Buddha Bahadur Karki, M. Bhattarai, Manil R Bajracharya, S. Karki, A. Devkota
{"title":"Correlation of neck and wrist circumference with waist circumference","authors":"Buddha Bahadur Karki, M. Bhattarai, Manil R Bajracharya, S. Karki, A. Devkota","doi":"10.3126/JAIM.V3I2.14063","DOIUrl":"https://doi.org/10.3126/JAIM.V3I2.14063","url":null,"abstract":"Background and aims: Body mass index, waist and hip circumference have been using for measurement of obesity, however practically it’s difficult to get these measures accurately because of the various reasons, so an alternative to this could be neck and wrist circumference measurement. As there is scarce report on such anthropometric studies from Nepal, we aimed to find out the correlation between neck and wrist circumference with waist circumference for obesity measure. Method: A cross sectional observational study of total 297(147 male and 150 female) participants, aged above 18 years conducted on 2013 at Kathmandu valley. Anthropometric markers of obesity were measured, including body weight, height, waist, hip, neck and wrist circumferences. Results: A strong positive Pearson correlation of neck circumference with waist circumference was found in both male and females(r=0.64 in male and r=0.86 in female). Neck circumference had strong positive correlation with waist circumference in obese female than in male(r=0.5 in male and r=0.82 in female).Similarly, neck circumference had positive correlation with body mass index(r=0.53in male and r=0.79 in female),hip(r=0.54in male and r=0.76in female), weight(r=0.59in male and r=0.77in female) except waist hip ratio(r=0.59in male and r=0.10in female). Neck circumference cutoff for abnormal waist (>=90cm for male and >=80cm for female) was 34.4cm for male and 32.5 cm for female. Similarly wrist circumference had also positive correlation with waist circumference(r=0.58 and r=0.64 in female) and with weight(r>0.6) in both sexes. Conclusion: Neck circumference which can be relatively easily measured has shown strong correlation with waist. Journal of Advances in Internal Medicine 2014;3(2):47-51.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V3I2.14063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Satyasrinivas, Y. S. Kanni, N. Rajesh, M. SaiSravanthi, Vijay Kumar
{"title":"D-penicillamine-induced Status Dystonicus in A Patient with Wilson’s Disease: A Diagnostic & Therapeutic Challenge","authors":"A. Satyasrinivas, Y. S. Kanni, N. Rajesh, M. SaiSravanthi, Vijay Kumar","doi":"10.3126/JAIM.V3I2.14066","DOIUrl":"https://doi.org/10.3126/JAIM.V3I2.14066","url":null,"abstract":"Wilson's disease is an autosomal-recessive disorder of copper metabolism resulting from the absence or dysfunction of a copper-transporting protein. The disease is mainly seen in children, adolescents and young adults, and is characterized by hepatobiliary, neurologic, psychiatric and ophthalmologic (Kayser-Fleischer rings) manifestations. Mechanism of status dystonicus in WD is not clear. We present here a case study of Wilson’s disease in 14 year old child with dystonia not responded with routine therapy. Journal of Advances in Internal Medicine 2014;3(2):62-64","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"62-64"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V3I2.14066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic Obstructive Lung Disease in young: Alpha 1 anti trypsin deficiency","authors":"S. Dhakal, K. Agrawaal, N. Bhatta","doi":"10.3126/JAIM.V3I2.14067","DOIUrl":"https://doi.org/10.3126/JAIM.V3I2.14067","url":null,"abstract":"Alpha-1 antitrypsin (AAT) deficiency is a clinically under recognized inherited disorder. The main clinical manifestations relate to three separate organs: the lung, the liver, and the skin. In the lung, severe deficiency of AAT predisposes to chronic obstructive pulmonary disease. We present a case of 34 years male with a history of recurrent chest infections in past and treated in the line of bronchial asthma but not relieved. He was admitted on 22nd May 2011 at BPKIHS. He presented with type 2 respiratory failure and had features of severe pulmonary arterial hypertension and left lower lobe pneumonia. The patient got improved with the treatment and is doing well on follow up. The diagnosis should be strongly suspected in patients with history suggestive of bronchial asthma and with obstructive features. Journal of Advances in Internal Medicine 2014;3(2):65-67","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"65-67"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V3I2.14067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hair Dye poisoning - A rare case Report","authors":"Ankur Jain, R. Bajaj, M. Jindal","doi":"10.3126/JAIM.V3I2.14069","DOIUrl":"https://doi.org/10.3126/JAIM.V3I2.14069","url":null,"abstract":"Hair dye poisoning is not uncommon but an emerging entity in India with increased morbidity and mortality. The main component of hair dye poisoning is paraphenylenediamine(PPD), which is highly toxic thus making it life threatening. PPD poisoning can result in various toxic effects, multiorgan failure and ultimatetly death. Clinical suspicion and timely management can improve the outcome. We report a case of 35 year old male presented to hospital within 4 hours of consuming hair dye with complaints of swelling of face and neck, vomiting and difficulty in breathing. He was satisfactorily managed with supportive therapy and endotracheal intubation and discharged without any ill effects.