AIDS最新文献

{"title":"Circulating markers of organ damage associate with COPD in people with HIV: an exploratory proteomic analysis.","authors":"Lennart Riemann, Lena Böger, Carina Dahl, Timo Gemoll, Sandra Steffens, Charisis Totsikas, Metodi V Stankov, Alexandra Dopfer-Jablonka, Christine Happle, Georg M N Behrens","doi":"10.1097/QAD.0000000000004618","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004618","url":null,"abstract":"<p><strong>Background: </strong>People with HIV (PWH) develop chronic obstructive pulmonary disease (COPD) more frequently and at younger ages than the general population, yet the circulating proteomic correlates of COPD in PWH remain poorly characterized.</p><p><strong>Methods: </strong>We applied a targeted 92-plex organ damage proteomics panel (Olink Organ Damage) to compare serum protein profiles between 38 PWH with established COPD and 49 PWH without COPD, enrolled in a prospective observational cohort.</p><p><strong>Results: </strong>Differential abundance analysis adjusted for age, sex, BMI, and current smoking status identified several proteins (NUCB2, ALDH3A1, CLEC1A, CALCA, BAMBI, PGF) significantly elevated in PWH with COPD after correction for multiple testing, with several additional proteins reaching nominal significance only. Using a repeated nested cross-validated LASSO framework, a proteomic model achieved modest discriminatory performance (area under the curve, AUC 0.67), comparable to a routine laboratory model (AUC 0.74). A clinical model incorporating FEV1 achieved higher discrimination (AUC 0.84), though this comparison is limited by the partial construct overlap with the GOLD-based COPD definition. Notably, the proteomic model showed statistically significant incremental discriminative value over a spirometry-free clinical model (age, sex, BMI, smoking status; AUC 0.47), suggesting the proteomic signature captures COPD-relevant biological information beyond demographics and smoking history. A stacked meta-model combining all modalities did not significantly outperform the FEV1-inclusive clinical model (AUC 0.87).</p><p><strong>Conclusions: </strong>Our findings provide exploratory evidence for candidate circulating organ damage markers of COPD in PWH and provide a basis for further studies into the mechanisms and immunopathology of this comorbidity, including studies in larger cohorts with HIV-negative comparator groups.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical phenotypes and incidence of acute or recent hepatitis C virus infection and bacterial sexually transmitted infections among MSM with HIV.","authors":"Juan Berenguer, Pablo Ryan, Luis Ramos-Ruperto, Luz Martín-Carbonero, Leire Pérez-Latorre, Ignacio De Los Santos, Adriana Pinto, María J Vivancos, Eva Orviz, Beatriz Álvarez, José Sanz, Pilar Ruiz-Seco, Rafael Torres, Marta De Miguel, Herminia Esteban, Inmaculada Jarrín, Salvador Resino, José M Bellón, Juan González-García","doi":"10.1097/QAD.0000000000004614","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004614","url":null,"abstract":"<p><strong>Objective: </strong>Risk of acute/recent hepatitis C virus infection (ARHCV) and bacterial sexually transmitted infections (STIs) among MSM (MSM-HIV) is heterogeneous. We aimed to identify clinical phenotypes and assess their association with incident ARHCV and bacterial STIs.</p><p><strong>Design: </strong>A prospective multicenter cohort study.</p><p><strong>Methods: </strong>Between 2022 and 2024, MSM-HIV were recruited from 10 centers in Madrid and followed for 12 months with HCV and bacterial STI screening. App-based questionnaires captured behavioral and mental health data. Thirty-eight variables were analyzed using principal component analysis and hierarchical clustering to derive clinical phenotypes.</p><p><strong>Results: </strong>A total of 529 participants were included (median age 41 years). Three phenotypes were identified: CP1 (n = 328, 62.0%), CP2 (n = 133, 25.1%), and CP3 (n = 68, 12.9%), representing different levels of sexual risk, substance use, and prior STI/HCV history. ARHCV incidence was 0.94, 0.72, and 11.76 per 100 person-years in CP1, CP2, and CP3, respectively, and was higher in CP3 than in CP1 (incidence rate ratio [IRR] 12.49, 95% confidence interval [CI] 3.00-73.08) and CP2 (16.25, 2.18-720.93). Bacterial STI incidence was 33.29, 60.83, and 61.76 per 100 person-years, respectively, and was higher in CP2 (IRR 1.83, 95% CI 1.36-2.46) and CP3 (IRR 1.86, 95% CI 1.27-2.68) than in CP1.