AIDS research and human retroviruses最新文献_第10页

Genomic Characteristics of the New HIV-1 CRF07_BC K₂₈E₃₂ Variant. 新型 HIV-1 CRF07_BC K28E32 变体的基因组特征

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2024-01-01 Epub Date: 2023-07-05 DOI: 10.1089/AID.2022.0182

Yingying Ma, Zhenzhou Wan, Min Zhang, Chiyu Zhang

{"title":"Genomic Characteristics of the New HIV-1 CRF07_BC K28E32 Variant.","authors":"Yingying Ma, Zhenzhou Wan, Min Zhang, Chiyu Zhang","doi":"10.1089/AID.2022.0182","DOIUrl":"10.1089/AID.2022.0182","url":null,"abstract":"Accompanied with the appearance and prevalence of the new K28E32 variant among men who have sex with men, HIV-1 circulating recombinant form 07_BC (CRF07_BC) was becoming the most predominant subtype circulating in China. The K28E32 variant with five specific mutations in reverse transcriptase coding region appears to have significantly higher in vitro HIV-1 replication ability than the wild-type strain. In this study, we characterized the special mutations/substitutions in the K28E32 variant at the genomic level. Ten specific mutations that rarely appeared in other six main HIV-1 subtypes/CRFs (A-D, CRF01_AE, and CRF02_AG) were identified in the coding genes/regions of the K28E32 variant, including S77L and a novel seven-amino acid detection (32DKELYPL38) (p6Δ7) in p6, I135L in integrase, T189S in Vif, H/Y15L/F in Vpr, I264V/A and LV/LI328-329VG in gp41, and H82C and S97P in Rev. The special locations of the novel p6Δ7, and gp41 mutations I264V/A and LV/LI328-329VG in crucial protein functional domains suggest that these mutations might be functionally important to the K28E32 variant. Furthermore, eight specific substitutions were identified in Rev responsive element (RRE) of the K28E32 variant, and were revealed to increase the stability of RRE structure with a lower minimum free energy. Whether these mutations/substitutions contribute to improved transmissibility of the CRF07_BC K28E32 variant needs to be further confirmed.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment of Reviewers 2023. 鸣谢 2023 年审稿人。

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2024-01-01 DOI: 10.1089/aid.2024.29005.ack

引用次数: 0

Problematic Cannabis Use Is Associated with Reduced Rectal Microbial Species Richness and Diversity Among a Pilot Sample of Young Sexual and Gender Minorities. 问题大麻的使用与减少直肠微生物物种丰富度和多样性的试点样本中的年轻性和性别少数相关。

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2024-01-01 Epub Date: 2023-04-05 DOI: 10.1089/aid.2022.0143

Ethan Morgan, Jennifer A Manuzak, Courtney Broedlow, Hannah Hudson, Richard D'Aquila, Adam W Carrico, Nichole R Klatt, Brian Mustanski

{"title":"Problematic Cannabis Use Is Associated with Reduced Rectal Microbial Species Richness and Diversity Among a Pilot Sample of Young Sexual and Gender Minorities.","authors":"Ethan Morgan, Jennifer A Manuzak, Courtney Broedlow, Hannah Hudson, Richard D'Aquila, Adam W Carrico, Nichole R Klatt, Brian Mustanski","doi":"10.1089/aid.2022.0143","DOIUrl":"10.1089/aid.2022.0143","url":null,"abstract":"Compared to young heterosexual men, young sexual and gender minorities (YSGM) have elevated systemic inflammation and unique intestinal microbial profiles, influenced by HIV infection and substance use. However, links between cannabis use and microbial dysbiosis in this population have not been well described. In this pilot study, we aimed to characterize the complex interrelationships between cannabis use and microbial community structure in YSGM in relationship to HIV status. Cannabis use was assessed by self-administered Cannabis Use Disorder Identification Test (CUDIT) questionnaires and rectal microbial community alpha-diversity metrics were assessed via 16S ribosomal ribonucleic acid (rRNA) sequencing in a subset of YSGM (n = 42) in the RADAR cohort (aged 16-29) in Chicago. Multivariable regression models were used to assess the relationship between cannabis use and microbiome alpha-diversity metrics, adjusting for HIV status and other risk characteristics, including inflammation, which was evaluated by plasma levels of C-reactive protein (CRP). Problematic cannabis use, but not general use, was significantly inversely associated with microbial community richness (Adj. Beta = -8.13; 95% confidence interval [CI]: -15.68 to -0.59) and Shannon diversity (Adj. Beta = -0.04; 95% CI: -0.07 to 0.009). No significant association was observed between CUDIT score and community evenness, nor was any significant moderation observed by HIV status. We observed that problematic cannabis use was associated with reduced microbial community richness and Shannon diversity, adjusting for within population differences in inflammation and HIV status. Future research should aim to assess how cannabis use contributes to microbiome-related health factors among YSGM and if decreasing cannabis use can restore gut microbial community structure.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10790549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and Phylogenetic Analysis of HIV-1 Subtype C in Bahia State, Northeastern Brazil. 巴西东北部巴伊亚州 HIV-1 亚型 C 的分子和系统发育分析。

