AIDS最新文献

{"title":"Persistence of intraocular JC-virus associated with a MacTel phenotype.","authors":"Nathan Hupin, Florence Hoogewoud, Ferenc B Sallo, Sandra Vermeirsch, Veronique Suttels, Yan Guex-Crosier","doi":"10.1097/QAD.0000000000004240","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004240","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 9","pages":"1307-1309"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using machine learning to predict poor adherence to antiretroviral therapy among adolescents with HIV in low resource settings.","authors":"Claire Najjuuko, Rachel Brathwaite, Ziqi Xu, Samuel Kizito, Chenyang Lu, Fred M Ssewamala","doi":"10.1097/QAD.0000000000004163","DOIUrl":"10.1097/QAD.0000000000004163","url":null,"abstract":"<p><strong>Objectives: </strong>Achieving optimal adherence to antiretroviral therapy (ART) and viral suppression is still insufficient for attaining the UNAIDS 95-95-95 target of 2030, especially among adolescents with HIV (AWHIV). This study sought to develop a model to predict poor adherence risk among AWHIV and identify associated risk factors.</p><p><strong>Design: </strong>We utilized machine learning to predict future ART adherence among AWHIV leveraging its ability to analyze complex, multidimensional data.</p><p><strong>Methods: </strong>We leveraged a dataset from a 6-year (2012-2018) longitudinal randomized control trial (RCT) with 635 AWHIV in Uganda. We evaluated six machine learning models and retained one with the highest area under receiver operating characteristic (AUROC), and area under precision-recall curve (AUPRC). We further identified principal factors associated with ART adherence based on the best model.</p><p><strong>Results: </strong>The random forest model outperformed others, with mean AUROC: 0.71 [BC 95% confidence interval (CI) (0.69-0.72)] and AUPRC: 0.55 (BC 95% CI 0.53-0.58). The principal risk factors of poor adherence were poor adherence history; poverty; biological relationship to caregiver; self-concept; savings confidence; duration on ART; frequency discussing sensitive topics with caregivers; household size; economic group assignment; and school enrollment.</p><p><strong>Conclusion: </strong>Our findings support potential use of machine learning methods and sociobehavioral data for predicting poor ART adherence risk among AWHIV. The predictive tool can help identify AWHIV at the highest risk of treatment failure, and enable early targeted interventions. However, the tool is still preliminary and its accuracy could be improved by incorporating HIV phenotypic and clinical data.</p><p><strong>Clinical trial number: </strong>ClinicalTrials.gov ID:NCT01790373.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1204-1213"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial stiffness in people with HIV: a cross-sectional, comparative study with echocardiographic outcomes in Tanzania.","authors":"Karl Reis, Ponsiano F Stephano, Salama Fadhil, Megan Willkens, Julie Karand, Elias Nyanza, Grace Ruselu, Ayubu Garubindi, Benson Issarow, Myung-Hee Lee, Cody Cichowitz, Robert N Peck","doi":"10.1097/QAD.0000000000004184","DOIUrl":"10.1097/QAD.0000000000004184","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiovascular disease (CVD) is a growing cause of morbidity and mortality in people with HIV (PWH). Arterial stiffness may be an intermediary between HIV-infection and CVD, necessitating holistic assessment of arterial stiffness and correlation with cardiac outcomes.</p><p><strong>Design: </strong>We conducted a cross-sectional study of PWH and HIV-uninfected community controls using multimodal assessment of arterial stiffness and echocardiographic outcomes.</p><p><strong>Methods: </strong>We performed ankle-brachial index (ABI) and pulse wave velocity (PWV) to characterize arterial stiffness in a cohort of PWH and HIV-uninfected community controls in Tanzania. Regression analysis was used to determine differential risk factors for phenotypes of arterial stiffness and echocardiographic outcomes of these phenotypes.</p><p><strong>Results: </strong>We enrolled 848 participants; 398/848 PWH (46.9%) and 450/848 community controls (53.1%). In multivariable models, elevated ABI was associated with HIV infection [3.29 (1.51, 7.21), P  = 0.003] and male sex [2.33 (1.15, 4.71), P  = 0.019], whereas elevated PWV was associated with age [1.11 (1.06, 1.17), P  < 0.001], SBP [1.58 (1.24, 2.01), P  < 0.001], and DBP [2.03 (1.38-2.98) P  < 0.001]. ABI was independently associated with average E:e' [0.74 (0.18, 1.30), P  = 0.010]. PWV was independently associated with left-ventricular mass index (LVMI) [10.73 (2.69-18.76), P  = 0.009].