AIDS Research and Therapy最新文献

{"title":"Human immunodeficiency virus-related renal cell carcinoma: a 13.5-year experience.","authors":"Mengmeng Zhang, Zhiqiang Zhu, Yu Zhang, Xiaopeng Hu","doi":"10.1186/s12981-025-00699-8","DOIUrl":"10.1186/s12981-025-00699-8","url":null,"abstract":"<p><strong>Background: </strong>Few reports have focused on renal cell carcinoma (RCC) in the people with HIV(PWH).</p><p><strong>Methods: </strong>We analyzed patients diagnosed with RCC at our center between January 2011 and June 2024, divided into groups based on their HIV status. Categorical variables were compared using the chi-square test, and continuous variables were analyzed with the t-test. We estimated median and 1-, 3-, and 5-year cancer-specific survival (CSS) using Kaplan-Meier curves and conducted univariate and multivariate Cox analyses to evaluate variables associated with CSS.</p><p><strong>Results: </strong>In total, 144 RCC patients were assigned to either PWH group (n = 48) or PWoH (people without HIV) group (n = 96). Patients in the PWH group were significantly more likely to be male (91.7% vs. 71.8%, p = 0.014), and their median age was 7 years younger than that in the PWoH group (51 vs. 58 years, p < 0.01). Both groups had small-diameter, early-stage, low-grade tumors, with no significant differences in short-term outcomes. Higher tumor stage (> T1 vs. T1: hazard ratio = 8.621, 95% confidence interval = 3.76-20, p < 0.01) and larger tumor diameter (≥ 7 vs. <7 cm: hazard ratio = 3.525, 95% confidence interval = 1.697-7.321, p < 0.01) were significantly associated with CSS, whereas the HIV status did not significantly affect long-term survival.</p><p><strong>Conclusions: </strong>RCC tends to be diagnosed at a younger age in PWH, highlighting the need for earlier RCC screening in this population. The HIV status does not affect postoperative recovery, short-term outcomes, or long-term survival in patients with RCC.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"16"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making.","authors":"Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu","doi":"10.1186/s12981-025-00712-0","DOIUrl":"10.1186/s12981-025-00712-0","url":null,"abstract":"<p><strong>Introduction: </strong>Data about impact of switch to dolutegravir (DTG)-based antiretroviral therapy (ART) on estimated glomerular filtration rate (eGFR) in Asians are scarce. RV254/SEARCH010 is a prospective observational cohort in Bangkok, Thailand with ART initiation during acute HIV infection (AHI) where participants switched to DTG-based ART.</p><p><strong>Methods: </strong>Participants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61-145). GFR was estimated by serum creatinine (eGFR_cre) every 24 weeks before and after switch. Estimated GFR by cystatin C (eGFR_cystC) was ordered at clinician's discretion for decreased eGFR_cre after switch. Random-effect linear regression model was used to assess changes in eGFR_cre over 96 weeks from starting ART, and from switching to DTG.</p><p><strong>Results: </strong>At study entry, 20 participants (9.3%) had eGFR_cre < 90 ml/min/1.73 m². During EFV-based ART, an additional 17 (8%) developed eGFR_cre < 90 ml/min/1.73 m², nearly all transient, while mean eGFR_cre remained stable and within normal range. At switch to DTG, 21 (9.8%) had eGFR_cre < 90 ml/min/1.73 m² but an additional 116 (54%) developed eGFR_cre < 90 ml/min/1.73 m² during follow-up with eGFR_cre decrease being mostly persistent. Mean eGFR_cre decreased 20.8% from 117.0 to 92.4 ml/min/1.73 m² (p < 0.001). Among 20 post-switch participants with eGFR_cystC measured within 4 weeks of eGFR_cre < 90 mL/min/1.73 m², 13 (65%) had normal kidney function by eGFR_cystC.</p><p><strong>Conclusions: </strong>Persistent eGFR_cre decrease to < 90 ml/min/1.73 m² after switch to DTG was common in this Thai population. eGFR_cystC was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART modifications. Trial registration Clinical Trials Registry Number: ClininicalTrials.gov NCT00796146.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"15"},"PeriodicalIF":2.