</p><p><strong>Conclusion: </strong>Clinical phenotypes stratified ARHCV and bacterial STI incidence among MSM-HIV. ARHCV was concentrated in a small high-exposure subgroup, whereas bacterial STIs were more frequent in intermediate and high-exposure phenotypes. Phenotype-based approaches may help guide risk stratification and prevention in HIV care.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-modulated associations between cytomegalovirus cell-associated DNA and cognition in people with HIV on ART.","authors":"Alfonso Cabello-Ubeda, Patricia K Riggs, Gordon Honerkamp-Smith, Alan Wells, Milenka Meneses, Gemma Caballero, Antoine Chaillon, Donald Franklin, Jennifer Ludicello, Leah H Rubin, Ronald J Ellis, Scott L Letendre, Sara Gianella","doi":"10.1097/QAD.0000000000004617","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004617","url":null,"abstract":"<p><strong>Background: </strong>People with HIV (PWH) remain at risk for cognitive impairment, despite effective antiretroviral therapy (ART), a phenomenon linked to chronic immune activation and inflammation. Cytomegalovirus (CMV) has been implicated in HIV-associated neurocognitive impairment, but most studies rely on serologic measures that may not capture biologically relevant viral-host interactions. Few studies have examined cell-associated CMV markers or evaluated sex-specific associations with cognition.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional analysis of 485 PWH on suppressive ART (HIV RNA<200 copies/ml). Cognitive performance was assessed globally and across seven domains. Cell-associated CMV, Epstein-Barr virus (EBV), and HIV cell-associated DNA in peripheral blood mononuclear cells (PBMCs) were quantified by ddPCR, and CMV and EBV immunoglobulin G (IgG) levels were measured by ELISA. Multivariable linear regression models adjusted for demographic and clinical covariates were used to assess associations with cognitive performance, including evaluation of sex interactions, with false discovery rate correction applied.</p><p><strong>Results: </strong>In adjusted models, lower cell-associated CMV DNA, but not CMV IgG, EBV markers, or HIV DNA, was associated with poorer working memory and global cognitive performance. Significant interactions between CMV DNA and sex were observed for global, executive function, processing speed, and memory. In sex-stratified analyses, these associations were present among women but not in men.</p><p><strong>Conclusions: </strong>Cell-associated CMV DNA demonstrates sex-modified associations with cognitive performance among ART-suppressed PWH, with effects observed primarily in women. These findings, based on cellular rather than serologic CMV measures, underscore the complexity of host-virus interactions and cautions against interpreting cell-associated CMV DNA as a simple proxy for pathogenic viral activity.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6.","authors":"Miłosz Parczewski, Maurizio Zazzi, Kaja Mielczak, Micha Böhm, Olaf Degen, Rolf Kaiser, Francesca Incardona, Anders Sönnerborg, Maarten A A van de Klundert","doi":"10.1097/QAD.0000000000004610","DOIUrl":"10.1097/QAD.0000000000004610","url":null,"abstract":"<p><strong>Objective: </strong>The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (BIC).</p><p><strong>Methods: </strong>The virological outcome of first-line DTG or BIC-containing antiretroviral therapy (ART) was assessed in 261 people with HIV-1A6 (PWH-1A6) and 1042 people with HIV-1B (PWH-1B) starting treatment between January 2014 and May 2025 with follow-up for at least one year in the EuResist Integrated Database.</p><p><strong>Results: </strong>Most PWH-1A6 were recent migrants from Ukraine. The event rates per 100 person-years follow-up were higher in PWH-1A6 for low-level viremia (LLV, 2.71 vs. 1.71, P  = 0.049) and virological failure with more than 1000 HIV RNA copies/mL (4.12 vs. 2.03, P  < 0.001) than in PWH-1B. At the end of follow-up, 226/261 (86.6%) PWH-1A6 and 936/1042 (89.8%) PWH-1B had viral load below 50 copies/ml ( P  = 0.132). INSTI DRMs were observed in 5/219 (2.3%) available integrase sequences of PWH-1A6, including two cases detected at virological failure with more than 1000 HIV RNA copies/ml and two cases in virologically suppressed PWH-1A6. In total, 12/261 PWH-1A6 discontinued DTG- or BIC-containing ART, including three individuals who were not virologically suppressed at discontinuation.