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"72-73"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V3I2.14069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69272053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Etiological profile, gender difference and age group patterns of 415 patients presenting with lower gastrointestinal bleeding in the western region of Nepal","authors":"U. Shrestha","doi":"10.3126/JAIM.V3I2.14064","DOIUrl":"https://doi.org/10.3126/JAIM.V3I2.14064","url":null,"abstract":"Background: Lower gastrointestinal bleeding (LGIB) is a common clinical condition associated with significant morbidity and mortality. The aims of our study were to determine the etiological profile, gender difference and age group patterns of LGIB in Nepal. Methods: A total of 415 consecutive patients presenting with LGIB from April 2011 to September 2014 underwent colonoscopy and the etiology of LGIB was determined. Each diagnosis was compared with respect to the gender and age group. Results: Among 415 LGIB patients (males 62.2%, females 37.8%), the different etiologies of LGIB were as following: hemorrhoid 35.2%, non-specific colitis 24.8%, colon polyp 18.3%, inflammatory bowel disease (IBD) 10.4%, colon cancer 6.5%, diverticulosis 1.7%, unknown 1.4%, upper gastrointestinal bleeding 1.2% and radiation colitis 0.5%. The overall LGIB was more common in male; however, colon polyps were diagnosed more commonly in female (p<0.001). Among LGIB patients, the hemorrhoid was more common in the age group of 30-49 years, colon polyp in 50-69 years, colon cancer in 70-84 years, and non-specific colitis and IBD in 16-29 years (p<0.001). Conclusion: Hemorrhoid and non-specific colitis were the common causes of LGIB in Nepal; colon polyp, IBD and colon cancer were the next common causes. More males presented with LGIB than females; however, colon polyp was diagnosed more in females, which needs to be explored further. When LGIB was presented after 50 years of age, the most likely causes were colon polyp and colon cancer; hence colonoscopy is recommended in all LGIB patients after 50 years. Journal of Advances in Internal Medicine 2014;3(2):52-55","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"52-55"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V3I2.14064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manil R Bajracharya, M. Bhattarai, Buddha Bahadur Karki, S. Prajapati, D. Karmacharya, S. Manandhar, A. Rajouria
{"title":"Insulin Resistance in firstborn offspring of mother who developed diabetes later in fourth decade: Are both related to possible maternal malnutrition?","authors":"Manil R Bajracharya, M. Bhattarai, Buddha Bahadur Karki, S. Prajapati, D. Karmacharya, S. Manandhar, A. Rajouria","doi":"10.3126/JAIM.V3I2.14065","DOIUrl":"https://doi.org/10.3126/JAIM.V3I2.14065","url":null,"abstract":"Back grounds and Aims: Diabetes mellitus is increasing each day. We aimed to study the insulin resistance (IR) in the offspring of people with diabetes and its relation with lifestyle and clinical factors. Methods: This is a cross sectional study of IR in offspring over the age of 18 years and having parents with diabetes. Participants already diagnosed as having diabetes, suffering from any illness or using drugs that may have altered blood sugar levels were excluded. A fasting blood sample was taken for blood glucose and serum insulin level and IR was calculated using homeostatic model assessment for IR (HOMA –IR). Results: Forty nine participants volunteered for the study of which 24.5% were found to have IR, the cut off value of HOMA –IR being 2.48. As compared to the later born offspring, the firstborn were six times more at risk for IR (Odds ratio 6.25, P value 0.015) and after adjustment for BMI, it was seven times (Odds ratio 7.29 , P value 0.011). IR was more in offspring with maternal diabetes than with paternal one. The mean age of diagnosis of diabetes in mothers having firstborn offspring with IR was 38.5 years as compared to 48.2 years of those having firstborn offspring without IR. Conclusion: Higher risk of IR seen in the firstborn offspring whose mother later developed diabetes at fourth decade indicate the probability of relation of both conditions with possible maternal malnutrition during the first pregnancy. Further larger studies are required focusing on these aspects. Journal of Advances in Internal Medicine 2014;3(2):56-61","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/JAIM.V3I2.14065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xing Zhao, R. Sahi, Yu-yang Zhao, Jun Wang, Chun-Hui Li
