Turkish archives of pediatrics最新文献_第5页

Blount Disease in Early-Onset Obesity: A Red Flag for Monogenic Obesity? 早发性肥胖中的布朗特病：单基因肥胖的危险信号？

IF 2.3

Turkish archives of pediatrics Pub Date : 2026-06-10 DOI: 10.65717/TurkArchPediatr.2026.25459

Lorenzo De Luca, Nicola Improda, Antonietta Ferrara, Giada Ballarin, Carmen Campanile, Simona Incoronato, Antonio Casaburi, Maria Rosaria Licenziati

引用次数: 0

Tuberculosis Diagnosis and Prevention in Children on Biological Treatment: Clinical Challenges and Considerations. 儿童结核病诊断和预防的生物治疗：临床挑战和考虑。

IF 2.3

Turkish archives of pediatrics Pub Date : 2026-06-10 DOI: 10.65717/TurkArchPediatr.2026.25480

Berrak Oztosun, Cigdem Korkmaz, Azer Kilic Baskan, Elif Kilic Konte, Nergis Akay, Ece Aslan, Ayse Ayzit Kilinc Sakalli

{"title":"Tuberculosis Diagnosis and Prevention in Children on Biological Treatment: Clinical Challenges and Considerations.","authors":"Berrak Oztosun, Cigdem Korkmaz, Azer Kilic Baskan, Elif Kilic Konte, Nergis Akay, Ece Aslan, Ayse Ayzit Kilinc Sakalli","doi":"10.65717/TurkArchPediatr.2026.25480","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25480","url":null,"abstract":"Unlabelled: Tuberculosis (TB) remains a major global health concern, especially for children with rheumatic diseases on biologic therapies. While these agents have improved disease management and quality of life, they also pose new challenges, mainly an increased risk of TB, particularly with tumor necrosis factor‑alpha (TNF‑α) inhibitors like infliximab, adalimumab, and etanercept. Since TNF‑α plays a crucial role in granuloma formation and controlling Mycobacterium TB, its inhibition can allow latent TB infection (LTBI) to develop into active disease. To reduce this risk, screening for LTBI before starting biologic therapy is highly recommended. However, accurately detecting LTBI in children-especially those who are immunosuppressed-remains challenging, as both the tuberculin skin test (TST) and interferon‑gamma release assays (IGRAs) have notable limitations in this context. Using both TST and IGRA together may improve case detection in selected pediatric populations. Preventive treatment for LTBI reduces the risk of developing active TB in patients receiving biologic therapies. Although non-anti-TNF therapies may offer a safer option in this regard, the evidence in pediatric patients is still limited. As the use of biologic and targeted therapies expands in children, further research is needed-especially on non-anti-TNF agents-to create internationally accepted guidelines and to optimize screening, diagnostics, and personalized prevention strategies.","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 7","pages":"575-580"},"PeriodicalIF":2.3,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospitalized Hepatitis A Cases in Jordan: A 10-Year Retrospective Comparison Between Pediatric and Adult Populations. 约旦住院甲型肝炎病例：儿童和成人人群的10年回顾性比较

IF 2.3

Turkish archives of pediatrics Pub Date : 2026-06-08 DOI: 10.65717/TurkArchPediatr.2026.25528

Eyad Altamimi, Ahlam Al-Shorman, Lana Alkhamaiseh, Bayan Ahmed

{"title":"Hospitalized Hepatitis A Cases in Jordan: A 10-Year Retrospective Comparison Between Pediatric and Adult Populations.","authors":"Eyad Altamimi, Ahlam Al-Shorman, Lana Alkhamaiseh, Bayan Ahmed","doi":"10.65717/TurkArchPediatr.2026.25528","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25528","url":null,"abstract":"Background: Hepatitis A virus (HAV) infection is generally self-limiting but may occasionally cause severe disease requiring hospitalization. As HAV epidemiology shifts in the Middle East with declining childhood seroprevalence and rising adult susceptibility, understanding age specific disease patterns is important. This study compared pediatric and adult patients hospitalized with HAV in northern Jordan.Methods: A retrospective cohort study was performed of 115 serologically confirmed HAV cases admitted to King Abdullah University Hospital (KAUH) from 2015-2024. Patients were categorized as pediatric (≤17 years) or adult (≥18 years). Demographics, clinical features, laboratory and imaging findings, and outcomes were compared.Results: Children accounted for 67.8% of admissions and more often lived in rural areas. Jaundice and ascites were more frequent among pediatric patients, whereas diarrhea, prolonged symptoms, and higher alanine aminotransferase (ALT) levels characterized adult cases. Gallstones were detected only in adults. Severe complications were uncommon; however, all 3 deaths occurred among pediatric patients and were associated with marked coagulopathy.Conclusion: Pediatric and adult HAV infections present with distinct clinical and biochemical patterns. While most cases are uncomplicated, severe pediatric outcomes, including mortality, highlight the need for strengthened prevention strategies, improved sanitation, and evaluation of routine HAV vaccination in Jordan.","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 9","pages":"807-814"},"PeriodicalIF":2.3,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Motor Competence and Weight Status from Childhood to Adolescence (3-19 Years). 儿童至青少年（3-19岁）运动能力与体重状况的关系

