Aging, Neuropsychology, and Cognition最新文献_第9页

Health appeal appraisal and memory in older adults: the effects of goal and valence framing. 老年人健康诉求评价与记忆:目标和效价框架的影响。

IF 1.9 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 DOI: 10.1080/13825585.2022.2079601

Lixia Yang, Dana Greenbaum, Justice Cupid, Maureen Reed

引用次数: 0

A graph theoretic approach to neurodegeneration: five data-driven neuropsychological subtypes in mild cognitive impairment. 神经退行性变的图论方法:轻度认知障碍的五种数据驱动的神经心理学亚型。

IF 1.6 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 Epub Date: 2023-01-17 DOI: 10.1080/13825585.2022.2163973

Jessica Pommy, L Conant, A M Butts, A Nencka, Y Wang, M Franczak, L Glass-Umfleet

{"title":"A graph theoretic approach to neurodegeneration: five data-driven neuropsychological subtypes in mild cognitive impairment.","authors":"Jessica Pommy, L Conant, A M Butts, A Nencka, Y Wang, M Franczak, L Glass-Umfleet","doi":"10.1080/13825585.2022.2163973","DOIUrl":"10.1080/13825585.2022.2163973","url":null,"abstract":"Mild cognitive Impairment (MCI) is notoriously heterogenous in terms of clinical presentation, neuroimaging correlates, and subsequent progression. Predicting who will progress to dementia, which type of dementia, and over what timeframe is challenging. Previous work has attempted to identify MCI subtypes using neuropsychological measures in an effort to address this challenge; however, there is no consensus on approach, which may account for some of the variability. Using a hierarchical community detection approach, we examined cognitive subtypes within an MCI sample (from the Alzheimer's Disease Neuroimaging Initiative [ADNI] study). We then examined whether these subtypes were related to biomarkers (e.g., cortical volumes, fluorodeoxyglucose (FDG)-positron emission tomography (PET) hypometabolism) or clinical progression. We identified five communities (i.e., cognitive subtypes) within the MCI sample: 1) predominantly memory impairment, 2) predominantly language impairment, 3) cognitively normal, 4) multidomain, with notable executive dysfunction, 5) multidomain, with notable processing speed impairment. Community membership was significantly associated with 1) cortical volume in the hippocampus, entorhinal cortex, and fusiform cortex; 2) FDG PET hypometabolism in the posterior cingulate, angular gyrus, and inferior/middle temporal gyrus; and 3) conversion to dementia at follow up. Overall, community detection as an approach appears a viable method for identifying unique cognitive subtypes in a neurodegenerative sample that were linked to several meaningful biomarkers and modestly with progression at one year follow up.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10540992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How well does the discrepancy between semantic and letter verbal fluency performance distinguish Alzheimer's dementia from typical aging? 语义和字母语言流畅性表现的差异在多大程度上区分了阿尔茨海默氏痴呆症和典型的衰老?

IF 1.9 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 DOI: 10.1080/13825585.2022.2079602

Jean K Gordon, Haoxuan Chen

{"title":"How well does the discrepancy between semantic and letter verbal fluency performance distinguish Alzheimer's dementia from typical aging?","authors":"Jean K Gordon, Haoxuan Chen","doi":"10.1080/13825585.2022.2079602","DOIUrl":"https://doi.org/10.1080/13825585.2022.2079602","url":null,"abstract":"In Alzheimer's dementia (AD), greater declines in semantic fluency (SF) relative to letter fluency (LF) have been assumed to reflect semantic disintegration. However, the same pattern is observed in typical aging and neurodegenerative disorders besides AD. We examined this assumption by comparing different aspects of SF and LF performance in older adults with and without dementia, and identifying which verbal fluency measures most clearly distinguish AD from typical aging. Verbal fluency data were compared from 109 individuals with AD and 66 typically aging adults. Correct items, clusters, and errors were analyzed using both raw counts and proportions. Regression analyses examined Task-by-Group interactions and the impact of demographic variables on verbal fluency measures. ROC analyses examined the sensitivity and specificity of the different outcome measures. In regressions, interactions were found for raw but not proportional data, indicating that different group patterns were driven largely by the number of correct items produced. Similarly, in ROC analyses, raw SF totals showed stronger discriminability between groups than either raw discrepancy scores (SF-LF) or discrepancy ratios (SF/LF). Age and cognitive status (MMSE) were the strongest individual predictors of performance. Findings suggest that AD entails quantitative declines in verbal fluency, but qualitatively similar patterns of performance relative to typically aging adults. Thus, SF declines in AD seem to be at least partially attributable to an exaggeration of the underlying mechanisms common to typical aging, and do not necessarily implicate semantic disintegration.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Frontal and temporal lobe correlates of verbal learning and memory in aMCI and suspected Alzheimer's disease dementia. 额叶和颞叶与aMCI和疑似阿尔茨海默病痴呆的言语学习和记忆相关。