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of HIV testing-seeking behaviors among women of reproductive age in Tanzania: analysis of the 2022 Demographic and health survey.","authors":"Jackson Micheal Asingwire, Isaac Isiko, Kuli Faith Rombe, Aaron Mwesigwa, Emmanuel Asher Ikwara, Haron Olot, Lenz Nwachinemere Okoro, Manankong Jane Precious Izunwanne, Blessing Onyinyechi Agunwa, Abdul Aziiz Bwana, William Yiga Kalemba, Ebuka Louis Anyamene","doi":"10.1186/s12981-025-00710-2","DOIUrl":"10.1186/s12981-025-00710-2","url":null,"abstract":"<p><strong>Aim: </strong>HIV remains one of the major epidemics and public health concerns within low and middle-income countries such as Tanzania. This study aimed to assess the prevalence and the factors associated with HIV testing-seeking behaviors among women of childbearing age in Tanzania.</p><p><strong>Methods: </strong>This study used the 2022 Tanzania Demographic and Health Survey dataset. The study utilized individual recodes (IR) files where data was collected using the Women's Questionnaire to analyze factors influencing HIV testing behavior among women, Descriptive analysis, and bivariate and multivariate logistic regressions were performed and all the data were processed and analyzed using STATA version 17 at 95% CI and significance level P < 0.05.</p><p><strong>Results: </strong>This study included 2531 women with 90.0% having ever tested for HIV while 7.0% had never tested for HIV. Not employed [AOR:0.35, CI (0.20-0.61)] has lower odds of HIV testing than All-year employed status. Rural residents have reduced odds of HIV testing [AOR:0.43, CI (0.21-0.88)] compared to women living in urban areas. Those able to ask their partner to use a condom are more likely to have been tested with increased odds [AOR: 3.52, CI (2.31-5.37)]. Participants with a history of genital discharge [AOR:4.30, CI (1.28-14.46)] and those who don't know their genital discharge history have [AOR: 0.20, CI (0.07-0.55)] are significant for HIV testing. Women who have heard about PrEP but are not uncertain about its approval [AOR: 36.07, CI (3.33-390.25)], respondents who have tested before with HIV testing kits [AOR:35.99, CI (4.00-324.13)] and women who are aware of HIV testing kids but never tested with them before [AOR: 2.80, CI (1.19-6.58)] are predictors of HIV testing seeking behaviors.</p><p><strong>Conclusion: </strong>The government and other concerned agencies should introduce mobile or community-based testing units and subsidize testing costs to reach economically disadvantaged or rural populations. Promote Open Communication on Sexual Health: Public health campaigns should encourage open discussions about sexual health within relationships, emphasizing condom negotiation and mutual health checks as preventive measures. Raise Awareness and Accessibility of HIV Prevention Tools: Expand education on PrEP and HIV self-test kits to improve familiarity and acceptance, which may empower individuals to proactively seek testing. Integrate Sexual Health Screening into Routine Healthcare: Health facilities should incorporate HIV testing when individuals present with symptoms like genital discharge to improve early detection and intervention.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"14"},"PeriodicalIF":2.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between health literacy and COVID-19 prevention behaviors among people living with HIV.","authors":"Iman Navidi, Raheleh Soltani","doi":"10.1186/s12981-025-00704-0","DOIUrl":"10.1186/s12981-025-00704-0","url":null,"abstract":"<p><strong>Background: </strong>Health literacy (HL)has been identified as one of the important determinants of healthy behaviors and the health of individuals and communities. The global attempts to control the HIV disease were emphasized, in the midst the new coronavirus disease (COVID-19) emerged as a pandemic. This study aimed to determine HL level and its relationship with COVID-19-prevention behaviors among people living with HIV(PLWH).</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 112 PLWH referred to behavioral disorders consulting center in Arak, Iran from May to December 2022. The data collection tool was a questionnaire including COVID-19 prevention behaviors (5 items) and a health literacy instrument (14 items). The data were analyzed using SPSS software version 18 and for all tests, the significance level of α was considered as 0.05.</p><p><strong>Results: </strong>The average (SD)age of the participants was 42.9 (10.6) and the education level of 11.6% of the participants were university. The mean score of HL was 3.5 (0.73) out of 5 and 36.6% of them had higher HL. The mean of behaviors was 17.2 (3.4) out of 25 and 53.6 had higher behaviors. The HL had a significant relationship with behaviors (r = 0.48; p < 0.001). Multiple linear regression indicated that HL had a significant association with age (P = 0.002), education (P = 0.046), and economic status (p < 0.001) and explained 32% of the variance of HL.