Advances in internal medicine最新文献_第10页

Tuberculosis status among patients visiting antiretroviral therapy centers of Seti Zonal Hospital and Mahakali Zonal Hospital of far western Nepal 尼泊尔西部塞提地区医院和马哈卡利地区医院抗逆转录病毒治疗中心患者的结核病状况

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10696

Dhungana Gp, M. S. Bohara, Sashi Sharma, Ananya Adhikari, P. Khadga, B. Rijal, B. Pokhrel, B. Thakuri, K. Pant

{"title":"Tuberculosis status among patients visiting antiretroviral therapy centers of Seti Zonal Hospital and Mahakali Zonal Hospital of far western Nepal","authors":"Dhungana Gp, M. S. Bohara, Sashi Sharma, Ananya Adhikari, P. Khadga, B. Rijal, B. Pokhrel, B. Thakuri, K. Pant","doi":"10.3126/JAIM.V3I1.10696","DOIUrl":"https://doi.org/10.3126/JAIM.V3I1.10696","url":null,"abstract":"B ackground and aims : Tuberculosis is still a major public health problem in Nepal. The situation is further worsened by the widespread epidemic of HIV. Knowledge of TB/HIV co-infection is essential for effective dual case management. The objective of this study was to determine the TB/HIV coinfection status among patients visiting antiretroviral therapy centers of Seti Zonal Hospital and Mahakali Zonal Hospital. Methods : A cross sectional study was carried out in the department of Microbiology at Siddhanath Science Campus, Mahendranagar between January 2012 and July 2012. One hundred three patients were randomly selected, and were investigated for tuberculosis by direct microscopy and cultural technique. Socio-demographic features were collected by pre structured questionnaire. Data were entered into SPSS 11.5 and analyzed. Results : Of the 103 people infected with HIV, 46 (44.7%) were males and 57(55.3%) were females. Majority (64.07%) of them were in the productive age group (21-40 years). Forty two (40.8%) of the respondents were not literate. As high as 43.9% of the women were widow and 10.7% of the studied subjects showed mother to child transmission. The overall prevalence of TB among HIV infected people was found to be 4.9%. Among five TB cases only two cases were detected by direct microscopy. Conclusion : The overall prevalence of TB among HIV infected people was found to be 4.9%. Youths of productive age groups with low socioeconomic status were more vulnerable to HIV/AIDS. Culture was found to be more superior method of diagnosis than microscopy. DOI: http://dx.doi.org/10.3126/jaim.v3i1.10696 Journal of Advances in Internal Medicine 2014;03(01):11-16","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"11-16"},"PeriodicalIF":0.0,"publicationDate":"2014-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cytomegalovirus: A possible cause of Persistent Refractory Immune Thrombocytopenic Purpura 巨细胞病毒:持久性难治性免疫性血小板减少性紫癜的可能病因

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10704

Raksha Shrestha, D. Rondelli, M. Sherpa

引用次数: 9

Study of hypovitaminosis D as a cause of chronic widespread pain in patients presenting to rheumatology clinic 维生素D缺乏症作为风湿病临床患者慢性广泛性疼痛原因的研究

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10694

B. Vaidya, S. Nakarmi, Arvind H Chaudhary, Poojan Batajoo, N. Rajbhandari

{"title":"Study of hypovitaminosis D as a cause of chronic widespread pain in patients presenting to rheumatology clinic","authors":"B. Vaidya, S. Nakarmi, Arvind H Chaudhary, Poojan Batajoo, N. Rajbhandari","doi":"10.3126/JAIM.V3I1.10694","DOIUrl":"https://doi.org/10.3126/JAIM.V3I1.10694","url":null,"abstract":"Background and aims: Hypovitaminosis D is common in south-east Asian countries. Deficient vitamin-D level is likely to be associated with chronic muscular pains. We do not have data from our country regarding the magnitude of this problem. Methods: A prospective open labeled study at rheumatology opd from December 2009 to December 2012. Patients with chronic widespread pain and bone pains of >3 months duration were included in the study. Hypothyroidism, chronic renal failure and other rheumatological diagnosis except fibromyalgia were excluded. Visual analogue score (VAS) for pain and serum Vitamin-D levels were measured. Patients with low Vitamin-D were given oral Vitamin-D 60,000IU for 6 months. Response to therapy was evaluated using improvement in VAS. Results: Among 1680 patients, 66?2% were females. Hypovitaminosis-D was seen in 1388(82?6%), of which 27?5% had severe deficiency with Vitamin D levels <10ng/ml. Fibromyalgia overlap present in 25?7%. Mean initial VAS score was 8?7, 8?2 and 7?4 for patients in severe deficiency, mild deficiency and insufficiency group respectively. At 6 months follow-up, the VAS scores were 0, 2?1 and 3?6 respectively. After 6 months of treatment, no improvement was seen in 196 patients (11?6%) and all non-responders had fibromyalgia overlap. Vitamin- D level was checked again in non-responders and repeat vitamin-D levels were still low in 10 of them. Conclusions: Hypovitaminosis-D can be a significant cause of Chronic widespread pain in the general population and seems to aggravate the pain of fibromyalgia. Improvement was rapid and better in severe cases. DOI: http://dx.doi.org/10.3126/jaim.v3i1.10694 Journal of Advances in Internal Medicine 2014;03(01):1-4","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2014-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association of hsCRP and soluble fraction of E-selectin with diabetic and non-diabetic individuals hsCRP和e -选择素可溶性部分与糖尿病和非糖尿病个体的关系

