AIDS最新文献

{"title":"Outcomes of children living with HIV during the COVID-19 pandemic in Vietnam.","authors":"Dewi K Wati, Lam V Nguyen, Du T Quy, Dinh Q Nguyen, Oanh N Le, Azar Kariminia","doi":"10.1097/QAD.0000000000004222","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004222","url":null,"abstract":"<p><p>We describe mortality in children living with HIV in Vietnam during the COVID-19 pandemic. We followed 1234 children (median age 11.9 years) at three hospitals during 2020-2023; 260 had COVID-19. Eleven (8.9%) children died, mostly due to poorly controlled HIV. Mortality was higher than in the pre-pandemic period (2016-2019) (0.29 vs 0.09 per 100 person-years; p = 0.033), likely due to decreased access to treatment, testing, and medical intervention during the lockdown, as well as financial difficulties.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and resistance patterns of Mycoplasma genitalium infection in people living with HIV: a systematic review and meta-analysis.","authors":"Rui Zhang, Sze Long Chung, Shui Shan Lee, Ngai Sze Wong","doi":"10.1097/QAD.0000000000004219","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004219","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to estimate the prevalence of M. genitalium infection and understand the patterns of resistance associated mutations (resistance hereafter) in people living with HIV (PLWH).</p><p><strong>Methods: </strong>We searched PubMed-MEDLINE, Embase and Web of Science to identify studies published as of 31st December 2023, reporting the prevalence of M. genitalium infection in PLWH. The pooled prevalence of M. genitalium infection and its resistance was calculated using random-effect models.</p><p><strong>Results: </strong>Totally 66 studies involving 22,763 PLWH were included, with 5 studies reporting resistance. The overall pooled prevalence of M. genitalium infection in PLWH was 12% (95%CI: 9%-14%), which differed across geographic regions (P < 0.01), with the highest observed in North America (20%, 95%CI: 10%-32%). The pooled prevalence was the highest in female sex workers (FSW) living with HIV (20%, 95%CI: 10%-32%), but without statistical difference between different population groups (P = 0.76). The pooled prevalence of macrolide resistance-mediating mutations (MRMMs), quinolone resistance-determining regions (QRDRs) mutations, and multidrug resistance with MRMMs and QRDRs mutations in PLWH was 36% (95%CI: 5%-77%), 25% (95%CI: 8%-47%), and 20% (95%CI: 12%-29%), respectively.</p><p><strong>Conclusion: </strong>The prevalence of M. genitalium infection in PLWH in this study was lower than HIV pre-exposure prophylaxis users and FSW, but higher than men who have sex with men in the community. There's substantial geographic variation in the prevalence of M. genitalium infection in PLWH. The variability reflects differences in exposure risks as well as the testing/treatment strategies in place for sexually transmitted infections.</p><p><strong>Prospero registration number: </strong>CRD42023480798.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of a 4 days-a-week triple therapy in persons living with HIV: an ancillary study of the QUATUOR trial.","authors":"Gilles Hejblum, Samih Daher, Paul Moulaire, Karine Amat, Sidonie Lambert-Niclot, Clotilde Allavena, Christine Katlama, Karine Lacombe, Diane Ponscarme, Jade Ghosn, Severine Gibowski, Jean-Claude Alvarez, Jacqueline Capeau, Laurence Morand-Joubert, Dominique Costagliola, Pierre De Truchis, Roland Landman, Lambert Assoumou","doi":"10.1097/QAD.0000000000004215","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004215","url":null,"abstract":"<p><strong>Objective: </strong>The ANRS 170 QUATUOR study demonstrated the noninferiority of a triple antiretroviral therapy (ART) taken 4 consecutive days on and 3 days off (hereafter referred to as a 4/7-days strategy) compared to a triple therapy taken 7 days a week (7/7-days strategy) for persons living with HIV and with suppressed viremia. We investigated corresponding cost-effectiveness issues.</p><p><strong>Design: </strong>Cost-effectiveness study.</p><p><strong>Setting: </strong>France.