AIDS最新文献

{"title":"Risk of hospitalization or death does not differ in children exposed to HIV, yet uninfected compared to nonexposed peers in Lusaka, Zambia.","authors":"Julie M Herlihy, Ethan Zulu, Lawrence Mwananyanda, Leah Forman, Tim Heeren, Christopher J Gill, Roma Chilengi, Natasha Namuziya, Barbara Payne-Lohman, Roy Chavuma, Cassandra R Duffy, Donald M Thea","doi":"10.1097/QAD.0000000000004152","DOIUrl":"10.1097/QAD.0000000000004152","url":null,"abstract":"<p><strong>Objective: </strong>Increased mortality and morbidity has been observed among children who are HIV-exposed, uninfected (CHEU). It is unknown if health disparities remain despite promotion of exclusive breastfeeding and adoption of universal combination antiretroviral therapy (cART) for pregnant women.</p><p><strong>Design: </strong>We conducted a longitudinal cohort study among pregnant women with and without HIV [Zambia Infant Cohort (ZICS)] with the primary goal to measure the morbidity/mortality experienced by CHEU in first 6 months of life, and secondarily whether such disparities could be explained by timing of cART initiation or elevated maternal immune activation.</p><p><strong>Methods: </strong>Pregnant women with/without HIV (1 : 1) were enrolled prior to 26 weeks gestation by ultrasound and assessed twice antenatally. Infants were seen at birth, 6 days, 6, 10, 14, 20, and 24 weeks of age and assessed for illnesses, sick visits/hospitalizations, infant feeding, immunizations, and co-trimoxazole compliance.</p><p><strong>Results: </strong>From 1276 livebirths, there were 36 deaths and 89 hospitalizations over 6 months. Preconception cART uptake was 73%, and majority of pregnant women with HIV had suppressed viral loads at enrollment. There was no difference in hospitalization or death rates for CHEU as compared to HIV-unexposed children [incidence rate ratio (IRR) 1.27, 95% CI 0.79-2.04, P  = 0.33]. This did not shift after adjusting for maternal immune activation prematurity or small for gestational age (SGA). Exclusive breastfeeding reduced risk of hospitalization by 43%.</p><p><strong>Conclusion: </strong>In this setting of moderate cART uptake, we found no evidence of increased hospitalizations or deaths among CHEU. We conclude that the observed increased morbidity among CHEU can be effectively mitigated through early initiation of cART and exclusive breastfeeding.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"964-974"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between switching to integrase strand transfer inhibitors and incident diabetes in people with HIV: Erratum.","authors":"Y Joseph Hwang, Catherine R Lesko, Todd T Brown, G Caleb Alexander, Lauren C Zalla, Jeanne C Keruly, LaQuita N Snow, Jarratt D Pytell, Oluwaseun Falade-Nwulia, Joyce L Jones, Richard D Moore, Anthony T Fojo","doi":"10.1097/01.aids.0001113564.82122.a2","DOIUrl":"10.1097/01.aids.0001113564.82122.a2","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 8","pages":"1094"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left behind? A longitudinal analysis of need for PrEP services among middle-aged and older adults in South Africa.","authors":"Maja E Marcus, Elizabeth Zang, Jennifer Hove, Hannah Jordan, Till Bärnighausen, Stephen Tollman, Kathleen Kahn, Julia Rohr, Brendan Maughan-Brown, Jennifer Manne-Goehler","doi":"10.1097/QAD.0000000000004283","DOIUrl":"10.1097/QAD.0000000000004283","url":null,"abstract":"<p><strong>Introduction: </strong>Despite 1.3 million cumulative Pre-exposure prophylaxis (PrEP) initiations in South Africa, 150,000+ people newly acquire HIV every year. A significant proportion of these are middle-aged adults, a population not previously prioritized for PrEP. Evidence on how many middle-aged and older adults in South Africa may benefit from PrEP services is needed.</p><p><strong>Methods: </strong>We estimate the need for PrEP counselling in a sample of 40+ year-old, rural South Africans in 2018 and 2022, using \"Health and Aging in Africa: A Longitudinal Study in South Africa (HAALSI)\" data. We first identify potential PrEP eligibility based on a negative HIV status and a body weight of 35+ kg. Within this sample, we define the population that should be counselled on PrEP as per South African Guidelines for the Provision of PrEP based on a recent history of having had sex without a condom. We estimate cross-sectional and longitudinal need for PrEP counselling at the pooled level and disaggregated by sex and age.