Translational sports medicine最新文献

{"title":"Is It Time to Step outside the Laboratory? The Feasibility of Field-Based Examination of Exercise-Induced Hypoalgesia in Elite Badminton Athletes with and without Knee Pain.","authors":"Brooke K Coombes, M Dilani Mendis, Felix Leung, Julie A Hides","doi":"10.1155/2024/2953220","DOIUrl":"10.1155/2024/2953220","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the feasibility of testing exercise-induced hypoalgesia (EIH) in a field setting. The effect of knee pain on EIH was also explored.</p><p><strong>Design: </strong>Within-group pre-post design.</p><p><strong>Materials and methods: </strong>Fourteen athletes (8 male, 6 female) competing at an international level in badminton were tested on the sideline during an in-season training session. Participants completed questionnaires and a single leg decline squat to evaluate the presence of knee pain. A blinded examiner measured PPT over the quadriceps muscle before and after two conditions (3-minute quiet rest and 3-minute isometric wall squat).</p><p><strong>Results: </strong>The exercise protocol was completed by 13 (93%) participants. Mean (SD) exertion was 8.4 (1.7), and mean thigh pain was 7.9 (2.0) at 3 minutes. Very high reliability was observed for PPT collected before and after rest (ICC 0.94, 95% CI 0.85, 0.98). PPT significantly increased by 22.4% (95% CI 15.1, 29.7) after wall squat but not after rest. Relative increases in PPT were similar in participants with and without knee pain on single leg decline squat (22.2% versus 22.6%, 7 participants each).</p><p><strong>Conclusion: </strong>Simple, field-based tests of endogenous analgesia are feasible and could provide new opportunities to evaluate an athlete's risk of persistent pain.</p>","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"2024 ","pages":"2953220"},"PeriodicalIF":1.2,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Countermovement Depth on the Neuromechanics of a Vertical Jump.","authors":"Malachy P McHugh, Josef Alexander Cohen, Karl F Orishimo, Ian J Kremenic","doi":"10.1155/2024/7113900","DOIUrl":"10.1155/2024/7113900","url":null,"abstract":"<p><p>The purpose of this study was to examine kinematic, kinetic, and muscle activation metrics during countermovement jumps (CMJs) with varying countermovement depths. The hypothesis was that a shallow countermovement depth would compromise jump height by disrupting neuromechanical control. Ten healthy men (age 26 ± 8 yr, height 1.81 ± 0.08 m, mass 83.5 ± 9.0 kg) performed maximal CMJs at self-selected countermovement depth (self-selected CMJ), at reduced countermovement depth (shallow CMJ), and at increased countermovement depth (deep CMJ). Three jumps were performed in each condition on force plates with ankle, knee, and hip motion recorded and electromyograms (EMG) recorded from the gluteus maximus (GM), vastus lateralis (VL), and medial gastrocnemius (MG) muscles. During CMJs, the knee flexion angle was recorded with an electrogoniometer. Jumpers were instructed to flex at least 15% less (shallow CMJ) and at least 15% more (deep CMJ) than the self-selected CMJs. Kinematic, kinetic, and EMG metrics were compared between the different CMJ depths using repeated measures ANOVA. Compared with self-selected CMJs, shallow CMJs had 26% less countermovement depth (<i>P</i> < 0.001, effect size 1.74) and the deep CMJs had 28% greater countermovement depth (<i>P</i> < 0.001, effect size 1.56). Jump height was 8% less for the shallow vs. self-selected CMJs (<i>P</i> = 0.007, effect size 1.09) but not different between self-selected and deep CMJs (<i>P</i> = 0.254). Shallow CMJs differed from self-selected CMJs at the initiation of the countermovement (unweighting). For self-selected CMJs, force dropped to 43% of body weight during unweighting but only to 58% for shallow CMJs (<i>P</i> = 0.015, effect size 0.95). During unweighting, VL EMG averaged 5.5% of MVC during self-selected CMJs versus 8.1% for shallow CMJs (<i>P</i> = 0.014, effect size 0.97). Percent decline in jump height with shallow versus self-selected CMJs was correlated with the difference in VL EMG during unweighting between shallow and self-selected CMJs (<i>r</i> = 0.651, <i>P</i> = 0.041). A deep countermovement prolonged the time to execute the jump by 38% (<i>P</i> < 0.010, effect size 1.04) but did not impair CMJ force metrics. In conclusion, self-selected countermovement depth represents a tradeoff between dropping the center of mass sufficiently far and executing the jump quickly. Unweighting at the initiation of a CMJ appears to be a critical element in the neuromechanics of the CMJ.