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Response to comment on "Extended-Spectrum Beta-Lactamase Positivity in Infants with Febrile Urinary Tract Infection: Risk Factors, Pathogen Distribution, and Temporal Trends". 对“热性尿路感染婴儿广谱β -内酰胺酶阳性:危险因素、病原体分布和时间趋势”评论的回应。
IF 1.7
Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2026.261901
Serap Ata, Sevgi Akova
{"title":"Response to comment on \"Extended-Spectrum Beta-Lactamase Positivity in Infants with Febrile Urinary Tract Infection: Risk Factors, Pathogen Distribution, and Temporal Trends\".","authors":"Serap Ata, Sevgi Akova","doi":"10.65717/TurkArchPediatr.2026.261901","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.261901","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 6","pages":"559-560"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic Inflammatory Myopathy Mimics in Children: Pearls and Challenges. 儿童特发性炎性肌病模拟:珍珠和挑战。
IF 1.7
Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2026.25526
Pınar Yavuz, Diclehan Orhan, Göknur Haliloğlu
{"title":"Idiopathic Inflammatory Myopathy Mimics in Children: Pearls and Challenges.","authors":"Pınar Yavuz, Diclehan Orhan, Göknur Haliloğlu","doi":"10.65717/TurkArchPediatr.2026.25526","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25526","url":null,"abstract":"<p><strong>Unlabelled: </strong>Idiopathic inflammatory myopathies represent a group of acquired and treatable myopathies characterized by distinct clinical features that should be distinguished from other neuromuscular diseases presenting with proximal muscle weakness or serum creatine kinase elevation. The approach to neuromuscular disorders requires a comprehensive evaluation of history and clinical phenotype. Depending on the presentation, diagnostic strategies vary from basic laboratory tests to complementary electrophysiological studies, muscle imaging, histopathology, and genomic tests. Since the approach to individualized treatments varies according to the accurate diagnosis, a close collaboration between pediatric neurologists and rheumatologists is crucial for the management and follow-up. This review aims to provide a structured diagnostic approach to pediatric myositis mimics, emphasizing the importance of accurate differential diagnosis and highlighting frequently overlooked conditions to improve clinical outcomes.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 6","pages":"471-478"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discriminatory Performance of Systemic Inflammation Response Index in Pediatric Eosinophilic Esophagitis. 儿童嗜酸性粒细胞性食管炎全身性炎症反应指数的鉴别表现。
IF 2.3
Turkish archives of pediatrics Pub Date : 2026-05-22 DOI: 10.65717/TurkArchPediatr.2026.25529
Yasin Maruf Ergen, Edibe Gözde Başaran
{"title":"Discriminatory Performance of Systemic Inflammation Response Index in Pediatric Eosinophilic Esophagitis.","authors":"Yasin Maruf Ergen, Edibe Gözde Başaran","doi":"10.65717/TurkArchPediatr.2026.25529","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25529","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the discriminatory performance of hemogram-derived inflammatory parameters in distinguishing pediatric eosinophilic esophagitis (EoE) from symptomatic controls. To determine their potential value as non-invasive tools for longitudinal monitoring, whether these markers correlate with endoscopic and histologic activity during follow-up was also assessed.</p><p><strong>Methods: </strong>This retrospective, longitudinal study included pediatric patients who underwent upper gastrointestinal endoscopy at a tertiary pediatric gastroenterology center between August 2022 and August 2025. Children presenting with dysphagia, vomiting, or abdominal pain who had esophageal, gastric, and duodenal biopsies were evaluated. Eosinophilic esophagitis was diagnosed based on symptoms and the presence of ≥15 eosinophils per high-power field in esophageal biopsies. Symptomatic children with similar age and sex distribution without esophageal eosinophilia served as controls. Hemogram results obtained within 1 week before each endoscopy were analyzed. Hemogram-derived indices (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, derived neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index [SIRI], aggregate index of systemic inflammation, mean platelet volume-to-lymphocyte ratio, mean platelet volume-to-platelet ratio, and red cell distribution width-to-platelet ratio) were calculated. Diagnostic performance was assessed using receiver-operating characteristic analyses, and associations with endoscopic and histologic findings were examined using linear mixed-effects models.</p><p><strong>Results: </strong>Children with EoE showed significantly higher absolute eosinophil counts and markedly elevated SIRI values at diagnosis compared with controls (P < .001). Systemic inflammation response index demonstrated excellent discriminatory performance, whereas most other hemogram-derived indices showed limited accuracy. During follow-up, none of the hemo- gram-derived parameters-including SIRI-correlated with endoscopic or histologic activity.