Xuanhe Zhao, Zhixia Chen, Jian Du, Haoxi Shi, Sisi Chen, Weiguang Fan
{"title":"Sequence Notes: Genomic Characterization of Two Novel HIV-1 Recombinant Forms (B/C) Among Men Who Have Sex with Men in Hebei, China.","authors":"Xuanhe Zhao, Zhixia Chen, Jian Du, Haoxi Shi, Sisi Chen, Weiguang Fan","doi":"10.1177/08892229251359663","DOIUrl":"https://doi.org/10.1177/08892229251359663","url":null,"abstract":"<p><p>The genetic diversity of HIV-1, driven by mutation and recombination, poses significant challenges to prevention and control efforts, particularly in regions like China where multiple subtypes and circulating recombinant forms co-circulate. Men who have sex with men (MSM) represent a key population for the emergence of novel recombinants. This study characterizes two novel unique recombinant forms (URFs) identified within the MSM population in Hebei, China. Viral RNA extraction, amplification, and near full-length genome (NFLG) sequencing were performed. Phylogenetic analysis based on NFLG alignments was conducted in MEGA 6 under the Kimura 2-parameter model with 1,000 bootstrap replicates. Recombination was assessed using the Recombinant Identification Program and SimPlot v3.5.1. Breakpoint-defined regions were phylogenetically analyzed, and recombination maps were generated. Phylogenetic and recombinant analysis based on NFLG sequences (designated BDL061 and BDL071) revealed that they originated from subtypes B and C. BDL061 exhibited a predominantly subtype B backbone with interspersed subtype C segments, while BDL071 displayed a predominantly subtype C backbone with subtype B segments. Phylogenetic analysis of recombinant segments strongly supported (bootstrap >90%) subtype B and C parental origins for the respective fragments. We report the identification and characterization of two phylogenetically distinct, novel HIV-1B/C URFs (BDL061 and BDL071) among MSM in Hebei, China. Their unique mosaic structures, differing predominant backbones, and confirmation as novel recombinants underscore the ongoing evolution and increasing complexity of the HIV-1 epidemic within this high-risk population in China. These findings highlight the critical need for NFLG-based surveillance to accurately track viral diversity and inform public health strategies.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comprehensive Cardiovascular Risk Profiling in People Living with HIV: Insights from the Japanese Adverse Drug Event Report Database.","authors":"Shigeru Hasebe, Masayuki Tanaka, Shiori Iwane, Toshikazu Tsuji, Hiroyuki Kushida, Maho Kikuta","doi":"10.1177/08892229251359555","DOIUrl":"https://doi.org/10.1177/08892229251359555","url":null,"abstract":"<p><p>Antiretroviral therapy (ART) has dramatically improved outcomes for people living with HIV (PLWH), yet concerns about cardiovascular disease (CVD) remain, especially in aging populations. In this study, we aimed to evaluate the association between ART regimens and CVD events in Japan using a nationwide pharmacovigilance database. We retrospectively analyzed reports from the Japanese Adverse Drug Event Report Database spanning April 2004 to September 2024. After removing duplicates and records with key missing data, 796,402 reports (Population A) were used for signal detection based on the reporting odds ratio (ROR) and information component (IC). A refined subset (Population B; 2,721 reports) underwent logistic regression to identify risk factors for major adverse cardiovascular events (MACE) and total cardiovascular events (MACE plus angina). ART regimen classes (e.g., integrase strand transfer inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors) and backbone therapies [e.g., abacavir (ABC)/lamivudine] were included in the analysis. Signal detection revealed significant ABC signals in both ROR and IC analyses for MACE and total CVD events. In logistic regression, advanced age (≥70 years), ABC-containing regimens, and diabetes emerged as independent risk factors for MACE and total CVD events. Dyslipidemia and hypertension were not significant in the adjusted models. Our findings underscore a potentially heightened cardiovascular risk associated with ABC, particularly in older PLWH or those with diabetes. These results highlight the need to consider individual CVD risk profiles when selecting ART regimens and reinforce the importance of ongoing pharmacovigilance to guide safer, more personalized treatment strategies worldwide.