HIV感染者转换抗逆转录病毒治疗方案的历史与血脂之间的关系:一项回顾性研究。

IF 1.5 4区 医学 Q4 IMMUNOLOGY
Lei Wang, Mingzhe Yan, Reyisaimu Wumaierjiang, Qiqi Zhang, Jie Xiang, Yong Feng, Rui Li
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引用次数: 0

摘要

目前尚不清楚转换抗逆转录病毒治疗(ART)方案的历史是否是HIV感染者(PLWH)血脂恶化的独立危险因素。本研究旨在探讨抗逆转录病毒治疗方案转换史与PLWH患者血脂谱之间的关系。这是对2018年1月至2022年6月期间在中国武汉金银潭医院登记的16-82岁艾滋病毒阳性个体数据的回顾性分析。我们调查了他们转换抗逆转录病毒治疗方案的历史和他们的脂质谱之间的潜在联系。局部加权散点图平滑(黄土)曲线用于描述脂质剖面随时间的动态变化。采用线性混合效应模型来评估有和没有ART开关史的个体之间脂质水平的差异。在2018年1月至2022年6月期间开始抗逆转录病毒治疗的708名艾滋病毒患者中,207名(29%)至少更换过一次治疗方案,而501名(71%)在整个研究过程中仍在使用最初的治疗方案。有ART转换史的个体表现出较不有利的脂质谱,这是由黄土分析确定的。线性混合效应模型表明,先前未改变ART方案的参与者与有ART方案改变史的参与者相比,总胆固醇与高密度脂蛋白(HDL)比率、总胆固醇和甘油三酯水平明显较低(总胆固醇与高密度脂蛋白比率,差异-0.19,95% CI: -0.34至-0.04;总胆固醇,差异-0.13,95% CI: -0.25 ~ 0.00;甘油三酯,差异-0.27,95% CI: -0.43至-0.11)。相比之下,有ART治疗方案转换史的个体高密度脂蛋白胆固醇(HDL- c)水平明显降低[差异:0.04;95%置信区间(CI) 0.00 ~ 0.07]。这意味着转换抗逆转录病毒治疗方案的历史可能与PLWH的脂质恶化有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Association Between the History of Switching Antiretroviral Therapy Regimens and Lipid Profile in People Living with HIV: A Retrospective Study.

It remains unclear whether the history of switching antiretroviral therapy (ART) regimens is a standalone risk factor for lipid deterioration in people living with HIV (PLWH). This study aims to explore the relationship between ART regimen switching history and lipid profiles in PLWH. This is a retrospective analysis of data from HIV-positive individuals aged 16-82, enrolled at Jinyintan Hospital in Wuhan, China, between January 2018 and June 2022. We investigated the potential link between their history of switching ART regimens and their lipid profiles. Locally weighted scatter plot smoother (LOESS) curves were used to depict the dynamic changes in lipid profiles over time. Linear mixed-effects models were employed to assess the differences in lipid levels between individuals with and without a history of ART switches. Out of 708 patients with HIV who began ART between January 2018 and June 2022, 207 (29%) switched regimens at least once, while 501 (71%) remained on their initial regimen throughout the study. Individuals with a history of switching ART exhibited less favorable lipid profiles as identified by LOESS analysis. Linear mixed-effects models indicate that participants who had not previously altered their ART regimens displayed notably lower levels of total cholesterol to high-density lipoprotein (HDL) ratio, total cholesterol, and triglycerides compared to those with a history of ART regimen changes (total cholesterol to HDL ratio, difference -0.19, 95% CI: -0.34 to -0.04; total cholesterol, difference -0.13, 95% CI: -0.25 to 0.00; triglycerides, difference -0.27, 95% CI: -0.43 to -0.11). In contrast, individuals with a history of ART regimen switching had noticeably lower HDL cholesterol (HDL-C) levels [difference: 0.04; 95% confidence intervals (CI) 0.00 to 0.07]. This means that the history of switching ART regimens may be associated with lipid deterioration in PLWH.

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来源期刊
CiteScore
3.10
自引率
6.70%
发文量
201
审稿时长
3-6 weeks
期刊介绍: AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes. AIDS Research and Human Retroviruses coverage includes: HIV cure research HIV prevention science - Vaccine research - Systemic and Topical PreP Molecular and cell biology of HIV and SIV Developments in HIV pathogenesis and comorbidities Molecular biology, immunology, and epidemiology of HTLV Pharmacology of HIV therapy Social and behavioral science Rapid publication of emerging sequence information.
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