</p><p><strong>Conclusion: </strong>According to the findings, HL affected COVID-19-prevention behaviors. Effective educational interventions intended for PLWH based on health literacy can be useful to this extent.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"12"},"PeriodicalIF":2.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV, smoking, and the brain: a convergence of neurotoxicities.","authors":"Benjamin L Orlinick, Shelli F Farhadian","doi":"10.1186/s12981-025-00714-y","DOIUrl":"10.1186/s12981-025-00714-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to characterize the combined effects of tobacco smoking and human immunodeficiency virus (HIV) infection in people with HIV (PWH) and identify possible therapeutic targets through shared mechanisms for neurotoxicity.</p><p><strong>Recent findings: </strong>HIV and tobacco smoke can exert neurotoxicity through shared mechanisms such as brain volume changes, microglial dysregulation, and dysregulation of the cholinergic anti-inflammatory pathway (CAP) through the alpha7-nicotinic acetylcholine receptor (nAChR). Evidence also suggests the potential for synergistic effects of HIV and tobacco smoking on neurotoxicity. People with HIV (PWH) are disproportionately affected by both neurocognitive impairment (NCI) and tobacco smoking compared to the general population. Both HIV and tobacco smoking are known to have neurotoxic effects and have the potential for clinically significant impacts on brain health and cognitive functioning. Less, however, is known about how PWH may be uniquely affected by the interactive neurotoxic effects of both HIV and tobacco smoking. Evidence suggests that smoking and HIV can have synergistic effects on neurotoxicity and NCI in PWH. Some mechanisms for neurotoxicity include increased oxidative stress from microglial activation and dysfunction in the alpha7- nAChR cholinergic anti-inflammatory pathway leading to increased neuroinflammation and neuronal apoptosis. Mechanisms may vary by cell type and brain region, however, and there is a need for more human-facing, longitudinal studies on smoking in PWH.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"13"},"PeriodicalIF":2.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalization outcomes in people living with HIV on Dolutegravir-based regimen in Mwanza, Tanzania: a comparative cohort.","authors":"Godfrey A Kisigo, Eric Barongo, Benson Issarow, Cody Cichowitz, Bahati Wajanga, Samuel Kalluvya, Robert N Peck","doi":"10.1186/s12981-025-00706-y","DOIUrl":"10.1186/s12981-025-00706-y","url":null,"abstract":"<p><strong>Introduction: </strong>Hospitalized people living with HIV (PLWH) experienced extremely high mortality rates in the first year after an index hospitalization in the pre-Dolutegravir (DTG) era. We conducted a multi-center study in Mwanza, Tanzania to (1) describe causes of hospitalization for PLWH on DTG; (2) determine in-hospital and 3-month post-hospital mortality; (3) examine factors associated with overall mortality; and (4) determine changes in trends and predictors of mortality pre- and post-DTG era.</p><p><strong>Methods: </strong>Between August 2020 and February 2021, hospitalized PLWH on dolutegravir-based antiretroviral therapy were enrolled and followed for three months after hospitalization. The primary outcome was mortality within 3-months of hospitalization. Cox regression analysis was used to calculate hazard ratios to identify predictors of mortality.</p><p><strong>Results: </strong>Of the 154 enrolled patients, the median [interquartile range] age was 42 [33-50] years and 57% were female. Suspected immune reconstitution inflammatory syndrome (IRIS) and antiretroviral therapy (ART) non-adherence leading to an HIV-associated admission were common. The overall all-cause mortality was 42%. Male sex, using DTG-based regimen for < 3 months, diagnosis of suspected IRIS, diagnosis of ART side effect, advanced WHO clinical stage, CD4 count < 200 cells/mm³, hemoglobin level 7-11.9 gm/dl and hemoglobin level < 7 gm/dl were all independent risk factors for death.