The HIV-1 Transmitted Drug Resistance in Newly Confirmed and ART-Naïve HIV-1-Infected MSM in Zhenjiang City, Jiangsu, China.

IF 1.5 4区 医学 Q4 IMMUNOLOGY
Li Shen, Yue Wu, Jin Liu, Lu Ye, Jing Yang, Xiao Wu, Hong Xu
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Abstract

Estimating the prevalence and characterizing the HIV-1 transmitted drug resistance (TDR) are crucial for the prevention and control of HIV/AIDS. However, there are limited data currently on TDR among men who have sex with men (MSM) in Zhenjiang, Jiangsu, a high-risk population for drug resistance. We conducted a retrospective analysis among the newly diagnosed and antiretroviral therapy (ART)-naive HIV-1-infected MSM in Zhenjiang, 2012-2018. We analyzed the HIV-1 subtypes, TDR prevalence, TDR-associated mutations, and predicted drug sensitivity. Among these 192 participants, CRF01_AE (50.0%) and CRF07_BC (34.9%) were the predominant HIV-1 strains, with an increasing diversity of circulating subtypes (p < .05). A total of nine patients infected with CRF01_AE exhibited one or more TDR mutations, including 3.6% for Protease Inhibitor (PI)-related mutations, 1.0% for NRTI-related mutations and 1.0% for NNRTI-related mutations. The most common mutation was M46L/I for PIs. Notably, TDR prevalence showed an upward trend from 2012 to 2018, with an average of 4.7%. The gradually diversified subtypes, the increased TDR prevalence, and the potential risk of transmitting drug-resistant strains to the general population highlight the necessity of TDR monitoring in MSM. This will be beneficial for the prevention and control of HIV/AIDS in Zhenjiang.

江苏省镇江市新确诊和ART-Naïve HIV-1感染男男性行为者HIV-1传播耐药性分析
估计HIV-1传播耐药(TDR)的流行情况和特征对于预防和控制HIV/AIDS至关重要。然而,目前关于江苏镇江男男性行为者(MSM) TDR的数据有限,该地区是耐药高危人群。我们对镇江市2012-2018年新诊断和未经抗逆转录病毒治疗(ART)的hiv -1感染的男男性行为者进行了回顾性分析。我们分析了HIV-1亚型、TDR患病率、TDR相关突变,并预测了药物敏感性。在这192名参与者中,CRF01_AE(50.0%)和CRF07_BC(34.9%)是主要的HIV-1毒株,并且循环亚型的多样性增加(p < 0.05)。共有9例CRF01_AE感染患者出现一个或多个TDR突变,其中蛋白酶抑制剂(PI)相关突变为3.6%,nrti相关突变为1.0%,nnrti相关突变为1.0%。pi最常见的突变是M46L/I。值得注意的是,从2012年到2018年,热带病流行率呈上升趋势,平均为4.7%。逐渐多样化的亚型、TDR患病率的增加以及向一般人群传播耐药菌株的潜在风险突出了在MSM中监测TDR的必要性。这将有利于镇江市艾滋病防治工作的开展。
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来源期刊
CiteScore
3.10
自引率
6.70%
发文量
201
审稿时长
3-6 weeks
期刊介绍: AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes. AIDS Research and Human Retroviruses coverage includes: HIV cure research HIV prevention science - Vaccine research - Systemic and Topical PreP Molecular and cell biology of HIV and SIV Developments in HIV pathogenesis and comorbidities Molecular biology, immunology, and epidemiology of HTLV Pharmacology of HIV therapy Social and behavioral science Rapid publication of emerging sequence information.
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