Research on Chemical Intermediates最新文献

{"title":"Redox-coupled manganese-periodate systems: mechanistic insights, iodine fate, and environmental implications","authors":"Ziyi Dong,&nbsp;Jian Lu,&nbsp;Chenyan Hu,&nbsp;Zhengyu Dong,&nbsp;Tianyang Zhang,&nbsp;Chuqiao Wang,&nbsp;Xiaoming Peng,&nbsp;Bin Xu","doi":"10.1007/s11164-026-06061-5","DOIUrl":"10.1007/s11164-026-06061-5","url":null,"abstract":"<div><p>Periodate (PI)-based oxidation has emerged as a promising alternative to conventional advanced oxidation processes in water treatment. Among various catalytic systems, manganese-periodate (Mn/PI) systems have attracted increasing attention due to their environmental compatibility, cost-effectiveness, and distinctive reactivity. However, existing studies predominantly interpret Mn/PI chemistry from an “activation” perspective, while a unified understanding of its intrinsic redox nature remains lacking. Herein, we propose that Mn/PI systems should be redefined as redox-coupled catalytic networks, in which manganese species and iodine species undergo mutual redox interactions, driving pollutant transformation through multiple intertwined pathways. This review systematically elucidates the fundamental physicochemical properties of PI and traces the evolution of Mn/PI systems, supported by bibliometric analysis to reveal emerging research trends. Manganese-based catalysts are categorized into six classes according to manganese speciation and structural configuration, and their performance in degrading representative emerging contaminants is critically evaluated. Mechanistically, Mn/PI systems are interpreted through four interconnected pathways: reactive manganese species, reactive iodine species, reactive oxygen species, and electron transfer. Special emphasis is placed on the pivotal role of electron transfer and high-valent manganese intermediates in governing selective oxidation and limited mineralization. Furthermore, emerging evidence suggests that such redox-driven pathways may induce transformation-oriented processes, including coupling or oligomerization of electron-rich contaminants, thereby underscoring the need to reassess Mn/PI systems from both pathway complexity and application-scenario perspectives. Beyond pollutant degradation, the transformation, cycling, and environmental fate of iodine species are comprehensively analyzed, highlighting potential risks associated with iodinated by-products and secondary pollution. Finally, key challenges related to mechanistic ambiguity, mineralization efficiency, material durability, and large-scale applicability are identified. Future research directions are proposed to shift the focus from simple contaminant removal toward redox regulation, iodine risk management, and scenario-oriented application. This review aims to establish a conceptual framework for understanding Mn/PI redox coupling and to provide theoretical guidance for the rational design and sustainable implementation of Mn/PI systems.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 9","pages":"6411 - 6443"},"PeriodicalIF":3.3,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphorus-doped carbon aerogels for the adsorption of light alkane and aromatic compounds","authors":"Mingmei Zhang,&nbsp;Lei Zhao,&nbsp;Xin Wang,&nbsp;Yifan Zhao,&nbsp;Han Sun,&nbsp;Haijun Chen","doi":"10.1007/s11164-026-06042-8","DOIUrl":"10.1007/s11164-026-06042-8","url":null,"abstract":"<div><p>The development of porous carbon materials (PCM) for the efficient adsorption of volatile organic compounds (VOCs) emitted by the petrochemical industry such as light alkane and aromatic compounds remains a big challenge. The doping of non-metal hetero atoms provides an effective method to construct functional groups on the surface of PCM in order to enhance the electrostatic interaction between VOCs and the carbon adsorbent. In this study, carbon aerogels doped by phosphorus with tailored pore structures were prepared, and they exhibit enhanced adsorption performance for light alkane and aromatic compounds, which was also validated by pilot test in a petrochemical plant. The adsorption mechanism was elucidated