World journal of experimental medicine最新文献

{"title":"Ophthalmologic implications to consider when using hydroxychloroquine to treat COVID-19 and induced arthritis.","authors":"Marco Zeppieri","doi":"10.5493/wjem.v13.i4.95","DOIUrl":"https://doi.org/10.5493/wjem.v13.i4.95","url":null,"abstract":"<p><p>As the world continues to grapple with the novel coronavirus [coronavirus disease 2019 (COVID-19)], many treatments have been proposed to help alleviate the symptoms and reduce the mortality rate. Hydroxychloroquine (HCQ) is an antimalarial drug that is typically used for several autoimmune, rheumatic, and dermatological conditions. It has also been considered to treat and prevent COVID-19 and subsequent arthritis associated with the infection. This drug is known to cause retinal toxicity, which can lead to vision impairment or loss. While the exact mechanism is not yet fully understood, it is thought to be due to the accumulation of the drug in the retinal pigment epithelium. The risk of toxicity increases with long-term use or with high doses of the drug and is more likely to occur in patients with pre-existing retinal diseases or those who are predisposed to retinal diseases. In this context, several steps can be taken to monitor and minimize the risk of ophthalmological adverse events when using HCQ to treat patients with COVID-19.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 4","pages":"95-98"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/34/WJEM-13-95.PMC10520758.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41123990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized clinical managements through exploring circulating neural cells and electroencephalography.","authors":"Parvin Mehdipour,&nbsp;Nima Fathi,&nbsp;Masoud Nosratabadi","doi":"10.5493/wjem.v13.i4.75","DOIUrl":"https://doi.org/10.5493/wjem.v13.i4.75","url":null,"abstract":"<p><strong>Background: </strong>Since an initial diagnosis of Alzheimer disease (AD) in 1907, early detection, was unavailable through 116 years. Up-regulation of V-Ets erythroblastosis virus E26 oncogene homolog 2 (Ets2) is capable to enhance neuronal susceptibility and degeneration. Protein expression (PE) of Ets2 has functional impact on AD and Down's syndrome, with diverse intensity. PE of Ets2 has an influential pathogenic impact on AD. Clinical aspects of neurological disorders directly interact with psychological maladies. However, deterioration requires an early management including programmed based protection.</p><p><strong>Aim: </strong>To include cell biology in neuro-genetics; personalized, prognostics, predictive, preventive, predisposing (5xP) platform, accompanied by stratifying brain channels behavior pre- and post-intervention by light music in the AD-patients.</p><p><strong>Methods: </strong>Include exploration of PE assay and electroencephalography of brain channels. The processes are applied according to: (1) Triangle style, by application of cellular network; and (2) PE assay of Ets2 in the peripheral blood of the patients with AD, by Manual single cell based analysis, and Flow-cytometry. (1) Applying the Genetic counselling and pedigree analysis; (2) considering the psychological status of the referral cases; (3) considering the macro-and/or micro-environmental factors; (4) performing the required Genetics' analysis; and (5) applying the required complementary test(s).</p><p><strong>Results: </strong>PE of Ets2 has pathogenic role in AD. PE unmasked the nature of heterogeneity/diversity/course of evolution by exploring Ets2, D1853N polymorphism in Ataxia Telangiectasia mutated gene (ATM), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and course of evolution at the single cell level of the brain. Ets2 revealed different cellular behavior in the blood and suggested the strategy as 'Gene Product-Based Therapy' and the personalized managements for the patients. PE reflected weak expression of ATM, mosaic pattern of Ets2; remarkable expression of VEGF and EGF by highlighting an early detective platform, considering circulating neural cells (CNCs) and the required molecular investigation, for the target individual(s) predisposed to AD or other neural disease including brain neoplasia. Brain channels-cooperation with diverse/interactive-ratios lead to strategic balancing for improving the life-quality in AD.