</p><p><strong>Conclusion: </strong>Systemic inflammation response index demonstrated high discriminatory performance in distinguishing pediatric EoE from symptomatic controls, but showed no association with longitudinal disease activity. Endoscopic and histologic assessments remain essential for diagnosis and monitoring.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 7","pages":"608-614"},"PeriodicalIF":2.3,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disappearance of Posterior Pituitary Hyperintensity in Arginine Vasopressin Resistance: A Case Report. 精氨酸抗利尿素抵抗中垂体后叶高强度消失1例。
IF 2.3
Turkish archives of pediatrics Pub Date : 2026-05-22 DOI: 10.65717/TurkArchPediatr.2026.25542
Tomás Ferrão, Mariana Sá Pinto, Francisca Guimarães, Fátima Hierro, Adriana Rangel, Graça Ferreira, Rosa Arménia Campos, Ana Luísa Leite
{"title":"Disappearance of Posterior Pituitary Hyperintensity in Arginine Vasopressin Resistance: A Case Report.","authors":"Tomás Ferrão, Mariana Sá Pinto, Francisca Guimarães, Fátima Hierro, Adriana Rangel, Graça Ferreira, Rosa Arménia Campos, Ana Luísa Leite","doi":"10.65717/TurkArchPediatr.2026.25542","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25542","url":null,"abstract":"<p><strong>Unlabelled: </strong>The evaluation of arginine vasopressin resistance (AVP-R) and arginine vasopressin deficiency (AVP-D), respectively, previously referred to as nephrogenic and central diabetes insipidus, often includes brain magnetic resonance imaging (MRI). Its purpose is to assess pituitary structural changes and identify the physiological T1 hyperintensity of the posterior pituitary, present in most individuals. This hyperintensity reflects vasopressin storage, which shortens the T1 relaxation time. Its absence supports a diagnosis of AVP-D over AVP-R. A 13-year-old boy was referred to endocrinology in his second year of life for polyuria and polydipsia. Brain MRI revealed normal pituitary morphology and a spontaneous T1 hyperintensity of the posterior pituitary. The AVP-R was confirmed by a hemizygous AVPR2 gene mutation. Treatment with hydrochlorothiazide, potassium supplementation, and dietary sodium restriction achieved good clinical control. During school age, progressive growth deceleration led to short stature and delayed puberty. At 13 years, repeated MRI showed a smaller pituitary gland and loss of the posterior pituitary T1 hyperintensity. Loss of posterior pituitary T1 hyperintensity is rare in AVP-R, and late disappearance has not been previously described in genetically confirmed cases. This case underscores the importance of integrating clinical, genetic, and imaging findings.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 10","pages":"945-948"},"PeriodicalIF":2.3,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute-Phase Amantadine Treatment in Children with Severe Traumatic Brain Injury: A Dual-Center Cohort Study. 急性期金刚烷胺治疗重型颅脑损伤儿童:一项双中心队列研究。
IF 2.3
Turkish archives of pediatrics Pub Date : 2026-05-22 DOI: 10.65717/TurkArchPediatr.2026.25421
Hüseyin Bahadır Şenol, Kaan Furkan Bıyık, Çağatay Günay, Gökay Gedik, Gazi Arslan, Fatma Ceren Sarıoğlu, Ayşe İpek Polat, Adem Aydın, Ayşe Semra Hız, Uluç Yiş
{"title":"Acute-Phase Amantadine Treatment in Children with Severe Traumatic Brain Injury: A Dual-Center Cohort Study.","authors":"Hüseyin Bahadır Şenol, Kaan Furkan Bıyık, Çağatay Günay, Gökay Gedik, Gazi Arslan, Fatma Ceren Sarıoğlu, Ayşe İpek Polat, Adem Aydın, Ayşe Semra Hız, Uluç Yiş","doi":"10.65717/TurkArchPediatr.2026.25421","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25421","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the neurological and systemic outcomes of amantadine treatment in the acute phase of severe traumatic brain injury (TBI) in children. In addition, the potential factors associated with functional outcomes were analyzed.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed data of pediatric patients with severe TBI. Amantadine treatment was administered to all patients who presented after 2022. The treatment protocol was initiated on the third day of hospitalization, at a daily dose of 6 mg/kg, and at 100 mg twice daily for older children. The Functional Status Scale (FSS) was used to assess mental status, vision, hearing, communication, motor abilities, respiration, and feeding both at discharge from intensive care unit (ICU) and again 6 months after the incident of TBI.