The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)最新文献_第2页

Odonto-hypophosphatasia with Tooth Agenesis: a Case Report. 牙髓-低磷发育伴牙齿发育1例。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-06-30 DOI: 10.3290/j.cjdr.b7044066

Tao Yun Xu, Xin Yue Guo, Bai Ze Zhang, Xiao Hong Duan

引用次数: 0

Cephalometric Norms for Chinese Individuals Based on Expert Consensus Evaluation of Lateral Cephalometric Radiographs. 基于侧位头颅x线片专家共识评价的中国个体头颅测量规范。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-06-30 DOI: 10.3290/j.cjdr.b7044059

Han Wei Zheng, Chen Da Meng, Huan Huan Chen, Guang Ying Song, Yue Lai, Bing Han, Tian Min Xu

{"title":"Cephalometric Norms for Chinese Individuals Based on Expert Consensus Evaluation of Lateral Cephalometric Radiographs.","authors":"Han Wei Zheng, Chen Da Meng, Huan Huan Chen, Guang Ying Song, Yue Lai, Bing Han, Tian Min Xu","doi":"10.3290/j.cjdr.b7044059","DOIUrl":"10.3290/j.cjdr.b7044059","url":null,"abstract":"Objective: To establish cephalometric normative reference values based on the subjective consensus of Chinese orthodontic experts regarding the evaluation of lateral cephalometric radiographs.Methods: This study included 120 patients in the permanent dentition stage who visited the Department of Orthodontics at Peking University School and Hospital of Stomatology between 2022 and 2025. The participants were divided into two groups: an adolescent group (n = 60, aged 14.40 ± 1.70 years, 30 boys and 30 girls) and an adult group (n = 60, aged 24.33 ± 5.65 years, 30 men and 30 women). Lateral cephalometric radiographs were analysed by two PhD students and one postdoctoral researcher from the Department of Orthodontics. Through statistical analysis, cephalometric normative values were established for Tweed, Downs, Steiner and Peking University analysis methods as well as for soft tissue measurements, and comparisons were made between the two age groups.Results: A reference standard for cephalometric normative values was developed, reflecting the consensus of Chinese orthodontic experts in assessing profile harmony. Significant differences (P 0.05) were identified between the adolescent and adult groups in the normative values of FMA (MPA), GoGN/SN, SE and G-Sn-Pos.Conclusion: Expert consensus evaluation of lateral cephalometric radiographs provides a more objective basis for identifying harmonious samples. This enables the derivation of more accurate cephalometric normative values for sagittal skeletal measurements and soft tissue parameters.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 2","pages":"151-161"},"PeriodicalIF":0.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Hydrogels for Intraoral Wound Care: Research Progress and Design Strategies. 口腔内伤口护理用功能性水凝胶：研究进展与设计策略。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-06-30 DOI: 10.3290/j.cjdr.b7044034

Zi Xin Pan, Wen Jie Ma, Chao Si, Chun Ru Kong, Jia Kai Qiao, Xiao Duo Tang, Bei Chang, Hong Chen Sun

{"title":"Functional Hydrogels for Intraoral Wound Care: Research Progress and Design Strategies.","authors":"Zi Xin Pan, Wen Jie Ma, Chao Si, Chun Ru Kong, Jia Kai Qiao, Xiao Duo Tang, Bei Chang, Hong Chen Sun","doi":"10.3290/j.cjdr.b7044034","DOIUrl":"https://doi.org/10.3290/j.cjdr.b7044034","url":null,"abstract":"Oral soft tissue defects resulting from trauma, infections, tumour resection or congenital disorders present significant clinical challenges, impairing functions like mastication, speech and aesthetics. Current therapeutic approaches, including free gingival grafts (FGGs) and connective tissue grafts (CTGs), are associated with certain clinical limitations, such as donor site morbidity and structural fragility. Hydrogels are attractive biomaterials for oral soft tissue repair owing to their biocompatibility, tunable mechanics and extracellular matrix-mimicking properties. This review comprehensively explores hydrogel applications in oral wound healing, focusing on the histological structure of oral mucosa and unique challenges of the oral environment; design strategies using natural and synthetic polymers; advanced manufacturing strategies, such as 3D bioprinting, electrospinning and microfluidic organ-on-a-chip technology; and therapeutic applications in mucosa repair, gingival regeneration and periodontal therapy.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 2","pages":"91-118"},"PeriodicalIF":0.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Labial-lingual Inclination of Maxillary Incisors on Aesthetic Assessment for Smile Profiles with Different Chin Positions. 上颌切牙唇舌倾斜度对不同颌位微笑轮廓美学评价的影响。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-06-30 DOI: 10.3290/j.cjdr.b7044060