</p><p><strong>Conclusion: </strong>In conclusion, the mortality rate of hospitalized PLWH in Africa remains high in the DTG era. Clinical trials are urgently needed to test novel interventions for improving survival in this high-risk group. In the meantime, hospital clinicians should be aware of the very high mortality among PLWH with IRIS and those with ART side effect to ensure that all possible diagnostic and therapeutic options are explored.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"11"},"PeriodicalIF":2.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Receipt of long-acting injectable antiretroviral therapy among people with HIV in Southern US states: an assessment using electronic health records and claims data.","authors":"Yiyang Liu, Rebecca J Fisk-Hoffman, Maitri Patel, Robert L Cook, Mattia Prosperi","doi":"10.1186/s12981-024-00690-9","DOIUrl":"10.1186/s12981-024-00690-9","url":null,"abstract":"<p><strong>Background: </strong>In January 2021, the United States (US) Food and Drug Administration (FDA) approved the first long-acting injectable antiretroviral therapy (LAI ART) regimen for the treatment of HIV providing an alternative to daily oral regimens. We analyzed electronic health records (EHRs) to provide real-world evidence of demographic and clinical characteristics associated with the receipt of LAI ART among people with HIV (PWH).</p><p><strong>Methods: </strong>Leveraging EHRs from a large clinical research network in the Southern US - OneFlorida + linked with Medicaid (updated to 08/2022) - we identified a cohort of PWH who have been prescribed at least one dose of LAI ART since January 2021 and characterized their demographics, clinical characteristics, and HIV care outcomes.</p><p><strong>Results: </strong>A total of 233 LAI ART recipients were identified: 56.7% female, 45.1% aged 30 to 44, 51.3% non-Hispanic Black, 78.1% on Medicaid and 4.7% on private insurance. Approximately three-quarters of injections (71.2%) were received within 37 days of the previous dose, and 84.4% were received within 67 days. About 8% of LAI ART recipients did not have optimal care engagement the year before LAI ART initiation; one in five recipients had a diagnosis of alcohol or substance use disorder in lifetime. All achieved viral suppression (< 50 copies/mL) before starting LAI ART. Of a subset of patients with HIV viral load test records, only 1 record of virologic failure (viral load > 200 copies/ml) was observed after the initiation of LAI ART.</p><p><strong>Discussion: </strong>There has been an increasing trend of LAI ART initiation since approval. People with suboptimal care engagement and with substance use disorder in lifetime were not excluded from LAI ART treatment.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"9"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scaling up access to antiretroviral treatment for HIV: lessons from a key populations program in Nigeria.","authors":"Abdulsamad Salihu, Ibrahim Jahun, David Olusegun Oyedeji, Wole Fajemisin, Omokhudu Idogho, Samira Shehu, Aminu Yakubu, Jennifer Anyanti","doi":"10.1186/s12981-025-00711-1","DOIUrl":"10.1186/s12981-025-00711-1","url":null,"abstract":"<p><p>Over the years, Nigeria has recorded significant progress in controlling the HIV epidemic in the country. HIV prevalence has reduced from 4.1% in 2010 to 1.4 in 2019. The number of people acquiring new HIV infections decreased from 120,000 in 2010 to 74,000 in 2021, and HIV-related deaths decreased from 82,000 in 2010 to 51,000 in 2021. However, the country still faces challenges such as high HIV transmission among key populations (KP) who account for 11% of new HIV infections. Over the years, the government and development partners involved in HIV response efforts in Nigeria have been establishing and scaling up access to services to help address the needs of KPs. Initially, services for KPs as with the general population in Nigeria were largely preventive. Treatment of PLHIV in Nigeria commenced in 2002 and has increased from about 15,000 to more than 1.78 million PLHIVs in 2023. Despite this progress in treatment coverage, however, KPs are not equitably covered. To address this gap, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) launched an ambitious initiative-the Key Population Investment Fund (KPIF)-to target the unaddressed HIV-related needs of key populations (KPs) who are disproportionately affected by HIV. The KPIF initiative was implemented through