AIDS research and human retroviruses最新文献

{"title":"Adherence to Bone Mineral Density Screening Recommendations in Older Adults with HIV.","authors":"Madison Martz, Nazar Akhverdyan, Melissa P Wilson, Jacob Walker, Sarah Gorvetzian, Lakshmi Chauhan, Kristine M Erlandson","doi":"10.1089/aid.2025.0009","DOIUrl":"10.1089/aid.2025.0009","url":null,"abstract":"<p><p>HIV guidelines recommend bone mineral density (BMD) screening by dual-energy x-ray absorptiometry (DXA) for all postmenopausal women and all men ≥50 years, but uptake of these recommendations has been low. We conducted a retrospective cross-sectional analysis of people with HIV (PWH) aged ≥65 or older engaged in routine care to determine DXA completion. We reviewed records of 300 patients (243 men; 57 women). 48% had a DXA scan ordered, and 85% of those with a DXA order had results available within the electronic record. Of those screened, 13% of women and 27% of men had normal BMD; 45% of women and 53% of men had osteopenia; and 42% of women and 20% of men had osteoporosis. Older PWH at the highest fracture risk were under-screened for low BMD, per current HIV guidelines. Improved fracture risk screening is needed for this high-risk patient population.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"419-422"},"PeriodicalIF":1.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Analysis of HIV Burden in India and Its States Over Three Decades: Insights from the Global Burden of Disease Study 2019.","authors":"Deepak Dhamnetiya, Tanishq Hitesh, Ravi Prakash Jha, Ritik Goyal","doi":"10.1089/aid.2025.0018","DOIUrl":"10.1089/aid.2025.0018","url":null,"abstract":"<p><p>Acquired immunodeficiency syndrome (AIDS) is a group of disorders caused by the human immunodeficiency virus (HIV). Globally, 1.7 million people became newly infected with HIV in 2019. This study aims to assess trends in HIV burden in India and its states from 1990 to 2019 for tracking the progress of the National AIDS Control Program (NACP). This study assesses the burden of HIV in India and its states from 1990 to 2019, using data on incidence, prevalence, mortality, and disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) study. The data are presented as age-standardized rates per 100,000 inhabitants, along with corresponding uncertainty intervals (95% UI) and the relative percentage change. Globally, there was a decrease in the age-standardized incidence rate of HIV from 37.59 cases per 100,000 in 1990 to 25.24 cases per 100,000 in 2019. However, in India, it increased from 3.43 cases per 100,000 to 5.01 cases per 100,000 during the same period. There was an increase in both HIV prevalence and HIV-related death rates in India and globally. The increases in estimates were smaller for the rest of the world compared to India. In India, age-standardized incidence, prevalence, mortality, and DALY rates of HIV were reportedly higher in males vis-à-vis females for all years between 1990 and 2019. Age-standardized HIV prevalence, HIV-associated mortality, and DALYs increased globally and in India from 1990 to 2019. Incidence increased in India, while it decreased globally during the same period. To identify bottlenecks in the current NACP recommendations, a multicentric study is needed.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"433-441"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking HIV-1 Genetic Epidemiological Characteristics Among Recent Infections in Yunnan, China.","authors":"Haoru Yang, Xiaomei Jin, Huichao Chen, Lijuan Dong, Jie Dai, Min Yang, Chaojun Yang, Yu Han, Yuhua Shi, Yanling Ma, Manhong Jia, Min Chen","doi":"10.1089/aid.2025.0021","DOIUrl":"10.1089/aid.2025.0021","url":null,"abstract":"<p><p>Yunnan Province is one of the provinces in China severely affected by HIV-1. To track the evolution and epidemiological characteristics of HIV-1 genetics in Yunnan Province, this study conducted a retrospective molecular epidemiological study of HIV-1 in new infections in Yunnan Province. From the newly reported HIV-infected individuals throughout Yunnan Province from January to March 2018, cases with CD4⁺ T lymphocytes less than 200 cells/µL were excluded for BED capture enzyme immunoassay (BED-CEIA). Samples identified as recent infections by BED-CEIA were subjected to viral gene amplification to analyze the distribution characteristics of HIV-1 genotypes and the prevalence of pretreatment resistance. Of the 1,740 samples tested by BED-CEIA, 448 were identified as newly infected, and 323 were successfully genotyped; 14 HIV-1 genotypes were identified, including 2 subtypes, 11 circulating recombinant forms (CRFs), and several unique recombinant forms (URFs), of which CRF08_BC (37. 