AIDS research and human retroviruses最新文献_第2页

Genomic Characterization of Two Novel HIV-1 CRF01_AE/CRF07_BC Unique Recombinant Forms in Shenzhen, China. 深圳两种新型HIV-1 CRF01_AE/CRF07_BC独特重组形式的基因组特征

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-07-23 DOI: 10.1177/08892229261471606

Dandan Lin, Bo Zhu, Shengya Liu, Chang Lu, Pinghui Wu, Borong Wen, Binglou He, Hanping Li, Yongjian Liu, Lei Jia, Bohan Zhang, Xiaolin Wang, Jingyun Li, Jingwan Han, Junjun Jiang, Lin Li

引用次数: 0

Sequence Notes: Identification of a Novel HIV-1 Circulating Recombinant Form (CRF200_0755) in a Southern Border Region of Yunnan, China. 序列注释：在中国云南南部边境地区鉴定了一种新的HIV-1循环重组形式（CRF200_0755）。

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-07-10 DOI: 10.1177/08892229261469040

Min Chen, Huichao Chen, Yanling Ma, Wenfei Ding, Manhong Jia

{"title":"Sequence Notes: Identification of a Novel HIV-1 Circulating Recombinant Form (CRF200_0755) in a Southern Border Region of Yunnan, China.","authors":"Min Chen, Huichao Chen, Yanling Ma, Wenfei Ding, Manhong Jia","doi":"10.1177/08892229261469040","DOIUrl":"https://doi.org/10.1177/08892229261469040","url":null,"abstract":"The long-term co-circulation of various HIV-1 subtypes and circulating recombinant forms (CRFs) in China has created an environment conducive to viral recombination. This study identified a novel HIV-1 CRF resulting from the recombination of CRF07_BC and CRF55_01B in Xishuangbanna Prefecture, Yunnan Province. Nearly full-length HIV-1 genome sequences were obtained from three individuals with no epidemiological link, including two men who have sex with men and one individual with heterosexual contact. These individuals were reported in 2023. These sequences form a monophyletic clade that is distinct from all known subtypes and CRFs. Recombination and phylogenetic analyses revealed that this recombinant strain exhibited a consistent mosaic genomic structure, with the CRF55_01B backbone incorporating two CRF07_BC segments. Bayesian phylogenetic analyses indicated that this recombinant form originated around 2019. In accordance with standard nomenclature, it has been designated CRF200_0755. In addition, this recombinant strain carries the V179E resistance mutation from CRF55_01B. The discovery of this novel CRF highlights the ongoing evolution of HIV-1 amid the co-circulation of prevalent strains and population mobility. It also emphasizes the importance of continuous molecular surveillance in guiding public health strategies, given the potential presence of preexisting resistance mutations.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"8892229261469040"},"PeriodicalIF":1.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porphyrins as Novel Therapeutics for HIV: Mechanism, Advances, and Challenges. 卟啉作为HIV的新疗法：机制、进展和挑战。

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-06-01 Epub Date: 2026-04-21 DOI: 10.1177/08892229261446362

Vidya Laxmi Jaishi, Arushi Dogra, Bangaluru Srihari, Ritu Gaur

{"title":"Porphyrins as Novel Therapeutics for HIV: Mechanism, Advances, and Challenges.","authors":"Vidya Laxmi Jaishi, Arushi Dogra, Bangaluru Srihari, Ritu Gaur","doi":"10.1177/08892229261446362","DOIUrl":"10.1177/08892229261446362","url":null,"abstract":"Porphyrins, a class of heterocyclic macrocycles, have garnered significant attention for their potential antiviral properties, particularly against human immunodeficiency virus (HIV). This review explores how porphyrins and their derivatives inhibit HIV replication, focusing on their interactions with key viral components, including reverse transcriptase, protease, and integrase. In addition, the review highlights the role of porphyrins in photodynamic therapy (PDT) as a novel approach to targeting HIV-infected cells. Recent studies have demonstrated that metalloporphyrins, in particular, exhibit enhanced antiviral activity due to their unique structural and electronic properties. Despite promising in vitro and preclinical results, challenges such as cytotoxicity, bioavailability, and resistance mechanisms remain unaddressed. This review provides a comprehensive analysis of the current state of research on porphyrins as anti-HIV agents, emphasizing their potential as a therapeutic strategy and identifying key areas for future investigation. The findings underscore the importance of porphyrins in the ongoing search for effective antiviral therapies against HIV.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"215-221"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frailty, Physical Function Impairment, and Pulmonary Function in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study. 多中心艾滋病队列研究中携带和不携带HIV的老年男性的虚弱、身体功能损害和肺功能

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-06-01 Epub Date: 2026-05-01 DOI: 10.1177/08892229261448283