Rui Ying Han, Fu Shuang Liu, Eunice Chan Jie Yu, Bin Li, Yi Kai He, Wan Xi Chen, Tian Yi Wang, Ding Bai, Yong Wen Guo

{"title":"Effect of Labial-lingual Inclination of Maxillary Incisors on Aesthetic Assessment for Smile Profiles with Different Chin Positions.","authors":"Rui Ying Han, Fu Shuang Liu, Eunice Chan Jie Yu, Bin Li, Yi Kai He, Wan Xi Chen, Tian Yi Wang, Ding Bai, Yong Wen Guo","doi":"10.3290/j.cjdr.b7044060","DOIUrl":"10.3290/j.cjdr.b7044060","url":null,"abstract":"Objective: To explore and visualise how different degrees of labio-lingual inclination of the maxillary incisors affect the aesthetic assessment of smiling profiles in people with various chin positions. Different perceptions from professionals and non-professionals are outlined in this study.Methods: A profile photograph with a clear facial contour and a full smile was captured and then edited into a series of 49 smiling profile pictures, with seven variations in both chin position and maxillary incisor inclination. A MaxDiff survey was conducted to rank the photos according to the aesthetic preference of orthodontists and laypeople. The data were then evaluated using count analysis and hierarchical Bayes estimation.Results: Upright and mild lingual inclination (0 to 5 degrees) of the maxillary incisors generally gained higher acceptance in both groups when chin protrusion was not taken into consideration, whereas the opposite was true for labial inclination. The acceptance of excessive lingual inclination (10 to 15 degrees) of the central incisor in laypeople was significantly higher than in orthodontists. Both groups suggested that as chin retrusion increases (6 mm), increasing maxillary incisor lingual inclination (10 degrees) is preferred. When chin retrusion was greater (6 mm), upright or mild lingual inclination (0 to 5 degrees) was considered acceptable by orthodontists, but greater lingual inclination (5 to 15 degrees) was also acceptable by laypeople.Conclusion: Both labio-lingual inclination of maxillary incisors and chin position play an essential role in the aesthetic assessment of smile profiles. The ideal value for maxillary incisor inclination varies with chin position.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 2","pages":"163-174"},"PeriodicalIF":0.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert Consensus on Clinical Application for Digital Full-contour High-translucent/Ultra-translucent Zirconia Restorations. 数字全轮廓高半透明/超半透明氧化锆修复体临床应用专家共识

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-06-30 DOI: 10.3290/j.cjdr.b7044042

Shi Ming Liu, Ya Ke Wang, Chen Min Yao, Jie Fei Shen, Wei Cai Liu, Li Na Niu, Chun Xu, Chu Fan Ma, Zhe Wu, Ke Zhao, Dan Dan Pei, Hong Bo Li, Ya Ming Chen, Yu Wei Wu, Jun Ling Wu, Xiao Dan Sun, Hai Lin Liu, Fei Lie Zhong, Zhuo Qun Yan, Hai Yan Wu, Mou Shan Liu, Hong Chang Lai, Jun Yu Shi, Zhong Hao Liu, Yi Man, Feng Liu, Cui Huang

