High triglyceride-glucose index is associated with diabetes mellitus in people with HIV in Southwest China: a 13-year retrospective longitudinal cohort study.

IF 3.1 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-09-18 DOI:10.1097/QAD.0000000000004342

Liangjia Wei, Chunxing Tao, Xinju Huang, Ruby Congjiang Wang, Jianhua Che, Aidan Nong, Rongye Huang, Zhiman Yan, Lijing Huang, Jiao Qin, Lincong Chen, Sanqi An, Junjun Jiang, Lixian Xiong, Hao Liang, Lijuan Bao, Bingyu Liang, Li Ye

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引用次数: 0

Abstract

Background: The triglyceride-glucose (TyG) index, an emerging marker of insulin resistance, has shown promise in predicting various non-communicable diseases. This study investigated the association between the TyG index and the incidence of type 2 diabetes mellitus (T2DM) within a 13-year retrospective longitudinal cohort of people with HIV (PWH).

Methods: This retrospective cohort study utilized data from the China National Free ART Program (CNFAP) in Guangxi, enrolling PWH who initiated ART between 2010 and 2022. The primary exposure, TyG index, was calculated as ln [TG(mg/dL) × FBG(mg/dL)/2]. The outcome, T2DM, was defined as two consecutive FBG measurements ≥7 mmol/L. Gaussian mixture model (GMM)-based multi-trajectory analysis identified TyG trajectories. Multivariate Cox proportional hazards models were used to estimate the associations between TyG trajectories and the risk of T2DM.

Results: A total of 15,370 patients were included, with 69.9% male, and a median age of 45 at ART initiation. Over 63,232 person-years of follow-up, 22.7% (3493/15370) developed T2DM.The "high Inverted U-shape" TyG trajectory was significantly associated with T2DM (aHR: 2.37, 95% CI: 2.21-2.54). Additionally, the TyG index outperformed FBG in predicting T2DM at both 5 and 10 years (5-year AUC: 0.640 vs. 0.621, P = 0.003; 10-year AUC: 0.655 vs. 0.592, P < 0.001).

Conclusions: This study highlights the clinical value of the TyG index as a predictive marker for T2DM in PWH, suggesting its potential for early risk stratification.

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高甘油三酯-葡萄糖指数与中国西南地区HIV感染者糖尿病相关：一项13年回顾性纵向队列研究

背景：甘油三酯-葡萄糖（TyG）指数是一种新兴的胰岛素抵抗标志物，在预测各种非传染性疾病方面显示出希望。本研究调查了13年HIV感染者（PWH）的TyG指数与2型糖尿病（T2DM）发病率之间的关系。方法：本回顾性队列研究利用了来自广西的中国国家免费ART计划（CNFAP）的数据，纳入了2010年至2022年间开始ART的PWH。初始暴露，TyG指数计算为ln [TG（mg/dL） × FBG(mg/dL)/2]。T2DM定义为连续两次FBG测量≥7 mmol/L。基于高斯混合模型（GMM）的多轨迹分析识别了TyG轨迹。使用多变量Cox比例风险模型来估计TyG轨迹与T2DM风险之间的关联。结果：共纳入15370例患者，其中69.9%为男性，开始ART时的中位年龄为45岁。在63232人年的随访中，22.7%（3493/15370）发展为T2DM。“高倒u型”TyG轨迹与T2DM显著相关（aHR: 2.37, 95% CI: 2.21-2.54）。此外，TyG指数在预测5年和10年T2DM方面均优于FBG（5年AUC: 0.640 vs. 0.621, P = 0.003； 10年AUC: 0.655 vs. 0.592， P）。结论：本研究强调了TyG指数作为PWH患者T2DM预测指标的临床价值，提示其具有早期风险分层的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.