</p>","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"2024 ","pages":"7113900"},"PeriodicalIF":1.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of the Muscle Protein Synthetic Response to Resistance Exercise in Healthy Adults: A Systematic Review and Exploratory Meta-Analysis.","authors":"Robert W Davies, Arthur E Lynch, Uttam Kumar, Philip M Jakeman","doi":"10.1155/2024/3184356","DOIUrl":"10.1155/2024/3184356","url":null,"abstract":"<p><strong>Methods: </strong>Five electronic databases (PubMed (Medline), Web of Science, Embase, Sport Discus, and Cochrane Library) were searched for controlled trials that assessed the MPS response to RE in healthy, adult humans, postabsorptive state. Individual study and random-effects meta-analysis arewere used to inform the effects of RE and covariates on MPS. Results from 79 controlled trials with 237 participants were analysed.</p><p><strong>Results: </strong>Analysis of the pooled effects revealed robust increases in MPS following RE (weighted mean difference (WMD): 0.032% h^-1, 95% CI: [0.024, 0.041] % h^-1, <i>I</i>² = 92%, <i>k</i> = 37, <i>P</i> < 0.001). However, the magnitude of the increase in MPS was lower in older adults (>50 y: WMD: 0.015% h^-1, 95% CI: [0.007, 0.022] % h^-1, <i>I</i>² = 76%, <i>k</i> = 12, <i>P</i> = 0.002) compared to younger adults (<35 y: WMD: 0.041% h^-1, 95% CI: [0.030, 0.052] % h^-1, <i>I</i>² = 88%, <i>k</i> = 25, <i>P</i> < 0.001). Individual studies have reported that the temporal proximity of the RE, muscle group, muscle protein fraction, RE training experience, and the loading parameters of the RE (i.e., intensity, workload, and effort) appeared to affect the MPS response to RE, whereas sex or type of muscle contraction does not.</p><p><strong>Conclusion: </strong>A single bout of RE can sustain measurable increases in postabsorptive MPS soon after RE cessation and up to 48 h post-RE. However, there is substantial heterogeneity in the magnitude and time course of the MPS response between trials, which appears to be influenced by participants' age and/or the loading parameters of the RE itself.</p>","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"2024 ","pages":"3184356"},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in Endurance Exercise: Individualized Regulation and Predictive Value","authors":"Sebastian Hacker, Johannes Keck, Thomas Reichel, Klaus Eder, R. Ringseis, Karsten Krüger, Britta Krüger","doi":"10.1155/2023/6614990","DOIUrl":"https://doi.org/10.1155/2023/6614990","url":null,"abstract":"The high interindividual variability of exercise response complicates the efficient use of blood-based biomarkers in sports. To address this problem, a useful algorithm to characterize the individual regulation and predictive value of different candidate markers will be developed. Forty-nine participants completed two identical exercise trials. Blood samples were collected before, immediately after, 3 hours after, and 24 hours after completion of exercise. Plasma concentrations of interleukin (IL-) 1RA, IL-6, IL-8, IL-10, IL-15, creatine kinase (CK), cortisol, c-reactive protein (CRP), lactate dehydrogenase (LDH), and thiobarbituric acid reactive substances (TBARS) were measured. Individualized regulation was analyzed using k-means clustering and a Group Assignment Quality (GAQ) score. Regression trees with a bootstrapped-aggregated approach were used to assess the predictive qualities of the markers. For most of the markers studied, a distinction can be made between individuals who show a stronger or weaker response to a particular endurance training program. The regulation of IL-6, IL-8, IL-10, and CK exhibited a high degree of stability within the individuals. Regarding the predictive power of the markers, for all dependent variables, the most accurate predictions were obtained for cortisol and IL-8 based on the baseline value. For CK, a good prediction of recovery of maximal strength and subjective feeling of exhaustion can be made. For IL-1RA and TBARS, especially their reregulation can be predicted if the baseline level is known. Focusing individual variations in biomarker responses, our results suggest the combined use of IL-6, IL-8, IL-10, and CK for the personalized management of stress and recovery cycles following endurance exercise.","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"29 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139002803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician