Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"The impact of narcolepsy and idiopathic hypersomnia on work-related outcomes: a systematic literature review.","authors":"Somraj Ghosh, Stephen Crawford, Sarah L Bermingham, Miriam L Zichlin, Fiona Stewart, Nicole Fusco, Evelyn Gomez-Espinosa, Kristin Kistler","doi":"10.1093/sleepadvances/zpag078","DOIUrl":"10.1093/sleepadvances/zpag078","url":null,"abstract":"<p><p>The symptoms experienced by people with narcolepsy and idiopathic hypersomnia (IH) have profound effects on individuals' lives, affecting daily functioning, relationships and mental health, and can impair performance at work or school. Although numerous studies have evaluated the impact of narcolepsy and IH on work-related outcomes, the evidence base is highly fragmented and difficult to meaningfully summarize. We conducted a systematic literature review of published evidence to better understand the impact of these disorders on employment, work productivity, work satisfaction, and related outcomes. We identified 54 publications representing 51 unique studies that met the study inclusion criteria and were included in the review. Although most people with narcolepsy or IH were employed, fewer were in paid work than control populations, and absenteeism and presenteeism were high. Having narcolepsy and IH resulted in lower wages and missed work time, leading to unfavorable impacts on career progression, promotion, job satisfaction, and income. The most frequently reported work-related problems were sleepiness at work, reduced performance, work accidents, and lateness. More severe excessive daytime sleepiness was associated with greater work impairment. Narcolepsy-specific medications that improved excessive daytime sleepiness were reported to improve work productivity in clinical trials; however, many people are left with substantial residual impairment despite treatment. These findings indicate that narcolepsy and IH impose a substantial burden on work functioning and employment, and there is a need for more research to inform interventions and policies aimed at mitigating the impact of these debilitating conditions on individuals' professional lives.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag078"},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of a medical device recall on individuals with obstructive sleep apnea and healthcare providers: a qualitative study.","authors":"Sachin R Pendharkar, Kenneth G Blades, Bashour Yazji, Najib T Ayas, Robert L Owens, Marta Kaminska, Constance Mackenzie, Andrea S Gershon, Diana C Ratycz, Vadym Lishchenko, Mark E Fenton, Kerry A McBrien, Marcus Povitz, Tetyana Kendzerska","doi":"10.1093/sleepadvances/zpag077","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag077","url":null,"abstract":"<p><strong>Study objectives: </strong>To understand how the Philips positive airway pressure device recall affected patient experiences, clinical practice, and health system responses.</p><p><strong>Materials and methods: </strong>We conducted a qualitative descriptive study using semi-structured interviews with individuals with obstructive sleep apnea (OSA), physicians, respiratory therapists, and health system leaders from November 2022 to August 2023. Emailed responses from Health Canada were also incorporated. Interviews explored participants' experiences with the recall announcement and communication, their own responses and perceptions of actions taken by others, the overall impact of the recall and suggestions for improving future recall processes. Data were analyzed using an inductive thematic approach with iterative coding and team-based analysis.</p><p><strong>Results: </strong>We interviewed 47 participants (16 individuals with OSA, 10 physicians, 17 public or private respiratory therapists, 5 health system leaders). Four domains emerged: recall communication, execution, lived experiences, and policy context. Across groups, participants described a fragmented and poorly coordinated recall process with unclear accountability. Participants reported confusion due to inadequate information from Philips. Responsibility for notifying patients and device tracing shifted largely to healthcare providers and vendors, while replacement processes were disorganized and frustrating. Individuals with OSA experienced emotional distress and decisional uncertainty regarding therapy continuation. Providers described moral distress due to limited ability to support patients adequately, and vendors reported logistical and financial strain. While regulatory authorities indicated that standard procedures were followed, participants perceived these to be discordant from the recall process, contributing to erosion of trust.