AIDS最新文献

{"title":"Higher plasma concentrations of von Willebrand factor in women than in men during both the acute and chronic phases of HIV infection.","authors":"Kathia Beddek, Faroudy Boufassa, Christelliah Mouanga, Marie Bitu, Véronique Avettand-Fenoel, Olivier Lambotte, Laurence Meyer, Cécile Goujard, Nicolas Noel, Christine Bourgeois","doi":"10.1097/QAD.0000000000004253","DOIUrl":"10.1097/QAD.0000000000004253","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic HIV infection is associated with increased cardiovascular risk, presumably due to the impact of chronic inflammation and immune activation on the vascular endothelium. We explored endothelial activation markers in people living with HIV (PWH) chronically under antiretroviral therapy (ART) or with spontaneous viral control.</p><p><strong>Design: </strong>Studies on 50 samples collected from HIV controllers (HIC), 50 ART-treated participants (ART) (median duration of infection: 8 years) enrolled in cohort studies and 50 uninfected individuals. Forty-five additional samples collected during primary HIV infection (PHI) were also included.</p><p><strong>Method: </strong>The plasma levels of endothelial activation markers (vWF, sICAM-1, sVCAM-1, sE-Selectin, angiopoietin-1, angiopoietin-2) were determined by ELISA. Multivariate analyses were performed with adjustment for traditional confounding factors for cardiovascular diseases.</p><p><strong>Results: </strong>In univariate analysis, vWF and sICAM-1 concentrations were higher in PWH than in uninfected individuals. A sex-stratified analysis revealed higher vWF levels in ART-treated women than in HIC and uninfected women and ART-treated men. A sex-specific profile was also observed for sVCAM-1 that was higher in ART-treated women than in HIC and uninfected women, whereas no such pattern was observed in men. sICAM-1 levels were higher in male and female PWH, but this effect was essentially modulated by confounding factors. A sex-related impact on vWF and sVCAM-1 concentrations was also detected in PHI.</p><p><strong>Conclusion: </strong>vWF concentrations were higher in ART-treated women but not in men. This may reflect sex-differences in the sensitivity of the vascular endothelium during HIV infection. These results argue for closer cardiovascular monitoring in women living with HIV.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1558-1567"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional analysis of factors associated with low intrinsic capacity among Malaysians ageing with HIV in ambulatory care.","authors":"Siew Hwei Yap, Syaza Hisham, Wen Ying Ho, William Boon Wei Hor, Xin Woen Tan, Nurul Syuhada Zulhaimi, Jessica Seh Min Loh, Malinee Neelamegam, Kejal Hasmukharay, Han Cheng Ong, Reuben Robbins, Pui Li Wong, Reena Rajasuriar","doi":"10.1097/QAD.0000000000004246","DOIUrl":"10.1097/QAD.0000000000004246","url":null,"abstract":"<p><strong>Objective: </strong>Intrinsic capacity is a component of WHO's model for Health Ageing and a key determinant of an individual's functional ability as they age. However, little is known about what factors negatively influence intrinsic capacity among people with HIV (PWH).</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Method: </strong>Participants included PWH [≥35 years and on antiretroviral therapy (ART) for a minimum of 12 months] attending HIV care in University Malaya Medical Centre. Intrinsic capacity scores were computed based on five key domains (sensory, mobility, cognition, vitality, and mood). Pareto analyses were performed to determine the domains impaired in the majority of participants, and multivariable linear regression to explore factors associated with low intrinsic capacity.</p><p><strong>Results: </strong>The median age in the 202 PWH were 50 years [interquartile range (IQR): 44-57 years] and median intrinsic capacity score was 5.60 (IQR: 4.80-5.80, max 6). Deficits in vitality were observed in 52.8% of participants, followed by cognition (18.8%) and mood (18.1%). Factors associated with low intrinsic capacity scores after adjusting for demographic and socioeconomic factors included multimorbidity [-0.130, 95% confidence interval (CI): -0.181, -0.079, P  = 0.000] and polypharmacy (-0.077, 95% CI: -0.119, -0.036, P  = 0.000), metabolic syndrome (-0.360, 95% CI: -0.568, -0.153, P  = 0.001), renal disease (-0.450, 95% CI: -0.871, -0.029, P  = 0.036) and diabetes (-0.337, 95% CI: -0.590, -0.085, P  = 0.009), social isolation (0.021, 95% CI: 0.003, 0.039, P  = 0.025), loneliness (-0.063, 95% CI: -0.114, -0.013, P  = 0.014) and high high-sensitive C-reactive protein (hsCRP) (-0.028, 95% CI: -0.054, -0.002, P  = 0.034).</p><p><strong>Conclusion: </strong>Poor social connectedness and multimorbidity, particularly metabolic syndrome and renal disease, are significant risk factors for low intrinsic capacity scores among PWH in our setting. This study provides critical insights into potential strategies to improve trajectories of healthy ageing in PWH.