</p><p><strong>Subject, participants: </strong>All 636 persons involved in the primary analysis of the QUATUOR trial (318 per arm). Analyses were based on 10,000 simulations replicating the trial. Additional analyses included estimating the national impact of spreading the 4/7-days strategy all over France.</p><p><strong>Intervention: </strong>a 4/7-days strategy, compared to a 7/7-days strategy.</p><p><strong>Main outcome measures: </strong>Effectiveness was considered as the noninferiority of the 4/7-days strategy, main criterion of the trial primary analysis. Direct health resource costs (year2022€) were considered and included costs for ART, laboratory tests, co-medications, hospitalizations, and medical consultations.</p><p><strong>Results: </strong>The mean individual costs for ART were € 3,678 (95% confidence interval: 3,593-3,763) and € 6,450 (6,301-6,596) in the 4/7-days and 7/7-days arm, respectively (p < 0.0001), and constituted the single element with a statistical difference between the two strategies. Adopting a 4/7-days regimen in 20% of the potential recipients in France was estimated to provide annual savings of € 61,752,467 (61,569,005-61,925,136).</p><p><strong>Conclusions: </strong>The 4/7-day strategy dominates the 7/7-day strategy, providing substantial ART-related cost savings while maintaining treatment effectiveness. Study results support generalizing the proposal of 4/7-days regimens in France, in persons eligible for this strategy.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of the re-engineered urinary FujiLAM2 assay amongst hospitalized adults with advanced HIV disease: a prospective cohort study.","authors":"Jayne Ellis, Biyue Dai, Mable Kabahubya, Gila Hale, Emmanuel Mande, George Katende, Enock Kagimu, Jane Gakuru, Jane Frances Ndyetukira, Asmus Tukundane, Tessa Adzemovic, Laura J Nsangi, Joseph N Jarvis, Nathan C Bahr, Fiona V Cresswell, David B Meya, David R Boulware","doi":"10.1097/QAD.0000000000004213","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004213","url":null,"abstract":"<p><strong>Background: </strong>A non-sputum based, point-of-care TB diagnostic test is a global health priority. The impact of urinary mycobacterial lipoarabinomannan (LAM) testing has been limited by the diagnostic performance of current assays. We assessed the diagnostic accuracy of the re-engineered TB-LAM SILVAMP (FujjLAM2) assay (Fujifilm, Japan) to diagnose TB amongst hospitalised adults living with advanced HIV disease.</p><p><strong>Methods: </strong>We consecutively enrolled adults presenting with suspected meningitis at two hospitals in Uganda. We implemented a standardised TB diagnostic package: 1) urine Alere TB lipoarabinomannan (TB-LAM), 2) urine Xpert MTB/Rif Ultra, 3) CSF Xpert MTB/Rif Ultra, 4) TB CSF culture, 5) mycobacterial blood culture, 6) chest radiography. We performed FujiLAM2 testing on cryopreserved or fresh urine. We compared diagnostic accuracy against a composite microbiological reference standard of any positive TB test (including Alere-LAM). We assessed 30-day mortality.</p><p><strong>Findings: </strong>We performed FujiLAM2 testing on urine of 436 hospitalised participants. The median CD4 count was 34 cells/mcL (IQR, 11-96). Using the microbiologic reference standard, FujiLAM2 sensitivity was 34% (95%CI, 25-43%), and specificity was 94% (95%CI, 91-96%). When grade-1 Alere TB-LAM positives were excluded, sensitivity was 38% (95%CI, 27-50%). Cryopreserved specimens were 3-fold more frequently positive.</p><p><strong>Interpretation: </strong>Amongst hospitalised adults with advanced HIV disease, the re-engineered FujiLAM2 urine assay had suboptimal sensitivity but high specificity for diagnosing TB disease. Antigen-antibody/protein complexes may be present accounting for better sensitivity with cryopreserved specimens.</p><p><strong>Funding: </strong>National Institute of Neurologic Disorders and Stroke, National Institute of Allergy and Infectious Diseases, Wellcome Trust.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post antiretroviral treatment dynamics of blood EBV DNA among people with HIV: A prospective cohort study.","authors":"Xuan Yang, Xiaoxiao Chen, Weiwei Shen, Shanling Wang, Tingting Wang, Yating Wang, Haijiang Lin, Na He","doi":"10.1097/QAD.0000000000004214","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004214","url":null,"abstract":"<p><strong>Objective: </strong>Epstein-Barr virus (EBV) is linked to both AIDS-defining and non-AIDS defining malignancies. This study investigated the variation and trajectory of blood EBV DNA load after antiretroviral treatment (ART) among a prospective cohort of people with HIV (PWH).