</p><p><strong>Results: </strong>Of the 1,654 individuals considered potentially eligible for PrEP in 2022, 39.6% overall, 55.7% of males, 26.7% of females, and 63.3% of 40-49 year-olds should be counselled on PrEP. Longitudinally, 29.9% and 22.9% should be counselled on PrEP in both waves or only one wave respectively. Further, we found significantly higher odds of need for PrEP counselling in male, younger, and married individuals.</p><p><strong>Conclusion: </strong>We find a high need for PrEP counselling among middle-aged and older South Africans - calling for greater attention to HIV prevention, including targeted PrEP for these age groups.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGE-Rx: frailty, falls, polypharmacy, and inappropriate medication use in a canadian cohort of people aged 65 and older living with HIV.","authors":"Julian J Hopwood-Raja, Alice L Tseng, Nancy L Sheehan, Sharon L Walmsley, Julian Falutz, Alice Zhabokritsky","doi":"10.1097/QAD.0000000000004284","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004284","url":null,"abstract":"<p><strong>Objective: </strong>To characterize the prevalence of polypharmacy, use of potentially inappropriate medications (PIMs), anticholinergic burden (ACB) and sedative burden (SB) and their association with the risk of frailty and falls in a Canadian cohort of older people with HIV.</p><p><strong>Design: </strong>CHANGE-Rx is a cross-sectional analysis of baseline data from CHANGE-HIV, a prospective Canadian cohort of people with HIV aged 65 years and older.</p><p><strong>Methods: </strong>Information on prescription, over-the-counter/natural-health product use, comorbidities, HIV-specific factors, frailty and fall history were assessed at the baseline visit at cohort entry. Proportion of people with polypharmacy (≥5 non-antiretroviral (ARV) drugs), severe polypharmacy (≥10 non-ARV drugs), PIMs, ACB and SB were determined. Chi-square tests and multivariate regression analysis were used to assess the association between medication factors and the risk of frailty and falls.</p><p><strong>Results: </strong>440 participants were included: median age 69 years (range: 65-89), 16.4% were classified as frail, 20.7% experienced a fall (last six months), 53.8% had polypharmacy, 14.6% had severe polypharmacy, 49.3% had ≥1 PIM. For prescribed comedications, 16.5% and 55.7% of participants had high ACB and SB, respectively. The odds ratios (OR) for frailty were 3.3, 2.6 and 2.9 among patients with high ACB, high SB and severe polypharmacy, respectively. The OR for falls were 1.9 and 1.8 for patients with high SB and ≥1 PIM, respectively.</p><p><strong>Conclusion: </strong>Polypharmacy, PIMs and high ACB and SB are common among older adults living with HIV in Canada. It remains to be determined if interventions addressing polypharmacy/PIMs would reduce falls and frailty.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive functioning in women living with HIV: A comparative study in a Low/Middle-income Country.","authors":"Janice Buckley, Haseena Cassim, Kennedy Otwombe, Khuthadzo Hlongwane, Nonhlanhla Yende-Zuma, Celeste Joyce, Given Leshabane, Lisa Galvin, Candice W Ramsammy, Sean S Brummel, Jim Aizire, Taha E Taha, Mary Glenn Fowler, Avy Violari","doi":"10.1097/QAD.0000000000004277","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004277","url":null,"abstract":"<p><strong>Objective: </strong>In untreated HIV infection, the prevalence of HIV-associated neurocognitive disorders was high. Studies from the ART era with appropriate controls from a resource-limited setting are lacking. Neurocognitive functioning of young women living with HIV (WLWH) was compared to women without HIV (WWOH) in South Africa between 2018 and 2019.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>WLWH from thePromise Ongoing Treatment Evaluation (PROMOTE) study and WWOH completed a neuropsychological battery targeted at domains affected by HIV. Factors known to be associated with neurocognitive impairment (NCI) were assessed by generalized linear model adjusting for covariates. Clinical symptoms were evaluated using WHODAS.