AIDS最新文献

{"title":"PrEP surfing: HIV preexposure prophylaxis use of sex partners as HIV prevention strategy among men who have sex with men.","authors":"Carien M Blomaard, Jeffrey C D Koole, Elske Hoornenborg, Maria Prins, Janneke C M Heijne, Udi Davidovich, Maarten F Schim Van Der Loeff","doi":"10.1097/QAD.0000000000004526","DOIUrl":"10.1097/QAD.0000000000004526","url":null,"abstract":"<p><strong>Objective: </strong>Having condomless anal sex while relying on the HIV preexposure prophylaxis (PrEP) use of one's sex partner is referred to as PrEP surfing. We aimed to estimate the proportion of men who have sex with men (MSM) practicing PrEP surfing, their intention to practice it, and determinants of both.</p><p><strong>Design: </strong>Open prospective cohort study.</p><p><strong>Methods: </strong>We included MSM participating in the Amsterdam Cohort Studies in 2021-2023. Biannually, participants completed questionnaires on recent (=preceding 6 months) sexual behavior, including PrEP use, PrEP surfing, and intention for both in the coming 6 months (7-point Likert scale). We assessed determinants of PrEP surfing with logistic regression and determinants of intention with linear regression.</p><p><strong>Results: </strong>We included 2187 visits from 636 participants to analyze intention for PrEP surfing. Median age was 45 [interquartile range (IQR) = 34-52] years, median number of recent sex partners 4 (IQR = 1-11), and 264 (41%) participants reported recent PrEP use. For recent PrEP surfing, 1779 visits from 562/636 (88%) participants with event-driven/no PrEP use were analyzed. Recent PrEP surfing was reported in 449/1779 (25%) visits. Median intention for PrEP surfing was 4 (IQR = 1-6); in 588/2187 (27%) visits, intention for PrEP surfing was high (=score 6-7). Recent PrEP use and high perceived probability of acquiring HIV were associated with recent PrEP surfing and higher intention, while age ≥45 and having a steady partner were inversely associated. Having ≥3 recent partners was associated with recent PrEP surfing.</p><p><strong>Conclusions: </strong>PrEP surfing is a common HIV prevention strategy among MSM in Amsterdam. Its effectiveness needs to be determined to optimize HIV prevention care.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1365-1375"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High blood pressure and associated metabolic disorders among young adults with and without perinatal HIV.","authors":"Ahmad T Aliyu, Patrick S Dakum, Patrick Ryscavage, Natalia Blanco, Oyewole Oyedele, Ayoola O Orisawayi, Nifarta Andrew, Jibreel Jumare, Modupe Coker, Charity Sanni, Stella Atema, Temitayo Oladimeji, Joel Abu, Olukemi Okojie, Oma Amadi, Rotimi Owolabi, Nadia A Sam-Agudu, Alash'le Abimiku, Kristen A Stafford","doi":"10.1097/QAD.0000000000004548","DOIUrl":"10.1097/QAD.0000000000004548","url":null,"abstract":"<p><strong>Background: </strong>People on HIV antiretroviral therapy are living longer but face shorter comorbidity-free lives, due to the early onset of non-communicable diseases associated with aging. We examined the association of perinatal HIV infection or exposure and cardiometabolic disorders among young adults.</p><p><strong>Methods: </strong>This cross-sectional study of cardiometabolic disorders included youths: perinatally acquired HIV (PHIV = 154), non-perinatally acquired HIV (NPHIV = 155), HIV-exposed uninfected (HEU = 154), and HIV-unexposed uninfected (HUU = 197), in two tertiary health centers in Nigeria. Hypertension prevalence and related metabolic disorders were assessed using criteria from the Seventh Joint National Committee and the Joint Interim Statement of the International Diabetes Federation (IDF) Task Force on Epidemiology and Prevention, respectively. Logistic regression models estimated the association between HIV status and these disorders.