</p><p><strong>Design: </strong>Prospective, observational, noninterventional study.</p><p><strong>Methods: </strong>Newly diagnosed PWH in Taizhou, China (2012-2014) received ART and were followed until December 2022. Whole blood samples were periodically collected for EBV DNA quantification. We used a nonlinear mixed-effects model to analyze EBV DNA dynamics, K-means clustering to categorize EBV load patterns, and Cox regression to determine hazard ratios for shifts in EBV DNA detection.</p><p><strong>Results: </strong>658 PWH were enrolled at baseline, with 609 (2439 samples) included in cohort analysis. Detectable EBV DNA decreased from 86% at baseline (TP0) to 60% 7-10 years post-ART (TP4). 311 (51%) patients consistently maintained detectable EBV DNA. Among the 238 patients with detectable EBV DNA at TP4, 82.8% achieved suppressed HIV. EBV DNA load initially declined rapidly, then slowed post-ART. Two EBV DNA patterns were identified. Higher baseline CD4+ T cell count was associated with detectable EBV DNA at baseline, but with decreased EBV viral load and undetectable EBV DNA post-ART. Older age was associated with detectable EBV DNA and increased EBV viral load.</p><p><strong>Conclusions: </strong>Although EBV DNA load significantly declined, it remained detectable in most PWH, even those with suppressed HIV, which highlights the need for ongoing EBV monitoring in PWH. The predictive values of CD4+ T cell count and age underscore the importance of early diagnosis and ART initiation.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of environment and in utero HIV exposure on neurodevelopment in infants.","authors":"Andrea G Buchwald, Maria M Crespo-Llado, Limbika Maliwichi, Christabell Mdhluli, Victoria Mapemba, Stella Chifumbi, Meraby Funsani, Chimwemwe Kalengo, Gregory R Hancock, Miriam K Laufer, Melissa Gladstone","doi":"10.1097/QAD.0000000000004217","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004217","url":null,"abstract":"<p><strong>Objective: </strong>Estimate the independent contributions of in-utero HIV exposure and post-natal environment on neurodevelopment at 24 months of age.</p><p><strong>Methods: </strong>We recruited mother-infant pairs from 2018-2022 during the second trimester of pregnancy in Malawi. Children who were HIV exposed and uninfected (CHEU) and children unexposed to HIV and uninfected (CHUU) were followed to 24 months of age for neurodevelopmental outcomes. Environmental data was collected at 18 or 24 months.Neurodevelopment was measured using Malawi Developmental Assessment Tool, Communication Development Inventory, and Behavioural Rating Inventory of Executive Functions. Post-natal factors included maternal mental health, home learning environment, observed mother-child interactions, and socioeconomic status. Exploratory factor analysis and structural equation modeling were used to simultaneously estimate the impact of exposures on latent developmental outcomes.</p><p><strong>Results: </strong>There were 643 children with 24-month outcome data, 49% of which were CHEU. Three latent factors were identified for neurodevelopment: Language, Executive Function, and Child Development. The factors did not correlate closely with each other and had different biological and environmental drivers. Quality of mother-child interactions was the strongest predictor of Child Development (p < 0.001) and maternal mental health was a strong predictor of Executive Function (p < 0.001). Despite adjustment for all environmental variables, CHEUs had lower Child Development scores than CHUU (p = 0.01).Conclusions: Developmental scores of CHEU were lower than those of CHUU despite high maternal ART use, after accounting for post-natal environment. Despite this, the impact of high quality maternal-child interactions on child development outweighed the impact of HIV exposure on neurodevelopment in this population.