AIDS Research and Therapy最新文献

{"title":"Incidence and characteristics of candidemia in hospitalised patients with advanced HIV in the Médecins Sans Frontières (MSF) hospital in Kinshasa, Democratic Republic of Congo (DRC).","authors":"Chadrack Walo, Patrick Kisaka, Jean-Claude Mikobi Maleshila, Ghislain Mwenemboka, Fidèle Kutomisa, Ridi Fuka, Nadine Ntabugi, Judith Mulanga, Augustin Nzembomba, Astan Dicko, Alain Tshimungu, Charles Kasenda, Gisèle Mucinya, Fabiola Gordillo Gomez, Rosie Burton, Pilar Garcia-Vello, Agnese Comelli","doi":"10.1186/s12981-026-00890-5","DOIUrl":"https://doi.org/10.1186/s12981-026-00890-5","url":null,"abstract":"<p><p>Candidemia is an underrecognised complication among patients with advanced HIV disease (AHD), particularly in low‑resource settings. We conducted a retrospective study at an MSF-supported hospital in Kinshasa (2022-2025) to describe the incidence, characteristics, and outcomes of candidemia. Among 3974 AHD admissions, 46 candidemia cases (1.2%) were identified, more than 80% of which were healthcare‑associated. Mortality was high (76.1%) and many deaths occurred before microbiological confirmation. Classical risk factors, such as indwelling catheters and parenteral nutrition, were uncommon, suggesting alternative pathogenic mechanisms. Findings highlight the need for improved diagnostics and access to antifungal susceptibility testing.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence and viremia of hepatitis C virus among HIV-infected patients on ART with unsuppressed HIV viral load in Ethiopia.","authors":"Desta Ayana, Gadissa Gutema, Atsbeha Gebreegziabxier, Hana Mekonnen Shewangizaw, Tolewak Sura, Gebremedhin Gebremicael, Dereje Leta, Getachew Tollera, Regasa Diriba, Kassu Desta Tulu, John F Dillon","doi":"10.1186/s12981-026-00884-3","DOIUrl":"https://doi.org/10.1186/s12981-026-00884-3","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From CCU to infectious disease ward: HIV-associated high-grade follicular lymphoma presenting with pulmonary thromboembolism and necrotizing pneumonia.","authors":"Hasti Charousaei, Shahram Sabeti, Nafise Mozafari, Azita Bathaie, Negin Shahibi, Houra Yeganegi, Hamed Azhdari, Ilad Alavi Darazam","doi":"10.1186/s12981-026-00880-7","DOIUrl":"https://doi.org/10.1186/s12981-026-00880-7","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to improve retention in care among people living with HIV at health facilities in Manaus, Brazil: insight from health care providers.","authors":"Zeca Manuel Salimo, Elizangela Farias da Silva, Michael Nosano Yakubu, Paulo Afonso Nogueira, Adele Schwartz Benzaken","doi":"10.1186/s12981-026-00885-2","DOIUrl":"10.1186/s12981-026-00885-2","url":null,"abstract":"<p><strong>Background: </strong>Retention in HIV care is a key component of the continuum of care and is essential for achieving the UNAIDS 95-95-95 targets. In Manaus, Northern Brazil, despite advances in HIV treatment and prevention, loss to follow-up among PLHIV remains a significant barrier to viral suppression and epidemic control. The present research explored health care providers' perspectives on strategies to improve retention in care among people living with HIV (PLHIV) at referral health facilities in Manaus.</p><p><strong>Methods: </strong>A qualitative cross-sectional study was conducted between November 2023 and October 2025 in six public health facilities in Manaus. Semi-structured, in-depth interviews were performed with 56 health care providers, including physicians, nurses, social workers, psychologists, pharmacists, and HIV/AIDS program state managers. Data were analyzed using thematic framework analysis with MAXQDA software.