</p><p><strong>Results: </strong>Of the 660 participants with a median age of 20 years, females comprised 53%. Hypertension prevalence was 16.1% [95% CI: (10.3-21.9)] in PHIV, NPHIV, and HEU, while HUU had the highest rate at 51.6% [95% CI: (49.1-62.9)]. No significant differences in cardiometabolic parameters among the groups were found, but elevated blood glucose [23.5% (95% CI: 20.4-26.9)] ( P < 0.001), low HDL-C [65.0% (95% CI: 61.3-68.5)] ( P = 0.004), and abdominal obesity [15.6% (95% CI: 13.0-18.6)] ( P = 0.024) were more common components of metabolic syndrome (MetS). PHIV showed lower likelihoods of prehypertension [adjusted odds ratio (AOR): 0.55 (95% CI: 0.32-0.93)] and elevated blood glucose [AOR: 0.23 (95% CI: 0.09-0.55)], but higher likelihood of low HDL-C [AOR: 2.08 (95% CI: 1.30-3.34)]. HEU had lower odds of MetS [AOR: 0.39 (95% CI: 0.16-0.93)] and abdominal obesity [AOR: 0.49 (95% CI: 0.24-0.99)] than HUU.</p><p><strong>Conclusion: </strong>Integrating NCD screening into HIV management for youth can enhance early detection and prevent complications.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1388-1394"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing ChatGPT's capability in understanding and reporting antiretroviral therapy drug-drug interactions (ACCURATE-DDI).","authors":"Erin A Ready, Corbin Patterson, Sara Gibbons, Deborah Yoong, Catia Marzolini, Lauren E Walker, Alice Tseng","doi":"10.1097/QAD.0000000000004522","DOIUrl":"10.1097/QAD.0000000000004522","url":null,"abstract":"<p><strong>Objectives: </strong>Artificial intelligence tools are transforming access to medication information. However, their ability to accurately identify antiretroviral (ARV) drug-drug interactions (DDIs) remains unclear. This study evaluated ChatGPT's analysis of ARV-related DDIs compared to established HIV-specific DDI resources.</p><p><strong>Design: </strong>Cross-sectional observational study.</p><p><strong>Methods: </strong>Using ChatGPT4o-mini in November 2024, we tested 94 ARV DDI pairs. ChatGPT was asked to classify each interaction as \"no interaction,\" \"potential interaction,\" or \"serious interaction.\" Accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated, using the HIV/HCV Drug Therapy Guide and the Liverpool HIV Drug Interactions Checker as the correct classification. A subset of 25 pairs was qualitatively analyzed for responses to the prompt, \"Can I take Drug A with Drug B?\" using a composite score incorporating severity, mechanism, clinical effects, and management (0 = incorrect, 1 = mixed, 2 = correct). Responses were independently assessed by two HIV-specialized pharmacist/pharmacologist reviewers.</p><p><strong>Results: </strong>ChatGPT correctly classified just 40.4% (38/94) of DDI pairs; errors were primarily false negatives (34/56 errors; 60.7%). Sensitivity was 46.0%, specificity 29.0%, PPV 56.9%, and NPV 20.9%. The mean composite score was 3.9/8. ChatGPT showed limited accuracy in identifying severity of serious DDIs (0.4/2), despite often correctly identifying mechanism (1.4/2) and clinical effects (1.6/2). Serious DDI management was often incorrect (0.9/2). ChatGPT performed poorly with ritonavir DDIs involving mechanisms other than CYP3A4 inhibition.</p><p><strong>Conclusion: </strong>ChatGPT demonstrated limited accuracy and specificity, often generating responses that combined correct and incorrect information. Currently, ChatGPT should not be considered a reliable tool for ARV DDI information.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1291-1296"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between expanded HIV testing and late diagnosis in older adults with HIV: evidence from southwest China.","authors":"Zhencen Liu, Shijiao He, Zhen Dai, Qinying He, Yadan Liu, Yunhe Tian, Zijun Li, Yongfei Dong, Lin Jiang, Ningxuan Zhao, Zengjun Li, Song Li, Zhicheng Su, Jing Yang, Yu Jin, Shiluo Lili, Guanqun Zhang, Cairong Zhu","doi":"10.1097/QAD.0000000000004524","DOIUrl":"10.1097/QAD.0000000000004524","url":null,"abstract":"<p><strong>Objectives: </strong>We examined the characteristics and time trends of late diagnosis among people with HIV (PWH) aged ≥50 years in southwest China from 2010 to 2023, and assessed the impact of the expanded HIV testing strategy and associated factors.</p><p><strong>Methods: </strong>We retrospectively analyzed cross-sectional data from 26 233 newly diagnosed older PWH in southwest China between 2010 and 2023, from the Chinese Comprehensive Response Information Management System for HIV/AIDS (CRIMS). A multilevel logistic regression model was used to identify factors associated with late diagnosis, with latent class analysis as a sensitivity analysis to test the robustness of the results.