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1524-1535"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-1 infection recency among individuals newly diagnosed with HIV in Greater Gaborone, Botswana.","authors":"Natasha O Moraka, Charity Ralegoreng, Goitseone M Lemogang, Richard Makwakwa, Marea N Pema, Patrick T Mokgethi, Ontlametse T Choga, Irene Gobe, Margaret Mokomane, Dorcas Maruapula, Salang T Moutswi, Laone Rabatoko, Queen Leteemane, Vanessa Strachan-Amaro, Phenyo Sabone, Terence Mohammed, Sikhulile Moyo, Simani Gaseitsiwe","doi":"10.1097/QAD.0000000000004239","DOIUrl":"10.1097/QAD.0000000000004239","url":null,"abstract":"<p><strong>Objective: </strong>We characterized individuals with HIV type 1 (HIV-1) recent infection using a two-step recent infection testing algorithm (RITA) in recently diagnosed, antiretroviral therapy (ART)-naive individuals within the Greater Gaborone area in Botswana.</p><p><strong>Design: </strong>Plasma samples from a prospective longitudinal cohort study of individuals recently diagnosed with HIV within the Greater Gaborone area (2023-2024), the Tekodiso study, were used.</p><p><strong>Methods: </strong>Recent infection classification was determined using Limiting Antigen Avidity (LAg-avidity), as well as HIV viral load greater than 1000 copies/ml. LAg-normalized optical density (ODn) 1.5 or less represented a recency window of within 130 days postinfection. HIV viral load in plasma was quantified by Abbott m2000sp/Abbott m2000rt.</p><p><strong>Results: </strong>A total of 157 participants were included in this analysis. Median age at enrolment was 34 years (Q1, Q3: 27, 41), and majority 102 (65%) were female. The median log 10 HIV viral load was 4.6 copies/ml (Q1, Q3: 3.9, 5.2). A total of 12 of 157: 7.6% [95% confidence interval (CI) 4.0-13] individuals were classified as having a recent infection. Recent infection was not associated with age, employment status, or nationality. We observed a lower likelihood of recent HIV infection with secondary or higher education level (OR = 0.1; 95% CI: 0.1- 0.9).</p><p><strong>Conclusion: </strong>We report a 7.6% rate of HIV recent infection by LAg-based RITA in recently diagnosed ART-naive individuals in Botswana. Our results highlight the need for continued HIV infection surveillance to improve targeted interventions for the prevention of HIV acquisition within the country.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1518-1523"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subpopulations with frequent healthcare barriers have increased risk of sexually transmitted infections and dropping out from HIV preexposure prophylaxis care.","authors":"Eline S Wijstma, Vita W Jongen, Anders Boyd, Henry J C De Vries, Maarten F Schim Van Der Loeff, Maria Prins, Elske Hoornenborg","doi":"10.1097/QAD.0000000000004224","DOIUrl":"10.1097/QAD.0000000000004224","url":null,"abstract":"<p><strong>Objective: </strong>Certain subpopulations (i.e., <25 years, transgender, sex worker, uninsured or migrant) were prioritized for inclusion in the Dutch preexposure prophylaxis (PrEP) pilot. We compared incidence of sexually transmitted infections (STI) during and drop-out from HIV PrEP care between prioritized and nonprioritized subpopulations.</p><p><strong>Design: </strong>Retrospective longitudinal study using routinely collected data at the Centre for Sexual Health Amsterdam, 2019-2024.</p><p><strong>Methods: </strong>We modelled incidence rates (IR) for any STI while on PrEP using Poisson regression, adjusting for testing frequency and calendar time. We modelled the probability of early loss-to-follow-up (LTFU) (i.e., no PrEP follow-up visit within 12 months of enrolment) using logistic regression, adjusting for sexual behaviour. We modelled the probability of later LTFU (i.e., no PrEP visit within 12 months of a prior PrEP follow-up visit) using competing risk regression, adjusting for sexual behaviour. We added subpopulations as indicator variables to all models to compare endpoints between groups.</p><p><strong>Results: </strong>Of 4781 individuals included (median age 32 years, IQR = 26-40), 50.2% ( n = 2402) belonged to prioritized subpopulations. The IR of any STI was 101.6/100 person-years. STI IR were higher among those belonging to prioritized groups (except for the transgender group). 494 individuals had early LTFU, which was associated with age <25 years, reporting sex work, and being a migrant. Later LTFU occurred 933 times and was associated with age <25 years, being transgender, and reporting sex work.</p><p><strong>Conclusion: </strong>People belonging to prioritized subpopulations had more STIs and were more often LTFU from PrEP care. Targeted interventions to support PrEP retention and prevent STIs are needed.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1610-1620"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level viremia linked to virological failure but not clinical events.","authors":"Enrique Bernal, Rodrigo Martínez-Rodríguez, José Miguel Gómez, Cristina Tomás, Eva García-Villalba, Salvador Valero, Ángeles Muñoz, Antonia Alcaraz, Cristina Díez, Lucio J García-Fraile, Teresa Gómez-García, María Navarro-Marcotegui, María Remedios Alemán-Valls, Julián Olalla, Mar Masiá, Félix Gutiérrez","doi":"10.1097/QAD.0000000000004248","DOIUrl":"10.1097/QAD.0000000000004248","url":null,"abstract":"<p><strong>Introduction: </strong>The main objective of antiretroviral therapy (ART) for people with HIV (PWH) is to maintain an undetectable viral load. This study evaluates the association between low-level viremia (LLV) (50-200 copies/ml) and virological failure, AIDS, and severe non-AIDS events, as well as the impact of sociodemographic and clinical factors.