Advances in internal medicine最新文献

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Study of Endoscopic Findings in First Episode of Upper Gastrointestinal Bleeding 首次上消化道出血的内镜表现研究
Advances in internal medicine Pub Date : 2021-05-14 DOI: 10.3126/JAIM.V10I1.37085
K. Adhikari, R. Mandal
{"title":"Study of Endoscopic Findings in First Episode of Upper Gastrointestinal Bleeding","authors":"K. Adhikari, R. Mandal","doi":"10.3126/JAIM.V10I1.37085","DOIUrl":"https://doi.org/10.3126/JAIM.V10I1.37085","url":null,"abstract":"gastrointestinal Upper has a crucial role in the gastrointestinal The to findings UGIB. Patient demographics, site and nature of lesions and risk factors for bleeding were analyzed. disease was the most common cause of first episode of UGI bleeding in our context. Among peptic ulcer diseases gastric ulcer was more common than duodenal ulcer. Haematemesis and melena were the commonest clinical presentation of UGI bleeding.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"10 1","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41992453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
COVID-19: Vaccine and antimicrobial resistance what are the global implications? 新冠肺炎:疫苗和抗微生物耐药性对全球有何影响?
Advances in internal medicine Pub Date : 2021-05-14 DOI: 10.3126/JAIM.V10I1.37099
J. Robinson, Alexandra Leclézio, I. Banerjee
{"title":"COVID-19: Vaccine and antimicrobial resistance what are the global implications?","authors":"J. Robinson, Alexandra Leclézio, I. Banerjee","doi":"10.3126/JAIM.V10I1.37099","DOIUrl":"https://doi.org/10.3126/JAIM.V10I1.37099","url":null,"abstract":"Antimicrobial resistance is a worldwide and highly quantified risk to global health and is more prevalent than resistance developed in vaccines as both antimicrobial resistance and vaccine resistance develop in different settings and because of alternate mechanisms. Vaccines act as a preventative measure and allow the immune system to kill any pathogen in the initial phases when the load is relatively low. This circumvents the replication of the pathogen and thus prevents the formation of mutations and furthermore resistance which is attributed to those mutations. Mutations in the target and or binding sites of a said therapeutic regime confer resistance more often in antimicrobials than they do vaccines. to counter new variants as they arise will be an ongoing process. It is evident in future that new vaccines to the mutations in COVID-19 may have to be developed as they are for the seasonal influenzae virus.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"10 1","pages":"51-53"},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47355187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association between lipid indices and 10-year cardiovascular risk of a cohort of black Africans living with type 2 diabetes mellitus 血脂指数与非洲黑人2型糖尿病患者10年心血管风险之间的关系
Advances in internal medicine Pub Date : 2021-05-14 DOI: 10.3126/JAIM.V10I1.37090
T. Azeez
{"title":"Association between lipid indices and 10-year cardiovascular risk of a cohort of black Africans living with type 2 diabetes mellitus","authors":"T. Azeez","doi":"10.3126/JAIM.V10I1.37090","DOIUrl":"https://doi.org/10.3126/JAIM.V10I1.37090","url":null,"abstract":"IntroductionDiabetes mellitus is an established cardiovascular risk factor. Diabetes mellitus impairs lipid metabolism and enhances atherosclerosis development. Absolute lipid parameter are inadequate in predicting cardiovascular risk and some lipid indices have been reported to circumvent this deficiency. The objective of the study was to determine the association between these lipid indices and 10-year cardiovascular risk among black Africans with diabetes. correlation. ResultsThe mean age of the participants was 53.34 ± 9.57 years. The mean duration of diabetes mellitus among the participants was 6.29 ± 2.78 years. The mean HbA1c and FPG were 6.98±0.72% and 6.32±0.87 mmol/L respectively. The mean QRISK 3 score was 7.58±4.80. There was a statistically significant and positive correlation between QRISK 3 score and AIP, AC, CR I and CR II. CHOLindex did not significantly correlate with QRISK 3 score. Among black Africans with diabetes, lipid indices (AIP, AC, CR I and CR II) significantly correlated with QRISK 3 score and therefore may be used as cheap markers of 10-year cardiovascular risk in these individuals.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"10 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45743014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
SARS-CoV-2 vaccines and their challenges against the variants 严重急性呼吸系统综合征冠状病毒2型疫苗及其对变种的挑战
Advances in internal medicine Pub Date : 2021-05-14 DOI: 10.3126/JAIM.V10I1.37080
U. Shrestha