</p><p><strong>Conclusion: </strong>In PWH treated with DTG or BIC-containing first-line ART, LLV and virological failure with more than 1000 HIV RNA copies/ml were observed more frequently in PWH-1A6 than in PWH-1B. However, such events rarely resulted in INSTI resistance or discontinuation of INSTI-containing ART.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of hepatic steatosis to subclinical atherosclerosis progression in people with HIV receiving integrase inhibitors: a 5-year prospective cohort study.","authors":"Javier García-Abellán, José A García, Sergio Padilla, Marta Fernández-González, Melissa Bello-Pérez, Paula Mascarell, Angela Botella, Leandro López, Mar Masiá, Félix Gutiérrez","doi":"10.1097/QAD.0000000000004512","DOIUrl":"10.1097/QAD.0000000000004512","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cardiovascular disease (CVD) remains elevated among people with HIV (PWH) despite virological suppression. Whether metabolic-hepatic abnormalities contribute to vascular remodeling during contemporary integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) remains uncertain. We evaluated long-term carotid intima-media thickness (cIMT) trajectories and their metabolic, hepatic, and inflammatory determinants.</p><p><strong>Methods and design: </strong>We conducted a 5-year prospective cohort study of virologically suppressed adults receiving INSTI-based ART. cIMT was measured at baseline, 48, 96, and 240 weeks. Mixed-effects models assessed longitudinal cIMT, and a complementary increment-based model evaluated predictors of visit-to-visit cIMT change. Measures of insulin resistance (TyG, HOMA-IR), hepatic steatosis (HSI, FLI), and inflammatory biomarkers (D-dimer, sCD14, sCD163, hsCRP, sICAM-1) were evaluated. Mediation through ASCVD risk was explored.</p><p><strong>Results: </strong>Among 101 participants, cIMT increased significantly over 5 years. In multivariable mixed-effects models, ASCVD risk, HSI, TyG, and D-dimer were independently associated with cIMT. In increment-based analyses (visit-to-visit change in cIMT), hepatic steatosis as assessed by the hepatic steatosis index (HSI) was the only metabolic or inflammatory variable independently associated with short-term cIMT progression [odds ratio (OR) 1.042, 95% confidence interval (CI) 1.008-1.079]. HSI exerted a fully direct effect on cIMT progression ( P  < 0.001), without mediation through ASCVD risk, and increased the explained variance by 5.1% beyond ASCVD alone. TyG, D-dimer and sCD163 were associated with cIMT in mixed-effects models, but not with cIMT increments.</p><p><strong>Conclusions: </strong>HSI-defined hepatic steatosis contributed independently and incrementally to subclinical atherosclerosis progression in PWH receiving INSTI-based ART, beyond traditional cardiovascular risk estimation. Incorporating simple hepatic-metabolic indices such as HSI may improve cardiovascular risk stratification in this population.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1243-1251"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocyte/monocyte activation and inflammation are associated with asymptomatic neurocognitive impairment in people with HIV on suppressive antiretroviral therapy.","authors":"Matteo Augello, Alessandra Mingione, Lidia Borghi, Andrea Corona, Valeria Bono, Roberta Rovito, Valentina Sala, Martina Giudice, Camilla Tincati, Elena Vegni, Filippo Martinelli Boneschi, Giulia Marchetti","doi":"10.1097/QAD.0000000000004534","DOIUrl":"10.1097/QAD.0000000000004534","url":null,"abstract":"<p><strong>Objective: </strong>Despite suppressive antiretroviral therapy (ART), people with HIV (PWH) frequently experience neurocognitive impairment, yet underlying mechanisms remain elusive. We hereby evaluated biomarkers of brain injury, inflammation and gut barrier dysfunction to identify factors associated with cognitive performance in PWH.</p><p><strong>Design: </strong>PWH on suppressive ART and people without HIV (PWoH) were cross-sectionally enrolled.</p><p><strong>Methods: </strong>PWH underwent a comprehensive neurocognitive assessment and HIV-associated neurocognitive disorder (HAND) was diagnosed. We measured plasma markers of neuroaxonal damage and astrocyte activation (NF-L/GFAP by Simoa), inflammation/monocyte activation (IP-10/IL-6/sCD14 by ELISA), gut barrier disruption (I-FABP/E-cadherin/zonulin by ELISA) and microbial translocation (LBP/EndoCAb IgG by ELISA). Non-parametric tests and multivariable regression were used for analyses.