Turkish archives of pediatrics最新文献

{"title":"Prognostic Value of Long Non-Coding RNAs GUSB Pseudogene 11 in Colorectal Cancer and Its Regulatory Effect on Tumor Progression.","authors":"Jia-Rui Hu, Jie-Ting Fan, Shao-Bo Qu, Xiao-Hua He, Dai-Wei Liu, Yong-Xia Wang, Xiao-Yuan Wu, Zhan-Lin Li","doi":"10.5152/tjg.2025.24450","DOIUrl":"https://doi.org/10.5152/tjg.2025.24450","url":null,"abstract":"<p><p>Background/Aims: Colorectal cancer (CRC) is the third most common cancer, and its progression to advanced diagnosis leads to a dismal prognosis. The long non-coding RNA (lncRNA) GUSB Pseudogene 11 (GUSBP11) can act in a variety of cancers. Nevertheless, the potential mechanism of GUSBP11 in CRC has not been reported. The purpose of this study is to investigate the relationship between the role of GUSBP11 expression in CRC progression as well as prognosis. Materials and Methods: Two hundred and fifty-nine CRC patients were recruited. Expression levels of GUSBP11 and downstream target genes in CRC cell lines were evaluated by quantitative reverse transcription polymerase chain reaction. The influence of clinical characteristics and GUSBP11 on prognosis was evaluated by the proportional hazards model. Cell-Counting-Kit-8 and transwell assays were conducted for detection of CRC cell proliferation, migration, and invasion. Dual luciferase and correlation analyses were used to validate GUSBP11 with predicted genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to analyze downstream gene function and signaling pathways. Results: The expression of GUSBP11 was upregulated in CRC and relevant to the deterioration of prognosis. The CRC cell proliferation, migration, and invasion were inhibited by GUSBP11 silencing. miR-605-3p was the downstream target gene of GUSBP11, and its expression is negatively regulated by GUSBP11. Conclusion: Taken together, this study highlights that the inhibition of miR-605-3p by GUSBP11 to regulate the downstream signaling pathway leads to prognostic malignancy and promotes tumor growth in CRC.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatologist-Performed Echocardiography versus Pediatric Cardiologist for the Patent Ductus Arteriosus in Preterm Newborns.","authors":"Meryem Beyazal, Nihan Hilal Hosagasi, Emine Gulsah Torun, Denizhan Bagrul, Abdullah Kurt","doi":"10.5152/TurkArchPediatr.2025.24260","DOIUrl":"10.5152/TurkArchPediatr.2025.24260","url":null,"abstract":"<p><p>Objective: Premature babies have a fragile circulatory system balance; therefore, rapid inter- vention may be needed in patients with patent ductus arteriosus (PDA). Echocardiography performed by a neonatologist can help to choose the best treatment option for newborns in a timely manner. The aim is to evaluate the performance of neonatologists in ductus assessment. Materials and Methods: Among the neonates born at the hospital, those diagnosed with PDA (n=40) under 32 weeks of gestational age were evaluated with echocardiography by a neo- natologist and a pediatric cardiologist. Interobserver variability analysis was done using the intraclass coefficient value and Cohen's kappa test results. Results: An excellent interobserver agreement was found in the peak systolic-to-end diastolic flow velocity ratio, a good agreement in the narrowest diameter of the ductus, peak systolic and diastolic velocities, and mitral A velocity. Raters had moderate to poor agreement in the rest of the variables such as left atrium/aorta ratio, ampulla diameter, length of the ductus, and left pulmonary artery diameter. Conclusion: It is suggested that neonatologists perform echocardiography to measure the nar- rowest diameter of the ductus and ductal flow velocities for PDA evaluation.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"274-279"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Characteristics of Mild Encephalopathy with Reversible Splenial Lesion in A Child with Shigella Infection.","authors":"Umur Anil Pehlivan, Ummuhan Cay, Merve Misirlioglu, Omer Kaya, Ozden Ozgur Horoz","doi":"10.5152/TurkArchPediatr.2025.24286","DOIUrl":"10.5152/TurkArchPediatr.2025.24286","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"349-351"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges Confronted by Coaches in Evaluation of Pediatric Athletes: Awareness on Pediatric Sports Medicine.","authors":"Abdullah Akkuş, Hüseyin Aslan, Ceylani Özkaymakoğlu, Ali Tatlici, Şinasi Özsaydi, Abdullah Yazar, Ahmet