</p><p><strong>Results: </strong>Of 451 women, with a median age of 35 (IQR: 31 - 39) years, 224 (49.7%) were WLWH. More WLWH had NCI (46% vs. 36%, p-value = 0.06) and mild to severe deficits in: verbal learning and memory (51% vs. 30%, p-value<0.001), motor speed (32% vs. 19%, p-value = 0.002), language (55% vs. 44%, p-value = 0.021) and information processing (40% vs. 25%, p-value = 0.001). The risk of neurocognitive impairment was higher in women ≥ 35 years (RR: 1.46, 95% CI: 1.16-1.84, p = 0.001), incomplete secondary education (RR: 1.26, 95% CI: 1.01-1.58, p = 0.04), HIV infection (RR: 1.26, 95% CI: 1.02-1.56, p = 0.03) and high alcohol use (RR: 1.42, 95% CI: 1.13-1.78, p = 0.003).</p><p><strong>Conclusion: </strong>WLWH on long-term ART had a high prevalence of NCI. High alcohol use and incomplete secondary education were significant risk factors in all women. This study highlights the higher risk of NCI in this population despite a younger age and successful ART.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating a mental health referral system within adolescent HIV clinics in Tanzania.","authors":"Dana Chow, Paul Pronyk, Rainald Mgimba, Winner Elimwaria, Regina Ndaki, Aloyce Ambokile, Blandina T Mmbaga, Dorothy Dow","doi":"10.1097/QAD.0000000000004279","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004279","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the acceptability and feasibility of integrating a mental health (MH) stepped-care referral pathway for young people with HIV (YPWH) who screened positive for MH distress using task-sharing and stepped-care approaches.</p><p><strong>Design: </strong>This is a longitudinal nested study within the Sauti ya Vijana (SYV: The Voice of Youth) randomised controlled trial, describing an integrated referral pathway created within adolescent HIV clinics. SYV is a peer-led, group-based MH intervention for YPWH. The study includes youth enrolled between March and September 2023 who completed a 6-month visit by March 2024.</p><p><strong>Methods: </strong>YPWH who knew their HIV status, received antiretroviral therapy, and could attend 10-weekly intervention sessions were included. Enrolled youth responded to interviewer-guided MH screening questionnaires at every study visit. Automatic referral alerts were generated if a YPWH had a total score ≥10 on the Patient Health Questionnaire (PHQ-9) or General Anxiety Disorder (GAD-7) Questionnaire, reported sexual abuse, self-harm, or suicidal ideation. An interviewer could self-refer a participant if they had a separate MH concern. Site-specific MH referrals were tracked using a REDCap database. Data were analysed for incidence of MH referrals, attendance to referral appointment, and outcome.</p><p><strong>Results: </strong>Of 349 YPWH included in this study, 62 (18%) generated referral alerts. Most attended their appointment (n = 50, 81%) and many (n = 28, 56%) experienced resolution of distress after one visit. Eight participants required stepped-up care to a MH professional.</p><p><strong>Conclusions: </strong>The integration of a MH stepped-care referral pathway was acceptable and feasible for YPLW within existing primary adolescent HIV clinics in Tanzania.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poverty and protection: the relationship between multidimensional poverty, social protections interventions, and HIV viral load.","authors":"Amrita Ayer, Rutendo W Mukondwa, Cesar Aviles Guaman, Kudakwashe Takarinda, Nora West, Tatenda Makoni, Sinokuthaba Mukungwa, Waraidzo Mukuwapasi, Mollie Hudson, Canice Christian, Karen Webb, Priya B Shete","doi":"10.1097/QAD.0000000000004276","DOIUrl":"10.1097/QAD.0000000000004276","url":null,"abstract":"<p><strong>Objectives: </strong>Social protections can mitigate poverty's effects on HIV, but program implementation may influence their impact. We explored relationships between multidimensional poverty, social protections programming, and HIV viral load (VL) among a population living with and seeking care for HIV (PLHIV) in Zimbabwe.