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The health impact of spiritual intimate partner abuse among women living with HIV in Ghana.","authors":"Eric Y Tenkorang","doi":"10.1097/QAD.0000000000004221","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004221","url":null,"abstract":"<p><strong>Objective: </strong>Although understudied, anecdotal evidence suggests spiritual/religious intimate partner abuse may be prevalent among women living with HIV/AIDS in sub-Saharan Africa and Ghana. This paper examines the prevalence and effects of spiritual/religious intimate partner abuse-spiritual coercion and spiritual control-on the psychosocial (depression) and sexual health (unwanted pregnancies) outcomes of women living with HIV/AIDS in Ghana.</p><p><strong>Methods: </strong>Data were collected from 1,007 women living with HIV who attended Voluntary Counseling and Testing services at two district hospitals in the Lower Manya Krobo Municipality in the Eastern region of Ghana. Descriptive and multivariate logit models were used to examine the prevalence and impact of spiritual intimate partner abuse, measured as coercion and control on depression and unwanted pregnancies.</p><p><strong>Results: </strong>Results showed that about 36% of the participants reported spiritual coercion, and 27% experienced spiritual control. Those who experienced spiritual coercion were significantly more likely to report unwanted pregnancies than those who did not. Women who experienced spiritual control reported more likely to report depression than those who did not.</p><p><strong>Conclusion: </strong>Our findings suggest the need to educate Ghanaian women living with HIV about spiritual/religious intimate partner abuse and to screen this type of violence as part of HIV care.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between HIV and cancer risk: a nationwide, population-based cohort study.","authors":"Tak Kyu Oh, Kyoung-Ho Song, Eunjeong Heo, In-Ae Song","doi":"10.1097/QAD.0000000000004210","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004210","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to examine whether people living with human immunodeficiency virus (HIV) infection (PLWH) show different cancer incidences compared to individuals without HIV infection in South Korea.</p><p><strong>Design: </strong>Population-based cohort study.</p><p><strong>Methods: </strong>This study included all PLWH diagnosed with HIV infections in South Korea between January 1, 2017, and December 31, 2017. The 2017 PLWH number includes both new and previous HIV diagnoses. The prevalence of newly diagnosed acquired immune deficiency syndrome (AIDS)-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) were evaluated from January 1, 2018, to December 31, 2022, as endpoints.</p><p><strong>Results: </strong>Following 1:5 propensity score matching, 20,703 PLWH and 89,881 controls were included. The incidence rate of ADCs was 165.9 per 100,000 person-years in PLWH and 51.8 per 100,000 person-years in the controls. In the Cox regression analysis, PLWH had a 3.17-fold higher incidence of ADCs than in the controls (hazard ratio: 3.17, 95% confidence interval: 2.60, 3.86; P < 0.001). The incidence rate of NADCs was 1,614 per 100,000 person-years in PLWH and 1,888 per 100,000 person-years in the controls. In the Cox regression analysis, no significant difference was observed in the incidence of NADCs between PLWH and the control group (P = 0.101). However, PLWH showed a higher incidence of NADCs than in the controls for nasopharyngeal, anal, and non-melanoma skin cancers; Hodgkin lymphoma; and, leukemia.</p><p><strong>Conclusion: </strong>PLWH had a greater risk of ADCs than individuals without HIV infection. Among the NADCs, PLWH showed a greater risk of nasopharyngeal, anal, non-melanoma skin cancers; Hodgkin lymphoma; and, leukemia.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile human papillomavirus prevalence in circumcised sexual minority men living with and without HIV.","authors":"Nginache Nampota-Nkomba, Kareshma Mohanty, Ruxton Adebiyi, Charles Ekeh, Lisa M Schumaker, Kareemah T Suleiman, Laura Powell, Kara Lombardi, Nicholas P Ambulos, Elizabeth Shoyemi, Abdulwasiu B Tiamiyu, Michael G Homan, Mohammad M Sajadi, Søren M Bentzen, Kevin J Cullen, Trevor A Crowell, Rebecca G Nowak","doi":"10.1097/QAD.0000000000004209","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004209","url":null,"abstract":"<p><strong>Objective: </strong>Understanding the burden of penile human papillomavirus (HPV) among high-risk groups is essential to inform tailored prevention strategies to reduce HPV-related morbidity. We estimated the prevalence of penile HPV and its association with HIV among circumcised sexual minority men (SMM).