Mayuri B. Thorat, Aniket N. Timble, Yatin U. Gadkari, Prashant Kurkute
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Ultrasound-assisted green synthesis of 1,8-dioxo-decahydroacridines catalyzed by guanidine hydrochloride
A novel, highly efficient, and eco-friendly method is introduced for synthesizing 1,8-dioxo-decahydroacridines via a multicomponent reaction involving substituted aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic amines, utilizing guanidine hydrochloride (GdnHCl) as a catalyst. This environmentally sustainable approach eliminates the need for hazardous solvents and extensive purification procedures, offering a column-free, high-yield, energy-efficient solution. This method demonstrates exceptional environmental sustainability, characterized by high atom economy (88.66%), minimal waste generation (E-factor = 0.041), and an excellent Eco-scale score of 95, underscoring its eco-friendly nature. The catalytic system exhibits remarkable efficiency, with a turnover number (TON) of 40 and a turnover frequency (TOF) of 0.044 s⁻1, while maintaining its activity across multiple reaction cycles.
期刊介绍：
Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry.
The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.
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