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Causal Relationship Between Matrix Metalloproteinase with Their Tissue Inhibitors and Human Immunodeficiency Virus Infection: A Two-Sample Bidirectional Mendelian Randomization Analysis.","authors":"Chao Guo, Yushan Zhang, Xiujuan Li, Yujing Duan","doi":"10.1177/08892229251359534","DOIUrl":"https://doi.org/10.1177/08892229251359534","url":null,"abstract":"<p><p>Studies have shown an association between matrix metalloproteinases (MMPs) along with tissue inhibitors of MMPs (TIMP) and human immunodeficiency virus (HIV) infection and CD4<sup>+</sup> T cell count, a key clinical indicator for HIV progression, but the causality remains unclear. This study aimed to investigate the bidirectional causal relationship between MMPs/TIMP and HIV. A genome-wide association study-based two-sample bidirectional Mendelian randomization (MR) analysis was conducted to elucidate the potential causal links between MMPs/TIMP and HIV. This approach utilized robust estimators, including inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode. Furthermore, sensitivity analyses including Cochran's Q, MR-Egger, leave-one-out, and MR pleiotropy residual sum and outlier (MR-PRESSO) tests were employed to assess heterogeneity and pleiotropic effects. The IVW analysis in the forward MR study indicated that genetically predicted levels of MMP-3 [odds ratio or OR (95% confidence interval or CI) = 0.69 (0.47-1), <i>p</i> = .047], MMP-20 [OR (95% CI) = 0.64 (0.43-0.97), <i>p</i> = .035], and TIMP-2 [OR (95% CI) = 0.68 (0.47-0.97), <i>p</i> = .034] were potentially associated with a lower risk of HIV. MMP-13 exhibited a genetically predicted association with a higher risk of HIV [OR (95% CI) = 2 (1.17-3.41), <i>p</i> = .011]. Additionally, MMP-19 demonstrated a genetic association with CD4<sup>+</sup> T cell absolute count [OR (95% CI) = 0.90 (0.81-1.00), <i>p</i> = .042). The reverse MR analysis indicated that genetically predicted liability to HIV was associated with a higher level of MMP-1 [OR (95% CI) = 1.04 (1.01-1.08), <i>p</i> = .024]. Heterogeneity and horizontal pleiotropy were found between MMP-9 and HIV by Cochran's Q test and MR-Egger, but MR-PRESSO indicated no outliers. This study revealed a complex MMPs-TIMPs interplay influencing HIV risk. Future research should clarify underlying mechanisms.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Wang, Mingzhe Yan, Reyisaimu Wumaierjiang, Qiqi Zhang, Jie Xiang, Yong Feng, Rui Li
{"title":"The Association Between the History of Switching Antiretroviral Therapy Regimens and Lipid Profile in People Living with HIV: A Retrospective Study.","authors":"Lei Wang, Mingzhe Yan, Reyisaimu Wumaierjiang, Qiqi Zhang, Jie Xiang, Yong Feng, Rui Li","doi":"10.1089/aid.2024.0079","DOIUrl":"10.1089/aid.2024.0079","url":null,"abstract":"<p><p>It remains unclear whether the history of switching antiretroviral therapy (ART) regimens is a stand-alone risk factor for lipid deterioration in people living with HIV (PLWH). This study aims to explore the relationship between ART regimen switching history and lipid profiles in PLWH. This is a retrospective analysis of data from individuals with HIV infection aged 16-82, enrolled at Jinyintan Hospital in Wuhan, China, between January 2018 and June 2022. We investigated the potential link between their history of switching ART regimens and their lipid profiles. Locally weighted scatter plot smoother (LOESS) curves were used to depict the dynamic changes in lipid profiles over time. Linear mixed-effects models were employed to assess the differences in lipid levels between individuals with and without a history of ART switches. Out of 708 patients with HIV who began ART between January 2018 and June 2022, 207 (29%) switched regimens at least once, while 501 (71%) remained on their initial regimen throughout the study. Individuals with a history of switching ART exhibited less favorable lipid profiles as identified by LOESS analysis. Linear mixed-effects models indicate that participants who had not previously altered their ART regimens displayed notably lower levels of total cholesterol to high-density lipoprotein (HDL) ratio, total cholesterol, and triglycerides compared to those with a history of ART regimen changes (total cholesterol to HDL ratio, difference -0.19, 95% CI: -0.34 to -0.04; total cholesterol, difference -0.13, 95% CI: -0.25 to 0.00; triglycerides, difference -0.27, 95% CI: -0.43 to -0.11). In contrast, individuals with a history of ART regimen switching had noticeably lower HDL cholesterol (HDL-C) levels [difference: 0.04; 95% confidence intervals (CI) 0.00 to 0.07]. This means that the history of switching ART regimens may be associated with lipid deterioration in PLWH.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"357-365"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huan Li, Qi Guo, Yi Feng, Lingjie Liao, Qi Li, Hui Xing, Zheng Wang