</p><p><strong>Conclusions: </strong>The Philips positive airway pressure device recall exposed gaps between regulatory frameworks and real-world implementation, with broad individual and system-level impacts. Future recalls should prioritize accountability, coordination, and patient-centered support.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag077"},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute sleep deprivation alters hypothalamic neuroinflammatory signaling independent of traumatic brain injury in the mouse.","authors":"Francois Labadie, Grant S Mannino, Jonathan Lifshitz, Rachel K Rowe","doi":"10.1093/sleepadvances/zpag076","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag076","url":null,"abstract":"<p><strong>Study objectives: </strong>Traumatic brain injury (TBI) is frequently accompanied by sleep disturbances and neuroinflammatory responses that contribute to long-term neurological dysfunction. Sleep deprivation commonly occurs during the acute post-injury period, yet its influence on early neuroinflammatory signaling remains poorly understood.</p><p><strong>Methods: </strong>Here, we investigated how acute sleep deprivation alters inflammatory gene expression following experimental TBI in mice. Adult male C57BL/6J mice underwent midline fluid percussion injury (mFPI) or sham surgery and were subsequently exposed to 6 hours of gentle-handling sleep deprivation or undisturbed sleep. Following the manipulation period, the hypothalamus, thalamus, hippocampus, motor cortex, and primary somatosensory cortex (S1BF) were collected for transcriptional profiling using the NanoString nCounter Mouse Neuroinflammation Panel.</p><p><strong>Results: </strong>Sleep deprivation emerged as the dominant driver of transcriptional changes across brain regions at 6 hours post-injury, whereas TBI alone produced comparatively modest effects. Transcriptional responses to sleep deprivation were highly localized to the hypothalamus, where 23 genes were differentially expressed, with minimal responses observed in other regions. Differentially expressed genes included Mapk1, Jun, Map2k1, and Il1rap. Gene set enrichment analysis demonstrated coordinated suppression of MAPK/ERK signaling, NF-κB-mediated inflammatory pathways, cytokine and chemokine signaling, complement activation, and pathways related to cytoskeletal remodeling and neuronal signaling. The combination of TBI and sleep deprivation did not produce a synergistic transcriptional response, suggesting that sleep deprivation dominates early neuroinflammatory signaling.</p><p><strong>Conclusions: </strong>These findings identify acute sleep deprivation as a potent modulator of early neuroimmune signaling and highlight sleep as a potential therapeutic target following TBI.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag076"},"PeriodicalIF":0.0,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parent and child-reported acceptability and preference of pediatric home sleep apnea testing versus In-lab polysomnography: a pilot study.","authors":"Anna Scott, Christopher M Cielo, Melissa Xanthopoulos, Ignacio Tapia, Darko Stefanovski, Mahalakshmi Somayaji","doi":"10.1093/sleepadvances/zpag075","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag075","url":null,"abstract":"<p><strong>Objectives: </strong>In-lab polysomnography (PSG) remains the gold standard for the diagnosis of pediatric obstructive sleep apnea (OSA), but its limited availability has prompted the exploration of home sleep apnea testing (HSAT) with encephalogram (EEG) in children. While the feasibility and accuracy of HSAT have been studied previously in children, parent- and child-reported acceptability and preferences of HSAT compared with PSG are unknown. We aimed to evaluate factors influencing parent and child acceptability and preference of HSAT versus PSG.