AIDS research and human retroviruses最新文献

{"title":"Identification of an Emerging HIV-1B/C Circulating Recombinant Form (CRF176_BC) in Heterosexual Populations in Yunnan Province, China.","authors":"Min Chen, Yanling Ma, Huichao Chen, Manhong Jia, Wenfei Ding","doi":"10.1177/08892229251382841","DOIUrl":"https://doi.org/10.1177/08892229251382841","url":null,"abstract":"<p><p>The current HIV-1 epidemic in China is characterized by the co-circulation of multiple subtypes and recombinant forms. A novel circulating recombinant form of HIV-1 (CRF176_BC) has been identified in Yunnan Province, China. Near-full-length genome sequences were obtained from four individuals who identified as heterosexual and were epidemiologically unlinked. Phylogenetic analysis revealed that these sequences formed a distinct monophyletic cluster from known subtypes and CRFs. Bootscanning analyses revealed a subtype C backbone with two subtype B insertions. Bayesian evolutionary dating estimated that the four genomes shared a common ancestor between 2014 and 2016, which was not far from the present. Unlike earlier CRF_BCs, which were associated with injecting drug use in the 1990s, the emergence of CRF176_BC indicates a shift toward sexual transmission. This finding emphasizes the continuous evolution of HIV-1 in Yunnan, driven by co-circulating lineages and evolving transmission dynamics. It also highlights the importance of targeted surveillance in informing public health strategies in the context of evolving epidemics.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Corrigendum to:</i> The Immunogenicity of AAV-Encoded HIV-1 bNAbs in Rhesus Macaques Is Unaffected by a Short Course of the Immunomodulator CTLA4Ig.","authors":"","doi":"10.1177/08892229251380258","DOIUrl":"https://doi.org/10.1177/08892229251380258","url":null,"abstract":"","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Identification of a Novel HIV-1 CRF80_0107/B Recombinant Form Among Men Who Have Sex with Men in Hebei Province, China.","authors":"Zhen Zhang, Jingwei Sun, Huijuan Yang, Haoxi Shi, Sisi Chen, Jianru Jia, Weiguang Fan","doi":"10.1177/08892229251378021","DOIUrl":"https://doi.org/10.1177/08892229251378021","url":null,"abstract":"<p><p>The emergence of CRF80_0107 resulted from recombination between co-circulating CRF01_AE and CRF07_BC genotypes. To date, no secondary recombinants involving CRF80_0107 as a parental strain have been documented in public sequence databases. Here, we report the identification and characterization of a novel HIV-1 CRF80_0107/B recombinant form isolated from a treatment-naïve men who have sex with men (MSM) individual in Baoding City, Hebei Province, China. While phylogenetic analysis of the near-full-length genome revealed clustering with the CRF80_0107 lineage, Bootscan and similarity-mapping analyses (RIP 3.0) identified a recombinant structure containing inserted B subtype fragments spanning the <i>env</i>, <i>nef</i>, and 3'LTR regions (HXB2: 7,907-9,342 nt). This represents the first documented CRF80_0107/B strain in the MSM population of northern China, highlighting the need for expanded molecular surveillance to track evolving HIV-1 diversity in this key population.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Anthropometry, Body Composition, and Fat Distribution by HIV Status and Antiretroviral Therapy Class in South African Women.","authors":"Hlengiwe P Madlala, Landon Myer, Hayli Geffen, Jennifer Jao, Mushi Matjila, Azetta Fisher, Demi Meyer, Lara Dugas, Amy E Mendham, Gregory Petro, Susan Cu-Uvin, Stephen T McGarvey, Julia H Goedecke, Angela M Bengtson","doi":"10.1177/08892229251374692","DOIUrl":"https://doi.org/10.1177/08892229251374692","url":null,"abstract":"<p><p>Pregnancy affects adiposity, which may be influenced by HIV infection or antiretroviral therapy (ART). The objective of this study was to examine adiposity measures in the perinatal period, by HIV status and ART class. A total of 214 women (113 women with HIV [WWH], 71 initiated ART postconception), enrolled between 24 and 28 weeks of gestation and followed until 6-12 months postpartum, were assessed for longitudinal weight and cross-sectional postpartum anthropometry. A subset of 65 (52 WWH, 42 initiated ART postconception) had cross-sectional adiposity (body composition and fat distribution) measured at 6-12 months postpartum using dual-energy X-ray absorption scan. Multivariable linear and modified Poisson regression, adjusted for maternal age, pre-pregnancy body mass index, socioeconomic status, and postpartum months, examined associations of HIV status and postconception ART (dolutegravir-based [DTG] vs. efavirenz-based [EFV]) with anthropometry and adiposity outcomes. At enrollment, the median age was 30 years (interquartile range, 26-34) and 82% were multiparous. Between