A convenient metal-free one-pot synthesis of some phthalazine derivatives mediated by 3-picolinic acid

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2025-07-20 DOI:10.1007/s11164-025-05682-6

Izarul Islam, Anamul Hossain, Shormila R. Das, Md. Mominuddin, Pijush K. Roy, Pran Gopal Karmaker, Harendra N. Roy

引用次数: 0

Abstract

A convenient four-component condensation reaction of phthalimide, hydrazine hydrate, malononitrile, and aromatic aldehyde has been executed by 3-picolinic acid in ethanol at reflux temperature in a very simple way. This developed method for synthesizing nitrilo-phthalazine derivatives is operationally simple, cost-effective, easy for product purification, environmentally benign, and high-yielding.

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以3-吡啶酸为媒介的一些邻苯二甲酸衍生物的无金属一锅合成

在回流温度下，以3-吡啶酸为原料，在乙醇中进行了邻苯二胺、水合肼、丙二腈和芳醛的四组分缩合反应。本发明的合成硝基-酞嗪衍生物的方法操作简单，成本低，易于产品纯化，对环境无害，收率高。图形抽象

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.