Osman Kiliç, Fatih Akin","doi":"10.5152/TurkArchPediatr.2025.25028","DOIUrl":"10.5152/TurkArchPediatr.2025.25028","url":null,"abstract":"<p><p>Objective: There are numerous athletes under 18 years of age in our country, whose physical, psychosocial and athletic developments have become more of an issue. The aim was to deter- mine challenges confronted by coaches of pediatric athletes in the referral of pediatric athletes for preparticipation medical clearance, management of injuries, pre- and postparticipation follow-up, and opinions of coaches about whether establishment of Pediatric Sports Medicine (PSM) would be warranted. Materials and Methods: This questionnaire addressed coaches' age, sex, the sport branch they were dealing with, physicians to whom they refer pediatric athletes, challenges experienced with the athlete and his/her parents during preparticipation evaluation (PPE), challenges experienced by parents during PPE, suggested branch for referral, awareness of coaches on PSM abroad, and their opinions on interests of PSM and establishment of PSM in our country. Results: A total of 352 coaches were included. The most common branch of coaching was foot- ball (21.4%). The most common physicians they were referring to were sports medicine special- ists (52.0%), family medicine specialists (44.9%), general pediatricians (33.8%), and pediatric cardiologists (29.3%). Of the participants, 69.0% had never heard about PSM. Regarding areas of interest of PSM, 55.1% stated they had no idea, 37.5% routine follow-up and 25.0% physical examination of pediatric athletes. Of the participants, 90.1% stated that establishment of PSM in our country would definitely contribute to PPE, and 94.9% stated that it should definitely be established. Conclusion: It was concluded that awareness on PSM is low among coaches and that the establishment of PSM would definitely make contribution in Türkiye.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"314-318"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate Crisis and Its Impacts on Health \"The Future Is Now\".","authors":"Saçkesen Cansın, Kocabıyık Kıvılcım Pınar, Medina Emir, Binbaşaran Tüysüzoğlu Banu","doi":"10.5152/TurkArchPediatr.2025.1112253","DOIUrl":"10.5152/TurkArchPediatr.2025.1112253","url":null,"abstract":"","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"248-250"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Frequency of Sugar and Protein Intake and Severity of Plaque-Induced Gingivitis in Children.","authors":"Ayshe Salim, Sirma Angelova, Bogdan Roussev, Todorka Sokrateva, Bistra Galunska, Pawel Olczyk, Katarzyna Komosinska-Vassev, Stefan Peev, Yoana Kiselova-Kaneva, Diana Ivanova","doi":"10.5152/TurkArchPediatr.2025.24166","DOIUrl":"10.5152/TurkArchPediatr.2025.24166","url":null,"abstract":"<p><p>Objective: The aim of this study is to evaluate how the frequent sugar and protein intake is associated with the severity of plaque-induced gingivitis in children. Materials and Methods: A cross-sectional study was conducted, involving 38 subjects (4-14 years) at a mean age of 8.5 ± 2.32 years with diagnosed plaque-induced gingivitis based on the Löe-Silness Gingival Index (GI) (0 < GI ≤ 3). The gingival status was assessed by the Silness-Lőe Plaque Index (PLI), GI, and Papillary Bleeding Index by Saxer and Muhlemann. The nutritional status was established through an in-depth questionnaire on protein and sugar intake. Results: The increased frequency of sugar consumption in children with plaque-induced gingivitis is related to enhanced gingival inflammation. Higher values of PLI among the rep- resentatives were established with frequent sugar intake (P = .04). Frequent dairy protein con- sumption was associated with lower levels of PLI (P = .04). This index is indicative of the amount of accumulated dental plaque, which is the main etiological factor involved in plaque-induced gingivitis. Conclusion: It can be concluded that uncontrolled sugar consumption in children was asso- ciated with enhancement of the severity of plaque-induced gingivitis. Frequent dairy protein intake has the potential to serve as an essential prevention strategy regarding the onset and aggravation of plaque-induced gingival inflammation in childhood. A well-balanced diet, rich in proteins and with restricted sugar intake, is considered a possible tool in the prevention and control of plaque-induced gingivitis in childhood.