World journal of experimental medicine最新文献

{"title":"Leukoplakia of oral cavity and urinary bladder are premalignant to squamous carcinoma.","authors":"Mohamed Wishahi","doi":"10.5493/wjem.v16.i1.114526","DOIUrl":"10.5493/wjem.v16.i1.114526","url":null,"abstract":"<p><p>A critical work published by Panchannavar <i>et al</i> on the close link between oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC), the expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin would predict the progression of OLK to OSCC. In connection with similar clinical status, there are cumulative data that the urinary bladder leukoplakia (Bladder-LK) progress to invasive bladder squamous cell carcinoma (SCC) which does not response to local therapy that indicates immediate cystectomy, these findings were established with multiple publications with clinical follow-up that showed the progression of leukoplakia to SCC in both oral cavity and urinary bladder. Oral leukoplakia, oral SCC, Bladder-LK, urothelial carcinoma (UC) of the bladder, squamous differentiation of UC, and bladder-SCC showed expression of programmed cell death-ligand 1 (PD-L1). In recent years, immune checkpoint inhibitors immunotherapy for malignant tumors became a promising cancer immunotherapy. However, the role of PD-L1 inhibitors in OLK OSCC is controversial. Objectives are to highlight the rationale for prospective treatment of OLK and OSCC with PD-L1 inhibitors immunotherapy.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"16 1","pages":"114526"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic effects of <i>Gymnema sylvestre</i> and metformin co-therapy in a type 2 diabetic rat model.","authors":"Ajay Kodiyatar, Akhilesh Mishra, Megh Singh Dhakad, Vandana Roy, Mirza Masroor Ali Beg, Niket Rai","doi":"10.5493/wjem.v16.i1.116252","DOIUrl":"10.5493/wjem.v16.i1.116252","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia. Metformin is the standard therapy, however plant-based adjuncts such as <i>Gymnema sylvestre</i> (GS) are gaining interest for their anti-diabetic potential.</p><p><strong>Aim: </strong>To evaluate the anti-diabetic effects of GS, alone and with metformin, on glycemic control, lipid profile, renal function, and body weight in high-fat diet and streptozotocin (STZ)-induced T2DM rats.</p><p><strong>Methods: </strong>Thirty male Sprague Dawley rats (150 ± 20 g) were divided into five groups: Normal control, diabetic control (DC), metformin-treated, GS-treated, and combination-treated (metformin + GS). T2DM was induced by 21 days of high-fat diet followed by two STZ injections (25 mg/kg, five days apart). Rats with fasting blood glucose (FBG) ≥ 270 mg/dL were treated for 28 days. Biochemical parameters (FBG, glycated hemoglobin, serum creatinine, and cholesterol) and body weight were assessed.</p><p><strong>Results: </strong>By day 28, all treatment groups showed significant improvements compared to DC. Metformin produced the greatest reductions in FBG, cholesterol, creatinine, and glycated hemoglobin. GS monotherapy had modest but significant effects, while metformin + GS improved glycemic control and lipid profile more effectively than GS alone. Metformin remained superior in renal protection. All treated groups showed significantly higher body weights than DC, indicating protection against STZ-induced weight loss.</p><p><strong>Conclusion: </strong>This study demonstrated that metformin and GS, individually and in combination, improved glycemic control and metabolic outcomes in T2DM rats. While metformin showed the greater efficacy, combination therapy provided additive benefits, supporting GS as a potential adjunct in T2DM management.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"16 1","pages":"116252"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute childhood leukemia and ophthalmic manifestations: An observational study from Eastern India.","authors":"Sucheta Parija, Shanmugasundaram Palanisamy","doi":"10.5493/wjem.v16.i1.111034","DOIUrl":"10.5493/wjem.v16.i1.111034","url":null,"abstract":"<p><strong>Background: </strong>The ocular manifestations in acute leukemia can occur due to primary leukemic infiltration or secondary to the disease and chemotherapy complications. As the life expectancy has increased in leukemia cases due to the advent of modern chemotherapy, the incidence of ocular features is more evident.</p><p><strong>Aim: </strong>To describe the clinical pattern of ocular manifestations at the time of diagnosis of acute leukemia in children.</p><p><strong>Methods: </strong>This was a hospital-based, cross-sectional study conducted at a tertiary care academic Institute in eastern India between July 2016 to December 2019. All children below 15 years diagnosed with acute leukemia underwent a comprehensive eye checkup before initiation of chemotherapy. The demographic details, type of leukemia, hematological findings, and chemotherapy regimen were documented.