</p><p><strong>Conclusion: </strong>Differential associations between HIV and multiple measures of arterial stiffness suggest that HIV is associated with peripheral but not central arterial stiffness. Arterial stiffness was correlated with cardiac hypertrophy and impaired cardiac filling, suggesting a mechanistic pathway for HIV-related CVD that includes peripheral arterial stiffness. We identified a subpopulation of young, male PWH at risk for early vascular aging.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1133-1140"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact and mechanism of HIV infection on tuberculous granuloma formation.","authors":"Geyang Luo, Bo Yan, Yinzhong Shen","doi":"10.1097/QAD.0000000000004216","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004216","url":null,"abstract":"<p><p>The co-infection of Mycobacterium tuberculosis (MTB) and HIV continues to pose a major challenge to healthcare systems. Currently, the effects of HIV infection on tuberculous granulomas are not fully understood. This review discusses the impact of HIV infection on the formation and function of tuberculous granulomas, highlighting key immunological mechanisms and the interactions between HIV and MTB infections. The co-infection results in atypical granulomas with weakened immune defenses, which facilitate the dissemination of MTB and accelerate the progression of tuberculosis. Additionally, this review explores current animal models used for studying HIV/MTB co-infection, including nonhuman primates, humanized mice, and zebrafish, and emphasizes their limitations in fully replicating human pathological characteristics. This review further emphasizes that the development of humanized animal models can enhance our understanding of the cellular and molecular mechanisms underlying HIV/MTB co-infection.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 9","pages":"1095-1105"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of HIV on respiratory symptoms, health status, and exertional capacity.","authors":"Ioannis Konstantinidis, Spyridon N Papageorgiou, Richard H Zou, Andreas Ronit, M Bradley Drummond, Ken M Kunisaki, Kristina Crothers, S Mehdi Nouraie, Alison Morris","doi":"10.1097/QAD.0000000000004179","DOIUrl":"10.1097/QAD.0000000000004179","url":null,"abstract":"<p><strong>Objective: </strong>People with HIV (PWH) have increased risk for worse pulmonary function and increased emphysema. HIV has been proposed as a risk factor for respiratory patient-reported outcomes (PROs). We assessed the association of HIV with respiratory symptoms, respiratory health status, and functional exercise capacity.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Methods: </strong>We searched PubMed, EMBASE, CENTRAL, CDSR, WoS, Scopus, CINAHL, and GIM through November 2023 for studies of PWH and people without HIV (PWOH) reporting respiratory PROs. Primary outcomes were activity-limiting dyspnea (defined as Modified Medical Research Council Dyspnea Scale score ≥2), respiratory health status by St. George's Respiratory Questionnaire (SGRQ), and exertional capacity by 6-min walking distance (6MWD). We performed random-effects meta-analyses estimating odds ratios (ORs) and mean differences with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>We included 89 publications corresponding to 56 studies. HIV was associated with activity-limiting dyspnea (OR 1.67; 95% CI 1.05-2.65), worse respiratory health status (SGRQ mean difference 2.9 units; 95% CI 0.6-5.2), worse exertional capacity (6MWD mean difference -58.9 m; 95% CI -115.3 to -2.4), and chronic cough, dyspnea, phlegm, and wheeze (OR 1.38-1.78). Respiratory symptom and adverse respiratory health status risk was greatest in European PWH. Certainty of evidence was very low, primarily due to studies' observational design and inconsistency.</p><p><strong>Conclusion: </strong>PWH have increased risk for worse respiratory PROs. Systematic respiratory PRO assessment should be incorporated into routine clinical care to facilitate active case-finding of chronic lung disease in PWH. Future studies should longitudinally co-assess objective physiologic measures and respiratory PROs.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1235-1245"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cumulative prevalence of HIV-1 drug resistance in perinatal HIV.","authors":"Jessica S Glenn, Aisleen Bennett, Nicola Mackie, Hermione Lyall, Sarah Fidler, Graham Taylor, Caroline Foster","doi":"10.1097/QAD.0000000000004202","DOIUrl":"10.1097/QAD.0000000000004202","url":null,"abstract":"<p><strong>Objective: </strong>To describe acquired drug resistance mutations (DRMs) among children and adults with perinatal HIV stratified by age.</p><p><strong>Design: </strong>A retrospective observational cohort study.</p><p><strong>Methods: </strong>Data on demographics, antiretroviral therapy (ART), viral load, CD4 + cell count, and lifetime cumulative acquired DRMs was collected and disaggregated by birth era; pre and post 2000; 0-24 and at least 25 years ( n  = 113 vs. 167).