{"title":"SARS-CoV-2 vaccines and their challenges against the variants","authors":"U. Shrestha","doi":"10.3126/JAIM.V10I1.37080","DOIUrl":"https://doi.org/10.3126/JAIM.V10I1.37080","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) pandemic has lead to the several researches for the development of the new severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) vaccines. During this process, spike (S) protein (particularly in its prefusion [native] conformation) was identified as the immunodominant antigen of the SARS-CoV 2 virus1; it was found that the binding and neutralizing antibodies primarily target the receptor-binding domain (RBD) of the S1 subunit.2 After identifying the vaccine target, several SARS-CoV-2 vaccines were developed with an objective to achieve the response which include production of neutralizing antibodies, generation of a T-cell response, and avoidance of immune-enhanced disease. The SARS-CoV-2 vaccines that have been developed to combat COVID-19 are shown in the table 1.3","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"10 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43199858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Safe management of bodies of deceased person with suspected or confirmed COVID-19 疑似或确诊新冠肺炎死者尸体的安全管理
Advances in internal medicine Pub Date : 2020-11-10 DOI: 10.3126/jaim.v9i2.32835
Aabishkar Bhattarai, B. Karki
{"title":"Safe management of bodies of deceased person with suspected or confirmed COVID-19","authors":"Aabishkar Bhattarai, B. Karki","doi":"10.3126/jaim.v9i2.32835","DOIUrl":"https://doi.org/10.3126/jaim.v9i2.32835","url":null,"abstract":"COVID-19 is a respiratory illness caused by COVID-19 the coronavirus that predominantly affects the lungs. Because of limited data and research studies, the transmission of the virus from dead bodies with COVID-19 has not been verified. However, to stay on a safe side, the safety and well-being of everyone who handles the corpses should be prioritized. All the personnel who interact with the dead bodies (Health Care Workers, Ambulance drivers, Mortuary staffs or Burial teams) should apply the standard precautionary measures including Personal Protective Equipment (gown, gloves, and face protection-face mask and face shield if risks of splashes from body fluids are high). Safety precautions should be taken by the forensic personnel involved in the autopsies of the people who died from COVID-19, as the lungs and other organs can still contain a live virus.  ","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"9 1","pages":"98-99"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41581833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balloon-Occluded Retrograde Transvenous Obliteration (BRTO): A Novel Method of Obliterating Gastric Varices. Report of Six Cases and Review of Literature 球囊闭塞逆行经静脉闭塞术(BRTO):一种闭塞胃静脉曲张的新方法。六例报告及文献复习
Advances in internal medicine Pub Date : 2020-11-10 DOI: 10.3126/jaim.v9i2.31049
A. Thapa, D. Koirala, R. Pathak, D. Chataut, Sashi Sharma, Brindeswari Kafle Bhandari, A. Jha, R. Hamal, R. Pandey, A. Gyawali, Mohan Bhusal
{"title":"Balloon-Occluded Retrograde Transvenous Obliteration (BRTO): A Novel Method of Obliterating Gastric Varices. Report of Six Cases and Review of Literature","authors":"A. Thapa, D. Koirala, R. Pathak, D. Chataut, Sashi Sharma, Brindeswari Kafle Bhandari, A. Jha, R. Hamal, R. Pandey, A. Gyawali, Mohan Bhusal","doi":"10.3126/jaim.v9i2.31049","DOIUrl":"https://doi.org/10.3126/jaim.v9i2.31049","url":null,"abstract":"Portal hypertension results in various complications, gastroesophageal varices being one of them. Although less common than esophageal varices, gastric varices are difficult to obliterate and carry a higher mortality rate when bleeding occurs. They are less amenable to sclerotherapy, endoscopic variceal ligation. Balloon-Occluded Retrograde Transvenous Obliteration (BRTO) has been developed as a minimal invasive procedure to obliterate gastric varices. BRTO is an endovascular procedure where a balloon catheter is inserted into a draining vein of gastric varix, and the sclerosant can be injected into the varices through the catheter during balloon occlusion. We report six cases where BRTO was done for gastric varices obliteration. Ajit Thapa1, Dinesh Koirala2*, Rahul Pathak2, Dinesh Chataut1, Sashi Sharma2, Brindeswari Kafle Bhandari2, Anurag Jha2, Rabin Hamal2, Rajesh Pandey2, Arun Gyawali2, Mohan Bhusal2 Department of Radiology and Imaging1, Department of Gastroenterology and Hepatology2 Maharajgunj Medical Campus, TUTH, Institute of Medicine, Kathmandu, Nepal Case Report","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"9 1","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44392990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19: Is herd immunity the answer? COVID-19:群体免疫是答案吗?