5%, 121/323), CRF07_BC (22.6%, 73/323), URFs (18.3%, 59/323), and CRF01_AE (14.9%, 48/323) were the predominant genotypes. CRF08_BC had higher proportions in the northeastern, southeastern, central, and southwestern regions of Yunnan Province than in the northwestern region and was more common in the 40-49-year age group, married, and heterosexual contacts. CRF01_AE had significantly higher proportions in the southeastern and northwestern regions and among those with homosexual contact, whereas no significant correlations were found for CRF07_BC and URFs. The overall prevalence of pretreatment resistance was 8.5% [95% confidence interval (CI): 5.5%-12.4%], with the highest proportion of resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs; 6.0%, 95% CI: 3.5%-9.4%). This study demonstrated the genetic diversity and regional and subpopulation distribution characteristics of the recently infected HIV-1 population in Yunnan Province, and that pretreatment resistance was at a moderate level, but resistance to NNRTIs needs attention. This study provided the baseline data for a systematic study of the evolution of HIV-1 genetics in a typical endemic area.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"389-399"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Signatures of Immune Recovery in People Living with HIV on Long-Term Contemporary Antiretroviral Therapy.","authors":"Damian Vangelov, Radoslava Emilova, Yana Todorova, Ivailo Alexiev, Nina Yancheva, Suresh J Gadher, Maria Nikolova","doi":"10.1089/aid.2024.0111","DOIUrl":"10.1089/aid.2024.0111","url":null,"abstract":"<p><p>The advances in antiretroviral therapy (ART) bring forth an ever-growing percentage of aging people living with HIV (PLHIV) with successful immune restoration (SIR) but increased comorbidities and reduced quality of life. The current criteria for SIR, CD4 absolute count (AC) >500 cells/µL, are proving not to be sufficiently informative enough for preventing or monitoring these unwelcome changes. Messenger RNA (mRNA) of genes, such as CXCL8, IL-6, and CSF-2, that have shown relations with HIV/HIV-associated comorbidities could represent early indicators of increase in viral load and/or pathological changes leading development of comorbidities. Our results display an underexpression of CXCL8 and IL-6 in ART+ PLHIV with CD4 AC >1,000, but not with CD4 AC <1,000, compared to ART-PLHIV and lower levels of CSF-2 mRNA in ART+ CD4 AC >1,000 compared to ART+ CD4 AC <1,000. Taken together, these findings indicate the need to stratify and expand HIV monitoring beyond CD4 AC >500.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"414-417"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Sometimes They Exclude Us because of Our Age-That's Not Right\": Perceptions of HIV Cure Research Among Diverse Long-Term Survivors in the United States.","authors":"Ali Ahmed, Jeff Taylor, Sithara Deshan Diunugala, Rachel Lau, Joyce Ching-Jung Lai, Michael Louella, Jeff Berry, Tricia H Burdo, Michael J Peluso, Lynda Dee, Karine Dubé","doi":"10.1089/aid.2024.0117","DOIUrl":"10.1089/aid.2024.0117","url":null,"abstract":"<p><p>HIV cure research has advanced, utilizing analytical treatment interruption (ATI) as a research tool alongside therapeutic strategies such as latency-reversing agents, block and lock strategies, immune-based therapies, cell and gene therapies, and combination approaches to overcome viral persistence. While promising, participation in cure trials remains limited, particularly for long-term survivors (LTS) who have lived with HIV for decades. Many LTS are willing to participate but face barriers such as age-based exclusions, comorbidities, and trial design constraints. With over half of the people with HIV in the United States aged 50 or older, addressing these barriers is crucial to designing inclusive, equitable, and representative cure trials. We conducted 32 semi-structured interviews with LTS of HIV, aged 60 years and older, recruited through community-based organizations and research networks across the United States. Participants were diverse in age, sex, gender, race, and ethnicity. We transcribed, anonymized, and analyzed interviews thematically. Most participants expressed a willingness to participate in HIV cure research, driven by a sense of responsibility and hope for future generations. However, concerns were raised about age-based exclusions from HIV cure trials, which many participants viewed as unjust given their long-term experience with HIV and commitment to finding a cure that could potentially benefit people of their age. Additional concerns included the risks of ATIs, such as viral rebound and the development of viral resistance, along with logistical challenges, including transportation and invasiveness of certain procedures. Despite these barriers, most LTS indicated they would participate in HIV cure trials if researchers addressed their concerns about safety, accessibility, and inclusion. LTS emphasized the need for transparent communication, clear informed consent, and flexible trial designs that accommodate their needs. By addressing these concerns, researchers can engage LTS more meaningfully in HIV cure research, enriching the field and promoting more inclusive and ethical study designs.