The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)最新文献_第3页

Characteristic and Import Mechanism of Protein Nuclear Translocation. 蛋白质核转运的特征和导入机制

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2024-03-28 DOI: 10.3290/j.cjdr.b5136729

Zi Yan Sun, Zhi Peng Fan

引用次数: 0

Editorial. 社论

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2024-03-28 DOI: 10.3290/j.cjdr.b5146731

Chuan-Bin Guo

引用次数: 0

Preserving Natural Teeth to Maintain Oral Health. 保护天然牙齿，保持口腔健康。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2024-03-28 DOI: 10.3290/j.cjdr.b5139365

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The Role of DSPP in Dentine Formation and Hereditary Dentine Defects. DSPP 在牙本质形成和遗传性牙本质缺陷中的作用

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2024-03-28 DOI: 10.3290/j.cjdr.b5136791

Jie Jia, Zhuan Bian, Yaling Song

引用次数: 0

Integrative Multi-omics Analysis Identifies Genetic Variants Contributing to Non-syndromic Cleft Lip with or without Cleft Palate. 多组学综合分析确定了导致非综合征性唇裂伴或不伴有腭裂的基因变异。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2024-03-28 DOI: 10.3290/j.cjdr.b5136745

Shu Lou, Jing Yang, Gui Rong Zhu, Dan Dan Li, Lan Ma, Lin Wang, Yong Chu Pan

{"title":"Integrative Multi-omics Analysis Identifies Genetic Variants Contributing to Non-syndromic Cleft Lip with or without Cleft Palate.","authors":"Shu Lou, Jing Yang, Gui Rong Zhu, Dan Dan Li, Lan Ma, Lin Wang, Yong Chu Pan","doi":"10.3290/j.cjdr.b5136745","DOIUrl":"10.3290/j.cjdr.b5136745","url":null,"abstract":"Objective: To provide novel insights into the aetiology of non-syndromic cleft lip with or without cleft palate (NSCL/P) by integrating multi-omics data and exploring susceptibility genes associated with NSCL/P.Methods: A two-stage genome-wide association study (GWAS) of NSCL/P was performed, involving a total of 1,069 cases and 1,724 controls. Using promoter capture Hi-C (pCHi-C) datasets in human embryonic stem cells (hESC) and chromatin immunoprecipitation sequencing (ChIP-seq) in craniofacial tissues, we filtered out single nucleotide polymorphisms (SNPs) with active cis-regulation and their target genes. Additionally, we employed expression quantitative trait loci (eQTL) analysis to identify candidate genes.Results: Thirteen SNPs were identified as cis-regulation units associated with the risk of NSCL/P. Five of these were proven to be active in chromatin states in early human craniofacial development (rs7218002: odds ratio [OR] 1.50, P = 8.14E-08; rs835367: OR 0.78, P = 3.48E- 05; rs77022994: OR 0.55, P = 1.05E-04; rs961470: OR 0.73, P = 1.38E-04; rs17314727: OR 0.73, P = 1.85E-04). Additionally, pCHi-C and eQTL analysis prioritised three candidate genes (rs7218002: NTN1, rs835367: FGGY, LINC01135). NTN1 and FGGY were expressed in mouse orofacial development. Deficiencies in NTN1, FGGY and LINC01135 were associated with cleft palate and cleft lip, abnormal facial shape and bifid uvula, and abnormality of the face, respectively.Conclusion: Our study identified five SNPs (rs7218002, rs835367, rs77022994, rs961470 and rs17314727) and three susceptibility genes (NTN1, FGGY and LINC01135) associated with NSCL/P. These findings contribute to a better understanding of the genetic factors involved.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"27 1","pages":"65-73"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge Mapping of Cowden Syndrome: a Bibliometric Analysis. 考登综合征的知识图谱：文献计量分析。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2024-03-28 DOI: 10.3290/j.cjdr.b5136733