Advances in internal medicine Pub Date : 2020-11-10 DOI: 10.3126/jaim.v9i2.32834
J. Robinson, I. Banerjee, B. Sathian
{"title":"COVID-19: Is herd immunity the answer?","authors":"J. Robinson, I. Banerjee, B. Sathian","doi":"10.3126/jaim.v9i2.32834","DOIUrl":"https://doi.org/10.3126/jaim.v9i2.32834","url":null,"abstract":"The measures introduced by the vast majority of countries are to Abstract The current global figures of COVID-19 is still rising. Many countries have enforced lockdowns to safeguard its citizens, however in most cases this has been to the dire detriment of the economy. Most leaders and governments have been holding out and looking to the development of a vaccine to be the answer to this COVID-19 pandemic, however at this point in time and for the foreseeable future a viable and widely available vaccine is not likely to be developed. In juxtaposition to the conventional methods countries such as Singapore, Israel, Iceland, Portugal, The Netherlands, Sweden, Hong Kong, Japan, South Korea, Indonesia, Taiwan and Turkey have adopted the concept of herd immunity. It is there for poignant and of the upmost importance that an alternate stratagem is developed and exercised to best facilitate the re-ignition of the country’s economy as well to best protect its citizens from the virus. Models such as herd immunity or a model based thereon are the most logical solution to attain this goal. At this time in the development of the global COVID-19 pandemic it is too early to conclude as to whether a fullyfledged lockdown is more effective and useful than the establishment of herd immunity. In order to achieve the goal of safeguarding the lives of a countries citizens as well as its economy, a mixed method of lockdown and herd immunity is advised. Individuals who are economically active and less susceptible to the virus should adopt the herd immunity model, whereas those who are elderly with concomitant comorbidities should exercise self-isolation and follow the lockdown model. The application of using both models simultaneously, will both capitalize on the advantages of either and negate the drawbacks thereof. This ultimately decreasing the loss of lives whilst still inducing a degree of herd immunity within the general populous. Jared Robinson1, Indrajit Banerjee1*, Brijesh Sathian2","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"9 1","pages":"94-97"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41554781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Angiotensin Converting Enzyme 2 in COVID-19 infections and the implications of COVID-19 on major body systems 新冠肺炎感染中的血管紧张素转换酶2及其对主要身体系统的影响
Advances in internal medicine Pub Date : 2020-11-10 DOI: 10.3126/jaim.v9i2.32604
M. Antoine, Yancheng Xu, Rimanatou Seyni-Boureima, Chrystal D. Antoine-Frank, C. Thiam, Mendame Ehya Regis Ernest
{"title":"Angiotensin Converting Enzyme 2 in COVID-19 infections and the implications of COVID-19 on major body systems","authors":"M. Antoine, Yancheng Xu, Rimanatou Seyni-Boureima, Chrystal D. Antoine-Frank, C. Thiam, Mendame Ehya Regis Ernest","doi":"10.3126/jaim.v9i2.32604","DOIUrl":"https://doi.org/10.3126/jaim.v9i2.32604","url":null,"abstract":"1Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China 2Department of Anaesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China 3Department of Anatomical Sciences, St. George’s University, True Blue, Grand Anse, St. George, Grenada, West Indies 4Department of Obstetrics and Gynaecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China 5Department of Orthopaedic hand and microsurgery, Zhongnan Hospital of Wuhan Univeristy, Wuhan, Hubei, China","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"9 1","pages":"78-85"},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44532850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Presenting with Dizziness-A Rare Case Report 心律失常性右室心肌病(ARVC)伴眩晕1例