</p><p><strong>Results: </strong>Among the 47 children diagnosed with acute leukemia only 19 cases (40.4%) had ocular involvement. There were 33 boys (70.2%) and 14 (29.8%) girls. Ocular involvement was more common in lymphoblastic leukemia in our study in 13 cases [39.4%; 11 B-acute lymphoblastic leukemia (B-ALL), 2 T-ALL] than in myeloid leukemia in 6 cases (42.9%). The most common manifestation was leukemic retinopathy mainly intraretinal hemorrhages in 12 cases (25.5%; B-ALL-10, and T-ALL-2).</p><p><strong>Conclusion: </strong>Ophthalmological manifestations are more common in ALL patients (39.4%). Periodic ophthalmic evaluations of all patients must be made to detect ocular findings in asymptomatic cases. Early detection, risk stratification, and regular follow-up are also needed.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"16 1","pages":"111034"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very low-density lipoprotein and the human health.","authors":"Alok Bharadwaj, Manas Taneja, Sneha Dubey, Aditya Saxena","doi":"10.5493/wjem.v16.i1.117024","DOIUrl":"10.5493/wjem.v16.i1.117024","url":null,"abstract":"<p><p>Very low-density lipoprotein (VLDL), released in the liver, is the only lipoprotein that includes apolipoprotein B (marker for cardiovascular risk), triglycerides, and cholesterol. VLDL is essential in transporting lipids and cholesterol to organs and cells for utilization. VLDL also contributes significantly to the advancement of atherosclerotic heart disease. We comprehensively summarize VLDL's physiological roles and data supporting its pathological effects. VLDL has been proven to promote atherosclerosis in the metabolic syndrome. VLDL isolated from metabolic syndrome patients is cytotoxic to atrial myocytes, causing atrial myopathy and contributing to atrial fibrillation. Several endocrine diseases may impact VLDL levels, which can be boosted by supplementing with progesterone, estrogen, cortisol, and growth hormones. VLDL stimulates high blood pressure by secreting aldosterone. VLDL induces neuroinflammation, which may lead to cognitive impairment. VLDL is linked to chronic renal illness, autoimmune disorders, and some skin diseases. VLDL production outside the liver caused by intestinal dysbiosis is considered harmful. New evidence reveals that VLDL metabolism has a role in the development and risk of cancer, as well as sleep disturbances. Aside from this, VLDL metabolism and carcinogenesis might be altered by the VLDL receptor. Overall, growing findings point to the role of VLDL in many illnesses.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"16 1","pages":"117024"},"PeriodicalIF":0.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kefir revisited: Insights from the North Caucasus.","authors":"Palina Kh Katchieva, Khalimat Kh Katchieva, Fairuza I Kipkeeva, Zaira F Kharaeva, Vladimir V Smeianov","doi":"10.5493/wjem.v15.i4.112191","DOIUrl":"10.5493/wjem.v15.i4.112191","url":null,"abstract":"<p><p>Kefir is a probiotic fermented milk product, distributed throughout the world from the North Caucasus, formed by fermenting milk with kefir grains. Kefir grains represent a striking example of microbial symbiosis between bacteria and fungi. Despite the extensive shifts in microbial composition during milk fermentation, the composition of kefir grains remains relatively constant. The evolutionary origin of such a stable symbiont remains unclear. There are multiple reports of differences between commercial kefir-like products and kefir prepared according to traditional techniques by fermenting milk with indigenous kefir grains. Modern research is aimed at studying the health properties of kefir and kefir grain components. To accurately represent the evolutionary origin of kefir grains, the characteristics of important species or consortia for the development of new promising products, it is essential to study the composition of samples of historical kefir origin, particularly the Karachay-Cherkess and Kabardino-Balkarian Republics of the North Caucasus.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 4","pages":"112191"},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteria in neoplastic diseases: A brief note on Wilms tumor.","authors":"Adam Burke, Adekunle Sanyaolu, Amitabha Ray","doi":"10.5493/wjem.v15.i4.108221","DOIUrl":"10.5493/wjem.v15.i4.108221","url":null,"abstract":"<p><p>Bacteria can be involved in the pathological processes of cancer in different manners - for instance, as an etiological factor or predisposing factor, in secondary infection, as well as modified bacteria or bacterial products in cancer treatment. The bacterial etiological connection or its role as a predisposing factor is mainly relevant to adult cancers, which are primarily associated with individual lifestyles and/or environmental issues. In contrast, genetic abnormalities are perhaps linked with tumorigenesis in the pediatric age group. Nonetheless, secondary infections significantly affect morbidity and mortality among pediatric cancer patients in spite of precautionary measures. On the other hand, bacterial products, <i>i.e.