{"title":"Expert Consensus on Clinical Application for Digital Full-contour High-translucent/Ultra-translucent Zirconia Restorations.","authors":"Shi Ming Liu, Ya Ke Wang, Chen Min Yao, Jie Fei Shen, Wei Cai Liu, Li Na Niu, Chun Xu, Chu Fan Ma, Zhe Wu, Ke Zhao, Dan Dan Pei, Hong Bo Li, Ya Ming Chen, Yu Wei Wu, Jun Ling Wu, Xiao Dan Sun, Hai Lin Liu, Fei Lie Zhong, Zhuo Qun Yan, Hai Yan Wu, Mou Shan Liu, Hong Chang Lai, Jun Yu Shi, Zhong Hao Liu, Yi Man, Feng Liu, Cui Huang","doi":"10.3290/j.cjdr.b7044042","DOIUrl":"10.3290/j.cjdr.b7044042","url":null,"abstract":"This expert consensus addressed the use of digital full-contour high-translucent/ultra-translucent (HT/UT) zirconia restorations. HT/UT zirconia, stabilised with 4 mol% to 6 mol% yttria, balances flexural strength (550 to 1100 MPa) and enhanced translucency (45% to 55% light transmission) through a cubic-tetragonal microstructure while maintaining excellent biocompatibility and aging resistance. Clinical applications include single crowns, short-span bridges, veneers (0.3 to 1.0 mm) and implant-supported prostheses (screw-/cement-retained with specific thickness requirements). The digital workflow involves precise preparation, digital impressions, computer-aided design, milling, sintering and post-processing (surface polishing to Ra ≤ 0.25 μm). A lack of unified standards causes variable practices in the clinic. This consensus provides guidelines to standardise procedures, promoting predictable quality and long-term success of HT/UT zirconia restorations.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 2","pages":"129-149"},"PeriodicalIF":0.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment and Validation of an Early Childhood Caries Prediction Model: a Multicentre Prospective Cohort Study. 儿童早期龋齿预测模型的建立与验证：一项多中心前瞻性队列研究。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-03-18 DOI: 10.3290/j.cjdr.b6953767

Yan Si, Han Jiang, Bao Jun Tai, Yi Zhen Yu, Li Cheng, Xi Chen, Yan Zhou, Si Si Wang, Tao Hu, Wen Hui Wang, Xi Peng Feng, Huan Cai Lin

{"title":"Establishment and Validation of an Early Childhood Caries Prediction Model: a Multicentre Prospective Cohort Study.","authors":"Yan Si, Han Jiang, Bao Jun Tai, Yi Zhen Yu, Li Cheng, Xi Chen, Yan Zhou, Si Si Wang, Tao Hu, Wen Hui Wang, Xi Peng Feng, Huan Cai Lin","doi":"10.3290/j.cjdr.b6953767","DOIUrl":"10.3290/j.cjdr.b6953767","url":null,"abstract":"Objective: To establish a risk assessment model for early childhood caries and verify its credibility.Methods: This 1-year multicentre cohort study comprised cohorts of 3-year-old children with and without caries recruited from kindergartens in Beijing, Shanghai, Sichuan, Hubei and Guangdong. Oral disease-related social and behavioural risk factors were collected from both children and their parents using questionnaires. Clinical examinations were performed according to World Health Organization standards, and the plaque's ability to produce acid, saliva pH value and saliva-buffering capacity were assessed. Logistic regression methods were employed to construct a risk-prediction model for caries incidence. Cross-validation methods were applied for the internal validation of the model, and the area under the curve (AUC) and calibration curves were used to evaluate the predictive performance of the constructed model.Results: A total of 4,381 children were included in the study and randomly allocated 1:1 to the development and validation sets. Using the new occurrence of decayed, missing and filled surfaces as the dependent variable, the predictive model demonstrated AUCs of 0.83 (95% confidence interval [CI] 0.81 to 0.84) in the development model and 0.80 (95% CI 0.78 to 0.82) in the validation model at 1 year. The training and validation sets exhibited high sensitivity (0.69 to 0.72) and specificity (0.73 to 0.81).Conclusion: The predictive models demonstrated good discriminability with both the training and validation sets and were suitable for primary oral care clinicians and stomatological hospitals.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 1","pages":"39-49"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Morphogenetic Protein Receptor Type II Promotes Odontogenic Differentiation of Human Dental Pulp Stem Cells Via Runt-related Transcription Factor 2. 骨形态发生蛋白受体II型通过矮子相关转录因子2促进人牙髓干细胞成牙分化。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-03-18 DOI: 10.3290/j.cjdr.b6953746

Jing Lei Zheng, Kai Sun, Bi Chen Lin, Hang Bo Liu, Lan Xin Su, Hao Chen Liu, Hai Lan Feng, Yang Liu, Miao Yu, Dong Han