</p><p><strong>Conclusion: </strong>We highlighted application of the single CNCs and correlated Ratio based between Brain channels by providing the 5xP personalized clinical management model for an early detection and therapy of the patients with AD and their targeted/predisposed relatives. Novel-evolutionary/hypothetic/heterogenic-results in brain-channels offer personalizd/constructive markers with unlimited cooperation in health and disease.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 4","pages":"75-94"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/74/WJEM-13-75.PMC10520756.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on hydroxychloroquine use in pregnancy.","authors":"Wassan Nori,&nbsp;Nabeeha Najatee Akram,&nbsp;Raid M Al-Ani","doi":"10.5493/wjem.v13.i4.99","DOIUrl":"https://doi.org/10.5493/wjem.v13.i4.99","url":null,"abstract":"<p><p>It is well-known that hydroxychloroquine (HCQ) treats malaria, systemic lupus erythematosus, and rheumatoid arthritis in women for its immunomodulatory and anti-inflammatory action. Additionally, HCQ was used in cases with refractory antiphospholipid syndrome. HCQ safety was reinforced in pregnant women owing to insignificant reports of adverse pregnancy outcomes and major congenital malformation. Recently, HCQ was tested in cases with chronic placental inflammation with a promising result of increased life birth; however, its benefit needs further validation. We aimed to highlight the recent updates for HCQ use in various conditions in pregnancy.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 4","pages":"99-101"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/f4/WJEM-13-99.PMC10520759.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proportion of thyroid cancer and other cancers in the democratic republic of Congo.","authors":"John Bukasa-Kakamba,&nbsp;Ayrton I Bangolo,&nbsp;Pascal Bayauli,&nbsp;Branly Mbunga,&nbsp;Francis Iyese,&nbsp;Aliocha Nkodila,&nbsp;Ali Atoot,&nbsp;Gaurav Anand,&nbsp;Stacy H Lee,&nbsp;Maimona Chaudhary,&nbsp;Pamela Q Fernandes,&nbsp;Hari Pss Mannam,&nbsp;Adithya Polavarapu,&nbsp;Merajunissa Merajunnissa,&nbsp;Abdullah Azhar,&nbsp;Mohan N Alichetty,&nbsp;Gauravdeep Singh,&nbsp;Georgemar V Arana,&nbsp;Imranjot Sekhon,&nbsp;Manbir Singh,&nbsp;José D Rodriguez-Castro,&nbsp;Adam Atoot,&nbsp;Simcha Weissman,&nbsp;Jean Rene M'buyamba","doi":"10.5493/wjem.v13.i3.17","DOIUrl":"https://doi.org/10.5493/wjem.v13.i3.17","url":null,"abstract":"<p><strong>Background: </strong>Cancer diagnosis is increasing around the world and in the Democratic Republic of the Congo (DRC). The proportion of thyroid cancer has increased over the past three decades. There are very few studies on cancer epidemiology, and in particular on thyroid cancer in the DRC.</p><p><strong>Aim: </strong>To establish the most recent proportion of thyroid cancer in the DRC compared to other cancers.</p><p><strong>Methods: </strong>This is a retrospective and descriptive study of 6106 consecutive cancer cases listed in the pathological registers of 4 Laboratories in the city of Kinshasa. This study included all cancer cases recorded in the registers between 2005 and 2019.</p><p><strong>Results: </strong>From a sample of 6106 patients, including all cancer types, 68.3% cases were female and 31.7% were male. Breast and cervical cancer were the most common types of cancer in women and, prostate and skin cancer were the most common types in men. Thyroid cancer was sixth in proportion in women and eleventh in men compared to all cancers. Papillary carcinoma was the most common of thyroid cancers. Rare cancers such as anaplastic and medullary thyroid carcinomas had a proportion of 7% and 2%, respectively.</p><p><strong>Conclusion: </strong>Newer diagnostic tools led to a surge in cancer diagnoses in the DRC. Thyroid cancer has more than doubled its proportion over the last several decades in the country.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 3","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/4e/WJEM-13-17.PMC10308319.