</p><p><strong>Results: </strong>In this study, 60 patients had a median age of 14.5 years (IQR 8; range 2-17 years), while 32 patients received amantadine treatment. The length of median ICU stay and hospital stay were 11 and 20 days, respectively. At the 6-month follow-up, there was a significant improvement in FSS scores compared to those estimated at ICU discharge (P < .001), but no significant difference was observed between the amantadine and non-amantadine groups in terms of functional recovery, and inotrope requirement was identified as an independent risk factor for poor neurological outcome.</p><p><strong>Conclusion: </strong>Administration of amantadine did not provide a significant functional benefit. However, craniectomy was performed less frequently for patients who received amantadine. Amantadine treatment was well tolerated with a favorable safety profile.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 7","pages":"601-607"},"PeriodicalIF":2.3,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plastic Versus Cotton Caps for Preventing Hypothermia in Very Preterm Infants: A Randomized Clinical Trial. 塑料帽与棉帽预防极早产儿低温症:一项随机临床试验。
IF 1.7
Turkish archives of pediatrics Pub Date : 2026-05-21 DOI: 10.65717/TurkArchPediatr.2025.25401
Roya Farhadi, Atekeh Hadinezhad, Mahmood Moosazadeh, Shahrokh Mehrpisheh, Seyed Amir Kazemi, Akram Valizadeh
{"title":"Plastic Versus Cotton Caps for Preventing Hypothermia in Very Preterm Infants: A Randomized Clinical Trial.","authors":"Roya Farhadi, Atekeh Hadinezhad, Mahmood Moosazadeh, Shahrokh Mehrpisheh, Seyed Amir Kazemi, Akram Valizadeh","doi":"10.65717/TurkArchPediatr.2025.25401","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2025.25401","url":null,"abstract":"<p><strong>Objective: </strong>Preventing hypothermia in very preterm infants is difficult. This study aims to compare the effect of plastic versus cotton caps in combination with polyethylene body wrapping in the prevention of hypothermia in very preterm infants.</p><p><strong>Materials and methods: </strong>A total of 95 newborns less than 32 weeks of gestation were enrolled in this randomized clinical trial. Immediately after birth, the infants were placed in polyethylene covers. In the intervention group (n=48), the heads of newborns were covered with plastic caps, while in the control group (n=47), the heads were covered with cotton caps. The primary outcomes were temperature at admission and 1 hour after admission in the neonatal intensive care unit, as well as the rate of hypothermia in both groups.</p><p><strong>Results: </strong>Mean axillary temperature on admission was higher in the plastic cap group compared to the cotton cap group (P = .009). After adjusting for gestational age, the difference in mean admission temperature was higher in the plastic cap group in the 28-31 weeks' gestation (P = .013); however, all babies born at 25-27 weeks' gestation remained hypothermic at neonatal intensive care unit admission. The temperature 1 hour after admission was similar between the groups (P=.846). The rate of hypothermia showed no significant difference between groups.</p><p><strong>Conclusion: </strong>Although plastic caps were associated with higher admission temperatures compared with cotton caps, they did not reduce the frequency of hypothermia. This points to the need for newer and combined strategies, especially in extremely preterm infants (25-27 weeks). Plastic caps remain a cost-effective and hygienic option for resource-limited settings. Trial registration: The trial was prospectively registered in the Iranian Registry of Clinical Trials (IRCT) under the registration number IRCT20091201002801N5 on February 9, 2023. The registration can be accessed at the following URL: https://irct.behdasht.gov.ir/trial/68485.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 6","pages":"523-530"},"PeriodicalIF":1.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Social Media on Parental Decision-Making in the Management of Pediatric Allergic Diseases. 社交媒体对儿童过敏性疾病管理中父母决策的影响
IF 2.3
Turkish archives of pediatrics Pub Date : 2026-05-21 DOI: 10.65717/TurkArchPediatr.2026.25487
Cankat Genis, Zeynep Sengul Emeksiz
{"title":"The Impact of Social Media on Parental Decision-Making in the Management of Pediatric Allergic Diseases.","authors":"Cankat Genis, Zeynep Sengul Emeksiz","doi":"10.65717/TurkArchPediatr.2026.25487","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25487","url":null,"abstract":"<p><strong>Objective: </strong>With the digital transformation, parents increasingly use social media (SM) for health information; however, the reliability of online content remains uncertain, posing risks of misinformation and unsupervised treatment changes. Therefore, the study aimed to evaluate the frequency of SM-driven treatment modifications and their clinical consequences among parents of children with allergic rhinitis (AR), asthma, or atopic dermatitis (AD) and to characterize parents' SM use patterns and trust in online health information.