IF 1.6 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 Epub Date: 2022-11-11 DOI: 10.1080/13825585.2022.2144618

Cierra M Keith, Marc W Haut, Kirk Wilhelmsen, Rashi I Mehta, Mark Miller, R Osvaldo Navia, Melanie Ward, Katharine Lindberg, Michelle Coleman, William T McCuddy, Gerard Deib, Angelo Giolzetti, Pierre-François D'Haese

{"title":"Frontal and temporal lobe correlates of verbal learning and memory in aMCI and suspected Alzheimer's disease dementia.","authors":"Cierra M Keith, Marc W Haut, Kirk Wilhelmsen, Rashi I Mehta, Mark Miller, R Osvaldo Navia, Melanie Ward, Katharine Lindberg, Michelle Coleman, William T McCuddy, Gerard Deib, Angelo Giolzetti, Pierre-François D'Haese","doi":"10.1080/13825585.2022.2144618","DOIUrl":"10.1080/13825585.2022.2144618","url":null,"abstract":"Alzheimer's disease is primarily known for deficits in learning and retaining new information. This has long been associated with pathological changes in the mesial temporal lobes. The role of the frontal lobes in memory in Alzheimer's disease is less well understood. In this study, we examined the role of the frontal lobes in learning, recognition, and retention of new verbal information, as well as the presence of specific errors (i.e., intrusions and false-positive errors). Participants included one hundred sixty-seven patients clinically diagnosed with amnestic mild cognitive impairment or suspected Alzheimer's disease dementia who were administered the California Verbal Learning Test and completed high-resolution MRI. We confirmed the role of the mesial temporal lobes in learning and retention, including the volumes of the hippocampus, entorhinal cortex, and parahippocampal gyrus. In addition, false-positive errors were associated with all volumes of the mesial temporal lobes and widespread areas within the frontal lobes. Errors of intrusion were related to the supplementary motor cortex and hippocampus. Most importantly, the mesial temporal lobes interacted with the frontal lobes for learning, recognition, and memory errors. Lower volumes in both regions explained more performance variance than any single structure. This study supports the interaction of the frontal lobes with the temporal lobes in many aspects of memory in Alzheimer's disease.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40682543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recall and recognition subtests of the repeatable battery for the assessment of neuropsychological status and their relationship to biomarkers of Alzheimer's disease. 用于评估神经心理状态的可重复电池的回忆和识别子测试及其与阿尔茨海默病生物标志物的关系。

IF 1.6 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 Epub Date: 2022-09-15 DOI: 10.1080/13825585.2022.2124229

Matthew J Euler, Kevin Duff, Jace B King, John M Hoffman

{"title":"Recall and recognition subtests of the repeatable battery for the assessment of neuropsychological status and their relationship to biomarkers of Alzheimer's disease.","authors":"Matthew J Euler, Kevin Duff, Jace B King, John M Hoffman","doi":"10.1080/13825585.2022.2124229","DOIUrl":"10.1080/13825585.2022.2124229","url":null,"abstract":"Recently, two new recognition subtests for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were developed and initially validated in a cohort of older adults who were cognitively intact or classified as amnestic Mild Cognitive Impairment (MCI) or mild Alzheimer's disease (AD). The current paper extends that validation by comparing the recall and recognition subtests of the RBANS, including the existing and recently developed scores, to three commonly used biomarkers in AD in an expanded sample from the initial validation. One hundred fifty-four older adults (65 intact, 46 MCI, 43 AD) were administered the RBANS, which included the recently developed subtests for Story Recognition and Figure Recognition (hits, false positives, total correct), as part of a study on memory and biomarkers. Participants also completed magnetic resonance imaging to obtain hippocampal volumes, positron emission tomography to obtain amyloid plaque deposition, and a blood draw to obtain APOE ε4 status. Whereas correlations between recall scores and biomarkers tended to be moderate (average r = ±0.48), these correlations were comparable across the three recognition total scores (average r = ±0.42), but tended to be lower for recognition hits (average r = ±0.28) and false positives (average r = ±0.38). These results further validate the existing and recently developed recognition scores on the RBANS as providing useful information about brain and genetic pathology in older adults with intact and impaired cognitive functioning.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10304842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not all mentally stimulating activities are alike: insights from a 4-factor model and implications for late-life cognition. 并非所有的精神刺激活动都是相似的:来自四因素模型的见解以及对晚年认知的影响。