</p><p><strong>Design: </strong>A Sequential Explanatory Mixed Methods Study.</p><p><strong>Methods: </strong>We analyzed retrospective cross-sectional data from client satisfaction surveys collected between January and July 2023 among adults with HIV in 15 districts of Zimbabwe. We employed descriptive analyses, generalized estimated equations, and moderation analyses to evaluate relationships between multidimensional poverty, social protections, and VL non-suppression. Between August and September 2023, we conducted semi-structured in-depth interviews (IDIs) with adults regarding access to tuberculosis care and social protections interventions. We applied the Exploration, Preparation, Implementation, and Sustainment framework for qualitative analysis and integrated results at the interpretation phase.</p><p><strong>Results: </strong>Among 13722 PLHIV (65.4% female, median age 44 years [Interquartile range: 36-52]), 44.4% were multidimensionally poor. Only 18% had ever received social protections. Poverty was associated with VL non-suppression [adjusted prevalence ratio (aPR) = 1.55; (95% confidence interval (CI): 1.13, 2.13], as was social protections receipt [aPR = 1.67; (95% CI: 1.07, 2.62)]. IDIs showed that PLHIV experienced significant impoverishment, had little information about and access to social protections, and reported limited quantities and durations of receipt.</p><p><strong>Conclusion: </strong>We observed a high burden of poverty and tenuous access to social protections. Multidimensional poverty was associated with virologic non-suppression, as was social protection receipt, which may signal significant vulnerability in our population and inadequacy of social protections coverage and responsiveness.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unit Costs of Opioid Agonist Therapy (OAT): A Global Systematic review and cost Extrapolation.","authors":"Anh Truc Vo, Adriane Wynn, Marycris Hernandez, Fern Terris-Prestholt, Peter Vickerman, Javier Cepeda, Natasha K Martin","doi":"10.1097/QAD.0000000000004263","DOIUrl":"10.1097/QAD.0000000000004263","url":null,"abstract":"<p><strong>Background: </strong>People who inject drugs (PWID) face elevated risks of HIV and viral hepatitis transmission. Opioid agonist therapy (OAT) like methadone and buprenorphine reduce drug-related harms and improve health outcomes among PWID. Despite effectiveness, global OAT coverage remains suboptimal. This study estimated the global unit cost of OAT provision to inform resource allocation and scale-up of harm reduction services.</p><p><strong>Methods: </strong>We conducted a systematic review to identify cost estimates of OAT provision and cost drivers. Data were extracted from peer-reviewed and grey literature sources. Mixed-effects multivariable regression models, incorporating country-level and program-level covariates, were developed to predict OAT unit costs. The best performing model was used to extrapolate the monthly per person costs of providing OAT in 210 countries.</p><p><strong>Results: </strong>We identified 175 cost estimates across 32 countries. Most estimates were from high-income countries. Higher unit costs were associated with higher country log GDP per capita, more program components, and inclusion of ancillary services in the cost estimations. The best-performing model predicted cost within 95% prediction intervals for 27 out of 32 countries when using the full dataset.</p><p><strong>Conclusion: </strong>The study highlights the scarcity of OAT cost data, particularly in low-income countries, and underscores the need for more research in diverse settings to improve the accuracy and generalizability of cost estimates. This study provides estimates of OAT unit costs, offering insights for policymakers to optimize resource allocation and expand harm reduction efforts.