Qiao Peng, Ning Duan, Xiang Wang, Wen Mei Wang

{"title":"Knowledge Mapping of Cowden Syndrome: a Bibliometric Analysis.","authors":"Qiao Peng, Ning Duan, Xiang Wang, Wen Mei Wang","doi":"10.3290/j.cjdr.b5136733","DOIUrl":"10.3290/j.cjdr.b5136733","url":null,"abstract":"Objective: To provide a comprehensive overview of the current knowledge structure and research hotspots of Cowden syndrome via bibliometrics.Methods: The articles and reviews related to Cowden syndrome were included from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace and GraphPad Prism were used to conduct the bibliometric analysis.Results: The number of papers focusing on Cowden syndrome was relatively low initially but increased rapidly from 1997 to 1999, and then maintained small-scale fluctuation. A total of 1,557 papers from 65 countries/regions and 1,762 institutions were identified. The USA was the most productive country, and Ohio State University was the most productive institution. In terms of the number of publications, Human Molecular Genetics ranked first, and Cancer Research was the most frequently cited journal. Eng was the most productive author, and Liaw was the most co-cited author. Phosphatase and tensin homologue (PTEN), germline mutations, gene, cancer, mutations, tumour suppressor gene and breast were high-frequency key words in this field.Conclusion: This study was the first comprehensive bibliometric overview of the current state and development of Cowden disease. The mutation of PTEN and associated cancers, especially breast, thyroid and endometrial cancer, could be the focus of future research in this field.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"27 1","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Genetic Analysis of Multiple Idiopathic Cervical Root Resorption. 多发性颈椎根吸收的临床和遗传分析

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2024-03-28 DOI: 10.3290/j.cjdr.b5128703

Yu Meng Wang, Wen Yan Ruan, Dan Dan Chi, Xiao Hong Duan

{"title":"Clinical and Genetic Analysis of Multiple Idiopathic Cervical Root Resorption.","authors":"Yu Meng Wang, Wen Yan Ruan, Dan Dan Chi, Xiao Hong Duan","doi":"10.3290/j.cjdr.b5128703","DOIUrl":"10.3290/j.cjdr.b5128703","url":null,"abstract":"Objective: To explore the genetic background and clinical phenotypes of multiple idiopathic cervical root resorption (MICRR) in a Chinese family.Methods: The proband and his three family members were clinically examined and had radiographs taken with a radiovisiography (RVG) system and CBCT to define the diagnosis of MICRR. Genomic DNA (gDNA) was extracted from peripheral blood samples of the patient, his father, mother and younger sister for whole exome sequencing (WES). The pathogenicity of rare variants with minor allele frequency (MAF) less than 0.005 were analysed following possible inheritance patterns, predicted results from 12 software programs, the American College of Medical Genetics (ACMG) 2015 criteria, and information from ClinVar, OMIM and HGMD databases as well as gene function.Results: The proband presented the typical MICRR phenotypes such as thin cervical pulp wall and apple core-like lesions in radiographs. Following the recessive inheritance pattern, WES analysis identified SHROOM2, SYTL5, MAGED1 and FLNA with a higher chance of causing MICRR. Four genes with compound heterozygous variants and another 27 genes with de novo variants either in autosomal-dominant or autosomal-recessive pattern were also found to have the potential pathogenicity.Conclusion: A total of 35 novel potential pathogenic genes were found to be associated with MICRR from a Chinese family through WES. The new genetic background of MICRR may be helpful for clinical and molecular diagnosis.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"27 1","pages":"89-99"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Sealer Remnants Using a Bioceramic Sealer Single-cone Technique after Post Space Preparation and its Influence on the Adhesion of Fibre Posts in vitro. 使用生物陶瓷封闭剂单锥技术评估空间预备后的封闭剂残留及其对纤维桩体体外附着力的影响。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2023-12-21 DOI: 10.3290/j.cjdr.b4784043

Di Qiao, Meng Meng Zhu, Jie Pan

{"title":"Evaluation of Sealer Remnants Using a Bioceramic Sealer Single-cone Technique after Post Space Preparation and its Influence on the Adhesion of Fibre Posts in vitro.","authors":"Di Qiao, Meng Meng Zhu, Jie Pan","doi":"10.3290/j.cjdr.b4784043","DOIUrl":"https://doi.org/10.3290/j.cjdr.b4784043","url":null,"abstract":"Objective: To compare calcium silicate-based endodontic sealer and epoxy resin-based sealer remnants on root canal walls after post space preparation and their influence on the bond strength of fibre posts fixed with a dual-cured resin cement.Methods: Thirty-six extracted single-root mandibular premolars were instrumented and divided randomly into two equal groups with different endodontic sealers. iRoot SP (Innovative BioCeramix, Vancouver, Canada) was employed in the experimental group and AH Plus (Dentsply Sirona, Charlotte, NC, USA) was used in the control group. Sealer remnants were observed under an endodontic microscope after root canal therapy and post space preparation. Fibre posts were fixed with dual-cured resin cement. Specimens were taken at each third of the post space. The push-out bond strength was measured using a universal testing machine and fracture modes were assessed. Statistical analysis was performed using an independent samples t test and one-way analysis of variance.Results: There was no statistically significant difference in bond strength of fibre posts between the control and experimental group (P > 0.05); however, sealer remnants were observed in 38.9% of the samples treated with iRoot SP and none of the samples treated with AH Plus. The major fracture mode in samples treated with iRoot SP was adhesive failure between the resin cement and the post, and no adhesive failure between the resin cement and dentine occurred at the site of the sealer remnant. The presence of iRoot SP remnants on the root canal walls after post space preparation did not interfere with bonding.Conclusion: iRoot SP is a viable option for root canal obturation before fibre post cementation.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"26 4","pages":"249-256"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Models in Dentine Development and Regeneration. 牙本质发育和再生研究模型。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2023-12-21 DOI: 10.3290/j.cjdr.b4784033