</i>, toxins, are potential molecules for targeted cancer therapy. These therapeutic agents have two parts: Usually a receptor-binding antibody (<i>e.g.</i>, anti-HER2 antibody) and a toxin (<i>e.g.</i>, <i>Pseudomonas</i> exotoxin A). Similarly, several investigators have been trying to develop therapeutic approaches that target Wilms tumor 1 protein, whose dysregulation is thought to be fundamentally responsible for the pathogenesis of Wilms tumor, the most common kidney tumor of childhood. However, the overexpression of Wilms tumor 1 protein has been documented in many cancer tissues - both solid tumors and hematological malignancies. This article briefly reviews both the pathological and clinical characteristics of Wilms tumor along with relevant secondary infections.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 4","pages":"108221"},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of sodium-glucose cotransporter 2 inhibitors in liver diseases.","authors":"Prajna Anirvan, Suprabhat Giri, Sayan Malakar, Dibya Lochan Praharaj","doi":"10.5493/wjem.v15.i4.106403","DOIUrl":"10.5493/wjem.v15.i4.106403","url":null,"abstract":"<p><p>Sodium-glucose cotransporter 2 (SGLT2) inhibitors compete with the SGLT2 protein for glucose binding in the renal tubules, reducing glucose reabsorption in the kidneys. This in turn leads to increased excretion of glucose, sodium, and water into the urine. These inhibitors, initially developed for diabetes management, have shown potential benefits beyond glycemic control, impacting liver health through various mechanisms. They have emerged as promising agents in managing liver conditions, including fatty liver disease, cirrhosis, and the prevention of hepatocellular carcinoma (HCC). They modulate processes like oxidative stress, inflammation, and autophagy, which are implicated in metabolic dysfunction-associated steatotic liver disease pathogenesis, potentially reducing steatosis and inflammation and preventing progression to more severe liver conditions. In patients with liver cirrhosis, SGLT2 inhibitors have been associated with a reduced need for large-volume paracentesis and lower mortality rates, indicating their potential in managing diuretic-resistant ascites. SGLT2 inhibitors have shown potential in modulating molecular pathways involved in HCC, such as inflammatory responses and oxidative stress, that could justify their use in the prevention of HCC and improving survival in patients with HCC. The present review synthesized findings from multiple studies to elucidate the role of SGLT2 inhibitors in these liver conditions.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 4","pages":"106403"},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and diabetes: Emerging insights from contemporary diabetes research.","authors":"Sanjana Aggarwal, Vatsalya Choudhary, Azra Kothawala, Denise Mourad, Charu Agarwal, Juhi V Amin, Maneeth Mylavarapu, Shaylika Chauhan, Rupak Desai","doi":"10.5493/wjem.v15.i4.109839","DOIUrl":"10.5493/wjem.v15.i4.109839","url":null,"abstract":"<p><p>This review summarizes the breakthrough studies on diabetes management in pregnancy presented at the 84^th American Diabetes Association Scientific Sessions, encompassing 31 presentations, categorized into basic science, clinical studies, therapeutic interventions, and maternal/neonatal outcomes. Basic science investigations reported the enduring impact of gestational diabetes mellitus on offspring adiposity, neurodevelopment, transgenerational metabolic risk, and key insights on β-cell functioning and islet dysfunctioning. Clinical studies explored novel diagnostic and monitoring approaches, highlighting the potential of continuous glucose monitoring for early detection, risk prediction, and personalized management. Therapeutic interventions demonstrated the efficacy of glucagon-like peptide 1 agonists in preventing cognitive deficits in offspring. Maternal and neonatal health studies emphasized the critical role of optimal glycemic control, early gestational diabetes mellitus intervention, and risk stratification utilizing HbA1c and electronic heart records.