Model for End-stage Liver Disease (MELD) in spontaneous bacterial peritonitis –a clinical study at a tertiary health center in Nepal

Advances in internal medicine Pub Date : 2013-09-29 DOI:10.3126/JAIM.V2I2.8776

R. Pathak, Kiran Niraula, P. Khadga, K. Singh, Ishwar Sharma

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Abstract

Background and Aims: The aim of this study was to assess the predictive value of different variables including the Model of End-stage Liver Disease (MELD) scores in hospitalized patients with spontaneous bacterial peritonitis (SBP) and its correlation with adverse outcomes. Methods: A cross-sectional study of 73 patients diagnosed with cirrhosis, ascites, and spontaneous bacterial peritonitis admitted to a gastroenterology department from February 2010 to November 2012. MELD scores were calculated using laboratory parameters and the United Network of Organ Sharing (UNOS) internet MELD tool. Results: Categorical variables and mortality status were analyzed for association by chi-square test. MELD scores and all-cause mortality were found to be positively correlated. Mortality was higher among the groups with MELD scores greater than 15. Upon stratification of the groups by mortality status, only age and urea level were novel and consistent predictors of mortality. Conclusions: In this Nepalese sample of cirrhotic patients, MELD scores along with age and urea level were confirmed as significant predictors of mortality. DOI: http://dx.doi.org/10.3126/jaim.v2i2.8776 J ournal of Advances in Internal Medicine 2013;02(02):47-51

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自发性细菌性腹膜炎终末期肝病(MELD)模型——尼泊尔一家三级卫生中心的临床研究

背景与目的:本研究的目的是评估终末期肝病模型(MELD)评分等不同变量对住院自发性细菌性腹膜炎(SBP)患者的预测价值及其与不良结局的相关性。方法:对2010年2月至2012年11月在消化内科确诊为肝硬化、腹水和自发性细菌性腹膜炎的73例患者进行横断面研究。使用实验室参数和联合器官共享网络(UNOS)互联网MELD工具计算MELD评分。结果:采用卡方检验分析分类变量与死亡率状况的相关性。MELD评分与全因死亡率呈正相关。MELD评分大于15的组死亡率较高。在按死亡率状况分组后，只有年龄和尿素水平是新的和一致的死亡率预测因子。结论:在尼泊尔的肝硬化患者样本中，MELD评分与年龄和尿素水平一起被证实是死亡率的重要预测因子。DOI: http://dx.doi.org/10.3126/jaim.v2i2.8776内科医学进展杂志2013;02(02):47-51

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Advances in internal medicine

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