</p><p><strong>Methods: </strong>This cross-sectional questionnaire-based study was conducted among parents of 200 children diagnosed with AR, asthma, or AD who were followed at the Pediatric Allergy and Immunology Clinic of Ankara Bilkent City Hospital. The survey assessed demographics, SM use, perceived reliability of online health content, SM influence on treatment behavior, and attitudes toward medical advice.</p><p><strong>Results: </strong>Daily SM use ≥1 hour was reported by 170 parents (85%). Half of the parents followed disease-related content; the most commonly followed sources were physicians (40%), other parents (30%), and influencer accounts (25%). Although 60% reported limited trust in online medical information, 44 parents (22%) changed their child's treatment based on SM, and 24 (55%) did so without consulting a physician. Following these changes, symptom worsening occurred in 7 children (16%) and adverse effects in 5 (11%). When information conflicted, 87% preferred physicians' advice.</p><p><strong>Conclusion: </strong>Despite limited trust, parents frequently rely on SM, sometimes leading to unsupervised treatment changes with potential harm. Targeted interventions to improve digital health literacy, promote evidence-based online content, and strengthen clinicians' digital engagement may reduce misinformation-related risks.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 7","pages":"593-600"},"PeriodicalIF":2.3,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Rheumatologic Comorbidities on Disease Severity in Pediatric Inflammatory Bowel Disease. 风湿病合并症对儿童炎症性肠病疾病严重程度的影响
IF 2.3
Turkish archives of pediatrics Pub Date : 2026-05-21 DOI: 10.65717/TurkArchPediatr.2026.25469
Buket Daldaban Sarıca, Ayşenur Paç Kısaarslan, Derya Altay, Duran Arslan
{"title":"Impact of Rheumatologic Comorbidities on Disease Severity in Pediatric Inflammatory Bowel Disease.","authors":"Buket Daldaban Sarıca, Ayşenur Paç Kısaarslan, Derya Altay, Duran Arslan","doi":"10.65717/TurkArchPediatr.2026.25469","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25469","url":null,"abstract":"<p><strong>Objective: </strong>Rheumatologic diseases (RDs) are major comorbidities that frequently occur with inflammatory bowel disease (IBD). Rheumatologic diseases (RDs), such as juvenile spondylo-arthritis, juvenile idiopathic arthritis, systemic autoinflammatory diseases, vasculitis, and mixed connective tissue diseases, can affect disease activity and clinical course in patients with IBD. Therefore, it is essential to assess children with IBD for comorbid RDs. This study was conducted to evaluate the effect of rheumatologic conditions accompanying IBD on disease severity.</p><p><strong>Materials and methods: </strong>This study was conducted in the Pediatric Gastroenterology and Pediatric Rheumatology Departments of Erciyes University. Patients diagnosed with histopathologically confirmed IBD who were followed between November 2020 and December 2022, including those with concomitant RDs, were included.</p><p><strong>Results: </strong>Forty-seven patients with IBD (ulcerative colitis (UC) and Crohn's disease (CD)), aged 14.0 (2.0-18.0) years [median, min-max], were included in the study. Twenty of 47 patients had accompanying RDs. Findings indicate that baseline disease activity for both CD and UC was higher in patients with IBD accompanied by RDs compared to those with IBD alone, both for CD and UC. In children with UC and CD, the decrease in disease activity scores in the group with concomitant RDs was found to be significantly more limited compared to those with IBD alone (P=.004 for CD; P=.006 for UC).</p><p><strong>Conclusion: </strong>These results emphasize the necessity for multidisciplinary management of comorbid RDs in patients with IBD, given its association with increased disease activity.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 7","pages":"587-592"},"PeriodicalIF":2.3,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of War-Related Internal Displacement on the Course and Consequences of COVID-19 in Ukrainian Children. 与战争有关的国内流离失所对COVID-19在乌克兰儿童中的发展过程和后果的影响。
IF 1.7
Turkish archives of pediatrics Pub Date : 2026-05-21 DOI: 10.65717/TurkArchPediatr.2026.25353
Vita Oleksandrivna Perestiuk, Tetyana Mykhailivna Kosovska, Liubov Avgustynivna Volianska, Oksana Romanivna Boyarchuk