{"title":"Identification of Two Novel HIV-1 Unique Recombinant Forms Among Men Who Have Sex with Men in Northern China.","authors":"Huan Li, Qi Guo, Yi Feng, Lingjie Liao, Qi Li, Hui Xing, Zheng Wang","doi":"10.1089/aid.2024.0131","DOIUrl":"10.1089/aid.2024.0131","url":null,"abstract":"<p><p>Although HIV-1 infection has now become a treatable chronic condition and not the deadly illness it once was, the costs of that treatment are substantial, and each infection prevented saves both financial and other costs. In China, the most predominant subtypes are CRF07_BC, CRF01_AE, and CRF55_01B, and the various second-generation recombinants are produced from the recombination between these subtypes. HIV full-length genome sequences can provide important information on their epidemiology. In this study, we identified two unique recombinant forms (URFs) designated as JLCC230106 and XJWQ230011, which are composed of CRF01_AE/CRF07_BC and CRF07_BC/CRF55_01B, respectively. Phylogenetic and recombinant analyses utilizing near-full-length genome (NFLG) confirmed that these URFs originated from CRF01_AE/CRF07_BC and CRF07_BC/CRF55_01B strains. The emergence of novel recombinants is increasing the genetic diversity of HIV in China. This information can be shared with clinicians, human behavior specialists, or public health policymakers and used as an aid in discovering which methods are best or most cost-effective in combating the spread of HIV.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"366-371"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David J Nolan, Gary B Fogel, Jonathan DaRoza, Rebecca Rose, Paige M Bracci, Susanna L Lamers, Michael S McGrath
{"title":"Indicators for Increased Likelihood of Epidemic Kaposi Sarcoma Progression After Antiretroviral Therapy Initiation.","authors":"David J Nolan, Gary B Fogel, Jonathan DaRoza, Rebecca Rose, Paige M Bracci, Susanna L Lamers, Michael S McGrath","doi":"10.1089/aid.2025.0007","DOIUrl":"10.1089/aid.2025.0007","url":null,"abstract":"<p><p>Kaposi sarcoma (KS) is a common malignancy for people living with HIV (PLWH), despite antiretroviral therapy (ART). Curiously, even with improved CD4<sup>+</sup> T-cell counts and low viral loads following ART, some PLWH with KS may still experience KS progression or even death and require adjuvant chemotherapy to manage their KS. The factors associated with persistent or unresponsive KS after ART initiation remain poorly characterized, and biomarkers to identify patients at risk of KS progression are needed, particularly in resource-limited areas where access to chemotherapy is limited. Here we analyzed baseline KS tumor biopsies from PLWH with KS who required chemotherapy due to unresolved KS after ART initiation and those who did not require chemotherapy after ART initiation. By examining participant metadata and viral copy number for Kaposi sarcoma-associated herpesvirus (KSHV), HIV, cytomegalovirus, and Epstein-Barr virus and KSHV gene expression in the tumor biopsies prior to ART initiation, we identified a model of factors associated with KS progression after ART initiation, including biological sex, age, and the log ratio of KSHV/HIV copy number in the tumor. We believe that the ratio of KSHV/HIV may be linked to the cell types that each virus infects, and future work exploring the relationship between tumor and immune cells in the baseline tumors is planned. Innovation would be necessary to reduce costs and simplify the viral quantification assays, enabling the translation of these findings into routine clinical care, particularly in resource-limited settings.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"348-356"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Body Fluid Biomarkers of Neurological Injury in HIV-1-Associated Neurocognitive Disorder.","authors":"Meijuan Yang, Xiaomei Zhang, Dong Zhang, Yamin Zhang, Jiamei Wang, Yi Zhang, Cheng Gu, Xingwang Zhang, Lianhua Wei","doi":"10.1089/aid.2024.0053","DOIUrl":"10.1089/aid.2024.0053","url":null,"abstract":"<p><p>Since combined antiretroviral therapy for human immunodeficiency virus-associated neurocognitive dysfunction (HAND) only slows the disease's progression, early identification and timely intervention are crucial for effective therapy. In this article, we review the latest evidence in body fluid biomarkers of HAND, providing an overview of research conducted on cerebrospinal fluid and blood samples to draw conclusions on promising biomarkers. Although the significance of biomarkers such as amyloid metabolites, tau proteins, neurofilament light chain, myelin oligodendrocyte glycoprotein, and brain-derived neurotrophic factor in the early detection of HAND may not be immediately clear, they could potentially play a crucial role in evaluating prognosis and tracking the effectiveness of treatment.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"327-337"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingji Lan, Zhiman Xie, Qin Cao, Chen Mai, Liping Cheng, Huan Ning, Qianqian Huang, Zhuoxin Li, Ping Cui, Li Ye, Hao Liang, Jiegang Huang