Mona Abdo, Ken M Kunisaki, Alison Morris, Valentina Stosor, Dong Chang, Gypsyamber D'Souza, Kristina Crothers, Madiha Abdel-Maksoud, Carolyn DiGuiseppi, Todd T Brown, Samantha MaWhinney, Kristine M Erlandson

{"title":"Frailty, Physical Function Impairment, and Pulmonary Function in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.","authors":"Mona Abdo, Ken M Kunisaki, Alison Morris, Valentina Stosor, Dong Chang, Gypsyamber D'Souza, Kristina Crothers, Madiha Abdel-Maksoud, Carolyn DiGuiseppi, Todd T Brown, Samantha MaWhinney, Kristine M Erlandson","doi":"10.1177/08892229261448283","DOIUrl":"10.1177/08892229261448283","url":null,"abstract":"People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments. Associations of frailty and physical function (gait speed [m/s], grip strength [kg]) with pulmonary function (<80% predicted diffusing capacity for carbon monoxide [DLCO] and forced expiratory volume [FEV1]) 3 years later were modeled; age, HIV status, and smoking were assessed as effect modifiers. Among 1,024 men (54% PAWH, 10% frail, 51% prefrail), mean (SD) age = 53 (12) years, cumulative smoking = 12 (19) pack-years, gait speed = 1.1 (0.2) m/s, and grip strength = 36.6 (9.2) kg. Frailty, prefrailty, and weak grip strength were associated with higher odds of subsequent impaired DLCO and FEV1. Slow gait speed was associated with higher odds of DLCO impairment but not FEV1. No statistically significant modifications were found. Interventions to improve physical function may help preserve pulmonary function.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"222-226"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Patterns of Discontinuation and Virologic Failure with Long-Acting Cabotegravir-Rilpivirine. 长效cabotegravity - rilpivirine停药和病毒学失败的真实世界模式。

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-06-01 Epub Date: 2026-05-05 DOI: 10.1177/08892229261449867

Sara Hockney, Dana Mueller, Alex Phillbrick, Jenna Berlet, Shannon Galvin

{"title":"Real-World Patterns of Discontinuation and Virologic Failure with Long-Acting Cabotegravir-Rilpivirine.","authors":"Sara Hockney, Dana Mueller, Alex Phillbrick, Jenna Berlet, Shannon Galvin","doi":"10.1177/08892229261449867","DOIUrl":"10.1177/08892229261449867","url":null,"abstract":"Long-acting injectable cabotegravir-rilpivirine (LA CAB/RPV) is an antiretroviral option for virologically suppressed people with HIV, but real-world discontinuation and failure patterns remain incompletely described. We retrospectively reviewed 201 adults who received LA CAB/RPV at a large academic infectious diseases clinic (January 2022-April 2025). Median time on therapy was 380 days (IQR 206-729). At the end of follow-up, 160 (80%) remained on LA CAB/RPV and 30 (15%) discontinued, most commonly due to insurance barriers (n = 8, 27%); adherence issues and patient preference each accounted for 23% (n = 7). Virologic failure occurred in 4 patients (2%) and was often accompanied by emergent or pre-existing non-nucleoside reverse transcriptase inhibitor and/or integrase strand transfer inhibitor resistance mutations; all patients achieved resuppression after switching back to oral ART. LA CAB/RPV was generally well tolerated, but system-level access and care-continuity barriers were major drivers of discontinuation, underscoring the importance of robust support systems and resistance-informed patient selection.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"227-229"},"PeriodicalIF":1.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic Characterization of Two Novel Human Immunodeficiency Virus-1 Recombinant Forms (CRF01_AE and B) in Men Who Have Sex with Men in Hebei, China. 两种新的人类免疫缺陷病毒-1重组形式（CRF01_AE和B）在河北省男男性行为者中的基因组特征

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-06-01 Epub Date: 2026-05-12 DOI: 10.1177/08892229261451042

Yimin Cao, Shanshan Zang, Jian Du, Shangyu Li, Ying Gao, Ziting Liu, Yujia Zhao, Haoxi Shi, Feng Zhao

引用次数: 0

Spatial Distribution and Multilevel Analysis of HIV/AIDS Awareness Among Women Aged 15-49 in Somaliland: Insight from DHS Data. 索马里兰15-49岁妇女艾滋病毒/艾滋病意识的空间分布和多层次分析：来自DHS数据的见解

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-05-01 Epub Date: 2026-04-06 DOI: 10.1177/08892229261439999

Mohamed Mohamoud Abdilleh, Khadar Jama Osman, Yahye Dayib Aw-Ali, Abdisalam Hassan Muse, Mustafa Hassan Dahir, Hamse Adam Abdi