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10697

S. Datta, M. Pal, Amit Kumar, Joydeep Ghosh, Rajarshi Rahut, A. Ganguly, S. Basu

{"title":"Association of hsCRP and soluble fraction of E-selectin with diabetic and non-diabetic individuals","authors":"S. Datta, M. Pal, Amit Kumar, Joydeep Ghosh, Rajarshi Rahut, A. Ganguly, S. Basu","doi":"10.3126/JAIM.V3I1.10697","DOIUrl":"https://doi.org/10.3126/JAIM.V3I1.10697","url":null,"abstract":"Background and aims: It is known that endothelial dysfunction and low-grade inflammation are important element of diabetic complications. The soluble E-selectin is a marker of endothelial dysfunction and C-reactive protein is the most important inflammatory marker. The present study is done to investigate the effect of diabetes on these two markers. Methods: The present hospital based case control study was conducted in the department of Biochemistry with the collaboration of department of Medicine of Burdwan Medical College, Burdwan, west Bengal India. All subjects were selected by simple random sampling between March 2011 and May 2013. Blood level of these soluble E-selectin and high sensitive C-reactive protein were measured in two hundred diabetic and two hundred age, sex and other non-modifiable as well as modifiable risk factors matched non-diabetic healthy controls. Results: Compared with control value of high sensitive C-reactive protein and soluble E-selectin levels were higher in diabetic subjects (p < 0.001). Our present study shows that levels of adhesion molecules and high sensitive C-reactive protein were higher in diabetic than non-diabetic. Conclusion: These data suggested that an increased level of inflammatory markers and adhesion molecules among diabetic compared with non-diabetic subjects. This suggests that chronic uncontrolled hyperglycemia contributes to progression of atherosclerosis associated with life-threading complications in middle-aged diabetic patients.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2014-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V3I1.10697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Takotsubo cardiomyopathy mimicking acute ST-segment elevation myocardial infarction in a 28-year-old woman 28岁女性Takotsubo心肌病模拟急性st段抬高型心肌梗死

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10703

L. Dubey, Sanjib K Sharma, S. Gautam, S. Dhungel, S. Laudari

引用次数: 0

Trends and in-hospital mortality of Acute Coronary Syndrome at Shahid Gangalal National Heart Centre, Kathmandu, Nepal during 2001-2012 2001-2012年期间尼泊尔加德满都Shahid Gangalal国家心脏中心急性冠状动脉综合征的趋势和住院死亡率

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10698

C. Adhikari, D. Sharma, R. Malla, S. Rajbhandari, R. Raut, S. Baidya, Murari Dhungana, D. Prajapati, M. Kc

{"title":"Trends and in-hospital mortality of Acute Coronary Syndrome at Shahid Gangalal National Heart Centre, Kathmandu, Nepal during 2001-2012","authors":"C. Adhikari, D. Sharma, R. Malla, S. Rajbhandari, R. Raut, S. Baidya, Murari Dhungana, D. Prajapati, M. Kc","doi":"10.3126/JAIM.V3I1.10698","DOIUrl":"https://doi.org/10.3126/JAIM.V3I1.10698","url":null,"abstract":"Background and aims: Acute coronary syndrome (ACS), which comprises acute ST-segment elevation myocardial infarction, non-ST segment elevation myocardial infarction and unstable angina is a major health problem and represents a large number of hospitalizations annually worldwide. We aim to describe pattern of the ACS admission and in-hospital mortality at tertiary national heart centre of the country. Methods: A hospital database was used to analyze all 7424 patients admitted in coronary care unit of the centre for ACS from September 2001 till December 2012. We evaluated trend of ACS admission and in-hospital mortality. Results: Five thousand three hundred ninety one (72.6%) were male and two thousand thirty three (27.4%) were female. Patient of 21years to 98 years were admitted for ACS .Four thousand five hundred and ninety nine(61.9%) patient were admitted due to ST elevation myocardial infarction, whereas one thousand nine hundred and thirteen (25.8%) were admitted for Unstable angina and nine hundred twelve (12.3%) were admitted for Non ST elevation myocardial infarction. In-hospital mortality was 5.74% for acute coronary syndrome. There was significant difference in in-hospital mortality between ST elevation myocardial infarction (7.76%), Non ST segment elevation acute coronary syndrome (3.61%) and Unstable Angina (1.88%).There is a gradual increase in Primary Percutaneous Coronary intervention as a mode of reperfusion therapy whereas there is a decrease in the rate of thrombolysis. Conclusion: Our study provides us some important information about the trend and in-hospital mortality rate in national heart centre. Though it is a single centre study can provide us the insight of the ACS outcome. DOI: http://dx.doi.org/10.3126/jaim.v3i1.10698 Journal of Advances in Internal Medicine 2014;03(01):23-26","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2014-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endoscopic en bloc resection of an esophageal leiomyoma 食管平滑肌瘤的内镜整体切除术

