AIDS Research and Therapy最新文献

{"title":"Rapid identification of antigen-specific monoclonal antibodies from HIV-1 elite controllers using the Beacon platform.","authors":"Xiangyu Zhang, Xinyuan Zheng, Rishen Liang, Lina Huang, Yu Shi, Zhi Zhang, Chengrui Yin, Chengchao Ding, Jiabing Wu, Jianjun Wu, Yong Gao","doi":"10.1186/s12981-026-00863-8","DOIUrl":"10.1186/s12981-026-00863-8","url":null,"abstract":"<p><p>Elite controllers (ECs) are rare human immunodeficiency virus (HIV)-infected individuals who manage viral replication without antiretroviral therapy. While their cellular immunity is well characterized, humoral responses remain limited, which provides an uncommon window into antibody responses to HIV-1. Using single-cell functional screening, this study aimed to isolate and characterize HIV-1 envelope (Env)-specific monoclonal antibodies (mAbs) from ECs. The Beacon platform was used for enrichment, activation, and screening of cluster of differentiation 27⁺ (CD27⁺) memory B cells. Among ~ 12,000 single B cells, 40 Env-specific IgG-secreting cells were identified. Although 18 mAbs were recovered, six showed high-affinity binding to multiple Env trimers (average EC50 < 100 ng/mL). Notably, one mAb (#2) demonstrated broad reactivity, neutralizing 15 of the 17 pseudoviruses, albeit with limited potency (geometric mean IC50 of 46.53 μg/mL). Sequence analysis revealed predominant usage of IGHV1-69 and varied somatic hypermutation levels. However, the high binding affinity could not consistently predict neutralization potency. This study demonstrated the utility of integrated single-cell screening for rapid discovery of antibodies from rare donors. This study also highlights the need for functional assessment in HIV-1 antibody development and identification of mAb candidates for potential therapeutic applications.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond protection: navigating biomedical HIV prevention and risk compensation in MSM, 2018-2024.","authors":"Junfeng Zhang, Zhan Lin, Jing Yang, Qingcui Wu, Jingran Dong, Xiaoyan Zhang, Nahom Kiros Gebregziabher, Jie Yang, Jianyun Bai, Changping Li, Maohe Yu, Zhuang Cui","doi":"10.1186/s12981-026-00864-7","DOIUrl":"10.1186/s12981-026-00864-7","url":null,"abstract":"<p><strong>Background: </strong>Men who have sex with men (MSM) face a disproportionately high HIV risk globally. Biomedical prevention strategies, including pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP), reduce HIV transmission, but their combined impact on sexual risk behaviors remains uncertain, raising concerns about risk compensation.</p><p><strong>Methods: </strong>From 2018 to 2024, MSM in Tianjin, China were recruited through snowball sampling and followed within a longitudinal cohort linked to routine HIV testing services. HIV testing frequency and HIV incidence were analyzed using Poisson regression and Cox proportional hazards models, respectively. Unprotected anal intercourse (UAI) risk scores were constructed from sexual behavior indicators. Mixed-effects models and trajectory modeling assessed the associations between biomedical intervention use and UAI risk.</p><p><strong>Results: </strong>Among 8790 repeat-testing MSM, 1858 (21.14%) used biomedical interventions. Intervention users had lower HIV incidence (0.40 vs. 0.62 per 100 person-years; HR = 0.53, 95% CI 0.35-0.80), more frequent testing (IRR = 1.30, 95% CI 1.27-1.33), higher risk scores (β = 0.191, 95% CI 0.162-0.219), more anal intercourse, and lower condom use at last sex and consistently. Trajectory analysis indicated users were more likely in high-risk group. Risk compensation effects tended to be greater among older MSM and those living in suburban areas.</p><p><strong>Conclusion: </strong>Biomedical interventions are associated with increased HIV testing and reduced incidence but may elevate UAI risk, especially in older and suburban MSM. Integrating behavioral support into biomedical prevention is essential to mitigate risk compensation and address the prevention paradox in key subgroups.