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"373-388"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Markers and Immunological Trajectories in a Cohort of Patients with HIV and Hepatitis C Virus Coinfection Treated with Direct-Acting Antivirals.","authors":"Gina Simoncini, Jun Li, Cynthia Mayer, Lauren F Collins, Linda Battalora, Kate Buchacz","doi":"10.1089/aid.2025.0001","DOIUrl":"10.1089/aid.2025.0001","url":null,"abstract":"<p><p>Persons with HIV (PWH) have disproportionate hepatitis C virus (HCV) infection prevalence and liver-related morbidity and mortality. These sequelae may be alleviated by curative direct-acting antiviral (DAA) treatment; however, longitudinal effects of DAAs on clinical biomarkers are not well-characterized. We included PWH enrolled in the HIV Outpatient Study (HOPS) who were prescribed DAAs and DAA-naïve PWH of comparable age, sex, race/ethnicity, and fibrosis-4 (FIB-4) profiles. We contrasted the DAA effect on longitudinal trajectories of immunological and hepatic markers using generalized linear mixed models (GLMM) from 2010 to 2020. Of 347 PWH/HCV coinfection, median age was 53.8 years, 30.5% were women, 67.1% were publicly insured, 44.4% were non-Hispanic Black, and 153 (44.1%) were prescribed DAAs (median follow-up = 3.55 years). In multivariable GLMM analysis, DAA treatment was associated with [mean (95% confidence interval)] faster decline in alanine aminotransferase of -7.86 mu/µL/year (-15.39, -0.33) and faster increase in platelets of 6.99 mu/µL/year (2.89, 11.09). Changes in aspartate aminotransferase were comparable between groups. FIB-4 decreased in the DAA-treated but not the DAA-naïve group: -0.26 (-0.41, -0.11) versus 0.02 (-0.16, 0.20)/year, respectively. There was a faster increase in cluster of differentiation (CD)4 count of 0.05 (0.03-0.08) and CD8 count of 0.04 (0.02-0.07) log cells/mL/year in the DAA-treated compared with the DAA-naïve group (<i>p</i> < .001), but not in the CD4/CD8 ratio (<i>p</i> = .36). Among U.S. PWH/HCV coinfection treated with DAAs, we found modest changes in immunological markers and substantial improvements in hepatic markers modeled over 4 years of DAA treatment. Curative DAA treatment is critical to mitigate advanced liver fibrosis.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"400-410"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Reprogramming of Peripheral Eosinophils in Lentivirus-Infected Rhesus Macaques.","authors":"Rhianna Jones, Ameera Afifi, R Keith Reeves, Cordelia Manickam","doi":"10.1089/aid.2024.0105","DOIUrl":"10.1089/aid.2024.0105","url":null,"abstract":"<p><p>As innate immune cells, granulocytic eosinophils form part of the first line of defense against pathogens. While recent studies indicate that granulocytes have additional functions including anti-inflammatory roles, tissue homeostasis maintenance, remodeling, and trained innate immune memory, they remain understudied in viral infections, specifically in human immunodeficiency virus (HIV) infection. Using a rhesus macaque model of simian-human immunodeficiency virus (SHIV) infection, we evaluated the functional responses of peripheral granulocytes using a newly developed whole blood intracellular cytokine staining assay. We observed elevated secretion of interleukin 8 and reduced secretion of tumor necrosis factor α in peripheral eosinophils from SHIV-infected animals stimulated with lipopolysaccharide compared to experimentally naive animals. Our data suggest potential functional skewing of peripheral eosinophils towards an enhanced effector response against secondary stimuli, warranting further investigation into the mechanistic understanding of granulocyte functions to inform developing HIV therapeutics.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"411-413"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between the History of Switching Antiretroviral Therapy Regimens and Lipid Profile in People Living with HIV: A Retrospective Study.","authors":"Lei Wang, Mingzhe Yan, Reyisaimu Wumaierjiang, Qiqi Zhang, Jie Xiang, Yong Feng, Rui Li","doi":"10.1089/aid.2024.0079","DOIUrl":"10.1089/aid.2024.0079","url":null,"abstract":"<p><p>It remains unclear whether the history of switching antiretroviral therapy (ART) regimens is a stand-alone risk factor for lipid deterioration in people living with HIV (PLWH). This study aims to explore the relationship between ART regimen switching history and lipid profiles in PLWH. This is a retrospective analysis of data from individuals with HIV infection aged 16-82, enrolled at Jinyintan Hospital in Wuhan, China, between January 2018 and June 2022. We investigated the potential link between their history of switching ART regimens and their lipid profiles. Locally weighted scatter plot smoother (LOESS) curves were used to depict the dynamic