through a combination of the structural characterization, kinetic analysis and theory calculations. It reveals that the treatment of phosphoric acid induces pore structure evolution of carbon aerogels, and the surface functional group of C–O–P–O(OH)₂ becomes more prevalent than that of C–P–O(OH)₂ as the doping amount of phosphorus increases. The adsorption of ethane and propane is dominated by the physisorption, respectively, whereas the adsorption of butane and benzene occurs more easily according to the chemisorption due to the formation of C–O–P–O(OH)₂ groups. This study provides a fundamental insight for the rational design of efficient carbon-based adsorbents for VOCs abatement.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 9","pages":"6493 - 6514"},"PeriodicalIF":3.3,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, spectroscopic investigation, x-ray analysis, and structure of 3,4-dibromo- and 3,4-diiodo-1,2,5-thiadiazoles","authors":"Győző G. Lajgut,&nbsp;Tibor Pasinszki,&nbsp;Ana Torvisco,&nbsp;Melinda Krebsz","doi":"10.1007/s11164-026-06058-0","DOIUrl":"10.1007/s11164-026-06058-0","url":null,"abstract":"<div><p>The 1,2,5-thiadiazole moiety serves as a valuable structural component in a diverse array of compounds and polymers, and small halogen-substituted derivatives may act as precursors in their synthesis. This study reports the first synthesis of 3,4-dibromo-1,2,5-thiadiazole (<b>1</b>) and 3,4-diiodo-1,2,5-thiadiazole (<b>2</b>), which were systematically characterized using mid-IR, Raman, UV–Vis, NMR, mass, and He I photoelectron spectroscopies. These analyses offered a comprehensive examination of the electronic and vibrational properties of the compounds. Vibrational spectroscopy indicates that solids <b>1</b> and <b>2</b> contain multiple crystalline phases. The solid-phase structure of <b>1</b> was determined using single-crystal X-ray diffraction. Depending on recrystallization conditions, <b>1</b> solidifies in either the triclinic P-1 or monoclinic P2/c space groups. <b>1</b> has sufficiently high vapor pressure for studying its thermal stability and decomposition in the gas-phase. Flash vacuum thermolysis of this compound yields quantitatively BrCN, NCCN, Br₂, and sulfur above 800 °C. Additionally, a synthetic method for the novel 3-bromo-4-iodo-1,2,5-thiadiazole (<b>3</b>) has been established.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 8","pages":"5683 - 5704"},"PeriodicalIF":3.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11164-026-06058-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective interference of carbon dioxide (CO2) during the catalytic conversion of carbon monoxide (CO) from automobile exhaust using portable horizontal packed beds","authors":"Debojyoti Das,&nbsp;Diptanshu Biswas,&nbsp;Anindya Mukherjee,&nbsp;Souvik Das,&nbsp;Ujjaini Sarkar","doi":"10.1007/s11164-026-06054-4","DOIUrl":"10.1007/s11164-026-06054-4","url":null,"abstract":"<div><p>The rapid growth of automobile usage has contributed to elevated ambient carbon monoxide (CO) concentrations, posing significant public health risks. To address these concerns, ceria–alumina-supported copper-based catalysts were synthesized using two variants of the Incipient Wet Impregnation method for application in automotive exhaust treatment. Comprehensive physicochemical analyses—including CHNS elemental analysis, thermogravimetric analysis (TGA), field emission scanning electron microscopy (FE-SEM), Brunauer–Emmett–Teller (BET) surface area measurements, Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD)—were performed to elucidate the catalysts’ composition, thermal stability, textural properties, and crystalline structure. The impact of carbon dioxide (CO_₂) interference on CO oxidation was systematically investigated by evaluating CO and CO_₂ removal efficiencies and catalyst selectivity. To mitigate CO_₂-induced suppression of catalytic activity, a secondary CO_₂ adsorbent-packed bed was incorporated upstream of the catalyst bed. Performance evaluations were conducted under cold start and accelerated operating conditions using horizontal packed-bed reactors installed in the tailpipe of a legacy Maruti-Suzuki 800 DX vehicle. Response Surface Methodology (RSM) was employed to validate experimental findings and optimize catalyst loading and operating parameters. Results indicate that increasing catalyst dosage and integrating an appropriate CO_₂ adsorbent substantially reduce CO_₂ interference, thereby enhancing overall CO oxidation efficiency. These findings provide a promising pathway for improving emission control in aging vehicle fleets.