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10700

U. Shrestha

引用次数: 0

Hypokalemic quadriparesis due to renal tubular acidosis in a patient with Sjögren’s syndrome: A case series Sjögren综合征患者肾小管酸中毒引起的低钾性四肢瘫:一个病例系列

Advances in internal medicine Pub Date : 2014-07-03 DOI: 10.3126/JAIM.V3I1.10701

A. Maskey, Neeraj Singh, S. Gautam, Prashant Bhattarai, Prakash Poudyal, D. Manandhar, Chhetri Pk

引用次数: 0

Six Minute Walk Test as a Monitoring tool in Chronic Obstructive Pulmonary Disease on Pulmonary Rehabilitation 6分钟步行试验作为慢性阻塞性肺疾病肺部康复的监测工具

Advances in internal medicine Pub Date : 2013-09-29 DOI: 10.3126/JAIM.V2I2.8774

Vignan Kumar, Gali Prakash, Sujatha Gogineni, R. Kumar, M. Shaik

{"title":"Six Minute Walk Test as a Monitoring tool in Chronic Obstructive Pulmonary Disease on Pulmonary Rehabilitation","authors":"Vignan Kumar, Gali Prakash, Sujatha Gogineni, R. Kumar, M. Shaik","doi":"10.3126/JAIM.V2I2.8774","DOIUrl":"https://doi.org/10.3126/JAIM.V2I2.8774","url":null,"abstract":"Background and Aims- The six minute walk test is widely used as an outcome measure in pulmonary rehabilitation programs. The objective of this study is to report the magnitude of change in the six minute walk test with test repetition in patients with chronic obstructive pulmonary disease on pulmonary rehabilitation program. Methods: A prospective study of 51 patients with moderate to very severe COPD was carried out. Clinical examination, spirometry, six minute walk distance were done. All were advised regular follow up visits at three, six and twelve months. Results: Four (8%) very severe cases completed all visits and one in those showed improvement in Forced Expiratory Volume in 1 second by 6% and six minute walk distance by 71 metres. Seven (31.37%) severe cases completed all visits; showed improvement in Forced Expiratory Volume in 1 second by 2.5%; the distance walked was a mean 381.5 metres and this was 2.5 % improvement over base line walking distance. Six (11%) moderately severe cases completed the study; the mean distance walked at the end of the study was 451 metres, which is an improvement of 53% and the mean change in Forced expiratory volume in 1 second was <2%. Totally, the mean of modified Burden of Lung disease Dyspnoea scale was 1.7 (baseline) and 4 (after the test). Conclusions: These findings support the recommendation of practice six minute walk test at baseline assessment in order to provide an accurate measure of the effects of rehabilitation on six minute walk distance. DOI: http://dx.doi.org/10.3126/jaim.v2i2.8774 Journal of Advances in Internal Medicine 2013;02(02):35-41.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"2 1","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2013-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V2I2.8774","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Model for End-stage Liver Disease (MELD) in spontaneous bacterial peritonitis –a clinical study at a tertiary health center in Nepal 自发性细菌性腹膜炎终末期肝病(MELD)模型——尼泊尔一家三级卫生中心的临床研究

Advances in internal medicine Pub Date : 2013-09-29 DOI: 10.3126/JAIM.V2I2.8776

R. Pathak, Kiran Niraula, P. Khadga, K. Singh, Ishwar Sharma

{"title":"Model for End-stage Liver Disease (MELD) in spontaneous bacterial peritonitis –a clinical study at a tertiary health center in Nepal","authors":"R. Pathak, Kiran Niraula, P. Khadga, K. Singh, Ishwar Sharma","doi":"10.3126/JAIM.V2I2.8776","DOIUrl":"https://doi.org/10.3126/JAIM.V2I2.8776","url":null,"abstract":"Background and Aims: The aim of this study was to assess the predictive value of different variables including the Model of End-stage Liver Disease (MELD) scores in hospitalized patients with spontaneous bacterial peritonitis (SBP) and its correlation with adverse outcomes. Methods: A cross-sectional study of 73 patients diagnosed with cirrhosis, ascites, and spontaneous bacterial peritonitis admitted to a gastroenterology department from February 2010 to November 2012. MELD scores were calculated using laboratory parameters and the United Network of Organ Sharing (UNOS) internet MELD tool. Results: Categorical variables and mortality status were analyzed for association by chi-square test. MELD scores and all-cause mortality were found to be positively correlated. Mortality was higher among the groups with MELD scores greater than 15. Upon stratification of the groups by mortality status, only age and urea level were novel and consistent predictors of mortality. Conclusions: In this Nepalese sample of cirrhotic patients, MELD scores along with age and urea level were confirmed as significant predictors of mortality. DOI: http://dx.doi.org/10.3126/jaim.v2i2.8776 J ournal of Advances in Internal Medicine 2013;02(02):47-51","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"2 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2013-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0