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 and mpox outbreaks on behaviours associated with HCV infection among MSM: results from the pre-randomization phase of a clinical trial.","authors":"Kris Hage, Anders Boyd, Udi Davidovich, Ellen Generaal, Elske Hoornenborg, Paul Zantkuijl, Marc Van Der Valk, Dominique Verhagen, Janneke Stalenhoef, Jan Den Hollander, Eliane Leyten, Tania Mudrikova, Hayette Rougier, Thibault Chiarabini, Marc-Antoine Valantin, Gilles Pialoux, Pauline Campa, Janke Schinkel, Karine Lacombe, Maria Prins","doi":"10.1097/QAD.0000000000004265","DOIUrl":"10.1097/QAD.0000000000004265","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether the COVID-19 and mpox outbreaks affected hepatitis C virus (HCV) related behaviours among men who have sex with men (MSM) with a cleared HCV infection.</p><p><strong>Design: </strong>Longitudinal analysis from the international ICECREAM trial (2021-2024).</p><p><strong>Methods: </strong>During the pre-randomization phase (i.e., without any intervention) individuals completed questionnaires on sexual and drug use behaviours and whether the COVID-19 (since start trial) or mpox (shortly after the mpox outbreak in 2022) outbreaks caused changes in these behaviours, all referring to the preceding six months. We used mixed-effects logistic regression to model changes in behaviours due to COVID-19 or mpox measures and mixed-effects linear regression to model the average HCV-MOSAIC risk score, as a proxy of HCV-associated risk behaviour, over calendar time.</p><p><strong>Results: </strong>220 MSM (n = 117 from the Netherlands, n = 103 from France) were included. Among 208 that completed the baseline questionnaire, 171 (82.2%) were MSM with HIV. The proportion of individuals reporting any impact of COVID-19 restrictions on risk behaviours, mainly lowering number of partners, decreased from 74.7% in September 2021 to 6.7% in September 2024 ( p  < 0.001) and reporting any impact of mpox from 41.9% in November 2022 to 6.0% in September 2024 ( p  = 0.001). The average HCV-MOSAIC risk score remained constant over time ( p  = 0.59) and was consistently ≥2.0, indicating high reinfection susceptibility.</p><p><strong>Conclusion: </strong>HCV-related behaviours decreased when COVID-19 and mpox measures were in place. However, individuals still engaged in behaviours associated with HCV, highlighting the importance of continued sexual health services and prevention efforts during such outbreaks.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer screening in women living with HIV: an audit of clinical care.","authors":"Patricia M Griffiths, Ranjit Samra, Geoffrey Lester, Phil Rawson-Harris, Jennifer F Hoy, James H McMahon","doi":"10.1097/QAD.0000000000004266","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004266","url":null,"abstract":"<p><strong>Objectives: </strong>Women living with HIV (WLHV) have an increased prevalence of cervical cancer and are recommended 3 yearly cervical cancer screening. This is compared with 5 yearly screening their counterparts. We aimed to describe cervical cancer screening practices for WLHV receiving HIV care at a large tertiary hospital.</p><p><strong>Methods: </strong>We performed a retrospective audit on all women who were in HIV care up until January 2023 at the Alfred Hospital, a tertiary hospital in Melbourne, Australia specialising in HIV care. Cervical cancer screening results for Medicare eligible people are recorded in The National Cervical Cancer Screening Register (NCCSR) and these were extracted for women in care. Screening was categorised as up-to-date and consistent with national screening guidelines or overdue.</p><p><strong>Results: </strong>We identified 156 WLHV in care of which 115 were included in the analysis. Of these, 57 (49.6%) had cervical screening on time and consistent with national guidelines, including 49 (86%) who had a normal last result and 8 (14%) with an abnormal last result. Half the women 58 (50.4%) were overdue screening. Of those overdue, 52 (89.7%) were more than 6 months and 45 (76.3%) were more than 12 months overdue. Among the women overdue, 47 (81%) had a normal last result and 7 (12.1%) an abnormal last result.</p><p><strong>Conclusions: </strong>We found that over half of the women included were overdue for their cervical screening test, with the vast majority being overdue by more than twelve months. Improved access to cervical cancer screening is needed in this population to achieve national guidelines targets.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}