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2024-01-01 Epub Date: 2023-08-07 DOI: 10.1089/AID.2023.0038

Rodrigo Cunha Oliveira, Juliana Sacramento Mota de Souza, Luiz Carlos Júnior Alcântara, Monick Lindenmeyer Guimarães, Carlos Brites, Joana Paixão Monteiro-Cunha

引用次数: 0

Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research. 生物医学研究中的脆弱性：生物医学研究中的脆弱性：历史反思及对艾滋病治疗相关研究的现实意义》（A Historical Reflection and Practical Implications for HIV Cure-Related Research.

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2024-01-01 Epub Date: 2023-06-21 DOI: 10.1089/AID.2022.0136

Emily Rao, Jeff Taylor, Andy Kaytes, Susanna Concha-Garcia, Patricia K Riggs, Davey M Smith, Karine Dubé, Sara Gianella

{"title":"Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research.","authors":"Emily Rao, Jeff Taylor, Andy Kaytes, Susanna Concha-Garcia, Patricia K Riggs, Davey M Smith, Karine Dubé, Sara Gianella","doi":"10.1089/AID.2022.0136","DOIUrl":"10.1089/AID.2022.0136","url":null,"abstract":"The concept of vulnerability in bioethics was first referenced in 1979, when the Belmont Report highlighted the need for special consideration of certain populations in the application of its general principles of respect for persons, beneficence, and justice in research with human participants. Since then, a body of literature has emerged regarding the content, status, and scope, as well as ethical and practical implications of vulnerability in biomedical research. The social history of HIV treatment development has at various points reflected and actively influenced bioethics' debate on vulnerability. In the late 1980s and early 1990s, people with AIDS activist groups drafted landmark patient empowerment manifestos like The Denver Principles, fighting to have greater involvement in the design and oversight of clinical trials related to HIV treatment, and in doing so, pushed against research ethics protocols created with the intention of protecting vulnerable populations. The determination of appropriate benefit/risk profiles in clinical trials was no longer limited to the purview of clinicians and scientists, but began to include the perspectives of people with HIV (PWH) and affected communities. In contemporary HIV cure-related research, where participants often risk health for no personal clinical benefit, the community's voiced motivations and objectives for participation continue to challenge population-based accounts of vulnerability. While the development of a framework for discussion and the establishment of clear regulatory requirements are necessary to support the practical and ethical conduct of research, they risk distraction from the fundamental value of voluntary participation and potentially overlook the unique history and perspectives of PWH in their participation in the quest toward an HIV cure.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10790546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9671268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral Persistence in the Gut-Associated Lymphoid Tissue and Barriers to HIV Cure. 病毒在肠道相关淋巴组织中的持续存在与艾滋病治愈的障碍。

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2023-12-13 DOI: 10.1089/AID.2022.0180