</p><p><strong>Results: </strong>Two hundred eighty individuals (median age 26 years, interquartile range 21-30), 235 (84%) Black ethnicity, 160 (57%) female, with median ART exposure 17 years. About 99.6% currently on ART, 205 (73%) integrase strand transfer inhibitor (INSTI) regimens, with 252 (90%) viral load less than 200 copies/ml. One hundred twenty-one of 280 (43%) acquired resistance to at least one ART class (37% 0-24 vs. 47% ≥ 25 years), 69/280 (25%) at least two (14 vs. 32%), and 13/280 (4.6%) at least three class; 11/13 (85%) aged at least 25 years. DRMs by ART class; 104/280 (37%), nonnucleoside reverse transcriptase inhibitor (NNRTI), 78 (28%) nucleoside reverse transcriptase inhibitor (NRTI), 15 (5%) protease inhibitor, and 4 (1%) INSTI. Uni/multivariate analysis; DRM acquisition was significantly associated with more than two anchor class exposure ( P  = 0.000), prior AIDS diagnosis ( P  = 0.001, 0.085), and early mono/dual NRTI exposure ( P  = 0.000, 0.029).</p><p><strong>Conclusion: </strong>Despite improved ART efficacy, DRMs limit treatment options, including long-acting injectable therapies with one-third having NNRTI-DRMs. Outcomes for second-generation INSTIs are promising with low rates of resistance but require continued monitoring. While multidrug resistance rates are lower in those born post2000, over one-third already have DRMs, highlighting the ongoing need for patient-centered approaches addressing adherence and novel ART class development.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1161-1177"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A promising prognostic model for patients with AIDS-related lymphoma in the combination antiretroviral therapy era.","authors":"Guang-Wei Yang, Qi-Wen Zhou, Xin Zhen, Ying Yang, Yuan-Lu Shu, Hao Sun, Hai-Yan Min, Xi-Cheng Wang","doi":"10.1097/QAD.0000000000004197","DOIUrl":"10.1097/QAD.0000000000004197","url":null,"abstract":"<p><strong>Objective: </strong>For patients with AIDS-related lymphoma (ARL), optimizing risk stratification is crucial to creating customized therapy regimens and enhancing their prognosis. This study aims to develop a more precisely predicted prognostic model for ARL patients.</p><p><strong>Design: </strong>A 7-year retrospective cohort study (2016-2023) of 136 ARL patients at a single institution randomly allocated training ( n  = 109) and validation ( n  = 27) cohorts.</p><p><strong>Methods: </strong>We assessed the relationship between HIV, lymphoma, and patient-specific factors and overall survival (OS) and progression-free survival (PFS) by univariate and multivariate analyses.</p><p><strong>Results: </strong>The median age was 48 (IQR: 40-56) years, 76.5% were men. The overall 2-year OS and PFS were 52.9 and 48.5%, respectively. In the multivariate analysis, Eastern Cooperative Oncology Group performance status (ECOG-PS), central nervous system (CNS) involvement, elevated lactate dehydrogenase (LDH), Hemoglobin (Hb), neutrophil-lymphocyte ratio (NLR), and chemotherapy cycles were independently related to OS. A new prognosis score was generated with these variables, including ECOG at least 2, CNS involvement, elevated LDH, Hb less than 130 g/l, NLR more than 5, and not exceeding 5 chemotherapy cycles, with 1 point for each variable, for a maximum of 6. The area under the curve and C-index of the new model were 0.79 and 0.76, respectively. Our model showed better risk stratification in ARL patients than aaIPI, NCCN-IPI, and ARL-IPI.</p><p><strong>Conclusion: </strong>In this study, we created a prognostic model for ARL patients that is clinically straightforward, feasible, and has good predictive power. Compared to the NCCN-IPI and the aaIPI, this model is more discriminative and predictively accurate in risk stratification and high-risk population identification.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1141-1151"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of infodemiology studies using artificial intelligence: social media posts on HIV preexposure prophylaxis.","authors":"Emiko Kamitani, Julia B DeLuca, Yuko Mizuno","doi":"10.1097/QAD.0000000000004193","DOIUrl":"10.1097/QAD.0000000000004193","url":null,"abstract":"<p><strong>Objectives: </strong>To explore how artificial intelligence (AI) can enhance infodemiology, which distributes and scans information in the electronic medium, to process social media posts for HIV preexposure prophylaxis (PrEP).</p><p><strong>Design: </strong>Systematic review.</p><p><strong>Methods: </strong>We searched in the U.S. Centers for Disease Control and Prevention's Prevention Research Synthesis database through June 2024 (PROSPERO: CRD42023458870). We included infodemiology studies published in English and reported using AI to process social media posts on PrEP. Two reviewers independently screened citations, extracted data, and conducted a risk of bias assessment using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. Findings are narratively summarized.