IF 2.3

Turkish archives of pediatrics Pub Date : 2026-06-02 DOI: 10.65717/TurkArchPediatr.2026.25460

André Pombo, Carlos Luz, Rita Cordovil, Gabriela Almeida, Miguel Rebelo, João Serrano, Luís Paulo Rodrigues

{"title":"Relationship Between Motor Competence and Weight Status from Childhood to Adolescence (3-19 Years).","authors":"André Pombo, Carlos Luz, Rita Cordovil, Gabriela Almeida, Miguel Rebelo, João Serrano, Luís Paulo Rodrigues","doi":"10.65717/TurkArchPediatr.2026.25460","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25460","url":null,"abstract":"Objective: To evaluate the relationship between motor competence (MC) and weight status (WS) from childhood through adolescence.Methods: A total of 4537 participants (2425 boys) aged 3-19 years were assessed. The MC was measured using the MC Assessment (MCA) instrument, and body mass index was calculated from height and weight.Results: An inverted U-shaped relationship was observed between WS and MC. Participants with a healthy weight (HW) consistently showed higher total MCA scores compared to those with underweight (UW) (P = .002), overweight (OW), and obesity (OB) (both P < .001). The OB participants had the lowest MC scores overall (OB < OW < HW; P < .001), with UW also performing significantly worse than HW. This pattern was consistent in the Stability and Locomotor components. However, in the Manipulative component, UW participants scored significantly lower than all other groups (HW P = .028; OW P = .024; OB P = .017), while HW, OW, and OB did not differ significantly. These patterns were consistent across sex and age groups (all Ps > .05).Conclusion: An association between WS and MC was observed across developmental stages, suggesting that HW profiles may be related to higher MC. The consistency of these patterns across age and sex suggests that biological and sociocultural mechanisms may jointly influence this relationship throughout development.","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 7","pages":"615-623"},"PeriodicalIF":2.3,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Comment on "Psychosocial and Developmental Predictors of Early Behavioral Problems in Preschool Children Referred for Developmental Risk". 对“学龄前儿童发展风险的早期行为问题的社会心理和发展预测因素”评论的回应。

IF 1.7

Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2026.261841

Emel Ömercioğlu, Aysel Hacısoy, Gökçenur Özdemir, Buse Şencan Karakuş, Ebru Öztürk, Elif N Özmert

引用次数: 0

Comment on "Extended-Spectrum Beta-Lactamase Positivity in Infants with Febrile Urinary Tract Infection: Risk Factors, Pathogen Distribution, and Temporal Trends". 对“热性尿路感染婴儿广谱β -内酰胺酶阳性：危险因素、病原体分布和时间趋势”的评论。

IF 1.7

Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2026.26190

John Dotis

引用次数: 0

Pediatric Liver Transplantation: A Single-Center Experience in the Intensive Care Unit. 儿童肝移植：重症监护病房的单中心经验。

IF 1.7

Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2026.25406

Ibrahim Bingol, Tonguc Utku Yilmaz, Ozge Umur, Guntulu Sık, Eda Erdem, Remzi Emiroglu, Agop Citak

