLQ quality of life questionnaire, current treatment, and need for medication to control symptoms were recorded during the study. Total serum IgE, serum specific IgE, and IgG4 levels to Der p 1 and Blo t were assessed at baseline, 6 and 12 months after treatment. Results: There was no significant difference in the number of adverse events between groups. The SLIT group showed a significant reduction in the consumption of antihistamines to control symptoms (p < 0.0001) when compared to placebo. There was no significant change in serum total IgE, serum specific IgE, and IgG4 to both allergens when comparing the SLIT and placebo groups. Conclusion: After one year, SLIT using a dose of 1 mcg of Der p 1/day and 753 UBE of Blo t/day proved to be effective and safe in controlling AR exacerbations.","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136238299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Issues in the Management of IgG Subclass Deficiencies in Adults With Chronic Respiratory Diseases.","authors":"Jae-Hyuk Jang,&nbsp;Joo-Hee Kim,&nbsp;Hae-Sim Park","doi":"10.4168/aair.2023.15.5.562","DOIUrl":"10.4168/aair.2023.15.5.562","url":null,"abstract":"<p><p>Primary immunodeficiency diseases (PIDs) are uncommon in adults; however, immunoglobulin G subclass deficiency (IGGSCD) is often found in a subset of adult patients with chronic respiratory diseases. As quantitative laboratory tests are used to diagnose IGGSCD, the clinical significance of IGGSCD remains controversial. However, respiratory infection is a common presenting feature of IGGSCD, and respiratory complications are responsible for subsequent morbidities, such as severe asthma, bronchiectasis, chronic obstructive airway diseases, and mortality. This review summarizes the current epidemiological data for PIDs, focusing on IGGSCD in the adult population. In addition, the investigation, treatment, and management strategies are detailed, including distinct issues faced by patients with chronic airway disease and their physicians in the proper diagnosis and treatment of IGGSCD.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 5","pages":"562-579"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/1b/aair-15-562.PMC10570785.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Chronic Rhinosinusitis on the Risk of Development of Rheumatoid Arthritis.","authors":"Il Hwan Lee,&nbsp;Hee Gyu Yang,&nbsp;Seung-Su Ha,&nbsp;Gil Myeong Son,&nbsp;Dae Woo Kim,&nbsp;Dong-Kyu Kim","doi":"10.4168/aair.2023.15.5.647","DOIUrl":"10.4168/aair.2023.15.5.647","url":null,"abstract":"<p><strong>Purpose: </strong>Several studies have reported a possible link between chronic rhinosinusitis (CRS) and rheumatoid arthritis (RA). However, it remains unclear whether CRS could influence the risk of developing RA. Therefore, in this study, we focused on examining the association between CRS and RA.</p><p><strong>Methods: </strong>A total of 14,867 individuals with CRS and 14,867 without CRS were enrolled after 1:1 propensity score match from a nationwide longitudinal cohort database in South Korea. RA incidence was assessed using person-years at risk, and the hazard ratio (HR) was examined using the Cox proportional hazards model.</p><p><strong>Results: </strong>The incidence of RA (per 1,000 person-years) was 6.51 for those with CRS, 6.55 for those with CRS without nasal polyps (CRSsNP), and 5.96 for those with CRS with nasal polyps (CRSwNP). We found that CRS individuals had a significantly increased risk of subsequent RA development with an adjusted HR of 1.41, regardless of the phenotype (adjusted HR was 1.42 in CRSsNP and 1.37 in CRSwNP patients). Moreover, the risk of developing RA over time was relatively higher within the first 4 years after the diagnosis of CRS.</p><p><strong>Conclusions: </strong>Our nationwide population-based cohort study suggests that CRS may be associated with a subsequent increase in RA events, regardless of the phenotype. Therefore, physicians should consider RA risk when diagnosing and treating CRS patients.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 5","pages":"647-658"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/80/aair-15-647.PMC10570781.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen Receptor-α Exacerbates EGF-Inducing Airway Remodeling and Mucus Production in Bronchial Epithelium of Asthmatics.","authors":"Lu Qin,&nbsp;Junqing Yue,&nbsp;Mingzhou Guo,&nbsp;Cong Zhang,&nbsp;Xiaoyu Fang,&nbsp;Shengding Zhang,&nbsp;Wenxue Bai,&nbsp;Xiansheng Liu,&nbsp;Min Xie","doi":"10.4168/aair.2023.15.5.614","DOIUrl":"10.4168/aair.2023.15.5.614","url":null,"abstract":"<p><strong>Purpose: </strong>Although estrogen receptors (ERs) signal pathways are involved in the pathogenesis and development of asthma, their expressions and effects remain controversial. This study aimed to investigate the expressions of ERα and ERβ as well as their mechanisms in airway remodeling and mucus production in asthma.</p><p><strong>Methods: </strong>The expressions of ERα and ERβ in the airway epithelial cells of bronchial biopsies and induced sputum cells were examined by immunohistochemistry. The associations of ERs expressions with airway inflammation and remodeling were evaluated in asthmatic patients. <i>In vitro</i>, the regulations of ERs expressions in human bronchial epithelial cell lines were examined using western blot analysis. The epidermal growth factor (EGF)-mediated ligand-independent activation of ERα and its effect on epithelial-mesenchymal transitions (EMTs) were investigated in asthmatic epithelial cells by western blot, immunofluorescent staining, and quantitative real-time polymerase chain reaction.