Aktuelle UrologiePub Date : 2025-04-01Epub Date: 2025-01-28DOI: 10.1055/a-2510-9757
Marie Christine Roesch, Lea Sophie Lütje, Nils Gilbert, Axel Stuart Merseburger, Daniar Osmonov
{"title":"[Gender-/Sex-Specific Differences in Clinical Trials in Uro-Oncology].","authors":"Marie Christine Roesch, Lea Sophie Lütje, Nils Gilbert, Axel Stuart Merseburger, Daniar Osmonov","doi":"10.1055/a-2510-9757","DOIUrl":"10.1055/a-2510-9757","url":null,"abstract":"<p><p>Subgroup analyses in clinical trials sometimes reveal gender-/sex-dependent differences in cancer outcomes. However, drug approvals are rarely restricted to a specific sex or gender, and recommendations regarding dosage are rarely tailored accordingly. Furthermore, discrepancies exist between the gender-/sex-dependent enrollment rates in clinical trials and real-world incidence or mortality rates. This article highlights gender-/sex differences in clinical trials in uro-oncology.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":"131-134"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aktuelle UrologiePub Date : 2025-04-01Epub Date: 2025-04-03DOI: 10.1055/a-2467-7721
Shahrokh F Shariat, Robert J Schulz
{"title":"Die Zukunft der geschlechtsspezifischen Urologie – Wissenschaftliche Evidenz, Medizin und Gesellschaft.","authors":"Shahrokh F Shariat, Robert J Schulz","doi":"10.1055/a-2467-7721","DOIUrl":"https://doi.org/10.1055/a-2467-7721","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"56 2","pages":"105-106"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aktuelle UrologiePub Date : 2025-04-01Epub Date: 2025-04-03DOI: 10.1055/a-2552-1170
Julia Weiss, Ekaterina Laukhtina, Irene Resch, Shahrokh F Shariat
{"title":"[Gender-specific differences in urological tumours].","authors":"Julia Weiss, Ekaterina Laukhtina, Irene Resch, Shahrokh F Shariat","doi":"10.1055/a-2552-1170","DOIUrl":"https://doi.org/10.1055/a-2552-1170","url":null,"abstract":"<p><p>Gender differences in medicine are playing an increasingly important role in diagnostic testing as well as therapy choices. Risk factors and mortality vary depending on gender. Diseases often manifest differently depending on gender. In diagnostic testing, gender-specific aspects need to be taken into consideration. For instance, bladder cancer diagnosis is often delayed in women compared to men as haematuria is frequently attributed to benign conditions like urinary tract infections. In therapy, decisive gender disparities should also be considered. To state an example, immune-checkpoint inhibitors have shown better response in men than in women when treating renal cell carcinoma. Furthermore, outcomes after treatment for urological tumours differ depending on gender.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"56 2","pages":"158-163"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aktuelle UrologiePub Date : 2025-04-01Epub Date: 2025-04-03DOI: 10.1055/a-2467-7694
{"title":"Adjuvante Therapie des Hochrisiko-Urothelkarzinom von Blase oder oberem Harntrakt nach radikaler Resektion.","authors":"","doi":"10.1055/a-2467-7694","DOIUrl":"https://doi.org/10.1055/a-2467-7694","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"56 2","pages":"128-129"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aktuelle UrologiePub Date : 2025-04-01Epub Date: 2024-09-11DOI: 10.1055/a-2383-0663
Silvia Clauser, Margherita Palermo, Salvatore Palermo, Evi Comploj, Esther Hanspeter, Christine Mian, Emanuela Trenti, Sara Krüger, Philipp Krause, Giovanni Mazzucato, Armin Pycha
{"title":"[An extremely rare case of multiple recurrences of urothelial carcinoma in an ileal neobladder: a case report and review of the literature].","authors":"Silvia Clauser, Margherita Palermo, Salvatore Palermo, Evi Comploj, Esther Hanspeter, Christine Mian, Emanuela Trenti, Sara Krüger, Philipp Krause, Giovanni Mazzucato, Armin Pycha","doi":"10.1055/a-2383-0663","DOIUrl":"10.1055/a-2383-0663","url":null,"abstract":"<p><p>In up to 18% of patients, recurrence is observed after curative radical cystectomy. Tumour recurrence occurs in most cases in the locoregional lymph node, as well as in the remaining urinary tract, but very rarely in the orthotopic neobladder. We report a case of multiple recurrence of urothelial carcinoma solely in the orthotopic neobladder of a male patient, 10 years after surgery, without involvement of the urethra or upper urinary tract. Therefore, the patient underwent resection of the neobladder with conversion to a sigmoid conduit. Nevertheless approximately 6 months later the patient developed widespread metastases and died a few months later. Currently, no guidelines are available for the treatment of these rare cases. We present our experience, together with revision of the current literature on this issue.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":"164-169"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aktuelle UrologiePub Date : 2025-04-01Epub Date: 2025-04-03DOI: 10.1055/a-2438-3848
{"title":"Ersatz von Ciprofoxacin führt zu Anstieg von Infektionen nach Prostatabiopsie.","authors":"","doi":"10.1055/a-2438-3848","DOIUrl":"https://doi.org/10.1055/a-2438-3848","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"56 2","pages":"116"},"PeriodicalIF":0.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}