{"title":"Bone Morphogenetic Protein Receptor Type II Promotes Odontogenic Differentiation of Human Dental Pulp Stem Cells Via Runt-related Transcription Factor 2.","authors":"Jing Lei Zheng, Kai Sun, Bi Chen Lin, Hang Bo Liu, Lan Xin Su, Hao Chen Liu, Hai Lan Feng, Yang Liu, Miao Yu, Dong Han","doi":"10.3290/j.cjdr.b6953746","DOIUrl":"10.3290/j.cjdr.b6953746","url":null,"abstract":"Objective: To investigate the molecular mechanism by which bone morphogenetic protein receptor type 2 (BMPR2) regulates the odontogenic differentiation of dental pulp stem cells.Methods: Human dental pulp stem cells (hDPSCs) with lentiviral vector-mediated BMPR2 overexpression and knockdown were generated. Cell proliferation was assessed using a cell counting kit-8 assay. The odontogenic differentiation potential of hDPSCs was examined using alkaline phosphatase and alizarin red S staining. The expression of odontogenic differentiation markers and critical mediators of bone morphogenetic protein (BMP)-suppressor of mothers against decapentaplegic (SMAD) signalling was analysed using real-time quantitative polymerase chain reaction and western blotting.Results: BMPR2 overexpression promoted odontogenic differentiation of hDPSCs but suppressed their proliferation, which was contrary to the findings in the BMPR2 knockdown group. Moreover, BMPR2 overexpression activated the BMP-SMAD-Runt-related transcription factor 2 (RUNX2) signalling cascade. RUNX2 overexpression partially recaptured the effects of BMPR2 knockdown on odontogenic differentiation of hDPSCs.Conclusion: These results indicate that BMPR2 promotes odontogenic differentiation of hDPSCs by activating BMPR2-SMAD1/5/8-RUNX2 signalling, and that targeting this cascade could be a promising strategy for gene therapy in human tooth development.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 1","pages":"29-38"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proenkephalin Inhibits the Osteogenic Differentiation of Bone Marrow-derived Mesenchymal Stem Cells. 前脑啡肽抑制骨髓间充质干细胞成骨分化。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-03-18 DOI: 10.3290/j.cjdr.b6953758

Xin Wang, Zhu Qing Wan, Long Wei Lv

{"title":"Proenkephalin Inhibits the Osteogenic Differentiation of Bone Marrow-derived Mesenchymal Stem Cells.","authors":"Xin Wang, Zhu Qing Wan, Long Wei Lv","doi":"10.3290/j.cjdr.b6953758","DOIUrl":"10.3290/j.cjdr.b6953758","url":null,"abstract":"Objective: To investigate the regulatory role of proenkephalin (PENK) on the osteogenic differentiation process of human bone marrow mesenchymal stem cells (hBMMSCs).Methods: PENK knockdown and overexpression in hBMMSCs were performed by using lentivirus containing the specific short hairpin RNA or whole coding region for PENK in vitro. The alkaline phosphatase level and mineralised nodule formation were observed by alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining and quantification. Meanwhile, the expression levels of osteogenic-related mRNA and protein were detected by qRT-PCR and Western blot.Results: Transfection of lentivirus in hBMMSCs was effectively confirmed by the green fluorescent protein-positive cells under fluorescence microscopy, and qRT-PCR and Western blot analyses verified the successful establishment of PENK knockdown and overexpression hBMMSCs. The results showed that knockdown of PENK effectively promoted the osteogenic differentiation of hBMMSCs, with enhanced ALP and ARS staining, and increased expression levels of osteogenic-related genes and proteins. Conversely, the overexpression of PENK inhibited the osteogenic differentiation of hBMMSCs.Conclusion: This finding identified PENK as a potential therapeutic target for bone regeneration of oral and maxillofacial bone defects.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 1","pages":"9-18"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Mutation of PTCHD3 Identified in a Chinese Family with Basal Cell Nevus Syndrome-associated Odontogenic Keratocysts. 在中国基底细胞痣综合征相关牙源性角化囊肿家族中发现一种新的PTCHD3突变。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-03-18 DOI: 10.3290/j.cjdr.b6953776

Si Yi Zhou, Zi Yu Zhu, Ke Jie Lu, Jian Lu Kong, Tian Yi Gu, Lixuen Siow, Ying Qian, Chao Ying Zhang, Si Yu Wang, Takseng Hong, Jia Xing Gong, Hui Yong Zhu, Meng Fei Yu, Hui Ming Wang