{"title":"Pediatric Liver Transplantation: A Single-Center Experience in the Intensive Care Unit.","authors":"Ibrahim Bingol, Tonguc Utku Yilmaz, Ozge Umur, Guntulu Sık, Eda Erdem, Remzi Emiroglu, Agop Citak","doi":"10.65717/TurkArchPediatr.2026.25406","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25406","url":null,"abstract":"Objective: Liver transplantation is the only definitive treatment for end-stage liver disease in children. Advances in surgical techniques, immunosuppression, and perioperative management have improved survival. This study evaluates outcomes of pediatric liver transplantation at a single center in Türkiye, focusing on complication rates, survival, and factors influencing mortality.Methods: This retrospective study included all pediatric patients (<18 years) who underwent liver transplantation between 2015 and 2023. Data on demographics, primary liver diseases, postoperative complications, PICU course, retransplantation, and mortality were collected. Descriptive analyses, group comparisons, and multivariate logistic regression were performed to identify independent mortality predictors.Results: A total of 140 children were evaluated; median age at transplantation was 23 months. Biliary atresia was the most common indication (45.7%), followed by metabolic diseases (22.1%). Postoperative complications occurred in 42.1% of patients: infectious (35%), biliary (15.7%), and gastrointestinal (15%). Vascular complications were seen in 8.6%, and acute rejection in 10.7%. Retransplantation was required in 5%. Overall mortality was 14.3%. Sepsis was the leading cause of death (35%), followed by central nervous system complications (25%). Prolonged PICU stay emerged as the only independent predictor of mortality, with each additional day increasing risk by 6%.Conclusions: Outcomes at the center align with international data, demonstrating acceptable complication and survival rates. The prominence of infectious and neurological complications underscores the need for strong infection-control measures, early detection of deterioration, and optimized intensive care. Future studies should evaluate long-term graft function and quality of life.","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 6","pages":"514-522"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Psychosocial and Developmental Predictors of Early Behavioral Problems in Preschool Children Referred for Developmental Risk". “学龄前儿童早期行为问题的社会心理和发展预测因素”评论。

IF 1.7

Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2026.26184

Burcu Ersöz Alan

引用次数: 0

Establishing Continuous Reference Intervals for Alkaline Phosphatase in the Pediatric Population from 2 Tertiary Centers in Türkiye. 建立连续参考区间的儿童人群碱性磷酸酶从两个三级中心在泰国。

IF 1.7

Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2025.25371

Hatice Saracoglu, Gozde Erturk Zararsiz, Fatma Demet Arslan, Cevat Yazici, Funda Ipekten, Gokmen Zararsiz, Mehmet Hicri Koseoglu, Cigdem Karakukcu

{"title":"Establishing Continuous Reference Intervals for Alkaline Phosphatase in the Pediatric Population from 2 Tertiary Centers in Türkiye.","authors":"Hatice Saracoglu, Gozde Erturk Zararsiz, Fatma Demet Arslan, Cevat Yazici, Funda Ipekten, Gokmen Zararsiz, Mehmet Hicri Koseoglu, Cigdem Karakukcu","doi":"10.65717/TurkArchPediatr.2025.25371","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2025.25371","url":null,"abstract":"Objective: The aim was to determine age- and sex-specific continuous alkaline phosphatase (ALP) reference intervals (RIs) for the pediatric population using an indirect sampling method on a large retrospective dataset. Furthermore, local RIs estimated from 2 geographically and climatically distinct regions of Türkiye (Kayseri and Izmir) were compared.Materials and methods: Pediatric patients (0-18 years) from 2 tertiary centers in Türkiye (Middle Anatolia and the West) were included. ALP activities were analyzed using the same method and instruments in both centers. Continuous RIs were developed using the Generalized Additive Models for Location, Scale, and Shape method. Discrete RIs were calculated using a nonparametric method according to the Clinical and Laboratory Standards Institute EP28-A3c guideline.Results: Sex-specific continuous RIs revealed distinct ALP patterns. In females, ALP decreased during the first 2 years of life, showed a slight, gradual decrease between ages 2 and 6, and a more pronounced rise until a peak at age 11, followed by a decline toward age 16. In males, ALP decreased during the first 4 years, then gradually increased until a peak at age 13, followed by a subsequent decrease. Regional differences showed higher ALP in Kayseri compared to İzmir, with significant differences emerging at age 13 in females and 16 in males.Conclusion: Continuous RIs provide more accurate and seamless interpretation of ALP test results, addressing age- and sex-related variability. This study underscores the importance of region- and sex-specific RIs in pediatric ALP evaluation, enhancing clinical practice.","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 6","pages":"479-486"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Children Under the Vapor Cloud: A Pediatric Call to Action on Next-Generation Nicotine Products. 烟雾笼罩下的儿童：儿童对下一代尼古丁产品的行动呼吁。

IF 1.7

Turkish archives of pediatrics Pub Date : 2026-06-01 DOI: 10.65717/TurkArchPediatr.2026.6001

Ayşe Ayzıt Kilinç Sakalli

引用次数: 0