pre-pregnancy and postpartum, women gained an average of 2.33 kg (0.90 kg WWH), 30% lost weight (35% WWH), and 48% gained weight (38% WWH). WWH gained weight slower during pregnancy (0.27 vs 0.38 kg/week, <i>p</i> = .03) and were less likely to gain weight postpartum (RR = 0.72 95% CI 0.55, 0.93; <i>p</i> = .01) compared with women without HIV. Postpartum, mean body mass index was 32 kg/m² (standard deviation = 7.33) and 58% (53% WWH) of women had obesity. HIV was not associated with cross-sectional measures of postpartum anthropometry and adiposity. Among WWH, compared with EFV-based ART, DTG-based ART was not associated with weight gain during pregnancy or anthropometry and adiposity postpartum. Despite high rates of postpartum weight gain and obesity, no significant differences were observed in anthropometry and adiposity measures by HIV status and postconception ART. Nonetheless, these findings underscore the need for interventions to support healthy weight gain in pregnancy and postpartum weight loss to minimize pregnancy-associated obesity.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Participant Perspectives in an HIV Treatment Interruption Study in San Francisco, United States.","authors":"Elizabeth Nguyen, Anastasia Korolkova, Ali Ahmed, Steven Meanley, Lynda Dee, Maryam Hussain, Fang Wan, Rebecca Hoh, Antonio Rodriguez, Tony Figueroa, Lillian B Cohn, Steven G Deeks, Michael J Peluso, Shadi Eskaf, Jeremy Sugarman, John A Sauceda, Karine Dubé","doi":"10.1177/08892229251375470","DOIUrl":"10.1177/08892229251375470","url":null,"abstract":"<p><p>HIV cure-related clinical research studies often include analytical treatment interruptions (ATIs), in which participants pause antiretroviral treatment (ART). During ATIs, researchers closely monitor laboratory values and adverse events. We assessed and compared the perspectives of two distinct groups of participants: HIV noncontrollers and controllers in a San Francisco-based ATI study focused on identifying biomarkers predicting HIV viral rebound. Data were collected from 2021 to 2024 over five study time points to assess motivations, understanding of the study, decisional regret, and partner protections. All participants (n = 16) endorsed the goal of helping advance HIV research as a motivator, about half were also driven by interest in their body's response to the ATI, and some indicated monetary compensation as a key motivator. Most participants (6 of 10 noncontrollers and 4 of 6 controllers) did not view personal health benefit as a primary study goal. All understood the option for an extended ATI if they had not met ART restart criteria after 28 days. At the study's onset, all sexually active participants (n = 14) were informed about the risk of transmission to sex partners and the need for partner protections during ATIs. Among noncontrollers, 2 of 5 reported using condoms, being abstinent or partner use of pre-exposure prophylaxis (PrEP) during sexual activity. Among controllers, 3 of 5 reported sexual activity: one with a partner on PrEP, one with a partner on ART, and one using other protection methods. Decisional regret about study participation, measured on a scale of 0-100, was low among both noncontrollers (range 1.67-13.57), and controllers (range 8.33-10) during the ATI, and remained low following it (noncontroller M = 5.07, SD = 4.52; controller M = 10.00, SD = 11.31). Participants generally understood the study, highlighted the need for partner protection support during ATI, and reported low decisional regret.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Two Novel HIV-1B/CRF01_AE/CRF07_BC Recombinant Forms Among Men Who Have Sex with Men in Hebei Province, China.","authors":"Feng Zhao, Ziting Liu, Jianru Jia, Zhen Zhang, Haoxi Shi, Weiguang Fan, Sisi Chen","doi":"10.1177/08892229251374704","DOIUrl":"https://doi.org/10.1177/08892229251374704","url":null,"abstract":"<p><p>The frequent recombination between subtypes has driven significant HIV-1 genetic diversity in recent years, especially in some areas with co-circulation of multiple subtypes. In this study, we obtained nearly full-length genome sequences of two novel HIV-1 B/CRF01_AE/CRF07_BC recombinants from BD076A and BDL161, with lengths of 8718 bp (HXB2:772-9490) and 8851 bp (HBB2:759-9610), respectively. Both recombination breakpoint and Bootscanning analysis revealed that the recombinant structure of BD076A was based on the CRF07_BC backbone, with the insertion of one subtype B and one CRF01_AE gene fragment, containing four subregions. Similarly, BDL161 was based on the CRF07_BC backbone, with the insertion of one subtype B fragment and two CRF01_AE gene fragments, containing seven subregions. These findings highlight the importance of sustaining molecular epidemiological surveillance to monitor HIV-1 diversity and take effective prevention and control strategies in the region.