Aktuelle Urologie最新文献

{"title":"„First-in-human“-Studie mit dem Antikörper CC-3 beim Peniskarzinom.","authors":"","doi":"10.1055/a-2703-9949","DOIUrl":"https://doi.org/10.1055/a-2703-9949","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 3","pages":"248-249"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Healthcare Research in Renal Cell Cancer: 7-Year-Data from the VERSUS Study by d-uo].","authors":"Manfred Johannsen, Rolf Eichenauer, Jörg Klier, Frank König, Robert Schönfelder, Jörg Schröder, Elke Hempel, Christian Doehn","doi":"10.1055/a-2787-4541","DOIUrl":"10.1055/a-2787-4541","url":null,"abstract":"<p><strong>Introduction: </strong>Renal cell carcinoma (RCC) accounts for approximately 13.5% of all urological tumors. Healthcare research analyses whether treatment concepts developed in controlled clinical trials and recommended in clinical guidelines are implemented in routine care. This article presents healthcare research data on RCC based on current results from the prospective VERSUS study (VERSorgUngsStudie) by d-uo (\"Deutsche Uro-Onkologen\", German Uro-Oncologists).</p><p><strong>Material and methods: </strong>The VERSUS study is a non-interventional, prospective, multicentric study designed to document and descriptively analyze diagnosis, treatment and aftercare of uro-oncological patients.</p><p><strong>Results: </strong>Out of 31.419 patients currently enrolled in the VERSUS study, 2.526 were diagnosed with RCC. The diagnosis was symptom-driven in 22.7% of cases and detected through screening in 38.1%. Among symptomatic patients, men presented with UICC stage III or IV disease in 38.3% of cases, compared with only 24.8% among women. Tumor stages were distributed as follows: T1a in 35.6%, T1b in 21.5%, T2 in 7.2%, T3 in 11.1%, T4 N0 M0 in 0.2%, T1-4 N1-3 in 1.0%, and T1-4 M1 in 3.6%. The nephrectomy rate in stage T1 was 25.9%. Systemic therapy was administered in 97 evaluable cases (13.1%), with 45.2% receiving adjuvant treatment and 46.4% receiving treatment in the presence of metastatic disease.</p><p><strong>Conclusion: </strong>Despite providing current and clinically relevant results, the VERSUS study is limited by the restricted depth of available data since it relies on the same dataset as the German cancer registry. To enable a more comprehensive healthcare research, organ-specific cancer registries such as the Urothelial Cancer National Registry (UroNAT) and the Prostate Cancer National Registry (ProNAT) by d-uo are required. These national cancer registries maintained by d-uo are unique in that they comprise all tumor stages. The Renal Cancer National Registry (ReNAT) by d-uo is in preparation and will be a valuable contribution to quality assurance of oncological care in Germany.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":"270-274"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zwischen Leitlinie und Lebenswirklichkeit: Registerdaten zur uroonkologischen Versorgung in Deutschland von d-uo.","authors":"Jörg Klier","doi":"10.1055/a-2703-9976","DOIUrl":"https://doi.org/10.1055/a-2703-9976","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 3","pages":"225-226"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current Data from the National Registry for Prostate Cancer (ProNAT) by d-uo].","authors":"Frank König, Manfred Johannsen, Jörg Klier, Rolf Eichenauer, Robert Schönfelder, Jörg Schröder, Elke Hempel, Christian Doehn","doi":"10.1055/a-2794-3373","DOIUrl":"10.1055/a-2794-3373","url":null,"abstract":"<p><strong>Introduction: </strong>The National Prostate Cancer Registry (ProNAT) of the German Uro-Oncologists (d-uo) was launched in 2022 to provide a real-world, cross-sector overview of prostate cancer management in Germany. Building on the VERSUS study, ProNAT collects detailed longitudinal data on quality of care, guideline adherence, and therapeutic strategies.</p><p><strong>Material and methods: </strong>ProNAT is a non-interventional, prospective, multicenter registry (DRKS00030737, ethics approval Berlin 2018). Patients with histologically confirmed prostate cancer from 55 urology centers are included. Collected data comprise demographics, clinical parameters, tumor stage, treatment modality, comorbidities, and psycho-oncological support.