</p><p><strong>Methods: </strong>In this pilot study children aged 2-17.9 years completed PSG and comprehensive HSAT with EEG within one week of each other. Parents and older children completed questionnaires assessing feasibility, acceptability, sleep disturbances, and their preference of the two tests. A single structured phone interview with the parent was conducted one day after all study procedures, using ten open-ended questions.</p><p><strong>Results: </strong>Fifteen children participated and all completed testing. HSAT was reported to be feasible by 15 (100%) and doable by 14 (92.8%) parents. Seventy-nine percent of parents and 87.5% children liked the HSAT. HSAT was accepted by 79% of parents and 75% of the children. Overall, 60% of parents and 33% of children preferred HSAT over PSG. During HSAT, 64.3% of the parents needed to adjust sensors, mostly the nasal cannula (42.9%) and the pulse oximeter (66.7%). However, the majority did not find this bothersome.</p><p><strong>Conclusion: </strong>HSAT was feasible in children and preferred over PSG by parents but not children. During HSAT, children frequently had to have the sensors adjusted by parents. HSAT has the potential to be more widely acceptable if there is improvement to the stability of the nasal cannula and pulse oximeter.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag075"},"PeriodicalIF":0.0,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstructive sleep apnea underdiagnosis: Prevalence and correlates from the Sleep Health and Knowledge in US Hispanics study.","authors":"Kimberly L Savin, Jose S Loredo, Kira Clare, Riona Yoshida, Breanna M Holloway, Robert L Owens, Brandon Nokes, Peter J Colvonen","doi":"10.1093/sleepadvances/zpag071","DOIUrl":"10.1093/sleepadvances/zpag071","url":null,"abstract":"<p><strong>Study objectives: </strong>To examine the prevalence of obstructive sleep apnea (OSA) underdiagnosis and sociodemographic, behavioral, and medical correlates of underdiagnosis among Hispanic participants of Mexican descent and non-Hispanic white participants in San Diego, CA.</p><p><strong>Methods: </strong>Participants underwent overnight home polysomnography (PSG) and were eligible for the study if they met OSA diagnostic criteria at an apnea-hypopnea index (AHI) ≥ 15/h, minimum 3% oxygen desaturation. Participants self-reported their medical history including past OSA diagnosis, demographics, anthropometrics, and completed the Epworth Sleepiness Scale, and the Short Acculturation Scale for Hispanics. Logistic regressions were used to test bivariate and adjusted associations of correlates with OSA diagnosis status (diagnosed or undiagnosed).</p><p><strong>Results: </strong>Participants (<i>N</i> = 156) had mean (<i>SD</i>) age = 56.3 (15.1) years, 33% were female, and 49% were Hispanic. In this sample with AHI ≥ 15/h, 81.4% had undiagnosed OSA (85.5% among the Hispanic participants of Mexican descent, 77.5% among the non-Hispanic white participants, not statistically significant difference). No prior high blood pressure diagnosis (odds ratio [OR] = 3.44, <i>p</i> = .005) and lower AHI (OR = 1.02, <i>p</i> = .030) were associated with increased likelihood of underdiagnosis. Age, gender, ethnicity, education, body mass index, daytime sleepiness, acculturation, and diabetes diagnosis were not associated with underdiagnosis.</p><p><strong>Conclusions: </strong>Most participants with moderate to severe OSA by home PSG were undiagnosed, regardless of their ethnicity. A lower AHI and no prior diagnosis of high blood pressure were associated with greater OSA underdiagnosis. Enhanced OSA screening, across groups, is needed to reach the large majority that are missed.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag071"},"PeriodicalIF":0.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bodily stimulation during rapid eye movement sleep: effects of muscle and vestibular cueing on lucid dreaming.","authors":"Emma Peters, Xinlin Wang, Johanna Heitmann, Kathrin Fischer, Nicole Bühler, Nicolas Morath, Eva Nussbaumer, Susanne Zulauf, Ralf Kredel, Simon Maurer, Martin Dresler, Daniel Erlacher","doi":"10.1093/sleepadvances/zpag074","DOIUrl":"10.1093/sleepadvances/zpag074","url":null,"abstract":"<p><strong>Study objectives: </strong>Sensory stimulation during rapid eye movement (REM) sleep has been proposed as a method to induce lucidity, yet most approaches rely on distal sensory modalities such as light and sound. We explored whether bodily stimulation targeting the muscle and vestibular systems differentially influences dream incorporation and lucid awareness during REM sleep.