新冠肺炎:疫苗和抗微生物耐药性对全球有何影响?

J. Robinson, Alexandra Leclézio, I. Banerjee
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引用次数: 1

摘要

抗菌素耐药性是一种世界范围的、高度量化的全球健康风险,比疫苗产生的耐药性更为普遍,因为抗菌素耐药性和疫苗耐药性都是在不同的环境中产生的,并且由于不同的机制。疫苗作为一种预防措施,允许免疫系统在负荷相对较低的初始阶段杀死任何病原体。这避免了病原体的复制,从而防止了突变的形成和进一步归因于这些突变的耐药性。在所述治疗方案的靶点和/或结合位点发生突变,使抗微生物药物比疫苗更容易产生耐药性。应对新变种的出现将是一个持续的过程。很明显,未来可能必须开发针对COVID-19突变的新疫苗,就像针对季节性流感病毒一样。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19: Vaccine and antimicrobial resistance what are the global implications?
Antimicrobial resistance is a worldwide and highly quantified risk to global health and is more prevalent than resistance developed in vaccines as both antimicrobial resistance and vaccine resistance develop in different settings and because of alternate mechanisms. Vaccines act as a preventative measure and allow the immune system to kill any pathogen in the initial phases when the load is relatively low. This circumvents the replication of the pathogen and thus prevents the formation of mutations and furthermore resistance which is attributed to those mutations. Mutations in the target and or binding sites of a said therapeutic regime confer resistance more often in antimicrobials than they do vaccines. to counter new variants as they arise will be an ongoing process. It is evident in future that new vaccines to the mutations in COVID-19 may have to be developed as they are for the seasonal influenzae virus.
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