Turkish archives of pediatrics最新文献

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Cystic Fibrosis Treatment Landscape: Progress, Challenges, and Future Directions. 囊性纤维化治疗前景:进展、挑战和未来方向。
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-03-03 DOI: 10.5152/TurkArchPediatr.2025.24257
Ceren Ayça Yıldız, Yasemin Gökdemir, Ela Erdem Eralp, Pınar Ergenekon, Fazilet Karakoç, Bülent Karadağ
{"title":"Cystic Fibrosis Treatment Landscape: Progress, Challenges, and Future Directions.","authors":"Ceren Ayça Yıldız, Yasemin Gökdemir, Ela Erdem Eralp, Pınar Ergenekon, Fazilet Karakoç, Bülent Karadağ","doi":"10.5152/TurkArchPediatr.2025.24257","DOIUrl":"10.5152/TurkArchPediatr.2025.24257","url":null,"abstract":"<p><p>Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that primarily affects the respiratory and gastrointestinal systems. It results from variants in the CFTR gene, leading to dysfunctional chloride channels, thickened mucus secretion, and subsequent multisystem complications. Significant advances have been made in CF treatment, particularly with the development of CFTR modulators, which are unique to genotypes and have improved clinical outcomes in many people with CF. However, the benefits of these therapies are not universal, with a considerable portion of the CF population-especially those with rare mutations-still without access to effective treatment options. This review provides a comprehensive overview of the pathophysiology and genetic basis of CF, explores current and emerging treatments, and discusses the ongoing challenges in the field.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 2","pages":"117-125"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient Thyroid Dysfunction in New-Onset Type 1 Diabetes: Reassessing Test Timing for Accurate Results. 新发1型糖尿病的短暂性甲状腺功能障碍:重新评估测试时间以获得准确结果。
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-03-03 DOI: 10.5152/TurkArchPediatr.2025.24159
Talha Üstüntaş, Mehmet Emre Atabek, Beray Selver Eklioğlu, Saime Ergen Dibeklioğlu
{"title":"Transient Thyroid Dysfunction in New-Onset Type 1 Diabetes: Reassessing Test Timing for Accurate Results.","authors":"Talha Üstüntaş, Mehmet Emre Atabek, Beray Selver Eklioğlu, Saime Ergen Dibeklioğlu","doi":"10.5152/TurkArchPediatr.2025.24159","DOIUrl":"10.5152/TurkArchPediatr.2025.24159","url":null,"abstract":"<p><p>Objective: Type 1 diabetes mellitus (T1DM) is a prevalent chronic disease affecting children, necessitating ongoing care from multidisciplinary clinics. This study aimed to determine the prevalence of thyroid dysfunction in newly diagnosed T1DM patients, investigating long-term thyroid function through periodic monitoring. Materials and Methods: A retrospective cohort study utilized the medical records of pediatric patients with newly diagnosed T1DM. Extracted data included age at initial diagnosis, presenting clinical manifestations, standard laboratory findings, and thyroid function panel results. Results: The sample included 208 T1DM patients, with a higher proportion of males (54.8%) than females (45.2%). Initial assessment revealed that 69.2% of patients were euthyroid, 24.5% exhibited euthyroid sick syndrome (ESS), 5.8% compensated hypothyroidism, and 0.5% primary hypothyroidism. About 76.5% of patients initially diagnosed with ESS were euthyroid at the second visit. Analysis confirmed a significant difference in the distribution of euthyroid and ESS patients between the first and second visits (P < .001). Temporal analysis indicated that thyroid function tended to normalize within 1-2 weeks of the initial presentation. Conclusion: Tests should be performed within 1-2 weeks following clinical stabilization to evaluate thyroid function in newly diagnosed T1DM patients. However, patients with a history of thyroid disease, or those with clinical signs indicative of thyroid dysfunction, should undergo immediate testing at the time of diagnosis.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 2","pages":"153-158"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surfactant Therapy in Late Preterm Infants with Respiratory Distress in Türkiye: An Observational, Prospective, Multicenter Study. 表面活性剂治疗晚期早产儿呼吸窘迫:一项观察性、前瞻性、多中心研究。
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-03-03 DOI: 10.5152/TurkArchPediatr.2025.24236
Sumru Kavurt, Nihal Demirel, İstemi Han Çelik, Ahmet Yagmur Bas, Makbule Ercan, Beyza Özcan, Zehra Aslan, Demet Oğuz, Musa Turgut, Melike Kefeli Demirel, Nilay Hakan, Ali Bülbül, Kadir Tekgündüz, Samet Benli, Hüseyin Altunhan, Murat Konak, Ferda Ozlü, Oğuz Tuncer, Ozge Aydemir