{"title":"Impact of War-Related Internal Displacement on the Course and Consequences of COVID-19 in Ukrainian Children.","authors":"Vita Oleksandrivna Perestiuk, Tetyana Mykhailivna Kosovska, Liubov Avgustynivna Volianska, Oksana Romanivna Boyarchuk","doi":"10.65717/TurkArchPediatr.2026.25353","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25353","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to compare the key clinical features and course of SARS-CoV-2 infection between the local population of the Ternopil region and internally displaced persons (IDPs), to analyze the quality of life in both participant groups, and to determine the frequency and symptoms of long COVID.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving children with confirmed COVID-19 from September 2022 to May 2024. Clinical symptoms, COVID-19 severity, 25(OH)D and zinc levels, long COVID symptoms, and quality of life were compared between internally displaced and local populations using structured questionnaires and medical records.</p><p><strong>Results: </strong>A total of 299 children with COVID-19 were included, consisting of 29 IDPs and 270 local population. Gastrointestinal symptoms were significantly more common among IDPs (P<.0001), while respiratory symptoms and severe fatigue predominated in the local population (P < .0001 and P=.0229, respectively). The IDPs experienced a more severe course of COVID-19 (P=.0141) and had a longer duration of hospital stay (P < .0001). Serum zinc levels were significantly lower in IDPs compared to local population (P=.0229). Assessment of quality of life demonstrated higher total, physical, psychosocial, and school functioning scores among IDPs, indicating a statistically better perceived health status. The overall frequency of long COVID did not differ between groups; however, its distribution varied by age: it was significantly higher in IDPs under 6 years (P=.0062), whereas among children ≥6 years, it was more common in the local population (P=.0092). Age-specific differences in long COVID symptom patterns were also observed between IDPs and local children.</p><p><strong>Conclusion: </strong>This study highlights the need to consider the impact of war, displacement, and chronic stress on the clinical presentation, timeliness of seeking care, and symptom reporting among children with COVID-19. Future efforts should focus on improving access to healthcare, health education, nutritional, and psychosocial support for displaced children to mitigate the combined negative effects of COVID-19 and war.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 6","pages":"531-542"},"PeriodicalIF":1.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tigecycline Use in Pediatrics: A Comprehensive Analysis of Clinical, Laboratory, and Microbiological Factors. 替加环素在儿科的应用:临床、实验室和微生物因素的综合分析。
IF 1.7
Turkish archives of pediatrics Pub Date : 2026-05-21 DOI: 10.65717/TurkArchPediatr.2026.25440
Gül Arga, Duygu Öcal, Halil Özdemir, Esra Çakmak Taşkin, Hatice Kübra Konca, Hatice Belkıs İnceli, Hacer Uçmak, Merve Havan, Tanıl Kendirli, Ergin Çiftçi
{"title":"Tigecycline Use in Pediatrics: A Comprehensive Analysis of Clinical, Laboratory, and Microbiological Factors.","authors":"Gül Arga, Duygu Öcal, Halil Özdemir, Esra Çakmak Taşkin, Hatice Kübra Konca, Hatice Belkıs İnceli, Hacer Uçmak, Merve Havan, Tanıl Kendirli, Ergin Çiftçi","doi":"10.65717/TurkArchPediatr.2026.25440","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25440","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the indications and clinical and microbiological outcomes of tigecycline use in pediatric patients and to analyze the factors associated with treatment success and mortality.</p><p><strong>Methods: </strong>The patients receiving tigecycline antibiotic therapy at a tertiary university hospital over a 12-year period were evaluated.</p><p><strong>Results: </strong>During the study period, tigecycline was used in 66 patients. The median age of the patients was 11 years (range: 2 months to 18 years), and 40 (60.6%) were male. While 53% of the patients received empirical treatment, 46.9% received targeted therapy. The majority of patients (81.8%) received tigecycline for \"off-label\" indications, with bacteremia being the most common \"off-label\" indication. Microbiological and clinical success rates were 77.1% and 66.7%, respectively. While clinical success did not differ significantly between empiric and targeted therapy groups (P=.22), microbiological success was significantly higher in the targeted therapy group (P=.02). No statistically significant differences were observed between indication types. However, mortality was higher in patients with bacteremia who were treated with tigecycline compared with the non-bacteremic group (P=.007). Tigecycline was combined with other antibiotics in all patients. No serious adverse events requiring discontinuation of tigecycline treatment or dose revision were observed during follow-up.</p><p><strong>Conclusions: </strong>This study suggests that tigecycline, due to its broad spectrum of antibacterial activity, may be an important option in children in combination with other antibiotics in the absence of alternative options or in the absence of response to treatment.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 6","pages":"495-501"},"PeriodicalIF":1.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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