{"title":"Severe Anemia Is an Independent Risk Factor for In-Hospital Death in Persons Living with HIV in Southern China: A Retrospective Cohort Study.","authors":"Yingji Lan, Zhiman Xie, Qin Cao, Chen Mai, Liping Cheng, Huan Ning, Qianqian Huang, Zhuoxin Li, Ping Cui, Li Ye, Hao Liang, Jiegang Huang","doi":"10.1089/aid.2024.0095","DOIUrl":"10.1089/aid.2024.0095","url":null,"abstract":"<p><p>To assess the impact of anemia severity during antiretroviral therapy (ART) on in-hospital mortality among persons living with HIV. We conducted a retrospective cohort study of hospitalized persons living with HIV at the Fourth People's Hospital of Nanning, Guangxi, China, from 2018 to 2020. Kaplan-Meier analysis was used to calculate cumulative mortality rates. The Cox proportional hazards model, 1:1:1 propensity score matching (PSM), and three-group inverse probability of treatment weighting (IPTW) were used to assess the impact of anemia severity on mortality in hospitalized persons living with HIV. A total of 2,217 hospitalized persons living with HIV were included, among whom 409 (18.4%) had anemia: 50 (2.3%) with mild anemia, 174 (7.8%) with moderate anemia, and 185 (8.3%) with severe anemia. Among all AIDS-related complications, patients with severe anemia had a higher mortality rate [20.34/100 person-months, 95% confidence interval (CI): 13.29-27.39], significantly higher than that of persons living with HIV without anemia (7.74/100 person-months, 95% CI: 6.02-9.45); the adjusted hazard ratio (AHR) was 2.422, with a 95% CI of (1.500, 3.913). After PSM and IPTW analyses, results were similar, with PSM (AHR: 4.745, 95% CI: 2.231-10.091) and IPTW (AHR: 1.920, 95% CI: 1.146-3.216). Patients with CD4<sup>+</sup> T cell counts below 350 per μL and severe anemia had an increased mortality risk. Severe anemia is an independent risk factor for in-hospital death in persons living with HIV in southern China. The importance of timely identification and assessment of anemia severity during ART and prompt treatment to correct anemia, which is crucial for improving anemia burden and prognosis for persons living with HIV.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"338-347"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Whole-Genome and RNA Sequencing Reveal Novel Insights into the Pathogenesis of Colorectal Cancer in Persons Living with HIV.","authors":"Yuxue Gao, Pengxiang Yang, Yuanyue Guan, Qiqi Ning, Jing Chang, Dexi Chen, Feili Wei, Yulin Zhang, Yuening Zhang","doi":"10.1089/aid.2025.0013","DOIUrl":"https://doi.org/10.1089/aid.2025.0013","url":null,"abstract":"<p><p>In persons living with HIV (PWH), non-AIDS-related tumors, including colorectal cancer (CRC), have become major health concerns worldwide since the introduction of highly active antiretroviral therapy. To date, no study has addressed the underlying molecular mechanisms in PWH with CRC. To explore the impact of PWH with CRC, we sequenced total RNA and DNA from individuals with HIV-negative and PWH formalin-fixed paraffin-embedded (FFPE) CRC for transcriptome and genome analyses. We performed RNA and DNA extraction from FFPE samples, library preparation, total RNA sequencing, and whole-genome sequencing. A total of 1,705 genes were found to be differentially expressed genes (DEGs), including 1,121 upregulated DEGs and 584 downregulated DEGs, in PWH compared with HIV-negative CRC. Functional pathway analysis revealed that the DEGs were enriched mainly in infectious and immune diseases and various metabolic processes. The immune infiltration results revealed that the numbers of activated dendritic cells (aDCs), natural killer T cells (NKT cells), and T follicular helper cells (Tfh cells) were greater and that the number of memory B cells was lower in patients with CRC than in PWH. Twelve hub genes involved in interferon-stimulated genes (ISGs)-IFI44, MX1, OAS1, OAS3, BST2, IFIT1, FGF2, EGF, CCL3, CCL4, SHH, and PPARG-are positively related to aDC, NKT, Tfh, and memory B cells. We found highly analogous insertions, deletions, and functional annotations of the detected single nucleotide polymorphisms and indel mutations in PWH and patients with HIV-negative CRC. This study provides new insights into crucial ISGs, immune infiltration, immune variants, and pathways involved in CRC with HIV infection.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Corrigendum to:</i> Incident HIV-Associated Wasting/Low Weight Is Associated with Nearly Doubled Mortality Risk in the Modern ART Era.","authors":"","doi":"10.1089/aid.2025.98899.correx","DOIUrl":"https://doi.org/10.1089/aid.2025.98899.correx","url":null,"abstract":"","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}