Perceptions of Cannabidiol (CBD) and Cannabis in Sports Medicine and Performance","authors":"Brendon Ross, Thomas Trojian, D. Cushman","doi":"10.1155/2023/8824466","DOIUrl":"https://doi.org/10.1155/2023/8824466","url":null,"abstract":"Objectives. There is growing evidence regarding cannabinoid use in sports medicine and performance, especially cannabidiol (CBD). This study aims to determine if sports medicine physicians are recommending cannabinoids for therapeutic purposes, as well as analyze perceptions of cannabinoids within sports medicine and performance. Methods. Physician members of the American Medical Society for Sports Medicine (AMSSM) completed an anonymous survey on demographics, CBD and Cannabis recommendations, as well as attitudes toward cannabinoid products within sports medicine. Factors associated with CBD and cannabis recommendations as well as perceptual differences were found using multivariate regression modelling. Results. Responses from 333 physicians were recorded. The following groups were less likely to agree with allowing cannabis for recreational purposes: female gender (coeff. = 0.79 (0.33–1.25), \u0000 \u0000 p\u0000 =\u0000 0.001\u0000 \u0000 ), increasing age (coeff. = 0.04 (0.02, 0.07), \u0000 \u0000 p\u0000  \u0000 <\u0000  \u0000 0.001\u0000 \u0000 ), and rural respondents (compared to baseline urban, coeff. = 1.16 (0.36, 1.95), \u0000 \u0000 p\u0000 =\u0000 0.004\u0000 \u0000 ). Similarly, these three factors were associated with a higher likelihood of disagreeing with WADA removing cannabis from the prohibited substance list and with the NCAA allowing CBD use by collegiate athletes (\u0000 \u0000 p\u0000 ≤\u0000 0.045\u0000 \u0000 ). CBD was less likely to be recommended by pediatricians, rural physicians, and academic physicians (\u0000 \u0000 p\u0000 ≤\u0000 0.030\u0000 \u0000 ). Male physicians and younger physicians were less likely to identify cannabis as performance-enhancing (\u0000 \u0000 p\u0000 ≤\u0000 0.042\u0000 \u0000 ). Conclusions. Sports medicine physicians have varying views on cannabinoids. While sports medicine physicians generally have favorable attitudes toward CBD and cannabis, these perceptions appear to be significantly affected by age, practice type, and gender.","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138979877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Be Aware of the Benefits of Drafting in Sports and Take Your Advantage: A Meta-Analysis","authors":"Floor A. P. van den Brandt, Mohammed Khudair, Florentina J. Hettinga, Marije T. Elferink-Gemser","doi":"10.1155/2023/3254847","DOIUrl":"https://doi.org/10.1155/2023/3254847","url":null,"abstract":"Purpose. In competitive sports, optimizing performance is the key. An interesting venue to explore is to consider drafting as a pacing strategy. The purpose of this study is to identify the magnitude of drafting benefits for biomechanical, physiological, and psychobiological parameters in and between athletes in cycling, kayaking, running, skating, skiing, and swimming. Design. A systematic review and meta-analysis. Methods. Systematic searches were performed in PubMed, Web of Science, and Embase databases. Results. In total, 205 studies were found, from which 22 were relevant (including 232 participants and 548 observations). Methodological quality was high for all the included articles. The meta-analyses for all parameters indicated strong evidence for a benefit of drafting, with moderate effects between leading and drafting athletes found for the heart rate (3.9%), VO2 (8.9%), power output (11.3%), and rating of perceived exertion (10.4%). Large effect sizes were found for blood lactate (24.2%), VE (16.2%), and EMG (56.4%). A moderator analysis showed differences between sports on the effect of drafting with most benefits in cycling. Discussion. Based on the observed effects of drafting in the biomechanical, physiological, and psychobiological parameters, it can be considered as an element of pacing, a strategy to conserve energy and optimize performance. Conclusion. There is strong evidence that drafting benefits athletes, with varying levels of effect for athletes in different sports. Knowledge about the magnitude of benefits can be used to improve training sessions, race strategies, and performance in competition.","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"220 S712","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Function among Young Women’s Football Players