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 9","pages":"6105 - 6142"},"PeriodicalIF":3.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable conductive polylactic acid/cashew gum/polypyrrole nanocomposites reinforced with boehmite for multifunctional applications","authors":"Ayisha Jemshiya Kalladi,&nbsp;Jithin Kundalam Kadavath,&nbsp;Sadasivan Shaji,&nbsp;Manammel Thankappan Ramesan","doi":"10.1007/s11164-026-06060-6","DOIUrl":"10.1007/s11164-026-06060-6","url":null,"abstract":"<div><p>Biopolymer‐based conductive nanocomposite films composed of polylactic acid (PLA), cashew gum (CG), and polypyrrole (PPy), reinforced with varying concentrations of boehmite (BHM) nanoparticles, were successfully fabricated and systematically investigated for their structural, morphological, thermal, electrical, dielectric, and mechanical properties. Fourier transform infrared spectroscopy (FTIR) confirmed the presence of characteristic functional groups. Field-emission scanning electron microscopy (FE-SEM) and high-resolution transmission electron microscopy (HR-TEM) revealed a homogeneous morphology at optimal filler loading, while higher concentrations led to slight agglomeration. X-ray diffraction (XRD) analysis indicated a semi-crystalline nature of the composites, with modifications in crystallinity upon BHM incorporation. Thermogravimetric analysis (TGA) demonstrated enhanced thermal stability of the BHM-filled nanocomposite films and increased char residue. AC electrical conductivity at room temperature exhibited frequency-dependent behavior, consistent with Jonscher’s universal power law. The Arrhenius plot revealed that the activation energy decreased with increasing BHM loadings up to an optimal concentration. Low-frequency dielectric measurements showed a high dielectric constant due to a significant Maxwell–Wagner–Sillars effect. The nanocomposite film containing 2 wt% BHM exhibited optimum electrical performance, with a maximum AC conductivity of 10^–7 Scm⁻¹ and a dielectric constant of 18.5 at 10² Hz, indicating the formation of efficient charge-transport pathways and enhanced polarization effects within the nanocomposite system. Mechanical characterization revealed significant improvements in tensile strength from 38.04 MPa for the parent matrix to 47.77 MPa (2 wt%), Young’s modulus, and Shore hardness with BHM nanofiller incorporation. PLA/CG/PPy/BHM nanocomposite films exhibit enhanced thermal, electrical, dielectric, and mechanical properties, making them suitable for flexible electronics and sustainable multifunctional materials.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 9","pages":"6469 - 6491"},"PeriodicalIF":3.3,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of CQDs/Mn0.5Cd0.5S composite photocatalyst and its photocatalytic hydrogen evolution study","authors":"Hengyu Ai,&nbsp;Fanqi Meng,&nbsp;Shanshan Wang,&nbsp;Oxana P. Taran,&nbsp;Fubao Sun,&nbsp;Hong Yan","doi":"10.1007/s11164-026-06056-2","DOIUrl":"10.1007/s11164-026-06056-2","url":null,"abstract":"<div><p>Mn_0.5Cd_0.5S (MCS) is widely used in photocatalytic hydrogen production via water splitting. However, its inherent drawbacks, including low separation efficiency of photogenerated electron–hole pairs, poor stability, and severe photocorrosion, limit hydrogen production efficiency. In this study, carbon quantum dots (CQDs) were synthesized using alkaline lignin as the carbon source and were loaded onto the surface of MCS via ultrasonic-assisted treatment to construct CQDs/MCS composite photocatalyst. Characterization results revealed that the introduction of CQDs did not alter the crystal structure of MCS but effectively broadened its light