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stigma, depression, and poor expectations regarding aging among older adults with HIV in Brazil.","authors":"Marília Bordignon Antonio, Thiago S Torres, Paula M Luz, Beatriz Grinsztejn, Sandra W Cardoso, Roberta S Nogueira, Lucas R Ramos, José Valdez R Madruga, Carlos Brites, Estela Luz, Tamara Cordeiro, Márlon J R Aliberti, Esper G Kallás, Jessica L Castilho","doi":"10.1186/s12981-026-00867-4","DOIUrl":"10.1186/s12981-026-00867-4","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disclosure of HIV status and its association with quality of life and depressive symptoms among children with HIV in North-Eastern Tanzania.","authors":"Veneranda M Bwana, Nahya S Masoud, Karim P Manji, Innocent S Yusufu, Pendael Z Machafuko, Claudia Hawkins, Bethann Conover, Erasto V Mbugi, Lisa R Hirschhorn, Matthew T Caputo, Craig Garfield, Sylvia F Kaaya","doi":"10.1186/s12981-026-00866-5","DOIUrl":"10.1186/s12981-026-00866-5","url":null,"abstract":"<p><strong>Background: </strong>Disclosing HIV status to children with HIV (CWHIV) is associated with improved antiretroviral therapy (ART) adherence, quality of life, and psychosocial well-being in many sub-Saharan Africa. However, little is known about this in Tanzania. We determine the prevalence of HIV status disclosure and its association with health-related quality of life (HRQOL) and depressive symptoms in CWHIV in the Tanga Region, Tanzania.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 11 public HIV clinics among caregiver-CWHIV pairs in 2023. Data were collected on socio-demographic, child's HIV disclosure, depressive symptoms, ART adherence, and HRQOL. Multiple linear and negative binomial regression analyses assessed associations between independent variables (HIV disclosure/other factors) and HRQOL (primary outcome), and depressive symptoms (secondary outcome), respectively.</p><p><strong>Results: </strong>Two hundred and seventy-eight CWHIV aged 8-14 years and their caregivers were enrolled. Most caregivers (80.58%) were female. Three-quarters (75.90%) of CWHIV knew their HIV status. Two-thirds (68.71%) of CWHIV reported adherence to ART. HIV disclosed versus non-disclosed CWHIV had 4.57 units higher HRQOL (coefficient = 4.57, 95% CI: 0.87, 8.27; p = 0.016). Higher depression scores (coefficient = -1.09, 95% CI: -1.30, -0.87; p < 0.001 and ART non-adherence (coefficient = -4.27, 95% CI: -7.07, -1.48, p = 0.003) were inversely associated with HRQOL. There was no significant association between HIV disclosure and depressive symptoms, whereas ART non-adherence was significantly associated with higher depressive symptom scores (coefficient = 0.28, 95% CI: 0.06, 0.49, p = 0.013).</p><p><strong>Conclusion: </strong>HIV disclosure was associated with better HRQOL but not with any worsened depressive symptoms. Interventions that promote HIV status disclosure at the recommended age are therefore important in the care of CWHIV.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of perceived stress on self-management behaviors among men who have sex with men living with HIV in China: the mediating role of self-regulatory fatigue.","authors":"Yuhan Wu, Wenwen Yang, Rui Huang, Mengya Wang, Yan Song","doi":"10.1186/s12981-026-00869-2","DOIUrl":"10.1186/s12981-026-00869-2","url":null,"abstract":"<p><strong>Background: </strong>As a chronic disease, effective HIV self-management is crucial for men who have sex with men (MSM) living with HIV. Psychosocial factors, including perceived stress and self-regulatory fatigue, have been shown to negatively impact self-management behaviors. However, research on the relationships among perceived stress, self-regulatory fatigue, and self-management behaviors remains limited. This study aimed to explore the mediating effect of self-regulatory fatigue in the relationship between perceived stress and self-management behaviors among MSM living with HIV in China.</p><p><strong>Methods: </strong>From December 2024 to March 2025, cross-sectional data were collected from 328 MSM living with HIV at an HIV-designated hospital in Jiangsu Province using convenience sampling. Data were collected using the Perceived Stress Scale, Self-Regulatory Fatigue Scale, and HIV Self-Management Scale. Descriptive statistics, univariate analysis, and Pearson correlation analysis were performed in this study. The mediating effect of self-regulatory fatigue in the relationship between perceived stress and self-management behaviors was assessed using Model 4 of the PROCESS macro for SPSS.</p><p><strong>Results: </strong>Among 328 MSM living with HIV, the average score of perceived stress was 30.67 ± 7.87, the average self-regulatory fatigue score was 43.99 ± 8.76, and the average HIV self-management score was 36.65 ± 7.88. Perceived stress was positively related to self-regulatory fatigue (r = 0.544, p<0.05), whereas self-management behaviors were proven to be negatively associated with perceived stress (r = -0.486, p<0.05) and self-regulatory fatigue (r = -0.504, p<0.05). Self-regulatory fatigue partially mediated the association between perceived stress and self-management behaviors, accounting for 34.39% of the total effect.