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus.","authors":"Ioannis G Lempesis, Vasiliki E Georgakopoulou","doi":"10.5493/wjem.v13.i3.7","DOIUrl":"10.5493/wjem.v13.i3.7","url":null,"abstract":"<p><p>Overweight, obesity, and type 2 diabetes mellitus pose global health problems that are ever-increasing. A chronic low-grade inflammatory status and the presence of various pro-inflammatory markers either in circulation or within dysfunctional metabolic tissues are well established. The presence of these factors can, to some extent, predict disease development and progression. A central role is played by the presence of dysfunctional adipose tissue, liver dysfunction, and skeletal muscle dysfunction, which collectively contribute to the increased circulatory levels of proinflammatory factors. Weight loss and classical metabolic interventions achieve a decrease in many of these factors' circulating levels, implying that a better understanding of the processes or even the modulation of inflammation may alleviate these diseases. This review suggests that inflammation plays a significant role in the development and progression of these conditions and that measuring inflammatory markers may be useful for assessing disease risk and development of future treatment methods.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 3","pages":"7-16"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/86/WJEM-13-7.PMC10308320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis: An experimental study in Brazil\".","authors":"Fabrício Freire de Melo,&nbsp;Lilian Martins Oliveira Diniz,&nbsp;José Nélio Januário,&nbsp;João Fernando Gonçalves Ferreira,&nbsp;Rafael Santos Dantas Miranda Dórea,&nbsp;Breno Bittencourt de Brito,&nbsp;Hanna Santos Marques,&nbsp;Fabian Fellipe Bueno Lemos,&nbsp;Marcel Silva Luz,&nbsp;Samuel Luca Rocha Pinheiro,&nbsp;Gifone Aguiar Rocha,&nbsp;Dulciene Maria de Magalhães Queiroz","doi":"10.5493/wjem.v13.i3.47","DOIUrl":"https://doi.org/10.5493/wjem.v13.i3.47","url":null,"abstract":"<p><p>[This corrects the article on p. 100 in vol. 12, PMID: 36196438.].</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 3","pages":"47-49"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/41/WJEM-13-47.PMC10308321.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Writing strategies for improving the access of medical literature.","authors":"Pratishtha B Chaudhari,&nbsp;Akshat Banga","doi":"10.5493/wjem.v13.i3.50","DOIUrl":"https://doi.org/10.5493/wjem.v13.i3.50","url":null,"abstract":"<p><p>When conducting a literature review, medical authors typically search for relevant keywords in bibliographic databases or on search engines like Google. After selecting the most pertinent article based on the title's relevance and the abstract's content, they download or purchase the article and cite it in their manuscript. Three major elements influence whether an article will be cited in future manuscripts: the keywords, the title, and the abstract. This indicates that these elements are the \"key dissemination tools\" for research papers. If these three elements are not determined judiciously by authors, it may adversely affect the manuscript's retrievability, readability, and citation index, which can negatively impact both the author and the journal. In this article, we share our informed perspective on writing strategies to enhance the searchability and citation of medical articles. These strategies are adopted from the principles of search engine optimization, but they do not aim to cheat or manipulate the search engine. Instead, they adopt a reader-centric content writing methodology that targets well-researched keywords to the readers who are searching for them. Reputable journals, such as <i>Nature</i> and the <i>British Medical Journal</i>, emphasize \"online searchability\" in their author guidelines. We hope that this article will encourage medical authors to approach manuscript drafting from the perspective of \"looking inside-out.\" In other words, they should not only draft manuscripts around what they want to convey to fellow researchers but also integrate what the readers want to discover. It is a call-to-action to better understand and engage search engine algorithms, so they yield information in a desired and self-learning manner because the \"Cloud\" is the new stakeholder.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 3","pages":"50-58"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/fe/WJEM-13-50.PMC10308323.