Turkish archives of pediatrics最新文献

{"title":"Protecting Kidneys by Protecting the Planet: A Pediatric Nephrology Perspective for World Kidney Day 2026.","authors":"Aysun Karabay Bayazıt, Nur Canpolat, Rukshana Shroff","doi":"10.65717/TurkArchPediatr.2026.25001","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25001","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"179-182"},"PeriodicalIF":1.7,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile Localized Scleroderma with Cutaneous and Extracutaneous Involvement: Long-Term Observational Outcomes from a Referral Center.","authors":"Elif Kilic Konte, Ozge Kaynar, Berivan Kilinc, Zeynep Torunoglu, Ece Aslan, Nergis Akay, Umit Gul, Esma Aslan, Aybuke Gunalp, Fatih Haslak, Mehmet Yildiz, Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur","doi":"10.65717/TurkArchPediatr.2026.25004","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25004","url":null,"abstract":"<p><strong>Objective: </strong>To describe demographic, clinical, and laboratory characteristics of patients with juvenile localized scleroderma (JLS), determine the presence of extracutaneous involvement (ECI) and other comorbidities, and assess treatment response.</p><p><strong>Materials and methods: </strong>Retrospective single-center cohort study of JLS patients followed between 2015 and 2025 who met Padua classification criteria and had ≥6 months of regular follow-up. Clinical, laboratory, and treatment data were systematically collected, and ECI was analyzed using comparative statistics.</p><p><strong>Results: </strong>Among 87 patients, 77% were female. Mean ages at symptom onset, diagnosis, and last visit were 7.1, 9.0, and 14.4 years, respectively, with a median diagnostic delay of 1.2 years. The most frequent subtype was linear scleroderma (36.7%), followed by circumscribed (31.0%), generalized (20.6%), mixed-type (6.8%), and pansclerotic morphea (4.6%). The lower extremities were the most commonly affected, accounting for 54 of 136 sites (39.7%). The ECI occurred in 47.1% of patients, mainly musculoskeletal, and was linked to generalized/pansclerotic subtypes, limb involvement, higher erythrocyte sedimentation rate, higher disease activity scores, and poorer response to conventional disease-modifying antirheumatic drugs (cDMARDs). Overall, 85 patients received at least 1 cDMARD, with 85.9% responding. Methotrexate regimens had high response rates; 14.1% were non-responsive to at least 2 cDMARDs, and 5.7% had active disease at last visit.</p><p><strong>Conclusion: </strong>The JLS carries substantial cutaneous and extracutaneous morbidity, particularly in generalized and pansclerotic subtypes with limb involvement. These findings underscore the importance of early recognition, systematic assessment of ECI, and close longitudinal monitoring in specialized centers and support the need for prospective studies to refine risk stratification and optimize treatment strategies for refractory JLS.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"206-213"},"PeriodicalIF":1.7,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of the February 6 Earthquake on the Pediatric Health and Diseases Service: A Dual-Center Experience.","authors":"Utku Dönger, Osman Fırat Çalışkan, Ezgi Çay, Sevinç Püren Yücel, Gül Trabzon, Ufuk Utku Güllü, Çiğdem El","doi":"10.65717/TurkArchPediatr.2025.25203","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2025.25203","url":null,"abstract":"<p><strong>Objective: </strong>The Kahramanmaraş-centered earthquakes of February 6, 2023 severely disrupted healthcare services, with children-one of the most vulnerable groups-being at particular risk for trauma, infections, and interruptions in chronic disease management. This study evaluated the demographic and clinical characteristics of pediatric inpatients in 2 hospitals in Hatay (Defne State Hospital and Mustafa Kemal University Hospital) by comparing pre- and post-earthquake periods.</p><p><strong>Materials and methods: </strong>This retrospective cross-sectional study included pediatric patients admitted between December 2020-March 2022 (pre-earthquake) and December 2023-March 2024 (post-earthquake). Medical records were reviewed for demographic data, diagnoses, length of hospital stay, and discharge outcomes.</p><p><strong>Results: </strong>A total of 920 patients were included (313 pre-earthquake, 607 post-earthquake). After the earthquake, children admitted were younger (mean age 3.6 ± 4.3 years), had shorter hospital stays (2.6 ± 2.1 days), and were less often foreign nationals compared to the pre-earthquake cohort. Respiratory system infections were the leading diagnosis overall (61.7%), with a notable increase in the post-earthquake period (75.9%). Pediatric neurology and nephrology wards were entirely closed, while endocrinology admissions nearly disappeared. Most patients (90.1%) were discharged in good condition, and referral rates to higher-level centers remained low.</p><p><strong>Conclusion: </strong>Respiratory infections emerged as the leading cause of pediatric hospitalizations after the earthquake. The rapid re-establishment of pediatric inpatient services allowed most cases to be treated locally, yet the closure of pediatric subspecialty wards underscores long-term challenges. Disaster preparedness must therefore encompass not only acute trauma care but also sustained management of pediatric infections and chronic diseases.