Ya Lu Sun, Xi Heng Li, Shuang Shuang Wang, Hu En Li, Bei Chang, Hong Chen Sun

{"title":"Research Models in Dentine Development and Regeneration.","authors":"Ya Lu Sun, Xi Heng Li, Shuang Shuang Wang, Hu En Li, Bei Chang, Hong Chen Sun","doi":"10.3290/j.cjdr.b4784033","DOIUrl":"https://doi.org/10.3290/j.cjdr.b4784033","url":null,"abstract":"Dentine is a major component of teeth and is responsible for many of their functions, such as mastication and neural sensation/transduction. Over the past decades, numerous studies have focused on dentine development and regeneration using a variety of research models, including in vivo, ex vivo and in vitro models. In vivo animal models play a crucial role in the exploration of biochemical factors that are involved in dentine development, whereas ex vivo and in vitro models contribute mainly to the identification of biophysical factors in dentine regeneration, of which mechanical force is most critical. In the present review, research models involved in studies related to dentine development and regeneration were screened from publications released in recent years and summarised comprehensively, particularly in vivo animal models including prokaryotic microinjection, Cre/LoxP, CRISPR/Cas9, ZFN and TALEN, and scaffold-based in vitro and ex vivo models. The latter were further divided by the interactive forces. Summarising these research models will not only benefit the development of future dentine-related studies but also provide hints regarding the evolution of novel dentine regeneration strategies.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"26 4","pages":"195-208"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Powered versus Manual Tooth Brushing for Safety and Efficacy in Patients with Gingivitis: A Randomised, Multicentre Clinical Trial in China. 牙龈炎患者电动刷牙与手动刷牙在安全性和有效性方面的比较：中国多中心随机临床试验》。

The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2023-12-21 DOI: 10.3290/j.cjdr.b4784023

Dan Ying Tao, Yan Si, Tao Hu, Shu Guo Zheng, Han Jiang, Ye Tao, Yan Zhou, Fang Zhi Zhu, Bao Jun Tai, Xi Ping Feng

{"title":"Comparison of Powered versus Manual Tooth Brushing for Safety and Efficacy in Patients with Gingivitis: A Randomised, Multicentre Clinical Trial in China.","authors":"Dan Ying Tao, Yan Si, Tao Hu, Shu Guo Zheng, Han Jiang, Ye Tao, Yan Zhou, Fang Zhi Zhu, Bao Jun Tai, Xi Ping Feng","doi":"10.3290/j.cjdr.b4784023","DOIUrl":"10.3290/j.cjdr.b4784023","url":null,"abstract":"Objective: To evaluate the effects of powered and manual tooth brushing on gingival inflammation in a Chinese population with mild to moderate gingivitis.Methods: The present randomised, single-blind, parallel clinical trial was conducted in five cities in China. Generally healthy participants aged 18 to 65 years, who were non-smokers and had at least 20 sites of gingival bleeding, were included as eligible subjects. The subjects were randomly assigned to either the powered tooth brushing (PTB) group or standard manual tooth brushing (MTB) group. All subjects were supplied with a fluoride-containing toothpaste, Gingival Bleeding Index (GBI), Modified Gingival Index (MGI) and the Turesky modification of the Quigley-Hein Plaque Index (MPI) were used to evaluate the outcomes.Results: A total of 235 subjects completed the study, 118 in the PTB group and 117 in the MTB group. The mean age and sex distribution for the PTB and MTB groups were 34.40 ± 9.99 years, 89 women and 29 men, and 34.20 ± 10.14 years, 82 women and 35 men, respectively. After 6 months, the percentage decrease in MGI was 26.150% ± 26.897% for the PTB group and 14.768% ± 38.544% for the MTB group (P = 0.0092). Statistically significant differences between types of tooth brushing were also observed at 6 months for GBI, and at all time points for MPI.Conclusion: Tooth brushing with a powered toothbrush twice a day was shown to be more effective than use of a manual toothbrush in reducing gingival inflammation, gingival bleeding and surface plaque after a 6-month period. Both kinds of toothbrushes were safe for the oral tissues.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"26 4","pages":"257-264"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0