{"title":"Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance","authors":"Xing Zhao, R. Sahi, Yu-yang Zhao, Jun Wang, Chun-Hui Li","doi":"10.3126/JAIM.V4I2.16897","DOIUrl":"https://doi.org/10.3126/JAIM.V4I2.16897","url":null,"abstract":"Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma. Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue. Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P 0.05). Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"4 1","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"2015-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69272438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Harsh, Ananya Adhikari, Parmatma Parazuli, R. Pathak, P. Khadga, Sashi Sharma
{"title":"Demographic Profile and Extra Intestinal Manifestations of Ulcerative Colitis in Nepalese population : Study from TUTH a Tertiary Care Centre , Kathmandu , Nepal","authors":"S. Harsh, Ananya Adhikari, Parmatma Parazuli, R. Pathak, P. Khadga, Sashi Sharma","doi":"10.3126/jaim.v4i1.14173","DOIUrl":"https://doi.org/10.3126/jaim.v4i1.14173","url":null,"abstract":"Background and Aims: This study aims at determining the demographic profile and extra-intestinal manifestations of Ulcerative Colitis in the Nepalese patients treated in a tertiary referral centre. Methods: The study was conducted between February 1, 2014 and January 31, 2015 at the Department of Gastroenterology Tribhuvan University Teaching Hospital, Kathmandu, Nepal. The clinical and epidemiologic data from patients diagnosed to have Ulcerative Colitis were obtained and analysed. Results: During the study period, 60 patients were identified as having ulcerative colitis. Mean age at diagnosis was 34.6 years. The mean duration of illness at diagnosis was 3.7 years. Extra-intestinal manifestations (EIM) were seen in 16.6% of the patients. Sacroilitis was the most common EIM seen in11.6% followed by peripheral arthritis in 6.6% of the patients. Episcleritis, Primary Sclerosing Cholangitis and Erythema Nodosum were seen only in 1.6% each. At the time of presentation, 38.3% (n=23) had proctosigmoiditis , 50% (n=30) left sided colitis and pancolitis was seen in 11.7% (n=7).53.3% patients had mild disease, 38.3% and 8.3 % presented with moderate to severe disease respectively. Conclusion: Peak age of onset for UC in the study was third and fourth decade which was similar to the various studies from Asia and West. Musculoskeletal manifestation was the most common extraintestinal manifestation of UC in Nepalese population. As Nepal is perhaps the most diverse country in terms of ethnicity, cultural variation, socio-economic status and health care facilities, a comprehensive nationwide data bank involving ethnicity and geographical variation is needed for a better definition of the disease characteristics. DOI Name http://dx.doi.org/10.3126/jaim.v4i1.14173","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69272217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HIV Cure: Are we there yet?","authors":"S. Khanal","doi":"10.3126/JAIM.V3I1.10705","DOIUrl":"https://doi.org/10.3126/JAIM.V3I1.10705","url":null,"abstract":"","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"46-46"},"PeriodicalIF":0.0,"publicationDate":"2014-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69271704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A single but prolonged and eventually fatal episode of capillary leak syndrome with a diagnosis of a small tumor mass B cell lymphoma","authors":"Marjorie Schlier, M. Rondeau-Lutz, J. Weber","doi":"10.3126/JAIM.V3I1.10702","DOIUrl":"https://doi.org/10.3126/JAIM.V3I1.10702","url":null,"abstract":"The capillary leak syndrome is a rare and serious condition. It is characterized by acute episodes of extravasation of liquids and proteins through the capillary wall to the interstitial space, with generalized edema, hemoconcentration, hypoproteinemia. Most often, capillary leak syndrome is idiopathic. Some cases are associated with neoplastic diseases. We describe a new case of capillary leak syndrome as a paraneoplastic syndrome of a large-B-cell lymphoma. This case is unusual because of the evolution of the capillary leak syndrome during a single but extended and fatal episode. The etiologic diagnosis in this case was particularly difficult to prove because of the small tumour mass. Our case report is thus the fourth reported case of capillary leak syndrome revealing a B-cell lymphoma with a small tumour mass. Accepted on February 29th, 2014 DOI Name http://dx.doi.org/10.3126/jaim.v3i1.10702","PeriodicalId":75443,"journal":{"name":"Advances in internal medicine","volume":"3 1","pages":"34-37"},"PeriodicalIF":0.0,"publicationDate":"2014-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69272032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}