{"title":"Surfactant Therapy in Late Preterm Infants with Respiratory Distress in Türkiye: An Observational, Prospective, Multicenter Study.","authors":"Sumru Kavurt, Nihal Demirel, İstemi Han Çelik, Ahmet Yagmur Bas, Makbule Ercan, Beyza Özcan, Zehra Aslan, Demet Oğuz, Musa Turgut, Melike Kefeli Demirel, Nilay Hakan, Ali Bülbül, Kadir Tekgündüz, Samet Benli, Hüseyin Altunhan, Murat Konak, Ferda Ozlü, Oğuz Tuncer, Ozge Aydemir","doi":"10.5152/TurkArchPediatr.2025.24236","DOIUrl":"10.5152/TurkArchPediatr.2025.24236","url":null,"abstract":"<p><p>Objective: Surfactant therapy (ST) is commonly used in late preterm (LPT) infants with respiratory distress despite a lack of definitive recommendation for these infants. Our aim was to establish a national prospective database to evaluate the use of surfactants in LPT infants. Materials and Methods: A multicenter, prospective observational cohort study was conducted among LPT infants treated with surfactant between January 1, 2022, and December 31, 2022. Twenty neonatologists from 16 neonatal intensive care units (NICUs) participated in the study. Results: During the study period, a total of 3327 LPT infants were admitted to the participating NICUs. Among them, 1866 infants experienced respiratory distress, and 288 received surfactant treatment. In this study, respiratory distress syndrome (RDS) was the most common indication for surfactant administration, affecting 158 infants (54.8%), followed by congenital pneumonia in 79 infants (27.4%) and transient tachypnea of the newborn (TTN) in 32 infants (11.1%). Conclusion: We demonstrated that ST is administered with significant variability among LPT infants experiencing respiratory distress. Additionally, respiratory issues in LPT infants beyond RDS, such as congenital pneumonia and TTN, are also frequently treated with surfactant.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 2","pages":"164-171"},"PeriodicalIF":1.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of Quality of Life Change After Catheter Ablation in Children with Arrhythmia. 心律失常患儿导管消融后生活质量变化的研究。
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-03-02 DOI: 10.5152/TurkArchPediatr.2025.24184
Kardelen Yagmur Isin, Meryem Beyazal, Ilker Ufuk Sayici, Tamer Yoldas, Senem Ozgur
{"title":"Investigation of Quality of Life Change After Catheter Ablation in Children with Arrhythmia.","authors":"Kardelen Yagmur Isin, Meryem Beyazal, Ilker Ufuk Sayici, Tamer Yoldas, Senem Ozgur","doi":"10.5152/TurkArchPediatr.2025.24184","DOIUrl":"10.5152/TurkArchPediatr.2025.24184","url":null,"abstract":"<p><p>Objective: Arrhythmia in children is a serious health problem. The role of pharmacological treatment in the treatment of arrhythmia in children is limited. Therefore, ablation has an important role in the treatment of arrhythmia. The aim of this study is to evaluate the quality of life (QoL) after catheter ablation. Materials and Methods: Patients and their parents completed the scales independently but simultaneously, before ablation and 6 months after ablation. Seventy-two children and their parents were included in the study. The QoL Scale was designed as a five-point Likert scale and was divided into 2 age groups, 8-12 years and 13-18 years, with each age group having separate child and parent forms. The scale forms consisted of 4 sub-sections to understand physical, emotional, social, and school functioning. Results: Of the ablations, 65 (90.3%) were successful, 5 (6.9%) were unsuccessful and 2 (2.8%) were suboptimally successful. Accordingly, there was a statistically significant increase in quality of life after successful ablation (P =.001). There was also a significant difference in the magnitude of the increase in QoL according to the type of ablation (P =.025). However, when the sex, age groups, and sub-diagnosis groups of the patients were compared, no significant difference was observed in terms of change in quality of life. Conclusion: This study is the first in Türkiye to investigate the impact of catheter ablation on QoL of children who underwent catheter ablation for various cardiac arrhythmias.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 2","pages":"200-207"},"PeriodicalIF":1.3,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodevelopmental Impact of Pesticides: A Silent Threat. 杀虫剂对神经发育的影响:一个无声的威胁。
IF 1.7