</p><p><strong>Results: </strong>Six major themes emerged from the analysis: (1) monitoring and follow-up of PLHIV, (2) challenges related to loss to follow-up, (3) impact of loss to follow-up on UNAIDS 95-95-95 goals, (4) barriers to retention, (5) strategies to optimize retention, and (6) state-level initiatives to improve retention. Providers identified poverty, food insecurity, unemployment, stigma, discrimination, transportation barriers, substance use, and health system constraints such as workforce shortages, long waiting times, and lack of privacy as key drivers of disengagement. Proposed strategies included strengthening multidisciplinary teams, promoting continuous professional training, implementing patient-centered and stigma-free care, enhancing active patient tracing, expanding digital communication tools, decentralizing services, and ensuring adequate financial and human resources.</p><p><strong>Conclusions: </strong>Retention in HIV care in Manaus is shaped by complex social and systemic factors. Integrated, multisectoral strategies addressing socioeconomic vulnerabilities and service-level barriers are essential to improve long-term engagement in care and advance progress toward the UNAIDS 95-95-95 targets.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful multidisciplinary management of non-muscle-invasive upper tract urothelial carcinoma in a patient with HIV and concurrent staghorn calculus: a case report.","authors":"Tao Huang, Yi Mu, Xiangbo Wu, Guobing Li, Hao Tang, Qiu Zhong, Hua Chen, Wanting Chen, Fangfang Qi, Shengming Pi, Tao Li","doi":"10.1186/s12981-026-00870-9","DOIUrl":"https://doi.org/10.1186/s12981-026-00870-9","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representativeness of participants in a randomized controlled trial on modalities of monitoring oral HIV pre-exposure prophylaxis use.","authors":"Marije L Groot Bruinderink, Maarten F Schim Van Der Loeff, Florien Dusseldorp, Katja Van Der Velde, Laura Blitz, Jean-Marie Brand, Colette Van Bokhoven, Joey Woudstra, Koenraad Vermey, Sophie Boers, Maudy Sluimer, Hannelore M Götz, Anders Boyd, Lotte Werner, Maaike L Soors d'Ancona, Frenk Van Harreveld, Maria Prins, Elske Hoornenborg, Udi Davidovich, Vita W Jongen","doi":"10.1186/s12981-026-00886-1","DOIUrl":"https://doi.org/10.1186/s12981-026-00886-1","url":null,"abstract":"<p><strong>Background: </strong>We assessed whether participants in the EZI-PrEP study, a non-inferiority trial evaluating online and six-monthly monitoring of oral HIV pre-exposure prophylaxis (PrEP), represent the broader population of PrEP users in the Netherlands.</p><p><strong>Methods: </strong>We conducted a cross-sectional study using routinely collected data from September 2021 to August 2022 at four centres for sexual health (CSHs) in the Netherlands. Socio-demographic characteristics, sexual behaviour, and prevalence of bacterial STIs were compared between EZI-PrEP participants at baseline and other PrEP users during their first PrEP monitoring visit during the same period.</p><p><strong>Results: </strong>The analysis included 469 EZI-PrEP participants and 5161 other PrEP users, of whom 99% and 96% were men who have sex with men (MSM), respectively. EZI-PrEP participants were less often transgender or gender-divers persons (TGDP) (1% vs. 4%, p < 0.001), older (median age = 36 vs. 34 years, p = 0.004), more often born in the Netherlands (68% vs. 58%, p < 0.001), and more often completed a university/college degree (81% vs. 76%, p = 0.01). They also reported more group sex (38% vs. 33%, p = 0.023) and condomless anal sex (95% vs. 92%, p = 0.004), but less often sex work (1% vs. 6%, p < 0.001). Prevalence of bacterial STIs were no different between groups (19% vs. 18%, p = 0.77).</p><p><strong>Conclusions: </strong>The comparable STI prevalence suggests no difference in risk for HIV acquisition among EZI-PrEP participants and other PrEP users, making study outcomes applicable to a broader population of PrEP users. However, under-representation of TGDPs, sex workers, individuals not born in the Netherlands, and individuals without university or college degree may limit generalizability.