</p><p><strong>Methods: </strong>28 participants were assigned to electrical muscle stimulation (EMS) or galvanic vestibular stimulation (GVS) and completed a 2-week cognitive training protocol including dream journaling, reality checks, and association training, followed by two counterbalanced morning naps. One in the stimulation and one in the control condition, during which cues were delivered during REM sleep. Lucidity was assessed using external dream-report ratings and Dream Lucidity Questionnaire scores.</p><p><strong>Results: </strong>Neither EMS nor GVS significantly increased direct or indirect dream incorporation relative to Control. EMS did not significantly increase lucidity. In contrast, GVS was associated with higher externally rated lucidity and higher Dream Lucidity Questionnaire-7 scores than Control. Lucidity rates were high across EMS conditions, suggesting possible contributions of cognitive training, expectancy, and baseline lucid dream frequency.</p><p><strong>Conclusions: </strong>Targeted stimulation of bodily systems during REM sleep may differentially influence dream experience. While somatosensory stimulation showed limited effects, vestibular stimulation was associated with increased lucid awareness despite minimal explicit incorporation into dream content. These findings suggest that modulation of bodily self-processing during REM sleep may influence reflective awareness independently of direct sensory incorporation. Non-invasive vestibular stimulation may therefore represent a promising approach for investigating mechanisms of lucid awareness during sleep.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag074"},"PeriodicalIF":0.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thalamic transcranial electrical stimulation with temporal interference enhances sleep spindle activity during a daytime nap.","authors":"Simone Bruno, Beril Mat, Erin L Schaeffer, Ido Haber, Zhiwei Fan, Sean P Prahl, Mackenzie R Wilcox, Emma P Strainis, Madelynn D Loring, Tariq Alauddin, Richard F Smith, Peter Achermann, Stefan Beerli, Myles Capstick, Esra Neufeld, Niels Kuster, William Marshall, Larissa Albantakis, Stephanie G Jones, Chiara Cirelli, Melanie Boly, Giulio Tononi","doi":"10.1093/sleepadvances/zpag069","DOIUrl":"10.1093/sleepadvances/zpag069","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep spindles are electroencephalographic elements characteristic of non-rapid eye movement sleep (NREM) generated by thalamo-cortical interactions. Spindles have been linked to some of the cognitive benefits afforded by sleep and increased arousal threshold. This proof-of-concept study demonstrates that targeting the thalamus with Transcranial Electrical Stimulation with Temporal Interference (TES-TI) can enhance spindle activity.</p><p><strong>Materials and methods: </strong>46 participants (24 ± 9.5 years; 58.7% F) underwent thalamic TES-TI stimulation during daytime naps. Three stimulation protocols with 15 kHz carrier frequency were tested during stage NREM 2: fixed difference frequency of 10 Hz (TES^15kHz-TI^10Hz), difference frequency matched to individual spindle peak, and no difference frequency. Spindle (sigma) band power and integrated spindle activity (ISA) were compared before and during the stimulation, and across stimulation protocols.</p><p><strong>Results: </strong>TES^15kHz-TI^10Hz stimulation was associated with increased sigma power (∆<i>x~</i> _STIM-PRE = 0.46 log₁₀ μV², <i>p</i> = .0042) and ISA (∆<i>x~</i> _STIM-PRE = 4.064 μV/s, <i>p</i> = .030). Cluster-based analysis localized the increase in sigma power across the entire scalp (<i>p</i> = .008). Linear mixed-effects models showed that both sigma power and ISA during stimulation increased significantly more in TES^15kHz-TI^10Hz compared to the other stimulation protocols.</p><p><strong>Conclusions: </strong>This study provides evidence supporting the successful use of TES-TI targeting the thalamus to enhance sleep spindle activity. Stimulation at a fixed difference frequency of 10 Hz increased sigma band power and ISA, whereas neither stimulation matched to individual sigma band peak nor TES alone produced comparable effects. These promising results warrant further investigations into the cognitive and clinical impact of TES-TI.