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"319-325"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mother-to-Child Transmission of Human Immunodeficiency Virus and Its Determinants: Lessons Learnt from the Test and Treat Strategy at a Regional Hospital in Cameroon.","authors":"Andreas Chiabi, Adel Vershiyi Bongakeh, Yolande Djike Puepi Fokam, Esther Neba Ngum, Samuel Angwafor, Denis Nsame Nforniwe","doi":"10.5152/TurkArchPediatr.2025.24144","DOIUrl":"10.5152/TurkArchPediatr.2025.24144","url":null,"abstract":"<p><p>Objective: With the World Health Organization's (WHO) implementation of the \"test and treat all\" policy in 2016, there should have been a great change in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV), and its determinants. This study aimed to assess MTCT of HIV after the adoption of the universal \"test and treat\" policy. Materials and Methods: A retrospective cohort study of HIV-exposed infants (HEIs) between the ages of 6 weeks to 18 months enrolled from 1 January 1, 2017 to December 31, 2021. The study was carried out at the \"Prevention of Mother to Child Transmission\" center (PMTCT) of the HIV unit, Regional Hospital Bamenda (RHB) of the Northwest region of Cameroon. Data was col- lected from files with the aid of predesigned data collection forms. Results: During the study, out of the 294 HEIs included, 13 were positive, giving a frequency of 4.4%. Not taking antiretrovirals by the mother, or taking them 4 weeks prior to delivery, or after delivery, mixed feeding, and breastfeeding duration greater than 12 months were determinants of MTCT of HIV. Also, 4 out of the 294 exposed infants died, giving a death rate of 1.4%. No fac- tor analyzed was found to be significantly associated with the death rate of HEIs at 18 months. Conclusion: This study showed a reduction in the frequency of MTCT of HIV due to the imple- mentation and adoption of the universal \"test and treat\" policy. Also, starting maternal anti- retroviral treatment after delivery and a breastfeeding duration greater than 12 months were associated with MTCT of HIV.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"301-306"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and Validity of the Turkish Version of a Self-Reported Sizing Me Up and a Parent-Proxy Sizing Them Up: Obesity Specific Health- Related Quality of Life Measures.","authors":"Deniz Özalp Kızılay, Derya Tepe, Betül Ersoy, Şermin Yalın Sapmaz","doi":"10.5152/TurkArchPediatr.2025.24196","DOIUrl":"10.5152/TurkArchPediatr.2025.24196","url":null,"abstract":"<p><p>Objective: Investigating the validity and reliability of the Turkish versions of the obesity-specific health-related quality of life perception scales for children and parents , Sizing Me Up/Sizing Them Up (SMU/STU), was the aim of this study. Materials and Methods: Sizing me up/sizing them up were translated into Turkish following a standardized translation procedure. Test-retest reliability, internal consistency, discriminant and convergent validity, as well as confirmatory factor analysis (CFA) were all assessed. Results: Sizing me up /sizing them up had a total scale Cronbach's alpha of 0.873, 0.872. In the test-retest evaluations, significant correlation was found in the SMU (except the Teasing/ Marginalization subscale), while no correlation was found in the Physical Functioning, Teasing/ Marginalization, School and Mealtime Difficulties subscales in the STU. The Pediatric Quality of Life Generic Core Scales (PedsQL) total mean score and the SMU/STU total mean scores exhibited a significant correlation (r=0.671, P < .0001/r=0.663, P < .001). Regarding the SMU total scale score and other subscale scores, excluding the Social Avoidance subscale, and the STU total scale score and other subscale scores, excluding Mealtime and School Functioning, a significant difference was found between the OB and non-OB samples. In CFA, the com- parative fit index (CFI) and root mean square error of approximation (RMSEA) values were not compatible with the expected values. Conclusion: The results demonstrated that both scales are suitable for use in the Turkish context and showed the validity and reliability of the Turkish versions of the SMU/STU; however, some inconsistencies were found in the items related to social avoidance in the SMU scale and posi- tive social attributes, mealtime challenges, and school functioning in the STU, so it is recom- mended that these items should be interpreted separately and carefully when evaluating scale scores by researchers or clinicians.