</p><p><strong>Results: </strong>Forty PWH [17 HAND+ (asymptomatic neurocognitive impairment), 23 HAND-] and 10 PWoH were included. Compared to PWoH, PWH had higher levels of inflammation/monocyte activation (IP-10/sCD14), gut barrier disruption (I-FABP) and microbial translocation (LBP/EndoCAb-IgG). PWH HAND+ showed higher levels of GFAP/IL-6/sCD14 compared to PWH HAND-. At logistic regression adjusting for age, sex and CD4 T-cell nadir , HAND confirmed associated with higher GFAP/sCD14. More specifically, at linear regression adjusting for the same variables, higher GFAP levels were associated with lower global cognitive performance, worse attention and working memory, speed of information processing, motor skills, as well as learning and memory; higher IL-6 with worse abstraction and executive functions; higher IL-6 and sCD14 with worse verbal fluency.</p><p><strong>Conclusion: </strong>In our cohort of ART-suppressed PWH, asymptomatic neurocognitive impairment was associated with markers of astrocyte/monocyte activation and inflammation rather than with markers of neuroaxonal damage, gut barrier disruption, or microbial translocation.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1297-1304"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal molecular network analysis in Guangxi: implications for HIV control.","authors":"Xianwu Pang, Kailing Tang, Qin He, Jie Ma, Ningye Fang, Haomin Xie, Shujia Liang","doi":"10.1097/QAD.0000000000004474","DOIUrl":"10.1097/QAD.0000000000004474","url":null,"abstract":"<p><strong>Objective: </strong>Guangxi faces a persistent HIV epidemic driven by heterosexual transmission and aging populations. This study uses molecular network to examine network topology and dynamics over time, providing insights for HIV control strategies.</p><p><strong>Methods: </strong>A total of 9751 samples were collected from HIV-infected individuals across Guangxi between 2005 and 2024. HIV pol gene was extracted, and molecular networks were constructed based on the TN93 genetic distance. Network indicators, including clustering rate, network density, degree distribution, transmission rate, and proportional detection rate, were calculated across four time periods (≤2009, 2010-2014, 2015-2020, 2021-2024). Stratified analyses were further conducted.</p><p><strong>Results: </strong>Population characteristics revealed pronounced epidemic aging (individuals aged ≥50 years increased from 10.6% to 62.3%) and a predominance of heterosexual transmission (rising from 50.4% to 90.6%). The network structure evolved from centralized to fragmented: clustering rate declined from 70.64% to 49.92%, network density decreased from 0.084 to 0.037, and the proportion of nodes with degree ≥4 fell from 37.50% to 13.34%. Degree distribution narrowed, suggesting a reduction in superspreading. Transmission rate and proportional detection rate also shifted downward, indicating suppressed network expansion in later periods. Stratified analyses showed higher clustering rates among heterosexual transmission, older adults, individuals with low education, and farmers, although overall declines were consistent across subgroups.</p><p><strong>Conclusions: </strong>This study highlights evolving HIV molecular network characteristics in Guangxi after three rounds of AIDS Conquering Project, offering evidence of reduced complexity and intensity over time. These findings inform planned HIV control efforts, underscoring the need for targeted interventions and enhanced monitoring, particularly for older, less-educated farmers.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1305-1313"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147288926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major ECG abnormalities and risk of incident cardiovascular disease in people with HIV compared to people without HIV.","authors":"Manon C Vanbellinghen, Iris A J van der Wulp, Pieter G Postema, Jan A Kors, Maarten F Schim van der Loeff, Peter Reiss, Marc van der Valk, Anders Boyd","doi":"10.1097/QAD.0000000000004547","DOIUrl":"10.1097/QAD.0000000000004547","url":null,"abstract":"<p><strong>Objectives: </strong>People with HIV (PWH) have an increased risk of cardiovascular disease (CVD). In the general population, major electrocardiographic (ECG) abnormalities have been associated with increased risk of incident CVD. We compared the role of major ECG abnormalities in CVD between PWH and people without HIV (PWoH).