{"title":"A Novel Mutation of PTCHD3 Identified in a Chinese Family with Basal Cell Nevus Syndrome-associated Odontogenic Keratocysts.","authors":"Si Yi Zhou, Zi Yu Zhu, Ke Jie Lu, Jian Lu Kong, Tian Yi Gu, Lixuen Siow, Ying Qian, Chao Ying Zhang, Si Yu Wang, Takseng Hong, Jia Xing Gong, Hui Yong Zhu, Meng Fei Yu, Hui Ming Wang","doi":"10.3290/j.cjdr.b6953776","DOIUrl":"10.3290/j.cjdr.b6953776","url":null,"abstract":"Objective: To elucidate the genetic aetiology of basal cell nevus syndrome (BCNS) within a Chinese cohort featuring an affected family.Methods: The patient's and their parents' peripheral venous blood was collected for high-throughput exon sequencing. Tools such as Mutation Taster2 and SIFT were used to predict mutation harmfulness and obtain the most suspected pathogenic mutation. GeneMANIA was employed to construct the protein interaction network between the gene and Hedgehog pathway. SWISS-MODEL was used to simulate the bioinformatics structure changes of the mutant gene and HDOCK was utilised to simulate molecular docking. Finally, the function of this gene mutation was verified by q-PCR.Results: A novel pathogenic mutation of PTCHD3 was identified. CCDC57 in the Hedgehog pathway was found to interact with PTCHD3 through GeneMANIA. SWISS-MODEL predicted that PTCHD3 mutation would lead to changes in the 3D structure of the protein. HDOCK showed that the binding between PTCHD3 and CCDC57 was significantly reduced. The mutation of PTCHD3 may result in decreased binding ability of PTCHD3 to CCDC57, activate the Hedgehog pathway and lead to the occurrence of the disease. The diagnosis and treatment pathway for clinical discovery of OKC was provided.Conclusion: A novel pathogenic mutation of PTCHD3 was identified in Chinese BCNS patients. PTCHD3 may play a role in various biological processes mediated by the Hedgehog signalling pathway and is expected to be a new potential therapeutic target.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 1","pages":"61-70"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Al-enhanced Dynamic Virtual Patient Workflow for Full-arch Implant Rehabilitation. 全弓种植体康复的人工智能增强动态虚拟患者工作流程。

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The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA) Pub Date : 2026-03-18 DOI: 10.3290/j.cjdr.b6953770

Hong Lei Lin, Yong Qing Guo, Zhi Cen Lu, Hao Yu

{"title":"Al-enhanced Dynamic Virtual Patient Workflow for Full-arch Implant Rehabilitation.","authors":"Hong Lei Lin, Yong Qing Guo, Zhi Cen Lu, Hao Yu","doi":"10.3290/j.cjdr.b6953770","DOIUrl":"10.3290/j.cjdr.b6953770","url":null,"abstract":"Accurately recording implant positions and maxillomandibular relationships in completely edentulous patients for the fabrication of fixed implant-supported immediate prostheses presents a challenge. This study aimed to introduce a fully digital workflow incorporating artificial intelligence (AI) technology and a dynamic virtual patient to create a screw-retained, full-arch implant-supported prosthesis for a completely edentulous patient. Virtual surgical planning was conducted using digital software (3Shape dental system, 3Shape, Copenhagen, Denmark) that integrates intraoral mucosal information, anatomical images of bone tissue and the radiographic guide based on radiopaque markers of the radiopaque guide. After this, immediate implant-supported fixed complete-arch dentures (IFCDs) were fabricated based on the alignment of intraoral scans and the extraoral scans of the implant position with the scan bodies and preoperative and postoperative CBCT images. Digital impressions of interim and mucosal contours, CBCT images, facial scans and mandibular motions of the patients were collected to construct a dynamic virtual patient. The craniomaxillofacial complex and mandible were automatedly segmented using 3D Slicer via the deep learning system. Subsequently, a definitive restoration was fabricated, and the patient expressed satisfaction with the functionality, aesthetics and passive fit of the IFCDs. This technical procedure presents a digital registration method using AI technology to accurately capture the aesthetic features and maxillomandibular relationship and ensure a passive fit, potentially improving aesthetics and functionality and maintaining the long-term stability of peri-implant soft and hard tissues.Keywords: digital workflow, implant-supported full-arch prosthesis, virtual patient.","PeriodicalId":74983,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA)","volume":"29 1","pages":"71-79"},"PeriodicalIF":0.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0