</p><p><strong>Results: </strong>The late diagnosis rate declined from 2010 to 2023 ( P for trend <0.05). Compared with the pre-strategy period (2010-2017), the post-strategy period (2018-2023) was associated with lower odds of late diagnosis [adjusted odds ratio (aOR) = 0.900, 95% confidence interval (CI): 0.854-0.950]. Across all age groups (50-59, 60-74, and ≥75 years), primary education or below was associated with lower odds of late diagnosis (aOR range: 0.804-0.892). Late diagnosis rates were higher than the overall average for HIV testing approaches (i.e., the specific route or setting through which HIV was diagnosed) including testing of other patients (i.e., provider-initiated testing in general medical settings), testing at sexually transmitted infection clinics, and pre-testing of receiving blood/products.</p><p><strong>Conclusions: </strong>Targeted health education should focus on high-risk subgroups including males and married individuals, and community-based testing should be promoted. The higher odds with facility-based testing underscore the need to integrate routine HIV testing into healthcare services.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1327-1336"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Toll-like receptor driven monocyte activation by JAK-STAT inhibitors in people with HIV.","authors":"Marion Camard, Léo Plaçais, Marie Bitu, Christelliah Mouanga, Katia Bourdic, Rick-Ryan Magagi, Audrey Paoletti, Christine Bourgeois, Olivier Lambotte, Nicolas Noel","doi":"10.1097/QAD.0000000000004530","DOIUrl":"10.1097/QAD.0000000000004530","url":null,"abstract":"<p><strong>Objective: </strong>Chronic immune activation and systemic inflammation persist in people with HIV (PWH) despite effective antiretroviral therapy, contributing to increased cardiovascular and cancer risk. Monocytes play a central role in this process, partly through type I interferon (IFN-I) signalling. As Toll-like receptor (TLR) 3 and 7 are key inducers of endogenous IFN-I in response to viral RNA, we investigated how TLR3 and TLR7 stimulation contributes to IFN-I-driven monocyte activation, and whether this response - potentially involving both direct TLR signalling and IFN-I-mediated amplification - can be modulated by JAK-STAT inhibition.</p><p><strong>Design: </strong>We assessed IFN-mediated monocyte activation following TLR3 and TLR7 stimulation and evaluated the effect of JAK-STAT inhibition on the expression of activation markers, immune checkpoint ligands, and cytokine production.</p><p><strong>Methods: </strong>Monocytes isolated by negative selection from peripheral blood mononuclear cells (PBMCs) of PWH were stimulated with the TLR3 agonist Poly(I:C), the TLR7 agonist Imiquimod, or IFN-α2a. Cells were treated with the JAK1/2 inhibitor Baricitinib or the TYK2-selective inhibitor Deucravacitinib. Activation markers, immune checkpoint proteins, and cytokines were analyzed at 4 h and/or 24 h using flow cytometry, qPCR, and ELISA.</p><p><strong>Results: </strong>TLR stimulation induced IFN-mediated activation in monocytes from PWH, with increased PD-L1, CD80 and HLA-DR expression, CXCL10 production, and a shift toward pro-inflammatory subsets. JAK-STAT inhibitors significantly reduced PD-L1 and CXCL10 levels and partially decreased TIM-3 expression, particularly at 24 h.</p><p><strong>Conclusion: </strong>TLR3 and TLR7 agonists induce IFN-driven monocyte activation in PWH, which is effectively modulated by JAK-STAT inhibitors. These findings support their potential as therapeutic agents to mitigate inflammation in chronic HIV infection.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1236-1242"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risks and possible implications of weight gain after switch to dolutegravir in a large Ugandan cohort of people with HIV.","authors":"Eva Laker Agnes Odongpiny, Brian Otaalo, Joseph Musaazi, Esther Alice Nalugga, Ronald Kiguba, Derek Ngabirano, Ahmed Ddungu, Noela Owarwo, Mike Kesby, Matthew Holden, Barbara Castelnuovo, Aggrey Semeere, Derek J Sloan, Christine Sekaggya-Wiltshire","doi":"10.1097/QAD.0000000000004540","DOIUrl":"10.1097/QAD.0000000000004540","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated weight gain amongst people with HIV (PWH) in Kampala after switching their antiretroviral therapy (ART) anchor drug from nevirapine, efavirenz, or a protease inhibitor to dolutegravir.