</p><p><strong>Conclusion: </strong>This study demonstrated that self-regulatory fatigue partially mediated the relationship between perceived stress and self-management behaviors and underscored the importance of designing targeted interventions aimed at reducing perceived stress and self-regulatory fatigue to improve self-management behaviors among MSM living with HIV in China. Multidimensional strategies, achieved through collaborative efforts among patients, healthcare providers, government, and community, should incorporate personalized mental care and stress management, available social support, trained peer navigation, and consistent health education.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with antiretroviral therapy adherence among adolescents living with HIV in Addis Ababa, Ethiopia: structural equation modeling.","authors":"Gebre G Gudisa, Sangeun Jun","doi":"10.1186/s12981-026-00865-6","DOIUrl":"10.1186/s12981-026-00865-6","url":null,"abstract":"<p><strong>Background: </strong>Adolescents living with HIV experience persistent challenges in achieving optimal adherence to antiretroviral therapy (ART), threatening viral suppression and long-term treatment success. In sub-Saharan Africa, including Ethiopia, developmental transitions, limited resources, and socio-cultural factors further complicate adherence. This study aims to develop and validate a model of antiretroviral therapy (ART) adherence determinants among Ethiopian adolescents living with HIV by extending the information-motivation-behavioral skills (IMB) model through the integration of HIV-related stigma as an additional construct, given its significant influence on adherence in this population.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from March to October 2024 among 219 adolescents living with HIV in ALERT hospital, Addis Ababa. The data were analyzed via SPSS and the lavaan 0.6-18 package in R. The pathways through which the study constructs influenced ART adherence were estimated via the diagonally weighted least squares (DWLS) method. Model fit was evaluated via the chi-square to degrees of freedom ratio (χ²/df), comparative fit index (CFI), Tucker-Lewis index (TLI), and root mean square error of approximation (RMSEA).</p><p><strong>Results: </strong>A total of 210 adolescents were included in the final analysis, of whom 68.6% were adherent to ART. The proposed model demonstrated excellent fit to the data (χ²/df = 1.23, CFI = 0.99, TLI = 0.98, RMSEA = 0.033). Treatment self-efficacy mediated the effects of ART knowledge and ART attitude on ART adherence. While social support exerted both significant direct (β = 0.20, p = .029) and indirect effects via treatment self-efficacy, resulting in a significant total effect on ART adherence (β = 0.26, p = .004), HIV-related stigma did not demonstrate significant direct or indirect effects on ART adherence.</p><p><strong>Conclusion: </strong>Interventions that strengthen ART-related knowledge, foster positive treatment attitudes, enhance social support, and build treatment self-efficacy may substantially improve ART adherence among adolescents living with HIV.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune and hematologic alterations associated with CD4⁺ T-cell depletion in people living with HIV in Morocco.","authors":"Zakaria Elkodmiri, Abdelmouine Salami, Moulay Yassine Belghali, Rajaa Hazime, Fatima-Ezzohra Eddehbi, Saad Lamjadli, Salma Rouhi, Wafaa Qiddi, Sanaa Sayagh, Malika Idalene, Maryame Ahnach, Noura Tassi, Bouchra Ghazi, Brahim Admou","doi":"10.1186/s12981-026-00856-7","DOIUrl":"10.1186/s12981-026-00856-7","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13040705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second-line virologic failure and elevated bilirubin as a potential surrogate marker of ART adherence among people living with HIV in Eastern Uganda.","authors":"Simiyu Melap Lynnet, Jacob Stanley Iramiot, Rebecca Nekaka, Patrick Okware, Mary Abwola Olwedo, Joshua Epuitai, Paul Oboth, Herbert Itabangi, Lydia V N Ssenyonga, Julius Nteziyaremye, David Okia","doi":"10.1186/s12981-026-00861-w","DOIUrl":"10.1186/s12981-026-00861-w","url":null,"abstract":"<p><p>Second-line antiretroviral therapy (ART) failure remains a challenge in HIV Programs. We conducted a cross-sectional study among people living with HIV on second-line ART in Eastern Uganda to determine the prevalence and associated factors of virological failure and to assess elevated serum bilirubin as a surrogate marker of adherence. The prevalence of virological failure was 7.5%. Elevated bilirubin showed poor sensitivity and specificity for predicting adherence or virological failure. The findings highlight the need for routine viral load monitoring, as bilirubin is not a reliable surrogate marker of treatment adherence or virological failure.