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"254-259"},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Evaluation of Pediatric Patients with Symptomatic HyperCKemia.","authors":"Pınar Özkan Kart, Elif Acar Arslan","doi":"10.65717/TurkArchPediatr.2026.25300","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25300","url":null,"abstract":"<p><strong>Objective: </strong>Elevated serum creatine kinase (CK) levels, or hyperCKemia, are frequently observed in pediatric patients with muscle weakness, fatigue, or gait abnormalities. Although often associated with neuromuscular disorders (NMD), CK elevation may also result from non-neuromuscular causes such as infection, trauma, exercise, or systemic illness. This study aimed to investigate the underlying causes and clinical features of pediatric patients referred with symptomatic CK elevation.</p><p><strong>Materials and methods: </strong>In this retrospective cohort study, 1,688 pediatric patients with symptomatic hyperCKemia (CK>200 U/L) were analyzed. Patients were categorized into NMD and non-NMD groups and stratified by CK severity: mild (<2000 U/L) and moderate to severe (≥2000 U/L). Symptomatic cases were further classified as acute sporadic, hereditary neurometabolic/genetic, hereditary neuromuscular, or non-hereditary/chronic cases.</p><p><strong>Results: </strong>The cohort included 27.2% female and 72.8% male, with a mean age of 7.4 years. The mean CK level was 1615.1 ± 5390.7 U/L (range: 201-121480), with moderate-to-severe hyperCKemia in 12.7%. CK showed a weak positive correlation with age (r=0.146, P < .001) and was significantly higher in male (P = .020). Acute sporadic cases constituted 67.2% (n=1134), predominantly infections (17.5%) and trauma (14.7%). Hereditary neurometabolic/genetic cases accounted for 2.4% (n=41), hereditary neuromuscular for 5.4% (n=91), and non-hereditary/chronic cases for 25.0% (n=422). Detailed NMD was detected in 7.5%, with significantly higher CK, and NMD diagnosis rose to 33.2% at CK ≥2000 U/L.</p><p><strong>Conclusion: </strong>This study demonstrates that symptomatic hyperCKemia in pediatric patients has diverse etiologies and emphasizes the importance of clinical correlation and a multidisciplinary diagnostic approach.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"230-240"},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"About \"Addressing Pediatric Antimicrobial Resistance in Türkiye: Closing Policy Gaps to Protect Child Health\": Being AWaRe of Surveillance Opportunities in Türkiye.","authors":"Zeynep Ergenc","doi":"10.65717/TurkArchPediatr.2026.25561","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25561","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"283-284"},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Extubation Failure in Critically Ill Children in Pediatric Intensive Care Unit.","authors":"Irene Yuniar, Daendy Nova Setia, Devina June","doi":"10.65717/TurkArchPediatr.2025.25215","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2025.25215","url":null,"abstract":"<p><strong>Objective: </strong>Mechanical ventilation is a common intervention in the pediatric intensive care unit (PICU). Identifying readiness for extubation in patients on mechanical ventilation is essential. However, predicting the right timing for weaning and extubation in the pediatric population remains challenging for clinicians. Extubation failure is associated with higher mortality, prolonged duration of mechanical ventilation, and longer hospital stays. This study aims to determine the clinical characteristics of patients with extubation failure in the PICU.</p><p><strong>Materials and methods: </strong>This observational cross-sectional study included pediatric patients aged 1 month to 18 years who were admitted to the PICU and treated with a mechanical ventilator from January to May 2024. Inclusion criteria are patients with a mechanical ventilator who are eligible for the weaning process and ready for the extubation readiness test. Patients with incomplete data and do-not-resuscitate status were excluded from this study.</p><p><strong>Results: </strong>This study included 112 pediatric patients, aged 1 month to 18 years, who received mechanical ventilators. Extubation failure occurred in 29 patients (25.9%), with 8 patients requiring reintubation and 21 patients requiring noninvasive ventilation. Most participants were younger than 1 year (39.3%), with surgical cases being the leading cause of intubation (61.6%) in the PICU. This study found that extubation failure is associated with younger age (P = .008), patients with pneumonia (P < .001), and longer duration of mechanical ventilation (P = .041).</p><p><strong>Conclusion: </strong>Pediatric patients with critical illness experienced 25.9% extubation failure in the PICU. Patients with a medical indication for intubation and prolonged duration of mechanical ventilation were significantly associated with extubation failure.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"241-245"},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial and Developmental Predictors of Early Behavioral Problems in Preschool Children Referred for Developmental Risk.","authors":"Emel Ömercioğlu, Aysel Hacısoy, Gökçenur Özdemir, Buse Şencan Karakuş, Ebru Öztürk, Elif N Özmert","doi":"10.65717/TurkArchPediatr.2026.25472","DOIUrl":"10.65717/TurkArchPediatr.2026.25472","url":null,"abstract":"<p><strong>Objective: </strong>Behavioral problems in children may be associated with developmental characteristics and parental stress levels. This study aimed to identify potential early risk indicators and focal points for preventive intervention related to behavioral problems among preschool children suspected of developmental delay before diagnosis or formal intervention.