IF 1.9 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 DOI: 10.1080/13825585.2022.2094878

Adam Vujic, Loren Mowszowski, Susanne Meares, Jennifer Batchelor, Sharon L Naismith

{"title":"Not all mentally stimulating activities are alike: insights from a 4-factor model and implications for late-life cognition.","authors":"Adam Vujic, Loren Mowszowski, Susanne Meares, Jennifer Batchelor, Sharon L Naismith","doi":"10.1080/13825585.2022.2094878","DOIUrl":"https://doi.org/10.1080/13825585.2022.2094878","url":null,"abstract":"It is not yet known which specific qualities of cognitively stimulating activities are most likely to enhance cognitive reserve in older adults. Taking an inductive approach to this problem, we asked 504 older adults with subjective and/or cognitive impairment to complete the Cognitively Stimulating Activities Questionnaire (CSA-Q). Exploratory factor analysis identified a 4-factor structure within a split-half sample, after which confirmatory factor analysis cross-validated the model. Retaining 12 CSA-Q items, the 4 factors were dubbed CSA-Processing, CSA-Challenging, CSA-Connecting and CSA-Socializing. Resulting factor weights were analyzed relative to cognitive reserve proxies and neuropsychological domains. All factors except CSA-Challenging were positively linked to cognitive reserve. Neuropsychologically, CSA-Challenging was modestly and positively correlated with processing speed and executive function, while CSA-Processing was positively correlated with executive function. CSA-Socializing had a small positive correlation with processing speed. Our findings offer new insights into late-life stimulating activities, laying the groundwork for longitudinal and intervention studies.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive reserve and emotion recognition in the context of normal aging. 正常衰老背景下的认知储备与情绪识别。

IF 1.9 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 DOI: 10.1080/13825585.2022.2079603

Sofia Guerrini, Edyta Monika Hunter, Costanza Papagno, Sarah E MacPherson

{"title":"Cognitive reserve and emotion recognition in the context of normal aging.","authors":"Sofia Guerrini, Edyta Monika Hunter, Costanza Papagno, Sarah E MacPherson","doi":"10.1080/13825585.2022.2079603","DOIUrl":"https://doi.org/10.1080/13825585.2022.2079603","url":null,"abstract":"ABSTRACT The Cognitive Reserve (CR) hypothesis accounts for individual differences in vulnerability to age- or pathological-related brain changes. It suggests lifetime influences (e.g., education) increase the effectiveness of cognitive processing in later life. While evidence suggests CR proxies predict cognitive performance in older age, it is less clear whether CR proxies attenuate age-related decline on social cognitive tasks. This study investigated the effect of CR proxies on unimodal and cross-modal emotion identification. Sixty-six older adults aged 60–78 years were assessed on CR proxies (Cognitive Reserve Index Questionnaire, NART), unimodal(faces only, voices only), and cross-modal (faces and voices combined) emotion recognition and executive function (Stroop Test). No CR proxy predicted performance on emotion recognition. However, NART IQ predicted performance on the Stroop test; higher NART IQ was associated with better performance. The current study suggests CR proxies do not predict performance on social cognition tests but do predict performance on cognitive tasks.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Awareness of age-related change and its relationship with cognitive functioning and ageism. 认识到年龄相关的变化及其与认知功能和年龄歧视的关系。

IF 1.9 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 DOI: 10.1080/13825585.2022.2088682

Abigail R Voelkner, Grace I L Caskie

引用次数: 4

Subjective cognitive complaints in White and African American older adults: associations with demographic, mood, cognitive, and neuroimaging features. 白人和非裔美国老年人的主观认知主诉:与人口统计学、情绪、认知和神经影像学特征的关系

IF 1.6 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 Epub Date: 2023-08-21 DOI: 10.1080/13825585.2023.2249181

Felicia C Goldstein, Maureen Okafor, Zhiyi Yang, Tiffany Thomas, Sabria Saleh, Ihab Hajjar