Advances in internal medicine Pub Date : 2020-11-10 DOI: 10.3126/jaim.v9i2.32833
S. Adhikari, S. Jha, R. Gajurel, Chandra Mani Paudel, S. Acharya, S. Thapa, R. Khanal, S. Thapa, V. Yadav, Manju Sharma, D. Sapkota
{"title":"A Case Of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Presenting with Dizziness-A Rare Case Report","authors":"S. Adhikari, S. Jha, R. Gajurel, Chandra Mani Paudel, S. Acharya, S. Thapa, R. Khanal, S. Thapa, V. Yadav, Manju Sharma, D. Sapkota","doi":"10.3126/jaim.v9i2.32833","DOIUrl":"https://doi.org/10.3126/jaim.v9i2.32833","url":null,"abstract":"Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder. Its hallmark is the fibrofatty replacement of myocardium leading to cardiomyopathy. It can have various presentations which can range from silent disease to sudden cardiac death. Here, we report a case of ARVC in a 42 years old female who presented to us with dizziness as her first clinical presentation. We clinched the diagnosis with the help of electrocardiogram, echocardiography and cardiac magnetic resonance imaging (CMR).","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69272483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Risk Factors in Pre-dialysis Chronic Kidney Disease patients of Nepal 尼泊尔慢性肾脏病透析前患者心血管危险因素分析
Advances in internal medicine Pub Date : 2020-11-09 DOI: 10.3126/jaim.v9i2.32813
K. Dahal, A. Baral, K. Sah, J. R. Shrestha, Apeksha Niraula, R. Hada
{"title":"Cardiovascular Risk Factors in Pre-dialysis Chronic Kidney Disease patients of Nepal","authors":"K. Dahal, A. Baral, K. Sah, J. R. Shrestha, Apeksha Niraula, R. Hada","doi":"10.3126/jaim.v9i2.32813","DOIUrl":"https://doi.org/10.3126/jaim.v9i2.32813","url":null,"abstract":"Background and Aims: Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality in patients with chronic kidney disease (CKD) due to increased prevalence of traditional and nontraditional CVD risk factors. Our study aimed to evaluate these risk factors in pre-dialysis Nepalese CKD patients. Methods: This was a cross-sectional study conducted in Department of Nephrology, Bir hospital. Total 100 consecutive pre-dialysis CKD patients were enrolled. Ten traditional and six nontraditional CVD risk factors were analyzed and compared between CKD stages. Descriptive statistics was used to illustrate the socio-demographic and clinical characteristics, chi square test for categorical variables and multiple logistic regression analysis was done to determine the risk factors of CVD in CKD patients. p-value<0.05 was considered to be statistically significant. Results: Mean patient age was 52.03±13.64 years with majority (60%) of the patients being male. Comparison of traditional risk factors in different stages depicted similar trend except for old age in Stage 3 CKD (p=0.002). Anemia (p<0.001), hyperphosphatemia (p=0.01), hyperparathyroidism (p<0.01) and cumulative nontraditional risk factors were significantly higher (p=0.01) in stage 5 CKD. The predicted CVD events by Framingham risk score showed high risk in 37% with no significant difference among the stages. Multiple logistic regression analysis showed increased body mass index, low serum albumin and increased serum phosphate as the three significant predictors for left ventricular hypertrophy. Conclusion: Our study shows that the CVD risk factors were prevailing along the various stages of CKD. The occurrence of non-traditional risk factors increased with increasing stage of CKD. Dahal K1*, Baral A1, Sah KK1, Shrestha JR1, Niraula A2, Hada R1 1= Department of Nephrology, National Academy of Medical Sciences, Bir Hospital, Mahaboudha, Kathmandu, Nepal 2= Department of Biochemistry, B. P. Koirala Institute of Health Sciences, Dharan, Nepal","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"9 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45223632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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