changes in lipid profiles over time. Linear mixed-effects models were employed to assess the differences in lipid levels between individuals with and without a history of ART switches. Out of 708 patients with HIV who began ART between January 2018 and June 2022, 207 (29%) switched regimens at least once, while 501 (71%) remained on their initial regimen throughout the study. Individuals with a history of switching ART exhibited less favorable lipid profiles as identified by LOESS analysis. Linear mixed-effects models indicate that participants who had not previously altered their ART regimens displayed notably lower levels of total cholesterol to high-density lipoprotein (HDL) ratio, total cholesterol, and triglycerides compared to those with a history of ART regimen changes (total cholesterol to HDL ratio, difference -0.19, 95% CI: -0.34 to -0.04; total cholesterol, difference -0.13, 95% CI: -0.25 to 0.00; triglycerides, difference -0.27, 95% CI: -0.43 to -0.11). In contrast, individuals with a history of ART regimen switching had noticeably lower HDL cholesterol (HDL-C) levels [difference: 0.04; 95% confidence intervals (CI) 0.00 to 0.07]. This means that the history of switching ART regimens may be associated with lipid deterioration in PLWH.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"357-365"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Two Novel HIV-1 Unique Recombinant Forms Among Men Who Have Sex with Men in Northern China.","authors":"Huan Li, Qi Guo, Yi Feng, Lingjie Liao, Qi Li, Hui Xing, Zheng Wang","doi":"10.1089/aid.2024.0131","DOIUrl":"10.1089/aid.2024.0131","url":null,"abstract":"<p><p>Although HIV-1 infection has now become a treatable chronic condition and not the deadly illness it once was, the costs of that treatment are substantial, and each infection prevented saves both financial and other costs. In China, the most predominant subtypes are CRF07_BC, CRF01_AE, and CRF55_01B, and the various second-generation recombinants are produced from the recombination between these subtypes. HIV full-length genome sequences can provide important information on their epidemiology. In this study, we identified two unique recombinant forms (URFs) designated as JLCC230106 and XJWQ230011, which are composed of CRF01_AE/CRF07_BC and CRF07_BC/CRF55_01B, respectively. Phylogenetic and recombinant analyses utilizing near-full-length genome (NFLG) confirmed that these URFs originated from CRF01_AE/CRF07_BC and CRF07_BC/CRF55_01B strains. The emergence of novel recombinants is increasing the genetic diversity of HIV in China. This information can be shared with clinicians, human behavior specialists, or public health policymakers and used as an aid in discovering which methods are best or most cost-effective in combating the spread of HIV.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"366-371"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indicators for Increased Likelihood of Epidemic Kaposi Sarcoma Progression After Antiretroviral Therapy Initiation.","authors":"David J Nolan, Gary B Fogel, Jonathan DaRoza, Rebecca Rose, Paige M Bracci, Susanna L Lamers, Michael S McGrath","doi":"10.1089/aid.2025.0007","DOIUrl":"10.1089/aid.2025.0007","url":null,"abstract":"<p><p>Kaposi sarcoma (KS) is a common malignancy for people living with HIV (PLWH), despite antiretroviral therapy (ART). Curiously, even with improved CD4⁺ T-cell counts and low viral loads following ART, some PLWH with KS may still experience KS progression or even death and require adjuvant chemotherapy to manage their KS. The factors associated with persistent or unresponsive KS after ART initiation remain poorly characterized, and biomarkers to identify patients at risk of KS progression are needed, particularly in resource-limited areas where access to chemotherapy is limited. Here we analyzed baseline KS tumor biopsies from PLWH with KS who required chemotherapy due to unresolved KS after ART initiation and those who did not require chemotherapy after ART initiation. By examining participant metadata and viral copy number for Kaposi sarcoma-associated herpesvirus (KSHV), HIV, cytomegalovirus, and Epstein-Barr virus and KSHV gene expression in the tumor biopsies prior to ART initiation, we identified a model of factors associated with KS progression after ART initiation, including biological sex, age, and the log ratio of KSHV/HIV copy number in the tumor. We believe that the ratio of KSHV/HIV may be linked to the cell types that each virus infects, and future work exploring the relationship between tumor and immune cells in the baseline tumors is planned. Innovation would be necessary to reduce costs and simplify the viral quantification assays, enabling the translation of these findings into routine clinical care, particularly in resource-limited settings.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"348-356"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}