partner organizations such as the Society for Family Health (SFH), a KP-friendly and indigenous non-governmental organization. Earlier, the program implemented by SFH was largely an HIV prevention program. SFH's transformation, transition, and growth to a comprehensive HIV prevention, care, and treatment service provider was necessary to bridge the gap in the needed expansion of HIV services to adequately meet the care needs of KPs and scale up programs. Therefore, this paper's aim is to share experiences in the transformation of SFH into a comprehensive HIV prevention, treatment, and care service provider in the hope that it may serve as a lesson for organizations with similar objectives.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"10"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique.","authors":"Anna Maria Doro Altan, Noorjehan Majid, Stefano Orlando, Elton Uamusse, Marcia Rafael, Zita Sidumo, Giovanni Guidotti, Fausto Ciccacci","doi":"10.1186/s12981-025-00708-w","DOIUrl":"10.1186/s12981-025-00708-w","url":null,"abstract":"<p><p>The global HIV epidemic remains a major public health challenge, with DTG playing a key role in ART regimens due to its efficacy and tolerability. This study evaluated virological outcomes and resistance mutations in patients on DTG in Mozambique through a retrospective cohort study in seven DREAM centers. Data from 29,601 patients (98.1% on DTG) revealed a virological suppression rate of 95% (27,622/29,051). Factors positively associated with suppression included age > 50, longer ART duration, and being female. Of 17 resistance tests, 8 showed major mutations, including G118R and E138K. Results highlight DTG's effectiveness and the need for resistance surveillance.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"8"},"PeriodicalIF":2.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low dietary diversity and associated factors among adult people with HIV patients attending ART clinics of Ethiopia. Systematic review and meta-analysis.","authors":"Bitew Tefera Zewudie, Yihenew Sewale","doi":"10.1186/s12981-025-00702-2","DOIUrl":"10.1186/s12981-025-00702-2","url":null,"abstract":"<p><strong>Introduction: </strong>Dietary diversity is the utilization of food and food groups consumed by individuals over 24 h, which is an indicator of a diet's micronutrient adequacy. Dietary management in people with HIV patients is the key to sustaining their day-to-day activities and contributing to their lively hood. The level of dietary diversity among HIV-positive patients in Ethiopia shows considerable variation, ranging from 29 to 71.3%. This study aimed to assess the pooled prevalence of low dietary diversity and associated factors among HIV-positive patients attending ART clinics in Ethiopia.</p><p><strong>Method: </strong>Multiple international database searching methods (articles found in PubMed/MEDLINE, Google scholar Africa, Hinari journal online, Embase, Scopus) and Ethiopian university repository online have been covered in this systemic review and meta-analysis. Data were extracted using Microsoft excel and analyzed by using the Stata version 14 software program. The heterogeneity between studies and publication bias was detected by using the I² test and a funnel plot test respectively.</p><p><strong>Results: </strong>The pooled prevalence of low dietary diversity among People with HIV patients on antiretroviral therapy in Ethiopia was 55.9% 95% CI (45.73, 66.09) based on the random effect analysis. This systemic review and meta-analysis showed that only HIV positive patients with an antiretroviral therapy duration of less than one year (AOR = 2.3, 95% CI 1.3, 4.1), and having low wealth quintile (AOR = 2.5, 95% CI 1.5, 4.4) were factors significantly associated with low dietary diversity among People with HIV patients on ant-retroviral therapy clinics of Ethiopia.</p><p><strong>Conclusion and recommendation: </strong>The overall pooled prevalence of low dietary diversity among People with HIV patients attending antiretroviral therapy clinics in Ethiopia was high. We strongly recommend holistic nutritional interventions to address nutritional problems and promote the overall health status of HIV-positive patients in Ethiopia.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"7"},"PeriodicalIF":2.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11765892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}