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reason for hospitalization contrasting adjudication versus ICD-10-CM coding among persons with HIV, 2016-2019.","authors":"Alexander C Commanday, Lindsay E Browne, Amanda E Moy, Heather I Henderson, John P Franzone, Geargin B Wilson, Claire E Farel, Darren A Dewalt, Joseph J Eron, Sonia Napravnik","doi":"10.1186/s12981-026-00855-8","DOIUrl":"10.1186/s12981-026-00855-8","url":null,"abstract":"<p><strong>Background: </strong>People with HIV (PWH) have disproportionately high hospitalization rates, the reasons for which are incompletely understood. Hospitalization reasons based on International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) discharge codes may lead to misclassification. We evaluated the performance of ICD-based reason for hospitalization with adjudication in PWH.</p><p><strong>Methods: </strong>We randomly sampled 302 of 1428 hospitalizations (21%) between 2016 and 2019 among PWH in the UNC CFAR Clinical Cohort Study (UCHCC). ICD-based reason was defined as first-listed ICD discharge diagnosis, or second if the principal diagnosis was HIV. We contrasted ICD-based reason and adjudication with four outcomes: complete agreement (same category and diagnosis), partial agreement (same category, different diagnosis), disagreement (different category and diagnosis), and inadequate ICD coding (no single ICD-10-CM code was appropriate).</p><p><strong>Results: </strong>Overall the 302 hospitalizations occurred among 204 PWH, 69% of whom were male, with median age 51 years (interquartile range [IQR], 40-58), and CD4 count 539 (IQR, 242-789), at time of hospitalization. Adjudication completely agreed with ICD-based reason in 73% hospitalizations, partially agreed in 14%, disagreed in 8%, and ICD codes were inadequate in 6%. Patient characteristics associated with lower proportion of complete or partial agreement were recent CD4 count < 200, nadir CD4 < 50, ≥ 15 discharge diagnoses, length of stay ≥ 4 days, and HIV as a principal diagnosis.</p><p><strong>Conclusions: </strong>Overall ICD codes performed well in capturing reason for hospitalization in most cases. However, adjudications are needed among certain groups of patients, including those with poorly controlled HIV and complex hospitalization course.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminatory attitudes toward people living with HIV/AIDS in East Africa: a multilevel analysis of socioeconomic and behavioral determinants using DHS 2019-2023 data.","authors":"Getasew Kibralew, Betelhem Mulugeta Worku, Yilkal Abebaw Wassie, Gidey Rtbey, Fantahun Andualem, Setegn Fentahun, Ashenafi Worku Woretaw, Mamaru Melkam, Tesfaye Segon, Mekidem Aderaw, Girum Nakie, Eshet Gebrie, Shegaw Marie Bishaw, Gebresilassie Tadesse, Mulualem Kelebie","doi":"10.1186/s12981-026-00859-4","DOIUrl":"10.1186/s12981-026-00859-4","url":null,"abstract":"<p><strong>Introduction: </strong>Despite global efforts to reduce HIV-related stigma, discriminatory attitudes toward people living with HIV/AIDS (PLHIV) remain widespread, especially in Sub-Saharan Africa. This study aimed to assess the prevalence and determinants of discriminatory attitudes toward PLHIV in five East African countries using Demographic and Health Survey (DHS) data from 2019 to 2023.</p><p><strong>Methods: </strong>A cross-sectional, secondary data analysis was conducted using DHS data from Kenya, Madagascar, Mozambique, Rwanda, and Tanzania. A total weighted sample of 106,639 sexually active individuals aged 15-49 was included. Discriminatory attitudes were assessed based on responses to two standard DHS questions. Multilevel logistic regression models were used to identify factors associated with discriminatory attitudes at both individual and community levels.</p><p><strong>Results: </strong>The overall prevalence of discriminatory attitudes toward PLHIV was 34.03% (95% CI 33.74, 34.31). Country-specific prevalence ranged from 12.98% in Rwanda to 76.18% in Madagascar. Key factors significantly associated with discriminatory attitudes included lower wealth status (AOR = 2.12, CI 1.73, 3.80), having multiple sexual partners (AOR = 2.11, CI 1.97, 2.60), and being unemployed (AOR = 3.10, CI 2.06, 3.70).</p><p><strong>Conclusion: </strong>Discriminatory attitudes toward PLHIV remain high in East Africa, particularly among economically disadvantaged, unemployed individuals and have multiple sexual partners. Integrated interventions targeting socio-economic inequalities, sexual health education, and employment opportunities help reduce discriminatory attitudes toward PLHIV.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}