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 89 children aged 24-60 months referred for their first evaluation for suspected delays and 37 typically developing (TD) peers. Development was assessed with the Ages and Stages Questionnaire-Turkish version (ASQ-TR). Mothers completed the ASQ: Social-Emotional, Child Behavior Checklist (CBCL/1.5-5), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Parenting Stress Index-Short Form (PSI-SF). Groups were compared, and regression analyses identified child and parent factors associated with behavioral problems. Concurrently, the study examined the developmental, psychological, and familial factors associated with behavioral problems among children at developmental risk. In this subgroup, regression analyses assessed the associations between predefined child variables (age, sex, ASQ-TR domain scores) and maternal measures (BDI, STAI, PSI-SF, parental education, socioeconomic status) with CBCL outcomes.</p><p><strong>Results: </strong>Children with developmental risk had significantly higher CBCL total, internalizing, and externalizing scores than TD peers. Maternal depression symptom and anxiety scores did not differ between groups, but parenting stress was higher among mothers of children with risk. Within the developmental risk group, parenting stress was consistently associated with total, internalizing, and externalizing problems. Delays in personal-social and social-emotional domains were linked to total and externalizing difficulties, while gross motor delays were related to internalizing problems. The number of delayed developmental domains correlated with both behavioral problems and parenting stress.</p><p><strong>Conclusion: </strong>Behavior problems are higher among children identified as being at developmental risk through screening, and parenting stress is closely associated across behavioral domains even before formal diagnosis or intervention. Multiple delays appear to exacerbate both child and parent outcomes. These findings highlight the need for early, family-centered interventions addressing children's developmental and behavioral needs alongside parental well-being.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"260-268"},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Treatment Outcomes of Pediatric Pancreatic Solid Pseudopapillary Tumors: A Single-Center Experience.","authors":"Selma Cakmakci, Ahmet Erturk, Esra Karakus, Merve Meryem Kiran, Arzu Yazal Erdem, Derya Ozyoruk, Neriman Sari, Emrah Senel, Inci Ergurhan Ilhan","doi":"10.65717/TurkArchPediatr.2026.25324","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.25324","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate clinical characteristics, surgical management approaches, and long-term outcomes of pediatric patients with histopathologically-confirmed pancreatic solid pseudopapillary neoplasm (SPN) at a single tertiary center over 10 years.</p><p><strong>Materials and methods: </strong>A retrospective review was conducted of 16 pediatric patients with pancreatic SPN who were treated at the hospital between 2015 and 2025. Data on demographics, clinical presentation, imaging, surgery, pathology, and follow-up were analyzed.</p><p><strong>Results: </strong>Among the 16 patients, 15 were female and 1 was male, with a median age of 14 years (range: 7-16). Abdominal pain was the most frequent presenting symptom (n=12) and other presentations included jaundice, abdominal swelling, or amenorrhea, while 2 patients reported no symptoms. The pancreatic head was the most common tumor site (n=9), and the median tumor size was 5 cm (range: 1-14 cm). Surgical procedures included enucleation (n=10), distal pancreatectomy (n=3), and the Whipple procedure (n=3). Despite positive surgical margins in 9 patients, only 2 experienced local recurrence. No patients received adjuvant therapy. Postoperative complications occurred in 2 cases. One patient developed papillary thyroid carcinoma during follow-up. The median follow-up duration was 50 months (range: 2-108), and all patients were alive and all but one are disease-free at the last evaluation.</p><p><strong>Conclusion: </strong>Pediatric pancreatic SPN predominantly affects adolescent girls and often presents incidentally. Surgical resection yields excellent long-term outcomes even in the presence of positive margins. Continued follow-up is essential due to potential recurrence and rare secondary malignancies.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 3","pages":"246-253"},"PeriodicalIF":1.7,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tips For Writing A Medical Review.","authors":"Özgür Kasapçopur","doi":"10.65717/TurkArchPediatr.2026.260201","DOIUrl":"https://doi.org/10.65717/TurkArchPediatr.2026.260201","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 2","pages":"92-94"},"PeriodicalIF":1.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staphylococcal Septic Arthritis Following Influenza A Infection.","authors":"Fidan Khalilova, Murat Hüseyin Yiğit, Caner Günerbüyük, Hacer Aktürk","doi":"10.5152/TurkArchPediatr.2025.25361","DOIUrl":"https://doi.org/10.5152/TurkArchPediatr.2025.25361","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"61 8","pages":"742-743"},"PeriodicalIF":2.3,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}