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing HIV Genotyping and Drug-Resistance Detection in Low Viral Load Samples Through Exosome Enrichment Technology.","authors":"Jun Peng, Yebin Song, Zhong Chen, Lei Xu, Lei Guo, Xiaoxin Xie, Yanhua Fu, Hai Long, Yanmeng Feng, Kai He","doi":"10.1177/08892229251374705","DOIUrl":"https://doi.org/10.1177/08892229251374705","url":null,"abstract":"<p><p>Genotypic drug-resistance testing for HIV-1 with low viral loads (VLs) (<1,000 copies/mL) is clinically important but technically challenging. Due to the overlapping physical size characteristics of HIV-1 viral particles (100-120 nm) and exosomes (40-150 nm), simultaneous enrichment of both using size separation technology may offer a new strategy to improve the success rate of genotypic resistance testing in low VL samples. To evaluate the application of exosome enrichment technology in genotypic drug resistance testing for HIV-1 in low VL samples. We conducted a study with the following design. Whole blood samples were collected from HIV/AIDS patients at the Guiyang Public Health Treatment Center, who had been receiving antiretroviral therapy for over 6 months, with HIV-1 RNA levels ranging from 20 to 1,000 copies/mL, between June 2023 and November 2024. Plasma was separated, and HIV-1 RNA genotypic resistance testing was performed both directly on the plasma and after exosome enrichment. The amplification success rates of HIV-1 genotypic resistance testing before and after exosome enrichment were compared, and resistance mutation sites were analyzed. Among the 26 participants, 22 were male (84.62%) and 4 were female (15.38%), with a median age of 36.5 years. Exosome enrichment technology achieved amplification success rates for the HIV-1 genotypic resistance testing in the RT & PR regions and the INSTI region of 65.38% (17/26) and 42.31% (11/26), respectively, significantly higher than the pre-enrichment success rates of 19.23% (5/26) and 15.38% (4/26). These differences were statistically significant (χ² = 11.34, <i>p</i> = 0.001; χ² = 4.62, <i>p</i> = 0.032). Genotypic sequencing revealed K103N and L74M resistance mutations in two samples. These findings indicate that exosome enrichment technology enhances the amplification success rate of HIV-1 genotypic resistance testing in low VL samples and identifies clinically relevant resistance mutation sites. This approach may provide an innovative solution for resistance testing in low VL samples.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Matrix Metalloproteinase with Their Tissue Inhibitors and Human Immunodeficiency Virus Infection: A Two-Sample Bidirectional Mendelian Randomization Analysis.","authors":"Chao Guo, Yushan Zhang, Xiujuan Li, Yujing Duan","doi":"10.1177/08892229251359534","DOIUrl":"10.1177/08892229251359534","url":null,"abstract":"<p><p>Studies have shown an association between matrix metalloproteinases (MMPs) along with tissue inhibitors of MMPs (TIMP) and human immunodeficiency virus (HIV) infection and CD4⁺ T cell count, a key clinical indicator for HIV progression, but the causality remains unclear. This study aimed to investigate the bidirectional causal relationship between MMPs/TIMP and HIV. A genome-wide association study-based two-sample bidirectional Mendelian randomization (MR) analysis was conducted to elucidate the potential causal links between MMPs/TIMP and HIV. This approach utilized robust estimators, including inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode. Furthermore, sensitivity analyses including Cochran's Q, MR-Egger, leave-one-out, and MR pleiotropy residual sum and outlier (MR-PRESSO) tests were employed to assess heterogeneity and pleiotropic effects. The IVW analysis in the forward MR study indicated that genetically predicted levels of MMP-3 [odds ratio or OR (95% confidence interval or CI) = 0.69 (0.47-1), <i>p</i> = .047], MMP-20 [OR (95% CI) = 0.64 (0.43-0.97), <i>p</i> = .035], and TIMP-2 [OR (95% CI) = 0.68 (0.47-0.97), <i>p</i> = .034] were potentially associated with a lower risk of HIV. MMP-13 exhibited a genetically predicted association with a higher risk of HIV [OR (95% CI) = 2 (1.17-3.41), <i>p</i> = .011]. Additionally, MMP-19 demonstrated a genetic association with CD4⁺ T cell absolute count [OR (95% CI) = 0.90 (0.81-1.00), <i>p</i> = .042). The reverse MR analysis indicated that genetically predicted liability to HIV was associated with a higher level of MMP-1 [OR (95% CI) = 1.04 (1.01-1.08), <i>p</i> = .024]. Heterogeneity and horizontal pleiotropy were found between MMP-9 and HIV by Cochran's Q test and MR-Egger, but MR-PRESSO indicated no outliers. This study revealed a complex MMPs-TIMPs interplay influencing HIV risk. Future research should clarify underlying mechanisms.