{"title":"Subjective cognitive complaints in White and African American older adults: associations with demographic, mood, cognitive, and neuroimaging features.","authors":"Felicia C Goldstein, Maureen Okafor, Zhiyi Yang, Tiffany Thomas, Sabria Saleh, Ihab Hajjar","doi":"10.1080/13825585.2023.2249181","DOIUrl":"10.1080/13825585.2023.2249181","url":null,"abstract":"Subjective cognitive complaints (SCC) in cognitively intact older adults have been investigated as a clinically important symptom that may portend the onset of a neurodegenerative disorder such as Alzheimer's disease. Few studies have concurrently incorporated demographic features, depressive symptoms, neuropsychological status, and neuroimaging correlates of SCC and evaluated whether these differ in White and African American older adults. In the current study, 131 (77 White, 54 African American) healthy participants ≥50 years old completed the Cognitive Function Instrument (CFI) to assess SCC, and they underwent objective cognitive testing, assessment of mood, and brain magnetic resonance imaging. Pearson Product Moment correlations were performed to evaluate associations of the CFI self-ratings with the above measures for the combined group and separately for White and African American participants. SCC were associated with greater depressive symptoms in both White and African American participants in adjusted models controlling for overall cognitive status, education, and hypertension. Greater white matter hyperintensities, lower cortical thickness, older age, and slower set shifting speed were associated with increased SCC in White participants. Although the correlations were not significant for African Americans, the strength of the associations were comparable to White participants. Hippocampal volume was not associated with either total SCC or items specific to memory functioning in the entire group. Longitudinal studies are needed to further evaluate the clinical significance of these associations with risk of conversion to mild cognitive impairment and dementia.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10150880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitivity of memory subtests and learning slopes from the ADAS-Cog to distinguish along the continuum of the NIA-AA Research Framework for Alzheimer's Disease. 从ADAS-Cog的记忆子测试和学习斜率的敏感性来区分NIA-AA研究框架对阿尔茨海默病的连续性。

IF 1.6 4区心理学

Aging, Neuropsychology, and Cognition Pub Date : 2023-09-01 Epub Date: 2022-09-08 DOI: 10.1080/13825585.2022.2120957

Dustin B Hammers, Ralitsa V Kostadinova, Robert J Spencer, Jean N Ikanga, Frederick W Unverzagt, Shannon L Risacher, Liana G Apostolova

{"title":"Sensitivity of memory subtests and learning slopes from the ADAS-Cog to distinguish along the continuum of the NIA-AA Research Framework for Alzheimer's Disease.","authors":"Dustin B Hammers, Ralitsa V Kostadinova, Robert J Spencer, Jean N Ikanga, Frederick W Unverzagt, Shannon L Risacher, Liana G Apostolova","doi":"10.1080/13825585.2022.2120957","DOIUrl":"10.1080/13825585.2022.2120957","url":null,"abstract":"Despite extensive use of the Alzheimer's Disease (AD) Assessment Scale - Cognitive Subscale (ADAS-Cog) in AD research, exploration of memory subtests or process scores from the measure has been limited. The current study sought to establish validity for the ADAS-Cog Word Recall Immediate and Delayed Memory subtests and learning slope scores by showing that they are sensitive to AD biomarker status. Word Recall subtest and learning slope scores were calculated for 441 participants from the Alzheimer's Disease Neuroimaging Initiative (aged 55 to 90). All participants were categorized using the NIA-AA Research Framework - based on PET-imaging of β-amyloid (A) and tau (T) deposition - as Normal AD Biomarkers (A-T-), Alzheimer's Pathologic Change (A + T-), or Alzheimer's disease (A + T+). Memory subtest and learning slope performances were compared between biomarker status groups, and with regard to how well they discriminated samples with (A + T+) and without (A-T-) biomarkers. Lower Word Recall memory subtest scores - and scores for a particular learning slope calculation, the Learning Ratio - were observed for the AD (A + T+) group than the other biomarker groups. Memory subtest and Learning Ratio scores further displayed fair to good receiver operator characteristics when differentiating those with and without AD biomarkers. When comparing across learning slopes, the Learning Ratio metric consistently outperformed others. ADAS-Cog memory subtests and the Learning Ratio score are sensitive to AD biomarker status along the continuum of the NIA-AA Research Framework, and the results offer criterion validity for use of these subtests and process scores as unique markers of memory capacity.","PeriodicalId":7532,"journal":{"name":"Aging, Neuropsychology, and Cognition","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0