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor adherence to second-line antiretroviral therapy and its contributing factors among people living with HIV in Addis Ababa, Ethiopia.","authors":"Bekelech Bayou Feyissa, Abay Sisay, Anteneh Yalew, Geoffrey Setswe","doi":"10.1186/s12981-026-00878-1","DOIUrl":"https://doi.org/10.1186/s12981-026-00878-1","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of immune recovery and survival in HIV late presenters: a retrospective cohort study from Southwest China.","authors":"Die Li, Tongping Ren, Mei Liu, Jianjian Li, Meilin Li, Yungui Zhang, Rongjing Dong, Youwang Lu","doi":"10.1186/s12981-026-00882-5","DOIUrl":"https://doi.org/10.1186/s12981-026-00882-5","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three decades of HIV epidemic dynamics in The Gambia: a comprehensive analysis of prevalence, incidence, and mortality trends, 1990-2024.","authors":"Amadou Barrow, Lamin F S Badjie, Abdou Jarju, Elizabeth Sophie Gomez Ndow, Alpha Khan, Pa Ousman Bah","doi":"10.1186/s12981-026-00883-4","DOIUrl":"https://doi.org/10.1186/s12981-026-00883-4","url":null,"abstract":"<p><strong>Background: </strong>The Gambia has experienced major HIV epidemic shifts over three decades. As a low-prevalence country, understanding epidemic trends remains crucial for health planning and resource allocation. This study provides a comprehensive analysis of 35 years of HIV prevalence, incidence, and mortality trends in The Gambia from 1990 to 2024.</p><p><strong>Methods: </strong>We conducted epidemiological analysis using UNAIDS 2025 HIV estimates from 1990 to 2024. Temporal trends were examined across four phases. Log-linear regression estimated annual percent changes for people living with HIV (PLHIV), new infections, and AIDS deaths. Epidemic control was assessed using mortality-to-incidence and incidence-to-prevalence ratios.</p><p><strong>Results: </strong>PLHIV increased 24-fold from 1,035 (95% CI 784-1,342) in 1990 to 25,247 (95% CI 20,945-30,216) in 2024. Adult prevalence rose from 0·18% to 1·29%. The early phase showed explosive growth (annual percent change + 30·46% for PLHIV), followed by declining incidence concurrent with treatment scale-up (- 4·40% annually 2010-2019; -7·37% annually 2020-2024). New infections peaked at 2,439 (2009), declining to 1,124 (2024). The mortality-to-incidence ratio exceeded 1·0 in 2023. Progressive feminization emerged: female-to-male prevalence ratio increased from 1·06 to 1·57 (β = 0·0133/year, p < 0·0001), with women comprising 61·3% of PLHIV. Treatment cascade performance fell substantially below 95-95-95 targets (63·7% diagnosed, 44·3% on ART, 34·9% virally suppressed), with pronounced gender gaps (men: 52·7%/27·2%/21·2% vs. women: 72·1%/55·4%/44·4%). Pediatric infections increased 284% (44→169 cases), representing 15·0% of 2024 infections.</p><p><strong>Conclusions: </strong>Despite declining incidence, The Gambia faces critical gaps in treatment cascade, particularly among men, epidemic feminization, and persistent vertical transmission, requiring urgent gender-responsive and pediatric interventions.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, knowledge, perception and behavioral risk predictors of acceptability of long-acting injectable lenacapavir HIV pre-exposure prophylaxis in Ghana: a cross-sectional study.","authors":"Ebenezer Senu, Cornelia Quainoo Donkor, Success Acheampomaa Oppong, Daniel Dzemedo Nouwati, Emmanuel Ntori, George Kyei Agyen, Alfred Effah","doi":"10.1186/s12981-026-00881-6","DOIUrl":"https://doi.org/10.1186/s12981-026-00881-6","url":null,"abstract":"","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}