Hwa Young Lee, Da Woon Sim, Youngsoo Lee, So-Young Park, Sun-Kyung Lee, Hyun Lee, Min-Hye Kim, Ji-Su Shim, Sung-Yoon Kang, Ga-Young Ban, Young-Hee Nam, Joo-Hee Kim, Sook Young Lee, Chin Kook Rhee, Woo-Jung Song, Jae-Woo Kwon, Taehoon Lee, So Ri Kim, Heung-Woo Park, You Sook Cho, Young-Il Koh, Kwang-Ha Yoo, Byung-Jae Lee, Ho Joo Yoon, Hae-Sim Park, Sang-Heon Kim
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The baseline clinical characteristics, disease control status, and medication use of the patients were compared between elderly (≥ 65 years) and nonelderly groups.</p><p><strong>Results: </strong>Of the 864 patients with SA, 260 (30.1%) were in the elderly group. The elderly group had lower atopy rate, but had higher prevalence of chronic obstructive pulmonary disease (COPD), hypertension, and osteoporosis than did the nonelderly group. The elderly group had a lower rate of type 2 inflammation and lower levels of forced expiratory volume in 1 second (FEV1) (% predicted) and FEV1/forced vital capacity ratio than did the nonelderly group (<i>P</i> < 0.05 for all). However, asthma symptom scores and the frequency of asthma exacerbation were not significantly different between the 2 groups. Of controller medications, biologics were less frequently used in the elderly group (<i>P</i> < 0.05 for all).</p><p><strong>Conclusions: </strong>SA in the elderly is characterized by lower lung function, less type 2-low airway inflammation, and comorbidity with COPD. 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The baseline clinical characteristics, disease control status, and medication use of the patients were compared between elderly (≥ 65 years) and nonelderly groups.</p><p><strong>Results: </strong>Of the 864 patients with SA, 260 (30.1%) were in the elderly group. The elderly group had lower atopy rate, but had higher prevalence of chronic obstructive pulmonary disease (COPD), hypertension, and osteoporosis than did the nonelderly group. The elderly group had a lower rate of type 2 inflammation and lower levels of forced expiratory volume in 1 second (FEV1) (% predicted) and FEV1/forced vital capacity ratio than did the nonelderly group (<i>P</i> < 0.05 for all). However, asthma symptom scores and the frequency of asthma exacerbation were not significantly different between the 2 groups. 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引用次数: 0
摘要
目的:很少有研究将老年重症哮喘患者的临床特征与非老年患者的临床特征进行比较:很少有研究对老年重症哮喘(SA)患者与非老年患者的临床特征进行比较:我们分析了韩国哮喘登记处的数据,这是一项针对韩国哮喘患者的全国性真实世界观察研究。我们比较了老年组(≥ 65 岁)和非老年组患者的基线临床特征、疾病控制状况和药物使用情况:结果:在 864 名 SA 患者中,老年组有 260 人(30.1%)。与非老年组相比,老年组的阿特匹克发病率较低,但慢性阻塞性肺病(COPD)、高血压和骨质疏松症的发病率较高。与非老年组相比,老年组的 2 型炎症发生率较低,1 秒用力呼气容积(FEV1)(预测值%)和 FEV1/用力呼气容积比值也较低(P 均小于 0.05)。不过,两组患者的哮喘症状评分和哮喘加重频率并无明显差异。在控制药物中,生物制剂在老年组中的使用频率较低(P < 0.05):结论:老年人哮喘的特点是肺功能较低、2型气道炎症较少以及合并慢性阻塞性肺病。在实际临床实践中,老年 SA 患者的管理应考虑这些发现。
Characteristics of Severe Asthma in the Elderly: Observations From the Korean Severe Asthma Registry (KoSAR).
Purpose: Few studies have compared the clinical characteristics of severe asthma (SA) in elderly patients compared to that in nonelderly patients.
Methods: We analyzed data from the Korean SA Registry, a nationwide, real-world observational study of SA in Korea. The baseline clinical characteristics, disease control status, and medication use of the patients were compared between elderly (≥ 65 years) and nonelderly groups.
Results: Of the 864 patients with SA, 260 (30.1%) were in the elderly group. The elderly group had lower atopy rate, but had higher prevalence of chronic obstructive pulmonary disease (COPD), hypertension, and osteoporosis than did the nonelderly group. The elderly group had a lower rate of type 2 inflammation and lower levels of forced expiratory volume in 1 second (FEV1) (% predicted) and FEV1/forced vital capacity ratio than did the nonelderly group (P < 0.05 for all). However, asthma symptom scores and the frequency of asthma exacerbation were not significantly different between the 2 groups. Of controller medications, biologics were less frequently used in the elderly group (P < 0.05 for all).
Conclusions: SA in the elderly is characterized by lower lung function, less type 2-low airway inflammation, and comorbidity with COPD. These findings are being taken into consideration in the management of elderly patients with SA in real-world clinical practice.
期刊介绍:
The journal features cutting-edge original research, brief communications, and state-of-the-art reviews in the specialties of allergy, asthma, and immunology, including clinical and experimental studies and instructive case reports. Contemporary reviews summarize information on topics for researchers and physicians in the fields of allergy and immunology. As of January 2017, AAIR do not accept case reports. However, if it is a clinically important case, authors can submit it in the form of letter to the Editor. Editorials and letters to the Editor explore controversial issues and encourage further discussion among physicians dealing with allergy, immunology, pediatric respirology, and related medical fields. AAIR also features topics in practice and management and recent advances in equipment and techniques for clinicians concerned with clinical manifestations of allergies and pediatric respiratory diseases.