</p><p><strong>Methods: </strong>PWH and PWoH with ≥1 ECG across six biennial study visits and without prior CVD were included. Transition intensities (TI) between: no major ECG abnormality, major ECG abnormality, and CVD were estimated using a multistate Markov model. Hazard ratios (HRs) were adjusted for age and BMI. Post hoc analyses explored whether inflammatory markers influenced the association between HIV-status and transitions.</p><p><strong>Results: </strong>Overall, 1060 participants were included (540 PWH and 520 PWoH; median age = 52 years, IQR = 48-58). During a median follow-up of 10.8 years interquartile range, (IQR = 6.8-11.0), 69 (12.8%) PWH and 52 (10.0%) PWoH had any major ECG abnormality ( P = 0.16), while 65 (12%) PWH and 41 (8%) PWoH ( P  = 0.024) had an incident CVD event. There were 55 transitions from no major abnormality to major abnormality (TI = 0.76/100PY, 95% CI = 0.58-1.00) with no difference between PWH and PWoH (adjusted-HR = 1.57, 95% CI = 0.92-2.68). There were 18 transitions from major abnormality to CVD (TI = 3.38/100PY, 95% CI = 1.98-5.75), with a significantly higher TI for PWH (adjusted-HR = 3.24, 95% CI = 1.11-9.55). Adjustment for interleukin-6 attenuated the HR of HIV for this transition by 16%.</p><p><strong>Conclusion: </strong>PWH with major ECG abnormalities had a significantly higher risk of incident CVD than PWoH, possibly related to systemic inflammation. Given the low probability of developing these abnormalities, routine ECG screening is unlikely to be of benefit.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1280-1290"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with loss to follow-up among people with HIV in France.","authors":"Charlène Mafuta, Sophie Grabar, Laurence Lievre, Laurent Tran, Olivier Lambotte, Cécile Goujard, Karine Lacombe, Olivier Robineau, Laurence Meyer, Rémonie Seng, Sophie Abgrall","doi":"10.1097/QAD.0000000000004536","DOIUrl":"10.1097/QAD.0000000000004536","url":null,"abstract":"<p><strong>Introduction: </strong>People with HIV (PWH) with interrupted medical care have a higher risk of viral rebound. We investigated the factors associated with loss to follow-up (LTFU) by combining socioeconomic data from three research cohorts with the nationwide follow-up data of the French Hospital Database on HIV (ANRS-CO4-FHDH).</p><p><strong>Methods: </strong>We included individuals who entered the ANRS PRIMO (primary HIV-1 infection), CODEX (HIV-1 controllers), and COPANA (recent HIV-1 diagnosis) cohorts. Data were then linked to those of the FHDH. LTFU was defined as no clinical follow-up for at least 24 months on 31 December 2021. Fine and Gray's subdistribution hazard models taking the competing risk of death into account were used to identify factors associated with LTFU.</p><p><strong>Results: </strong>We included 2935 PWH in this study: 576 women, 1879 MSM and 480 MSW (men who have sex with women). In total, 605 participants were lost to follow-up in terms of hospital care. The cumulative incidence of LTFU was 16% [95% confidence interval (CI): 15-18] at 10 years. Migrant MSM and MSW had a higher risk of LTFU than French-born MSM [adjusted subdistribution hazard ratios (aSHR): 1.68 (95% CI: 1.27-2.21) and 1.38 (0.98-1.96), respectively]. Younger age, unemployment [aSHR: 1.24 (1.01-1.53)], antidepressant prescription [aSHR: 1.80 (1.21-2.67)] at inclusion, and lack of ART initiation [aSHR: 8.33 (6.25-12.50)] during follow-up were also associated with a higher risk of LTFU.</p><p><strong>Conclusion: </strong>A migrant background, unemployment, and antidepressant prescription were associated with LTFU, highlighting the need for targeted support for vulnerable groups to improve engagement with care.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1376-1387"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerability of lopinavir/ritonavir versus dolutegravir in ART regimens.","authors":"Subhash Hira, Jai P Narain, Shivangi Pawar","doi":"10.1097/QAD.0000000000004539","DOIUrl":"10.1097/QAD.0000000000004539","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"40 9","pages":"1395-1396"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}