</p><p><strong>Results: </strong>Of the 135 citations screened, eight infodemiology studies were identified, analyzing over 58.9 million posts. Infodemiology studies found the PrEP topics commonly discussed in communities (e.g., barriers of uptake), rumors that may raise public health concerns (e.g., PrEP is a prevention method against COVID-19 infection), geographic locations where concerns regarding risk of acquiring HIV were raised (e.g., most HIV-related posts were from the 10 states with the highest numbers of new HIV diagnoses), and predicted HIV trends (e.g., HIV-related tweets were negatively correlated with the county-level HIV incidence rate in the following year).</p><p><strong>Conclusions: </strong>Despite the limitations of this review including a small number of studies reviewed, our review suggests social media posts may provide information on real-time PrEP-related concerns, and AI can accelerate and enhance the processing of mass data to identify the information that communities need and the areas/locations that may need HIV prevention intervention.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1254-1261"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal microbiome composition in women with HIV undergoing treatment of cervical transformation zone in a screen and treat program in Zambia.","authors":"Leeya F Pinder, Pierre Bertrand, Veronica Fertitta, Vincent Cahais, Mulindi Mwanahamuntu, Namakau Nyambe, Samson Chisele, Aaron Lunda Shibemba, Sandrine McKay-Chopin, Cyrille Cuenin, Eric Lucas, Michael Korenjak, Richard Muwonge, Akram Ghantous, Zdenko Herceg, Groesbeck P Parham, Jiri Zavadil, Partha Basu, Tarik Gheit","doi":"10.1097/QAD.0000000000004187","DOIUrl":"10.1097/QAD.0000000000004187","url":null,"abstract":"<p><p>This study assessed the vaginal microbiome in women with HIV undergoing cervical transformation zone treatment in Zambia. 16S rRNA sequencing showed lower microbial diversity in successful outcomes (N = 18) than those with treatment failure (N = 17) treatment outcome, with Lactobacillus abundance correlated with success. Moreover, HPV-negative women (N = 12) had higher Lactobacillus levels and less pathogens than HPV-positive women (N = 12). These findings suggest a Lactobacillus-dominated microbiome may be associated with positive treatment outcomes.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 9","pages":"1303-1306"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms among women of reproductive age with and without HIV in the Southern United States.","authors":"Thuy Thi Dieu Dao, Teresa R Filipowicz, Andrew Edmonds, Catalina Ramirez, Brian W Pence, Maria L Alcaide, Deborah L Jones, Seble G Kassaye, Deborah Konkle-Parker, Anandi N Sheth, Elizabeth F Topper, Aadia Rana, Daniel Westreich","doi":"10.1097/QAD.0000000000004181","DOIUrl":"10.1097/QAD.0000000000004181","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the prevalence of depressive symptoms and associated factors among reproductive-aged women participating in the Study of Treatment and Reproductive outcomes (STAR) cohort.</p><p><strong>Design: </strong>Cross-sectional analysis.</p><p><strong>Methods: </strong>We analyzed baseline data from women with HIV (WWH) and women without HIV (WwoH) but at risk for HIV enrolled in the STAR, a prospective observational cohort of reproductive-aged women in six Southern US states. We used the Center for Epidemiologic Studies Depression (CES-D) scale to measure depressive symptoms. Crude prevalence ratios were used to describe depressive symptoms by sociodemographic, substance use, psychological, and reproductive characteristics.</p><p><strong>Results: </strong>A total of 473 WWH [median age 37, interquartile range (IQR): 32-42] and 286 WwoH (median age 32, IQR: 26-40) enrolled as of August 2023 in the STAR. Thirty-eight percentage of WWH and 34% of WwoH reported a CES-D score at least 16 (henceforth 'depressive symptoms'; WWH: median score 11, IQR: 5-21 and WwoH: median score 10, IQR: 6-21). Hazardous alcohol use and history of using crack/cocaine were each associated with increased prevalence of depressive symptoms. The prevalence of depressive symptoms rose with each one standard deviation increase in loneliness, perceived stress, and lack of neighborhood safety. In contrast, we found a lower prevalence of depressive symptoms with increasing resilience and social support scores.</p><p><strong>Conclusion: </strong>Depressive symptoms are common among reproductive-aged women regardless of HIV status. Future analyses will help to confirm these initial findings and begin to identify intervention targets to alleviate depressive symptoms.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1283-1289"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}