{"title":"Spatial Distribution and Multilevel Analysis of HIV/AIDS Awareness Among Women Aged 15-49 in Somaliland: Insight from DHS Data.","authors":"Mohamed Mohamoud Abdilleh, Khadar Jama Osman, Yahye Dayib Aw-Ali, Abdisalam Hassan Muse, Mustafa Hassan Dahir, Hamse Adam Abdi","doi":"10.1177/08892229261439999","DOIUrl":"10.1177/08892229261439999","url":null,"abstract":"Understanding the determinants and spatial distribution of HIV/AIDS awareness is crucial for effective public health interventions, particularly among women of reproductive age in low-resource settings. This study investigates these factors among women in Somaliland, a region facing unique challenges in health service access. This cross-sectional study utilized data from 6,259 women aged 15-49 from the 2020 Somaliland Demographic and Health Survey. We employed multilevel logistic regression to identify individual and community-level determinants of HIV/AIDS awareness and used spatial analysis to map its geographic distribution. Overall, 73.7% of women in Somaliland reported having heard of HIV/AIDS. Multilevel analysis revealed that awareness was significantly higher among older and more educated women, with those having higher education being 24 times more likely to be aware (adjusted odds ratios [AOR] = 24.04). Conversely, rural (AOR = 0.65), nomadic residence (AOR = 0.33), and no radio exposure (AOR = 0.49) were associated with significantly lower odds of awareness. Significant regional variations were also identified. A substantial portion of the variance in awareness (ICC = 24.3%) was attributable to community-level factors, confirming the appropriateness of the multilevel approach. Women's awareness of HIV/AIDS in Somaliland is shaped by a complex interplay of spatial location, education, media access, and residence type. These findings underscore the necessity for targeted public health interventions that address both individual and community-level barriers. Priority should be given to reaching women in rural and nomadic settings and those with lower educational attainment. This dual-method analysis provides crucial insights to inform more effective and geographically-tailored HIV prevention programs in Somaliland.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"201-210"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Full-Length Genomic Characterization of Two Novel Unique Recombinants (CRF01_AE/CRF07_BC) in Shenzhen, Guangdong Province, China. 中国广东深圳两个新的独特重组基因CRF01_AE/CRF07_BC的近全长基因组特征

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-05-01 Epub Date: 2026-04-09 DOI: 10.1177/08892229261439998

Chang Liu, Bo Zhu, Dandan Lin, Pinghui Wu, Wenbo Rong, Binglou He, Hanping Li, Yongjian Liu, Lei Jia, Xiaolin Wang, Jingyun Li, Bohan Zhang, Jingwan Han, Hongling Wen, Lin Li

{"title":"Near-Full-Length Genomic Characterization of Two Novel Unique Recombinants (CRF01_AE/CRF07_BC) in Shenzhen, Guangdong Province, China.","authors":"Chang Liu, Bo Zhu, Dandan Lin, Pinghui Wu, Wenbo Rong, Binglou He, Hanping Li, Yongjian Liu, Lei Jia, Xiaolin Wang, Jingyun Li, Bohan Zhang, Jingwan Han, Hongling Wen, Lin Li","doi":"10.1177/08892229261439998","DOIUrl":"10.1177/08892229261439998","url":null,"abstract":"Extensive cocirculation of CRF01_AE and CRF07_BC in China has created favorable conditions for ongoing intersubtype recombination, contributing to increasing genetic complexity within the local HIV-1 epidemic. In this study, two novel unique recombinant forms composed of CRF01_AE and CRF07_BC were identified in Shenzhen, Guangdong Province. Near-full-length genome sequences were obtained for isolates LS11654 and LS16824. Phylogenetic analysis indicated that both sequences clustered within a CRF01_AE-/CRF07_BC-related lineage but were distinct from previously reported strains. Recombination analysis revealed markedly different mosaic structures: LS11654 contained two recombination breakpoints, whereas LS16824 exhibited a more complex genome with eight breakpoints and multiple inserted fragments. Subregion phylogenetic analysis further confirmed the parental origins of the recombinant segments. These findings reflect ongoing recombination driven by sustained cocirculation of CRF01_AE and CRF07_BC in Shenzhen and highlight the importance of continued molecular surveillance.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"175-181"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting HIV-Associated Wasting: Results from a U.S. Cross-Sectional Survey of Health Care Providers' Knowledge, Attitude, and Current Practices. 重新审视hiv相关的消瘦：来自美国卫生保健提供者的知识、态度和当前做法的横断面调查结果。

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-05-01 Epub Date: 2026-04-11 DOI: 10.1177/08892229261437509

Daniel Lee, Scott Brawley, Brooke Hayward, Elisabeth Mari, Michael Harbour, Jesus Felizzola