</p><p><strong>Design: </strong>This was a retrospective cohort analysis.</p><p><strong>Methods: </strong>Data were extracted from electronic medical records of nonpregnant PWH who were virally suppressed on dolutegravir-based therapy for at least 12 months following switch. We studied the rate of weight gain using a piecewise spline random effects model and used Cox-proportional hazard models to describe risk factors for weight gain more than 10% after dolutegravir switch. We assessed the potential impact if we applied proposed switch criteria for away from dolutegravir, proposed by an expert group including ADVANCE trial investigators.</p><p><strong>Results: </strong>We included 5489 PWH, 59.6% of whom were female individuals, who had switched to dolutegravir after a median duration of 9 [interquartile range (IQR): 6.1-12.8] years of prior ART. The rate of weight gain was 0.12 kg/month [95% confidence interval (CI): 0.11 to -0.14] in the first 12 months postswitch but varied by prior anchor drug. The cumulative risk of at least 10% weight gain by 36 months was 37.8%, and this was more likely if they were female, aged 25-49 years or their previous ART included efavirenz or a protease inhibitor but less likely if the preswitch BMI was at least 25 kg/m 2 . Overall, 15.7% would be eligible for further ART change according to proposed switch criteria.</p><p><strong>Conclusion: </strong>We found significant weight gain regardless of the pre- dolutegravir (DTG) regimen. More than a third of PWH had weight gain of more than 10% by 36  months.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1271-1279"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parallel declines in antiretroviral therapy adherence by dried blood spot and electronic monitoring in Cape Town, South Africa.","authors":"Christopher M Ferraris, Paul A D'Avanzo, Justin Knox, Lauren Jennings, Catherine Orrell, Robert H Remien","doi":"10.1097/QAD.0000000000004513","DOIUrl":"10.1097/QAD.0000000000004513","url":null,"abstract":"<p><p>Among 250 adults with HIV (median age 34 years, IQR 27-42; 78% women), tenofovir diphosphate (TFV-DP) concentrations in dried blood spots and electronic adherence declined over 12 months. Mean TFV-DP fell from 1219 to 939 fmol/punch in men and 1148 to 894 in women, while electronic adherence declined from 65 to 49% in men and from 62 to 52% in women. Visit predicted declines in TFV-DP (F = 7.17, P < 0.001) and electronic adherence (F = 2.57, P = 0.003).</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"40 9","pages":"1402-1405"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under pressure: a call to increase access to spinal manometers as a critical component of the management of cryptococcal meningitis.","authors":"Jonathan Falconer, Jack Adams, Sile Molloy, Kennedy Mupeli, Nelesh P Govender, Joseph N Jarvis, Thomas S Harrison, David S Lawrence","doi":"10.1097/QAD.0000000000004545","DOIUrl":"10.1097/QAD.0000000000004545","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"40 9","pages":"1219-1224"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hospitalization on cognitive and physical function in people with HIV.","authors":"Lakshmi Chauhan, Kunling Wu, Katherine Tassiopoulos, Leah H Rubin, Todd T Brown, Alison Abraham, Ronnie Kasirye, Susan Koletar, Frank J Palella, Kristine M Erlandson","doi":"10.1097/QAD.0000000000004532","DOIUrl":"10.1097/QAD.0000000000004532","url":null,"abstract":"<p><strong>Background: </strong>Hospitalization contributes to cognitive and physical decline among older adults. We aimed to determine the impact of hospitalization on cognitive and physical function among people with HIV (PWH).