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"334-340"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical Enthesitis in Children with Chronic Nonbacterial Osteomyelitis.","authors":"Seher Sener, Adalet Elcin Yildiz, Ezgi Deniz Batu, Erdal Atalay, Ozge Basaran, Yelda Bilginer, Seza Ozen","doi":"10.5152/TurkArchPediatr.2025.24300","DOIUrl":"10.5152/TurkArchPediatr.2025.24300","url":null,"abstract":"<p><p>Objective: Enthesitis is rare in chronic nonbacterial osteomyelitis (CNO) compared to enthesi- tis-related arthritis. It may be asymptomatic in CNO patients. This study aimed to evaluate the presence of subclinical enthesitis in patients with CNO using ultrasonography (US). Materials and Methods: Patients with CNO were included in this study and evaluated with US by an expert pediatric radiologist. The entheses of 7 tendons were assessed bilaterally, includ- ing the common extensor and flexor tendons, the quadriceps tendon, the proximal and distal patellar tendons, the Achilles tendon, and the plantar fascia. Results: Fifty CNO patients were included. The median age of the patients was 12.4 years, and 58% were female. Subclinical enthesitis was identified in 3 patients (6%). These 3 patients were male, older than 6 years at diagnosis, had bilateral sacroiliitis, and were positive for human leukocyte antigen-B27. The enthesitis was located in the right quadriceps, right plantar fascia, and bilateral Achilles. One of these patients also had a clinical history of enthesitis at diagnosis. Treatment modification was not done when subclinical enthesitis was detected since they were in clinical remission and acute phase reactants were within normal limits. However, the patient with bilateral subclinical Achilles enthesitis had a disease flare afterward, and methotrexate was switched to etanercept. Conclusion: Subclinical enthesitis can be observed especially in CNO patients with overlappin- genthesitis-related arthritis features. The use of US may prove beneficial in detecting subclini- cal enthesitis and predicting disease flare.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 2","pages":"289-293"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Etiology of Granulomatous Lymphadenopathy in Children Admitted to a Tertiary Pediatric Infectious Clinic.","authors":"Fatma Tugba Cetin, Ümmühan Çay, Özlem Özgür Gündeslioğlu, Derya Alabaz, Nazlı Totik, Aysun Hatice Uğuz","doi":"10.5152/TurkArchPediatr.2025.24316","DOIUrl":"10.5152/TurkArchPediatr.2025.24316","url":null,"abstract":"<p><p>Objective: Pediatric patients with histopathologically confirmed granulomatous lymphade- nopathy were evaluated etiologically. Materials and Methods: In this study, patients who presented to the tertiary pediatric infec- tious disease clinic with histopathologically confirmed granulomatous lymphadenopathy were retrospectively reviewed, and the etiological evaluation of granulomatous inflammation based on patient history, clinical findings, and additional tests were presented. Results: The study included 91 patients. In the study, 48 (52.7%) patients underwent biopsy from the cervical region, 21 (23.1%) patients underwent biopsy from the axillary region, 13 (14.3%) patients underwent biopsy from the submandibular and 9 (9.9%) patients underwent biopsy from lymph node sites other than these regions. Cervical lymphadenopathy was more common in patients over the age of 10, while axillary lymphadenopathy was more common in patients under the age of 5. A statistically significant difference was found between the age groups in the biopsy sites (P=.007). When the etiology of the patients was examined, it was found that 78 (85.7%) patients had infectious and 3 (3.3%) patients had non-infectious causes. The cause could not be determined for 10 (11%). There was a difference in etiology frequency according to the lymphadenopathy locations (P=.001). Conclusion: In this study, the most common etiology of granulomatous lymphadenopathy was shown to be infections, especially mycobacteria. Less common were toxoplasmosis, aspergil- lus, and cat scratches. Among non-infectious causes, chronic granulomatous disease should be kept in mind.</p>","PeriodicalId":75267,"journal":{"name":"Turkish archives of pediatrics","volume":"60 3","pages":"307-313"},"PeriodicalIF":1.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}