</p><p><strong>Results: </strong>As of August 2025, 3,417 patients were enrolled (analyzable n = 3,052; median age 69 years). Most patients (91.1%) had ECOG 0-1. Common comorbidities included arterial hypertension (30.6%), diabetes mellitus (8.2%), and cardiovascular disease (9.1%). Metastatic disease at diagnosis was present in 6.7%, while 77.6% had T1-T2 tumors. Multiparametric MRI prior to biopsy was performed in 36.6%. Curative surgery was robot-assisted in 87.7 of cases. Among Gleason 3 + 3 cases, 35.1% underwent active surveillance and 37.8% underwent surgery. Psycho-oncological support was documented in only 18.2%.</p><p><strong>Conclusion: </strong>ProNAT provides the first comprehensive real-world dataset on outpatient prostate cancer care in Germany. Findings demonstrate progress in diagnostic guideline adherence but highlight under-utilization of psycho-oncological services and multidisciplinary planning. With continued patient enrollment, ProNAT will enable more detailed analyses of treatment sequences and care quality.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":"260-265"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oligometastasiertes Prostatakarzinom: Systemische Therapie mit oder ohne Operation.","authors":"","doi":"10.1055/a-2812-7439","DOIUrl":"https://doi.org/10.1055/a-2812-7439","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 3","pages":"234"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kommentar.","authors":"","doi":"10.1055/a-2715-5166","DOIUrl":"https://doi.org/10.1055/a-2715-5166","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 2","pages":"147-148"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cryoablation for Renal Cell Carcinoma: Update on an Established Ablative Technique].","authors":"Timo Alexander Auer, Willie Magnus Lüdemann, Bernhard Ralla, Bernhard Gebauer, Federico Collettini","doi":"10.1055/a-2821-4268","DOIUrl":"10.1055/a-2821-4268","url":null,"abstract":"<p><p>In recent years, cryoablation has emerged as a minimally invasive, nephron-sparing treatment option for localized renal cell carcinoma. While partial nephrectomy remains the reference standard, percutaneous image-guided cryoablation represents an appealing alternative for elderly and/or morbid patients, providing short recovery times and aiming to preserve renal function to the greatest extent possible.Technically, the procedure relies on cryoprobes (argon/liquid nitrogen) and employes two freeze-thaw cycles. A key advantage is the excellent visualization of the developing \"ice ball\" on CT or MRI, which allows for real-time assessment of the ablation zone. A pre-procedural percutaneous tumor biopsy is recommended to confirm histology and grade of malignancy.The available evidence is largely based on retrospective cohort and registry data. There is a lack of randomized long-term comparative studies. Overall, high rates of oncologic control have been reported, but there is a tendency towards a higher risk of local recurrence compared with partial nephrectomy, particularly in larger lesions. Standardized follow-up protocols and prospective data are essential to better define indications, refine combination techniques, and assess long-term outcomes.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":"191-196"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kommentar.","authors":"","doi":"10.1055/a-2702-8111","DOIUrl":"https://doi.org/10.1055/a-2702-8111","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 2","pages":"140-142"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verzicht auf Ureterstents nach radikaler Zystektomie ist sicher und machbar.","authors":"","doi":"10.1055/a-2642-4343","DOIUrl":"https://doi.org/10.1055/a-2642-4343","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 2","pages":"142-144"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostatakarzinom: Hochintensiver fokussierter Ultraschall versus Prostatektomie.","authors":"","doi":"10.1055/a-2642-5573","DOIUrl":"https://doi.org/10.1055/a-2642-5573","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 2","pages":"146-147"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}