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"452-462"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Cardiovascular Risk Profiling in People Living with HIV: Insights from the Japanese Adverse Drug Event Report Database.","authors":"Shigeru Hasebe, Masayuki Tanaka, Shiori Iwane, Toshikazu Tsuji, Hiroyuki Kushida, Maho Kikuta","doi":"10.1177/08892229251359555","DOIUrl":"10.1177/08892229251359555","url":null,"abstract":"<p><p>Antiretroviral therapy (ART) has dramatically improved outcomes for people living with HIV (PLWH), yet concerns about cardiovascular disease (CVD) remain, especially in aging populations. In this study, we aimed to evaluate the association between ART regimens and CVD events in Japan using a nationwide pharmacovigilance database. We retrospectively analyzed reports from the Japanese Adverse Drug Event Report Database spanning April 2004 to September 2024. After removing duplicates and records with key missing data, 796,402 reports (Population A) were used for signal detection based on the reporting odds ratio (ROR) and information component (IC). A refined subset (Population B; 2,721 reports) underwent logistic regression to identify risk factors for major adverse cardiovascular events (MACE) and total cardiovascular events (MACE plus angina). ART regimen classes (e.g., integrase strand transfer inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors) and backbone therapies [e.g., abacavir (ABC)/lamivudine] were included in the analysis. Signal detection revealed significant ABC signals in both ROR and IC analyses for MACE and total CVD events. In logistic regression, advanced age (≥70 years), ABC-containing regimens, and diabetes emerged as independent risk factors for MACE and total CVD events. Dyslipidemia and hypertension were not significant in the adjusted models. Our findings underscore a potentially heightened cardiovascular risk associated with ABC, particularly in older PLWH or those with diabetes. These results highlight the need to consider individual CVD risk profiles when selecting ART regimens and reinforce the importance of ongoing pharmacovigilance to guide safer, more personalized treatment strategies worldwide.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"423-432"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance Characteristics of an HIV-1 Rapid Recency Assay Among Treatment-Naïve Individuals.","authors":"Xiaojuan Tan, Mervi Detorio, Vedapuri Shanmugam, Trudy Dobbs, Ernest L Yufenyuy, Bharat S Parekh","doi":"10.1089/aid.2024.0102","DOIUrl":"10.1089/aid.2024.0102","url":null,"abstract":"<p><p>Asanté HIV-1 Rapid Recency Assay identifies HIV-1 recent infection based on antibody avidity among newly diagnosed individuals. We estimated the mean duration of recent infection (MDRI), false recency rate (FRR), the probability of being classified as recent over time and examined the assay reproducibility. A total of 967 longitudinal plasma specimens from 180 HIV-1 seroconverting individuals, all antiretroviral treatment (ART) naïve, from multiple countries were used to determine the MDRI, while cross-sectional plasma specimens from individuals infected for >1 year (total <i>n</i> = 1,285; <i>n</i> = 926 without AIDS; <i>n</i> = 359 with AIDS; all ART naïve) were tested to estimate the FRR. All specimens were tested by two testers and results were interpreted visually, followed by a line intensity reader. Linear interpolation and polynomial regression were used to estimate the duration of recent infection by subject. MDRI was calculated as a mean of individual duration of recency while FRR was calculated as a fraction of long-term (LT) cases that were misclassified as recent. The LT line intensity, a reflection of antibody avidity, demonstrated an overall increase over time, especially during the first year after seroconversion. The MDRI was 160 days [95% confidence interval (CI), 140-181] by linear interpolation and 167 days (95% CI, 147-187) by polynomial regression among ART-naïve cases. Probability of individuals testing as recent infection was 97.9% (95% CI, 93.9%-99.3%) by 1 month post-seroconversion and decreased to 10.3% (95% CI, 6.3%-16.5%) by 12 months. FRR was 2.1% (95% CI, 1.3%-3.2%) among ART-naïve individuals infected >1 year and 5.1% (95% CI, 3.4%-7.8%) among patients with AIDS. The assay indicated high inter-tester reproducibility of 96.2%. It can be a valuable tool for program-based HIV-1 recent infection surveillance for a better understanding of risk factors of acquiring new infections. Our study provides evidence about the performance of the assay for data interpretation of recency surveillance among newly diagnosed individuals.</p>","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"442-451"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}