{"title":"Revisiting HIV-Associated Wasting: Results from a U.S. Cross-Sectional Survey of Health Care Providers' Knowledge, Attitude, and Current Practices.","authors":"Daniel Lee, Scott Brawley, Brooke Hayward, Elisabeth Mari, Michael Harbour, Jesus Felizzola","doi":"10.1177/08892229261437509","DOIUrl":"10.1177/08892229261437509","url":null,"abstract":"Advancements in antiretroviral therapy (ART) have significantly improved morbidity and mortality rates among people with human immunodeficiency virus (HIV) (PWH), leading to prolonged survival, and many are now living into middle and old age. However, this population now faces aging-related comorbidities, including cachexia HIV-associated wasting (HIVAW), which remains inadequately addressed in the context of contemporary ART. Effective management of HIVAW requires a multifaceted approach that targets underlying causes while addressing coexisting health conditions. Currently, recombinant human growth hormone (rhGH) (somatropin) is the only FDA-approved treatment for HIVAW that increases body weight and lean body mass and improves physical endurance. However, the lack of standardized definitions and clear treatment guidelines may contribute to the underdiagnosis and suboptimal management of HIVAW. This study aimed to assess health care providers' (HCPs) knowledge, attitudes, and contemporary clinical practices regarding HIVAW through a cross-sectional survey conducted in collaboration with the American Academy of HIV Medicine. Approximately half of the respondents recognized a 3% prevalence rate of HIVAW, noting its association with increased morbidity and health care resource utilization. However, nearly one-third faced challenges in diagnosing HIVAW due to unclear definitions, highlighting the need for standardized clinical guidelines. Less experienced providers demonstrated less familiarity with treatment options like rhGH compared to their more experienced colleagues. While 88.4% identified nutritional supplements as a management strategy, only 32.2% were aware of an FDA-approved treatment for HIVAW, indicating a substantial knowledge gap. This study underscores the need for enhanced educational initiatives and clear treatment guidelines to improve the recognition and management of HIVAW, particularly among less experienced HCPs.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"193-200"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpesvirus and GB Virus C Infections in Men With and Without HIV-1 Who Have Sex with Men. 男男性行为中携带和未携带HIV-1的男性的疱疹病毒和GB病毒C感染。

IF 1 4区医学

AIDS research and human retroviruses Pub Date : 2026-05-01 Epub Date: 2026-03-31 DOI: 10.1177/08892229261435255

Nikolas I Wada, Yue Chen, Arlene Bullotta, Natalie Suder-Egnot, Chengli Shen, Amber D'Souza, Marta Epeldegui, Jay H Bream, Eun-Young Kim, Charles R Rinaldo

{"title":"Herpesvirus and GB Virus C Infections in Men With and Without HIV-1 Who Have Sex with Men.","authors":"Nikolas I Wada, Yue Chen, Arlene Bullotta, Natalie Suder-Egnot, Chengli Shen, Amber D'Souza, Marta Epeldegui, Jay H Bream, Eun-Young Kim, Charles R Rinaldo","doi":"10.1177/08892229261435255","DOIUrl":"10.1177/08892229261435255","url":null,"abstract":"In men with (MWH) and without (MWOH) HIV-1 infection, we longitudinally evaluated the prevalence of human herpesvirus (HHV) and GB virus C (GBV-C) infections and examined associations with plasma HIV-1 load and inflammatory markers. We analyzed 11,874 plasma samples (collected from 1984 to 2009) from 1,882 men who have sex with men in the Multicenter AIDS Cohort Study to quantify four HHVs [cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 8 (HHV-8), and human herpesvirus 6 (HHV-6)] and GBV-C. HHV and GBV-C viral loads were measured using quantitative Polymerase Chain Reaction (PCR) and Reverse Transcription (RT)-PCR, respectively. Differences in viral prevalence and concentrations were assessed using multivariable logistic and linear regression. Associations between HHV viremia and 24 inflammatory and immune activation biomarkers were evaluated using generalized gamma models. Age-related biomarker trajectories were analyzed using linear mixed models among MWH with sustained suppression due to HIV-1 antiretroviral therapy. MWH with detectable plasma HIV-1 RNA had significantly higher odds of CMV, EBV, and HHV-8 viremia compared with those with undetectable plasma HIV-1 RNA, who in turn had higher odds than MWOH. CMV and EBV viremia were associated with higher levels of multiple inflammatory markers. Among MWH with consistent viral suppression, no significant differences were observed in age-related biomarker trajectories. Overall, active HHV infection, as indicated by viremia, was associated with significantly higher plasma HIV-1 loads and increased inflammatory marker levels-particularly in the presence of detectable plasma HIV-1 RNA. Our study supports the hypothesis that active HHV infections may exacerbate HIV-1 disease progression in MWH.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":" ","pages":"182-192"},"PeriodicalIF":1.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0