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 4","pages":"109839"},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal epithelial hyperplasia: Clinical features, diagnosis and management challenges.","authors":"Cesar Omar Ramos-Gregorio, Omar Tremillo-Maldonado, Felipe Silveira, Lauren Frenzel Schuch, Vanesa Pereira-Prado, Estefania Sicco, Ana Cristina Soto-Najera, Marcelo GómezPalacio-Gastélum, Mario Isiordia-Espinoza, Juan José Muñoz-Ibarra, Victor Toral-Rizo, Ronell Bologna-Molina","doi":"10.5493/wjem.v15.i4.114368","DOIUrl":"10.5493/wjem.v15.i4.114368","url":null,"abstract":"<p><p>Multifocal epithelial hyperplasia (MEH), also known as Heck's disease, is a rare and benign condition of the oral mucosa that is strongly associated with low-risk human papillomavirus (HPV) genotypes 13 and 32. This narrative review synthesizes recent findings regarding the epidemiology, viral mechanisms, clinical and histopathological features, diagnostic strategies-including molecular and immunohistochemical methods-and therapeutic approaches to MEH. This disease predominantly affects children and adolescents from Indigenous American countries, although cases have been increasingly reported in nonendemic regions. MEH manifests clinically as multiple, asymptomatic papules or nodules, typically exhibiting a characteristic cobblestone-like appearance. Histologically, it presents with epithelial hyperplasia, koilocytosis, and altered cytokeratin expression. Molecular techniques such as polymerase chain reaction and <i>in situ</i> hybridization are pivotal for accurate viral genotyping, while immunohistochemical markers such as CK4/13, Ki-67, and the absence of p16 can be useful adjuncts in differential diagnosis. Despite its self-limiting nature in most cases, treatment may be warranted in symptomatic or immunocompromised patients. This review highlights the need to improve diagnostic access, develop targeted vaccines, and implement public health strategies in vulnerable communities. It also highlights existing gaps in knowledge, particularly regarding host-virus interactions and the absence of standardized treatment protocols.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 4","pages":"114368"},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stepwise model to differentiate pathogenic from non-pathogenic organisms in urinary isolates: Effectiveness, safety, and feasibility prospective study.","authors":"Bimalesh Yadav, Jaideep Pilania, Ravi Kant, Balram Ji Omar, Sandeep Saini, Vikas Kumar Panwar, Yogesh Bahurupi, Prasan Kumar Panda","doi":"10.5493/wjem.v15.i4.109134","DOIUrl":"10.5493/wjem.v15.i4.109134","url":null,"abstract":"<p><strong>Background: </strong>Clinical decision-making in urinary tract infections depends heavily on accurately distinguishing between pathogenic and non-pathogenic organisms. The interpretation of urine culture results is influenced by proper sample collection, the patient's clinical context, and organism-specific characteristics. However, there is currently no definitive method to determine whether a urinary isolate is truly pathogenic. This distinction is critical, as treatment decisions hinge on it. This pioneering study systematically applies a stepwise model to differentiate pathogenic from non-pathogenic urinary isolates-an approach not previously described.</p><p><strong>Aim: </strong>To determine whether a urinary isolate is pathogenic (commensal, colonizer, or direct pathogen) or non-pathogenic (commensal, colonizer, or contaminant) using a structured, stepwise approach.</p><p><strong>Methods: </strong>This prospective, longitudinal, exploratory study was conducted over 24 months, starting in January 2022, at All India Institute of Medical Sciences Rishikesh, following approval from the Institutional Ethics Committee. A stepwise model developed by the investigators was applied to assess the nature of the isolates. Data recorded using REDCap, and analysis was performed using SPSS Version 25.</p><p><strong>Results: </strong>A total of 275 consecutive patients aged over 18 years with positive urine cultures-initially treated with antibiotics based on microbiological and clinical assessment-were included. The stepwise model classified 90.54% of cases as pathogenic (commensals: 61.81%, colonizers: 14.18%, and direct pathogens: 14.54%) and 9.45% as non-pathogenic. The model showed that there could be a significant reduction in average hospital stay by over 13 days, along with saving approximately Rs. 981 per patient in antibiotic costs in non-pathogenic cohort.</p><p><strong>Conclusion: </strong>This novel model identified that approximately one in ten urinary isolates, initially considered pathogenic and treated with antibiotics, were in fact non-pathogenic. The model is safe, feasible, and potentially valuable in resource-limited settings, warranting broader validation and implementation.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 4","pages":"109134"},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12767255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}