in the Summer Heat","authors":"Soichi Ando, Nana Ogoh, Shotaro Saito, Hironori Watanabe, Maki Ohsuga, Tetsuya Hasegawa, Shigehiko Ogoh","doi":"10.1155/2023/5516439","DOIUrl":"https://doi.org/10.1155/2023/5516439","url":null,"abstract":"Recently, there has been a growing focus on studies related to women’s football. However, the cognitive function of female football players has not been extensively characterized. Thus, we explored how the cognitive function of female football players was altered during a series of matches in summer and examined day-to-day variations in cognitive function with regard to dehydration status. Resting cognitive function was assessed from 17 young women football players during the Japan Club Youth Women’s football tournament, which spanned eight consecutive days. Cognitive function initially improved, with this improvement sustained throughout the tournament. It is worth noting that ten participants experienced symptoms of dehydration at least once during the tournament; however, these symptoms were not found to be linked to impaired cognitive function, suggesting that resting cognitive function remains unaffected during summer matches, even in the presence of dehydration symptoms.","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"4 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135972744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic Response in Ascending Aorta Surgery Patients during Moderate Intensity Resistance Training","authors":"Rikke Gottlieb, Kasper Arnskov, Marius Henriksen, Eva Prescott, Hanne Rasmusen, Christian Have Dall","doi":"10.1155/2023/7616007","DOIUrl":"https://doi.org/10.1155/2023/7616007","url":null,"abstract":"Background. In patients undergoing ascending aortic surgery (AAS), postsurgical physical exercise with a safe and effective exercise prescription is recommended. Resistance training is associated with blood pressure (BP) elevations that may increase the risk of new aortic dissection or rupture. However, the acute hemodynamic response to resistance training for this patient group is unknown. Aim. The aim of this study was to investigate peak systolic BP (SBP) increases in AAS patients during moderate intensity resistance training. Methods. SBP was measured continuously beat-to-beat with a noninvasive method during three sets of leg presses at moderate intensity. A 15-repetition maximum strength test was performed to estimate the maximal amount of resistance a participant could manage 15 times consecutively (equivalent to approximately 60–65% of their maximum strength). Results. The study had 48 participants in total, i.e., 24 cases and 24 controls. Both groups consisted of 10 females (42%) and 14 males (58%). The case group had a mean age of 60.0 (SD ± 11.9) years and a mean of 16.3 months since surgery (minimum 4.4 and maximum 39.6 months). 22 of the 24 cases received antihypertensive medication. The median baseline BP was 119/74 mmHg among cases and 120/73 mmHg among controls. During the first set of leg presses, the median peak SBP was 152 mmHg, in the second set 154 mmHg, and in the third set 165 mmHg. Corresponding values in controls were 170 mmHg, 181 mmHg, and 179 mmHg. The highest peak SBP registered in an AAS patient was 190 mmHg and in any healthy control was 287 mmHg. Conclusion. The findings indicate that AAS patients in control of their BP have the endurance to perform 3 sets of resistance training at moderate intensity as their SBP increases with a maximum of 39% from the baseline compared to the 51% increase in the control group.","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"128 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Injuries during Judo Tournaments.","authors":"Jeroen Mooren, Amber L von Gerhardt, Irene T J Hendriks, Johannes L Tol, Sander Koëter","doi":"10.1155/2023/2713614","DOIUrl":"10.1155/2023/2713614","url":null,"abstract":"<p><strong>Objective: </strong>To determine the injury incidence proportion, distribution of injuries by anatomical location; injury type; injury severity, time loss; mechanism and situations of injuries; and the relative risk of injuries by gender, age, and weight categories during judo tournaments. <i>Study Design</i>. It is a systematic review. <i>Data Sources</i>. A systematic review of the literature was conducted via searches in PubMed, EMBASE, Web of Science, CINAHL, SPORTDiscus, Google Scholar, and PEDro. <i>Eligibility Criteria</i>. All original studies on the incidence of injuries during judo tournaments were included.