</p><p><strong>Materials and methods: </strong>Data were collected from the Spanish HIV/AIDS research network (CoRIS), comprising ART-naive adults recruited from 47 centers across Spain. Eligible participants were those who achieved viral suppression (viral load <200 copies/ml) within 3-9 months post-ART initiation and had follow-up data. Participants were classified into two groups: No-LLV (viral load ≤50 copcies/ml or a single measurement >51 but <1000 copies/ml) and LLV1 (51-199 copies/ml in two consecutive measurements). The outcomes included virological failure, AIDS, and severe non-AIDS events (NAE). Statistical analyses involved Competing risk analysis and multinomial logistic regression.</p><p><strong>Results: </strong>Of 12 110 participants, 89.7% were No-LLV and 10.3% LLV1. LLV groups had higher median age and lower CD4 + counts. Virological failure occurred in 12.3% of LLV1 compared to 4.68% in the No-LLV group ( P  < 0.001). In the competitive risk analysis, the hazard ratio for virological failure of LLV1 was 1.39 [97.5% confidence interval (CI) 1.28-1.53, P  < 0.0001], ART from 2016 to 2021 was 0.70 (97.5% CI 0.64-0.77, P  < 0.001), ART with protease inhibitor was 1.09 (97.5% CI 1.01-1.19, P  < 0.001), HIV viral load at least 100 000 copies/ml 1.17 (97.5% CI, 1.01-1.35; P  = 0.036) and CD4 + cell count greater than 200 cells/μl was 0.73 (97.5% CI 0.61-0.87, P  < 0.001). LLV1 were not associated with an increased risk of AIDS, mortality or NAE.</p><p><strong>Conclusion: </strong>LLV (50-200 copies/ml) was associated with an increased risk of virological failure. However, it was not linked to a higher likelihood of clinical events (AIDS-related, non-AIDS-related, or death). Therefore, while close monitoring is necessary due to the risk of virological failure, these findings provide reassurance as LLV does not translate into adverse clinical outcomes.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1545-1557"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in adolescents with HIV.","authors":"Sampson Antwi, Hongmei Yang, Anthony Enimil, Charles Martyn-Dickens, Albert Dompreh, Eugenia Sly-Moore, Dennis Bosomtwe, Aikins Kofi Amissah, Oluwayemisi Ojewale, Priscilla Asiedu, Augustina Frimpong Appiah, Theresah Opoku, Ama D Sarfo, Isaac Kusi-Amponsah, Lane R Bushman, Lucas Ellison, Peter L Anderson, Awewura Kwara","doi":"10.1097/QAD.0000000000004245","DOIUrl":"10.1097/QAD.0000000000004245","url":null,"abstract":"<p><p>We investigated whether tenofovir diphosphate (TFV-DP) concentration in dried blood spot (DBS) predicted future virologic outcome. Of 52 adolescents with HIV, 46% had virologic suppression, and 44% had virologic failure. TFV-DP concentration in DBS was associated with virologic suppression but not virologic failure. Twenty-six percentage of participants with virologic failure had high levels of antiretroviral adherence at earlier visits. Virologic failure in the setting of high adherence may suggest the presence of HIV drug resistance.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 11","pages":"1668-1671"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rollback on PEPFAR will have far-reaching consequences in global health.","authors":"Faraan O Rahim, Nam T Nguyen, Jason K Chen, Erick V Mahatara, Blandina T Mmbaga, Patrick Ndeba, Philip Bakahirwa, Fernand Rwamwejo, Brandon A Knettel","doi":"10.1097/QAD.0000000000004256","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004256","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 11","pages":"1663-1665"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving data on heart failure reshape prevention and treatment strategies for people with HIV.","authors":"Iulia Filip","doi":"10.1097/QAD.0000000000004299","DOIUrl":"10.1097/QAD.0000000000004299","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"N15-N16"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the clinical implications of low-level viremia in ART-treated individuals.","authors":"Brian Conway, Pablo Tebas, Laurence Slama","doi":"10.1097/QAD.0000000000004291","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004291","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 11","pages":"1656-1657"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced bone density accrual among peripubertal boys with HIV in Zimbabwe: Erratum.","authors":"Lisha Jeena, Rashida A Ferrand, Victoria Simms, Cynthia Kahari, Tsitsi Bandason, Ruramayi Rukuni, Andrea M Rehmand, Sarah Rowland-Jones, Anthony Y Y Hsieh, Celia L Gregson","doi":"10.1097/01.aids.0001125364.32857.80","DOIUrl":"https://doi.org/10.1097/01.aids.0001125364.32857.80","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 11","pages":"1674-1675"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}