</p><p><strong>Methods: </strong>Participants who had been hospitalized and had cognitive or physical function assessments were included. Cognitive function (a composite of Z -scores for three cognitive tests; NPZ3), gait speed, and grip strength slope differences before and after hospitalization were adjusted for potential confounding variables.</p><p><strong>Results: </strong>Of 892 participants, 208 had ≥1 hospitalization: 198 had NPZ3 scores and 197 had gait/grip measures. The median age was 58 years, 37% were Black, and 14% Hispanic; median CD4 was 656 cells/mm 3 , 94% had HIV-1 <200 copies/ml. The NPZ-3 slope difference after vs. before hospitalization was -0.071 per year (95% CI = -0.167, 0.026), with significant difference among those admitted for 3-6 days (-0.177 [95% CI -0.336, -0.018]) but not <3 or >6 days. The grip strength slope difference was -0.626 kg per year (95% CI -1.749, 0.497), with significant decline among those admitted for 3-6 days (-1.60 kg per year [95% CI -3.04, -1.52], P  = 0.03) but not <3 or >6 days. The gait speed increase was significant among those admitted for 3-6 days (0.044 m/s [0.005,0.083], P  = 0.03) but not for those with <3 or >6 days.</p><p><strong>Conclusions: </strong>Intermediate duration of hospitalization was associated with modest declines in posthospitalization cognitive function (predominantly psychomotor performance) and grip strength.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1252-1260"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving cohort coverage estimation using a data triangulation framework: the Swiss HIV Cohort Study example.","authors":"Jessy J Duran Ramirez, Roger D Kouyos, Irene Abela, Charles Beguelin, Marco Bongiovanni, Philip Bruggmann, Alexandra Calmy, Matthias Cavassini, Alexia Cusini, Mirjam de Roche, Luigia Elzi, Andrée Friedl, Rosamaria Fulchini, Chistoph Fux, David Haerry, Benjamin Hampel, Markus Herold, Philipp Kaiser, Helen Kovari, Patrick Schmid, Delphine Sculier, Marcel Stöckle, Philip E Tarr, Frédéric Tissot, Jonathan Tschopp, Gilles Wandeler, Andri Rauch, Huldrych F Günthard, Katharina Kusejko","doi":"10.1097/QAD.0000000000004523","DOIUrl":"10.1097/QAD.0000000000004523","url":null,"abstract":"<p><strong>Objectives: </strong>To improve estimation of cohort coverage in the Swiss HIV Cohort Study (SHCS) using a data triangulation framework that compares SHCS data with multiple external data sources.</p><p><strong>Design: </strong>Retrospective longitudinal analysis of the SHCS.</p><p><strong>Methods: </strong>Cohort coverage of HIV diagnoses, AIDS diagnoses, and antiretroviral therapy (ART) uptake was triangulated across SHCS data (1985-2023), national HIV/AIDS surveillance (1985-2023), longitudinal antiretroviral therapy (ART) sales data (2017-2024), and a targeted literature comparison. Temporal trends in cohort coverage were assessed, and demographic representativeness was evaluated by sex, age, HIV acquisition mode, and region. Mean cohort coverage estimates were calculated for three outcomes: HIV and AIDS diagnoses (Step 1) and ART uptake (Step 2).</p><p><strong>Results: </strong>Over 38 years, mean SHCS coverage was 62.4% for HIV diagnoses, 74.0% for AIDS, and 64.9% for ART uptake, consistent with literature-based estimates. Coverage of HIV diagnoses declined in recent years, and geographical heterogeneity was observed. The SHCS remained broadly representative across most subgroups; however, females, older adults, and people with heterosexually acquired HIV or using psychoactive substances were underrepresented, while people on single-tablet and salvage ART regimens were overrepresented.</p><p><strong>Conclusions: </strong>A data triangulation framework provides a practical approach for monitoring cohort coverage and representativeness. While the SHCS captures a broadly representative sample of diagnosed individuals, tailored strategies are needed to improve inclusion of underrepresented subgroups and maintain cohort coverage. Sustained monitoring is essential to ensure that cohort-based research remains generalizable and continues to inform clinical care and public health responses in Switzerland and beyond.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1314-1326"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13566368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}