absorption range, leading to a red shift of the absorption edge and a narrowed band gap, as well as reduced charge transfer resistance and hydrogen evolution overpotential. The CQDs/MCS composite photocatalyst with the addition of 15 mL CQDs solution exhibited the optimal photocatalytic performance, with a hydrogen evolution rate of 13.11 mmol g⁻¹ h⁻¹, which was 1.33 times higher than that of pure MCS. Moreover, the composite showed excellent recyclability. The enhanced hydrogen evolution performance of CQDs/MCS can be attributed to the fact that CQDs can capture photogenerated electrons and accelerate the separation of electron–hole pairs. In conjunction with the hole consumption by sacrificial agents, the CQDs/MCS composite achieved significantly enhanced photocatalytic hydrogen evolution performance.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 8","pages":"5889 - 5908"},"PeriodicalIF":3.3,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic Performance of Sol–gel Derived NiFeCrO4 Spinel Ferrite Nanocatalyst for Green and Eco-friendly Synthesis of 1-(Benzothiazolylamino) methyl-2-naphthols","authors":"Vitthal K. Vikhe,&nbsp;Dilip S. Aute,&nbsp;Rahul M. Aher,&nbsp;Anil G. Gadhave,&nbsp;Vitisha V. Vikhe","doi":"10.1007/s11164-026-06059-z","DOIUrl":"10.1007/s11164-026-06059-z","url":null,"abstract":"<div><p>In the present study, nickel ferrichromate (NiFeCrO₄) spinel ferrite nanocatalyst was successfully synthesized via sol–gel method using cost-efficient glycine as a fuel. The structural, morphological, and compositional characteristics of the synthesized nanoparticles were systematically investigated using FT-IR, XRD, EDS, FE-SEM, TEM, and VSM analyses. XRD confirmed the formation of crystalline spinel NiFeCrO₄ with an average crystallite size of 38.21 nm. FE-SEM and TEM studies revealed nearly spherical nanoparticles, while VSM study revealed the magnetic nature of NiFeCrO₄ NPs. The as-prepared NiFeCrO₄ nanoparticles were subsequently employed as an eco-friendly heterogeneous nanocatalyst for the one-pot multicomponent condensation of aromatic aldehydes, 2-naphthol, and 2-aminobenzothiazole derivatives under ultrasonic irradiation (50 Hz, 230 V AC) in ethanol at room temperature. The protocol afforded excellent yields (90–94%) within 40–50 min using 15 mol% catalyst loading, leading to the efficient synthesis of 1-(benzothiazolylamino) methyl-2-naphthols. A variety of aromatic aldehydes bearing electron-donating as well as electron-withdrawing substituents were effectively converted, affording the desired products in excellent yields. Notably, the catalyst demonstrated remarkable recyclability and could be reused up to five consecutive cycles without significant loss of catalytic activity. The developed protocol offers several advantages, including operational simplicity, short reaction times, high product purity, and excellent yields, while adhering to green chemistry principles such as the use of non-toxic conditions and ultrasonic assistance.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 8","pages":"5663 - 5681"},"PeriodicalIF":3.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Samarium-promoted Ni/YSZ catalysts for enhanced CO2 dry reforming: insights into reducibility and surface basicity","authors":"Abdulaziz A. M. Abahussain,&nbsp;Tahani Saad Algarni,&nbsp;Hamid Ahmed,&nbsp;Ahmed A. Ibrahim,&nbsp;Salwa B. Alreshaidan,&nbsp;Maher M. Alrashed,&nbsp;Ahmed E. Abasaeed,&nbsp;Ahmed S. Al-Fatesh","doi":"10.1007/s11164-026-06055-3","DOIUrl":"10.1007/s11164-026-06055-3","url":null,"abstract":"<div><p>Nickel (Ni)-based catalysts supported on yttria-stabilized zirconia (YSZ) were investigated for dry reforming of methane (DRM) to evaluate the influence of samarium (Sm) promotion on catalytic performance. A series of Sm-promoted catalysts supported on 8 wt.% yttria-stabilized zirconia (8YZr) with a fixed Ni loading (5 wt.%) and varying Sm contents (0.5–2 wt.