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of children in the Bulgarian COVID-19 epidemic: A mathematical model study.","authors":"Latchezar Tomov,&nbsp;Hristiana Batselova,&nbsp;Snezhina Lazova,&nbsp;Borislav Ganev,&nbsp;Iren Tzocheva,&nbsp;Tsvetelina Velikova","doi":"10.5493/wjem.v13.i3.28","DOIUrl":"https://doi.org/10.5493/wjem.v13.i3.28","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic affects all aspects of our lives, including children. With the advancement of the pandemic, children under five years old are at increased risk of hospitalization relative to other age groups. This makes it paramount that we develop tools to address the two critical aspects of preserving children's health - new treatment protocols and new predictive models. For those purposes, we need to understand better the effects of COVID-19 on children, and we need to be able to predict the number of affected children as a proportion of the number of infected children. This is why our research focuses on clinical and epidemiological pictures of children with heart damage post-COVID, as a part of the general picture of post-COVID among this age group.</p><p><strong>Aim: </strong>To demonstrate the role of children in the COVID-19 spread in Bulgaria and to test the hypothesis that there are no secondary transmissions in schools and from children to adults.</p><p><strong>Methods: </strong>Our modeling and data show with high probability that in Bulgaria, with our current measures, vaccination strategy and contact structure, the pandemic is driven by the children and their contacts in school.</p><p><strong>Results: </strong>This makes it paramount that we develop tools to address the two critical aspects of preserving children's health - new treatment protocols and new predictive models. For those purposes, we need to understand better the effects of COVID-19 on children, and we need to be able to predict the number of affected children as a proportion of the number of infected children. This is why our research focuses on clinical and epidemiological pictures of children with heart damage post-COVID, as a part of the general picture of post-Covid among this age group.</p><p><strong>Conclusion: </strong>Our modeling rejects that hypothesis, and the epidemiological data supports that. We used epidemiological data to support the validity of our modeling. The first summer wave in 2020 from the listed here school proms endorse the idea of transmissions from students to teachers.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 3","pages":"28-46"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/69/WJEM-13-28.PMC10308322.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin's actions are not limited to sleep.","authors":"Evangelia Venaki,&nbsp;Eftychia Koukkou,&nbsp;Ioannis Ilias","doi":"10.5493/wjem.v13.i2.4","DOIUrl":"https://doi.org/10.5493/wjem.v13.i2.4","url":null,"abstract":"<p><p>Melatonin is widely available as a supplement, usually for sleep disorders. The consumption of melatonin supplements has increased considerably in recent years. An overlooked aspect of melatonin's administration is the resulting increase in prolactin secretion, <i>via</i> its action on hypothalamic dopaminergic neurons. We believe that since the effect of melatonin on prolactin is tangible, the laboratory finding of hyperprolactinemia could be encountered more often, given the increase in melatonin's use. This is an issue that merits further study.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 2","pages":"4-6"},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/36/WJEM-13-4.PMC10037225.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility outcomes following bariatric surgery.","authors":"Wassan Nori,&nbsp;Wisam Akram,&nbsp;Eham Amer Ali","doi":"10.5493/wjem.v13.i1.1","DOIUrl":"https://doi.org/10.5493/wjem.v13.i1.1","url":null,"abstract":"<p><p>Obesity impacts human health in more than one way. The influence of obesity on human reproduction and fertility has been extensively examined. Bariatric surgery (BS) has been used as an effective tool to achieve long-term weight loss in both sexes. BS improves hormonal profiling, increasing the odds of spontaneous pregnancy and success rates following assisted reproductive techniques in infertile females. For obese males, BS does improve sexual function and hormonal profile; however, conflicting reports discuss reduced sperm parameters following BS. Although the benefits of BS in the fertility field are acknowledged, many areas call for further research, like choosing the safest surgical techniques, determining the optimal timing to get pregnant, and resolving the uncertainty of sperm parameters.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"13 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/ed/WJEM-13-1.PMC9896585.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10716616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}