</p><p><strong>Results: </strong>ERα and ERβ were expressed on both bronchial epithelial cells and induced sputum cells, and the expressions showed no sex difference. Compared to controls, male asthmatic patients had higher levels of ERα on the bronchial epithelium, and there were cell-specific expressions of ERα and ERβ in induced sputum. The expression of ERα in the airway epithelium was inversely correlated to forced expiratory volume in 1 second (FEV1) % and FEV1/forced vital capacity. Severe asthmatic patients had significantly greater levels of ERα in the airway epithelium than mild-moderate patients. ERα level was positively correlated with the thickness of the subepithelial basement membrane and airway epithelium. <i>In vitro</i>, co-stimulation of interleukin (IL)-4 and EGF increased the expression of ERα and promoted its nuclear translocation. EGF activated the phosphorylation of ERα via extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways. ERα knockdown alleviated EGF-mediated EMTs and mucus production in airway epithelial cells of asthma.</p><p><strong>Conclusions: </strong>ERα contributes to asthmatic airway remodeling and mucus production through the EGF-mediated ligand-independent pathway.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 5","pages":"614-635"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/47/aair-15-614.PMC10570787.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series of Chronic Spontaneous Urticaria After COVID-19 Vaccination.","authors":"Jeong-Hee Choi,&nbsp;Soo Jie Chung","doi":"10.4168/aair.2023.15.5.695","DOIUrl":"https://doi.org/10.4168/aair.2023.15.5.695","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) vaccines play an important role in overcoming the global COVID-19 pandemic. Various immediate or delayed types of cutaneous adverse reactions, such as local site reactions, urticaria, mobilliform rashes, and delayed large local reactions, have been noted after COVID-19 vaccination, which are usually treatable with time.1,2 Chronic spontaneous urticaria (CSU) is defined by recurrent hives lasting > 6 weeks.3 Some patients have developed CSU after COVID-19 vaccination.4-6 Here, we report 12 patients with CSU after COVID-19 vaccination in Korea. We describe the clinical characteristics, treatment, and prognosis of these patients.","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 5","pages":"695-698"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/c2/aair-15-695.PMC10570777.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Transcriptome and Epigenome Analysis Identifies the Pathogenic Features of Aspirin-Exacerbated Respiratory Disease.","authors":"Eun-Kyung Kwon,&nbsp;Tae-Wook Kang,&nbsp;Taeyun Oh,&nbsp;Oak-Sung Choo,&nbsp;Young-Min Ye,&nbsp;Hae-Sim Park,&nbsp;Ga-Young Ban","doi":"10.4168/aair.2023.15.5.682","DOIUrl":"10.4168/aair.2023.15.5.682","url":null,"abstract":"<p><p>Dysregulation of the arachidonic acid metabolic pathway is the most widely known pathomechanism of aspirin-exacerbated respiratory disease (AERD). This study aimed to perform integrative analysis of transcriptomic and epigenomic profiling with network analysis to determine the novel pathogenic features of AERD. Ten patients with asthma including 5 patients with AERD and another 5 patients with aspirin tolerant asthma (ATA) were enrolled. Nasal scraping was performed and nasal mucosa was used in omics profiling. Peripheral eosinophil counts, sputum eosinophil counts, fractional exhaled nitric oxide levels, and pulmonary function test results were evaluated. Differentially expressed genes (DEGs), differentially methylated probes (DMPs) and differentially correlated genes (DCGs) between patients with AERD and those with ATA were analyzed. Network analysis using ingenuity pathway analysis (IPA) was performed to determine the gene connection network and signaling pathways. In total, 1,736 DEGs, 1,401 DMPs, and 19 pairs for DCGs were identified. Among DCGs, genes related to vesicle transport (<i>e.g.</i>, <i>RAB3B</i> and <i>STX2</i>) and sphingolipid dysregulation (<i>e.g.</i>, <i>SMPD3</i>) were found to be hypo-methylated and up-regulated in AERD. Using the canonical pathway analysis of IPA with 78 asthma-related DEGs, signaling pathways of T helper cell differentiation/activation and Fcε receptor I were generated. Up-regulation of <i>RORγt</i> and <i>FcER1A</i> were noted in AERD. Gene expression levels of <i>RAB3B</i>, <i>SYNE1</i>, <i>STX2</i>, <i>SMPD3</i> and <i>RORγt</i> were significantly associated with sputum eosinophil counts. Quantitative real-time polymerase chain reaction was performed and mRNA expression levels of <i>STX2</i>, <i>SMPD3</i>, <i>RORγt</i>, and <i>FcER1A</i> were significantly higher in AERD compared to ATA. Distinct pathogenic features were identified by using integrative multi-omics data analysis in patients with AERD.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 5","pages":"682-694"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/63/aair-15-682.PMC10570783.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41188248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}