%) were synthesized and systematically characterized. Sm incorporation was expected to improve oxygen mobility, strengthen metal–support interactions, and enhance resistance toward carbon deposition during DRM. X-ray diffraction (XRD) analysis indicated the retention of the tetragonal zirconia phase. Textural and surface characterization using Brunauer–Emmett–Teller (BET) analysis and X-ray photoelectron spectroscopy (XPS) indicated that Sm modified the electronic environment of 8YZr without significantly changing the overall textural characteristics of the catalyst. Temperature-programmed reduction (H₂-TPR) and temperature-programmed desorption (CO₂-TPD) analyses showed that moderate Sm loading enhanced the fraction of reducible Ni species and increased the contribution of weak-to-moderate basic sites. Catalytic evaluation at 800 °C and a gas hourly space velocity (GHSV) of 42,000 mL g⁻¹ h⁻¹ demonstrated that the catalysts containing 1 wt.% Sm exhibited the highest CH₄ and CO₂ conversions over 400 min time-on-stream. Post-reaction analyses indicated the presence of carbon species. However, no severe deactivation was observed within the tested duration, suggesting that active sites remained accessible under the investigated conditions.Kindly check and confirm the Article Title and corresponding author is correctly identified.Title confirmed. corresponding Ahmed S. Al-Fatesh; aalfatesh@ksu.edu.saoxy_aqreply_end</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 8","pages":"5639 - 5661"},"PeriodicalIF":3.3,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon nanotubes/heteropoly acid-coated stainless steel mesh as a green heterogeneous catalyst in chromene synthesis","authors":"Sara Ghavidel,&nbsp;Ghasem Aghapour,&nbsp;Seyedeh Fatemeh Hojati","doi":"10.1007/s11164-026-06048-2","DOIUrl":"10.1007/s11164-026-06048-2","url":null,"abstract":"<div><p>In the current work, stainless steel mesh was coated with a Keggin-type heteropoly acid (H₃PW₁₂O₄₀) and carbon nanotubes (SSM/CNT/HPA) using the sol–gel process and characterized by FT-IR, FE-SEM, EDS, TGA, XRD, and BET analyses. This new heterogeneous nanocomposite was used to synthesize chromene derivatives via multi-component reaction. Easy separation of the catalyst from the reaction mixture by a pair of tweezers is the most important advantage of the current work and make it a unique choice for organic transformations. Furthermore, the designed catalyst had features such as high surface area, stability in the air and reaction medium, reusability without significant reduction in catalytic performance, and high efficiency in multi-component reactions.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 8","pages":"5567 - 5593"},"PeriodicalIF":3.3,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel and green synthesis of pentacyclic-fused pyrano[3,2-b:5,4-b']diquinoline-8-carboxylic acids using Pfitzinger reaction","authors":"Xinyu Hou,&nbsp;Zhiwei Li,&nbsp;Wenyu Ma,&nbsp;Yang Li,&nbsp;Tianyu Liang","doi":"10.1007/s11164-026-06050-8","DOIUrl":"10.1007/s11164-026-06050-8","url":null,"abstract":"<div><p>In this work, a novel and green synthesis of pentacyclic-fused pyrano[3,2-<i>b</i>:5,4-<i>b'</i>]diquinoline-8-carboxylic acids (<b>7a-q</b>) has been developed via the Pfitzinger reaction of 5-methyl-1H-pyrano[3,4-<i>b</i>]quinolin-4(3H)-one (<b>9</b>) with various isatins (<b>8a-q</b>). The reaction employs the basic ionic liquid [BMIm]OH (0.5 equiv.) as an eco-friendly homogeneous catalyst in aqueous medium under ultrasonic irradiation at room temperature for 4–6 h, affording the desired products in 74–88% yields. This synthetic protocol offers several notable advantages, including experimental simplicity, mild and environmentally benign conditions (water as solvent, ultrasonic activation), elimination of conventional strong bases, easy work-up (filtration and recrystallization), and avoidance of hazardous organic solvents. The greenness of the method is further supported by Eco-scale scores (44–66), which fall within the range typical for pharmaceutical industry standards. This work provides a sustainable and practical approach to structurally novel pentacyclic quinoline derivatives of potential medicinal interest.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 8","pages":"5595 - 5611"},"PeriodicalIF":3.3,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}