</p><p><strong>Design: </strong>A cross-sectional study from a community-based cohort of SMM with and without HIV in Nigeria.</p><p><strong>Methods: </strong>Penile swabs were genotyped with a next-generation sequencing assay for any and high-risk HPV (HPV16/18/31/33/35/39/45/51/52/56/58/59/68). HIV status was ascertained using rapid diagnostic tests. Multivariable logistic regression models estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between HIV and any and high-risk penile HPV.</p><p><strong>Results: </strong>Among 498 participants, median age was 24 (interquartile range: 22-28) years and 70.5% (n = 351) were living with HIV. The prevalence of any (n = 362) and high-risk (n = 239) penile HPV was 72.7% [95% confidence interval (95% CI): 68.6-76.4] and 48.0% (95% CI: 43.6-52.4), respectively. The most common high-risk HPV types were 16, 51, 45, and 18, while the most common low-risk types were 6 and 11. HIV was significantly associated with increased odds of any penile HPV (aOR 1.93, 95% CI: 1.20-3.12). Similar to any HPV, the association of HIV with high-risk penile HPV trended in the positive direction (aOR 1.45, 95% CI: 0.96-2.27), but it was not statistically significant.</p><p><strong>Conclusion: </strong>Penile HPV and HIV were highly prevalent among circumcised SMM in Nigeria. The most prevalent strains were vaccine-preventable, highlighting the need to prioritize HPV vaccination for boys as an additional strategy to prevent HPV-related morbidities.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired autonomic cardiovascular control in people with HIV on long-term successful treatment.","authors":"Thomas Adriaan Bouwmeester, Iris A J van der Wulp, Yaw A Kusi Mensah, Ferdinand W N M Wit, Berend E Westerhof, Maarten F Schim van der Loeff, Henrike Galenkamp, Didier Collard, Marc van der Valk, Peter Reiss, Bert-Jan H van den Born","doi":"10.1097/QAD.0000000000004208","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004208","url":null,"abstract":"<p><strong>Objective: </strong>People with HIV have increased cardiovascular disease risk. Persistent inflammation and mitochondrial dysfunction are considered important contributors to impaired autonomic cardiovascular control, as evidenced by decreased baroreflex sensitivity (BRS) and heart rate variability (HRV). We assessed differences in cross-correlation BRS (xBRS) and HRV between people with and without HIV and explored associations with HIV-specific characteristics.</p><p><strong>Design: </strong>We included participants with and without HIV from the AGE h IV cohort study, and general population participants from the multi-ethnic HEalthy LIfe in an Urban Setting (HELIUS) study, all European males aged 50-70 years.</p><p><strong>Methods: </strong>Using a non-invasive continuous blood pressure measurement, we calculated xBRS and two HRV parameters (successive differences in normal-to-normal intervals (SDNN) and the root mean square of differences between successive normal-to-normal intervals (RMSSD)). Regression models, adjusted for traditional cardiovascular risk factors, assessed differences in xBRS and HRV between the participant groups and associated HIV-specific characteristics.</p><p><strong>Results: </strong>xBRS, SDNN and RMSSD were significantly higher in both control groups compared to participants with HIV. Longer time since HIV diagnosis and longer prior use of dideoxynucleosides and thymidine analogues were significantly associated with lower xBRS. Nadir CD4 count was positively associated with SDNN, while longer duration of thymidine analogue use was negatively associated with SDNN and prior use of dideoxynucleosides with lower RMSSD.</p><p><strong>Conclusions: </strong>Impaired autonomic cardiovascular control in men with HIV, potentially related to prior antiretroviral drug exposure and prior immunodeficiency, might contribute to HIV-associated cardiovascular disease risk.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}