</p><p><strong>Results: </strong>Twenty-five studies were included out of the 1979 studies. Using the modified AXIS tool score for quality assessment, seven were rated as having good quality, nine were rated as having fair quality, and four were rated as having poor quality. The injury incidence proportion during tournaments ranged from 2.5% to 72.5% for injuries requiring medical evaluation and 1.1% to 4.1% for injuries causing time loss (i.e., inability to continue game participation). The most commonly reported injury location was the head, followed by the hand, knee, elbow, and shoulder. The most frequent types of injury were sprains, followed by contusions, skin lacerations, strains, and fractures. In judo tournaments, injuries were more often sustained during standing fights (tachi-waza) than in ground fights (ne-waza).</p><p><strong>Conclusion: </strong>The tournament injury incidence proportion ranged from 2.5% to 72.5% for injuries requiring medical attention and 1.1% to 4.1% for injuries causing time loss. The head was the most frequently injured body part, and sprain was the most frequent injury type. However, current reports on injuries during judo tournaments are heterogeneous and inconsistent, limiting our understanding of in-match injury risks. Future studies should utilize the guidelines of the International Olympic Committee consensus meeting statement on the methodological approach to injury reporting. We recommend a judo-specific extension of this statement to fit the unique features of judo sports practice.</p>","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"1 1","pages":"2713614"},"PeriodicalIF":0.0,"publicationDate":"2023-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11022761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44076367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a 12-Month Exercise Intervention in Postsurgical Colorectal Cancer Patients.","authors":"Melanie Heitkamp, Bianca Spanier, Pia von Korn, Sebastian Knapp, Claudia Groß, Bernhard Haller, Martin Halle","doi":"10.1155/2023/4488334","DOIUrl":"10.1155/2023/4488334","url":null,"abstract":"<p><strong>Background: </strong>Extensive physical activity (PA; ≥18 MET<i>∗</i>h/week, MET metabolic equivalent of tasks hours) postcancer diagnosis has shown favorable effects on colorectal cancer disease-free survival. However, the feasibility of introducing this high volume of PA in this patient group is unclear. Therefore, the aim of the F-PROTECT study was to evaluate the feasibility of extensive and prolonged PA (≥18 MET<i>∗</i>h/week over 12 months) in colorectal cancer patients with the primary objectives to (1) recruit 50 patients within 12 months and (2) reach an attendance rate of ≥70%.</p><p><strong>Methods: </strong>Single-armed, bicentric, prospective intervention study in colorectal cancer patients (≤80 years; UICC II/III Union for International Cancer Control) after histopathological confirmed <i>R</i>0-resection who were consecutively recruited from visceral surgery units of 10 clinics in Germany. Recruitment rates were calculated using screening logs. Intervention was a 12-month endurance-focused exercise program with supervised and home-based training. Attendance rates defined as ≥70% participation in training sessions were calculated by training diaries.</p><p><strong>Results: </strong>Out of 521 patients who were screened for eligibility, 50 (23 female; 59 ± 10 years, UICC 44% II, 56% III; adjuvant chemotherapy 60%) were recruited within 15 months. Mean duration between surgery and first training was 103 ± 57 days. Training attendance rate was 64% (including 9 dropouts). Six (12%) participants reached ≥18 MET<i>∗</i>h/week in ≥70% of training sessions between 4-12 months. 28 adverse events (<i>n</i> = 9 serious) occurred, however, were not assessed as training related.</p><p><strong>Conclusions: </strong>The present intervention involving a combination of supervised and home-based exercise training in postsurgical colorectal cancer patients was not feasible. Strategies specifically designed for this patient group must be developed and investigated to motivate long-term PA. <i>Registration</i>. The study was prospectively registered at clinicaltrials.gov (NCT01991847).</p>","PeriodicalId":75247,"journal":{"name":"Translational sports medicine","volume":"1 1","pages":"4488334"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11022773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64794738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}