Turkish archives of pediatrics Pub Date : 2025-02-16 DOI: 10.5152/TurkArchPediatr.2025.1112252
Ertuğrul Kıykım
{"title":"Neurodevelopmental Impact of Pesticides: A Silent Threat.","authors":"Ertuğrul Kıykım","doi":"10.5152/TurkArchPediatr.2025.1112252","DOIUrl":"10.5152/TurkArchPediatr.2025.1112252","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 2","pages":"114-116"},"PeriodicalIF":1.7,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Severity of Gastroesophageal Reflux Disease in Indian Children Presenting with Symptoms of Acid Reflux: A Real-world Evidence Study. 以胃酸反流为症状的印度儿童胃食管反流病的患病率和严重程度:一项真实世界的证据研究
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-01-27 DOI: 10.5152/TurkArchPediatr.2025.24140
Dhanasekhar Kesavelu, Nithya Franklyn, C Venkatraghavan, Dev Narayan, Kumar P Ravindra, Akram Wasim
{"title":"Prevalence and Severity of Gastroesophageal Reflux Disease in Indian Children Presenting with Symptoms of Acid Reflux: A Real-world Evidence Study.","authors":"Dhanasekhar Kesavelu, Nithya Franklyn, C Venkatraghavan, Dev Narayan, Kumar P Ravindra, Akram Wasim","doi":"10.5152/TurkArchPediatr.2025.24140","DOIUrl":"10.5152/TurkArchPediatr.2025.24140","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":" ","pages":"341-343"},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Element Levels According to Biologic Matrix During Childhood Period. 儿童时期生物基质中的元素水平。
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-01-25 DOI: 10.5152/TurkArchPediatr.2024.24276
Merve Çiçek Kanatlı, Sıddika Songül Yalçın
{"title":"Element Levels According to Biologic Matrix During Childhood Period.","authors":"Merve Çiçek Kanatlı, Sıddika Songül Yalçın","doi":"10.5152/TurkArchPediatr.2024.24276","DOIUrl":"10.5152/TurkArchPediatr.2024.24276","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":" ","pages":"243-244"},"PeriodicalIF":1.3,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positron Emission Tomography Imaging and HScore-Based Diagnosis in Two Children with Malignancy-Associated Hemophagocytic Syndrome: Anaplastic Large-Cell Lymphoma and Precursor B-acute Lymphoblastic Leukemia. 2例儿童恶性相关噬血细胞综合征:间变性大细胞淋巴瘤和前体b急性淋巴细胞白血病的正电子发射断层成像和基于hscore的诊断
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-01-13 DOI: 10.5152/TurkArchPediatr.2025.24134
Zühre Kaya, Serap Kirkiz Kayalı, Büşra Topuz Türkcan, Ümit Özgür Akdemir, Ahmet Bayramlı, Özge Vural, Nuket Yurur Kutlay, Ülker Koçak
{"title":"Positron Emission Tomography Imaging and HScore-Based Diagnosis in Two Children with Malignancy-Associated Hemophagocytic Syndrome: Anaplastic Large-Cell Lymphoma and Precursor B-acute Lymphoblastic Leukemia.","authors":"Zühre Kaya, Serap Kirkiz Kayalı, Büşra Topuz Türkcan, Ümit Özgür Akdemir, Ahmet Bayramlı, Özge Vural, Nuket Yurur Kutlay, Ülker Koçak","doi":"10.5152/TurkArchPediatr.2025.24134","DOIUrl":"10.5152/TurkArchPediatr.2025.24134","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":" ","pages":"233-234"},"PeriodicalIF":1.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal Seizures as a First Sign of Inferior Vena Cava Thrombosis: Diagnostic and Therapeutic Challenges. 新生儿癫痫发作作为下腔静脉血栓形成的第一征兆:诊断和治疗的挑战。
IF 1.7
Turkish archives of pediatrics Pub Date : 2025-01-13 DOI: 10.5152/TurkArchPediatr.2025.24232
Mariana Oliveira Pereira, Rita Lages Pereira, Clara Machado, Albina Silva
{"title":"Neonatal Seizures as a First Sign of Inferior Vena Cava Thrombosis: Diagnostic and Therapeutic Challenges.","authors":"Mariana Oliveira Pereira, Rita Lages Pereira, Clara Machado, Albina Silva","doi":"10.5152/TurkArchPediatr.2025.24232","DOIUrl":"10.5152/TurkArchPediatr.2025.24232","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":" ","pages":"238-239"},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the Letter to the Editor Titled "A Possible Alternative in the Treatment of Obstructive Airway Disease in Paediatric Intensive Care Patients". 对题为“儿科重症监护患者治疗阻塞性气道疾病的一种可能选择”的致编辑信的回应。
IF 1.3
Turkish archives of pediatrics Pub Date : 2025-01-02 DOI: 10.5152/TurkArchPediatr.2025.242242
Ulkem Kocaoglu Barlas
{"title":"Response to the Letter to the Editor Titled \"A Possible Alternative in the Treatment of Obstructive Airway Disease in Paediatric Intensive Care Patients\".","authors":"Ulkem Kocaoglu Barlas","doi":"10.5152/TurkArchPediatr.2025.242242","DOIUrl":"10.5152/TurkArchPediatr.2025.242242","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 1","pages":"110-111"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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