Francesca Cossarini, Judith A Aberg, Benjamin K Chen, Saurabh Mehandru

引用次数: 0

Effectiveness, weight changes and metabolic outcomes on switch to generic dolutegravir/lamivudine amongst people with HIV in Western India: An observational study 印度西部艾滋病毒感染者转用多鲁特韦/拉米夫定非专利药后的疗效、体重变化和代谢结果：观察性研究

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2023-12-08 DOI: 10.1089/aid.2022.0167

Sanjay Pujari, S. Gaikwad, S. Panchawagh, A. Chitalikar, K. Joshi, Chaitrangi Rohekar, Digamber Dabhade, Vivek Bele

引用次数: 0

Virologic non-suppression and HIV drug resistance among people who inject drugs and their sexual and injecting partners in Kenya 肯尼亚注射吸毒者及其性伴侣和注射伴侣的病毒学抑制和艾滋病毒耐药性

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2023-12-08 DOI: 10.1089/aid.2023.0068

Bhavna H Chohan, H. Kingston, Ashley S. Tseng, B. Sambai, Brandon L. Guthrie, Eduan Wilkinson, J. Giandhari, L. Mbogo, A. Monroe-Wise, S. Masyuko, R. Bosire, Natasha T Ludwig-Barron, W. Sinkele, D. Bukusi, Tulio de Oliviera, Carey Farquhar, Joshua Herbeck

引用次数: 0

Effects of the NS1–NOLC1 protein interaction on rRNA synthesis through TRF2 regulation under nucleolar stress 核极应激状态下，NS1-NOLC1 蛋白相互作用通过 TRF2 调控对 rRNA 合成的影响

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2023-12-07 DOI: 10.1089/aid.2023.0067

Man Zhang, Yingyue Zeng, Fengchao Wang, Huawei Feng, Qingqing Liu, Feng Li, Shan Zhao, Jian Zhao, Zhikui Liu, Fangliang Zheng, Hongsheng Liu

引用次数: 0

Serum Selenium and Inflammation in Individuals with Human Immunodeficiency Virus Infection. 人类免疫缺陷病毒感染者的血清硒与炎症

IF 1.5 4区医学

AIDS research and human retroviruses Pub Date : 2023-12-01 Epub Date: 2023-07-31 DOI: 10.1089/AID.2023.0012

Kalpana Poudel-Tandukar, Elizabeth R Bertone-Johnson, Krishna C Poudel

{"title":"Serum Selenium and Inflammation in Individuals with Human Immunodeficiency Virus Infection.","authors":"Kalpana Poudel-Tandukar, Elizabeth R Bertone-Johnson, Krishna C Poudel","doi":"10.1089/AID.2023.0012","DOIUrl":"10.1089/AID.2023.0012","url":null,"abstract":"HIV infection has been linked to selenium deficiency and chronic inflammation. Both selenium deficiency and inflammation have been associated with poor health outcomes among individuals with HIV. However, the role of serum selenium levels in inflammation has not been studied among individuals with HIV. We assessed the relationship of serum selenium levels to C-reactive protein (CRP), a marker of inflammation, in individuals with HIV in Kathmandu, Nepal. In this cross-sectional study, we measured the normal serum CRP and selenium levels of 233 individuals with HIV (109 women and 124 men) using the latex agglutination turbidimetric and atomic absorption methods, respectively. We used multiple linear regression analysis in examining the association of serum selenium levels with CRP adjusting for sociodemographic and clinical parameters, including antiretroviral therapy, CD4+ T cell count, chronic diseases, and body mass index. The geometric means of CRP and selenium levels were 1.43 mg/liter and 9.65 μg/dL, respectively. Overall, serum selenium levels were inversely associated with CRP levels (β for one unit change in log selenium; β = -1.01, p = .06). Mean CRP levels significantly decreased with increasing selenium across selenium tertiles (p for trend = .019). The mean serum CRP levels were 40.8% lower in the highest selenium tertile than in the lowest. Our study suggests that high serum selenium levels may reduce serum CRP levels in individuals with HIV, although a longitudinal study is warranted to establish causality.","PeriodicalId":7544,"journal":{"name":"AIDS research and human retroviruses","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9895107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0