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag069"},"PeriodicalIF":0.0,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and incidence of sleep disorder symptoms, correlates, and sex-stratified longitudinal associations with mental and menstrual health outcomes in UK Service Personnel: a prospective survey-based cohort study protocol.","authors":"Alex J Rawcliffe, Charlotte Coombs, Andrea Docherty, Thomas O'Leary, Julie Greeves","doi":"10.1093/sleepadvances/zpag073","DOIUrl":"10.1093/sleepadvances/zpag073","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep disturbance is highly prevalent in military populations, associated with adverse mental health, physiological, and operational outcomes. However, the epidemiology and longitudinal course of sleep disturbances among UK Armed Forces personnel remain unknown. Emerging evidence suggests that sleep disturbance may act as an upstream vulnerability factor for mental health disorders, with additional links to broader outcomes such as menstrual dysfunction in women. Prospective data in UK military populations are scant. This study aims to quantify the prevalence, incidence, and longitudinal associations between sleep disorder symptoms, mental health, and menstrual health outcomes in UK service personnel. The study aims to further investigate demographic and service-related moderators and explore potential mediating pathways underlying these relationships.</p><p><strong>Methods: </strong>This prospective, survey-based cohort study will aim to recruit ~<i>n</i> 1316 Regular and <i>n</i> 1387 Reserve UK Armed Forces personnel, stratified by military service branch (Army, Royal Navy, Royal Air Force) and sex (male and female). Participants will complete validated self-report measures of sleep, mental health (e.g. PTSD, depression, anxiety, nightmares, suicidal ideation) combat exposure, and menstrual health (women only) at baseline, 6, 12, and 24 months. Participants will also undertake a 14-day sleep monitoring protocol using wrist-worn actigraphy and consensus sleep diaries to derive objective and subjective sleep-wake indices. Analyses will aim to assess prevalence, incidence and chronicity of sleep disturbances, along with multivariable regression and longitudinal mixed-effects models to examine associations with mental health outcomes and potential moderating factors. Longitudinal mediation analyses (four models) will determine potential mechanisms linking sleep disturbance with adverse health outcomes.</p><p><strong>Results: </strong>This protocol describes the study design and planned analyses.</p><p><strong>Conclusions: </strong>This study will provide the first comprehensive longitudinal assessment of sleep disturbance and its associations with mental and menstrual health in UK Armed Forces personnel. Findings will inform targeted interventions, including behavioural sleep strategies, and support evidence-based policy and practice within UK Defence.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag073"},"PeriodicalIF":0.0,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the tiredness identification index: a combined scale for the assessment of fatigue and sleepiness.","authors":"Sarah Reeve, Bryony Sheaves, Bao Sheng Loe, Daniel Freeman","doi":"10.1093/sleepadvances/zpag072","DOIUrl":"10.1093/sleepadvances/zpag072","url":null,"abstract":"<p><strong>Study objectives: </strong>Tiredness is a common presentation composed of sleepiness (propensity towards sleeping) and fatigue (feelings of physiological exhaustion). Differentiating between these presentations is important for diagnosis and management. The current study reports on the development and validation of an integrated measure of tiredness (Tiredness Identification Index-TIDI) incorporating assessment of sleepiness and fatigue, and the relationship of the measure with sleep and mental health outcomes.</p><p><strong>Methods: </strong>A sample of 6706 adult participants responded to a pool of sleepiness and fatigue items. Regularized structural equation modelling and confirmatory factor analysis were used to refine the items and factor structure based on convergence against validation measures of fatigue and sleepiness. Regression analyses were then applied to test relationships of the sleepiness and fatigue factors with sleep, mental health, and wellbeing variables.</p><p><strong>Results: </strong>An 8-item scale was developed, composed of a sleepiness (TIDI-sleepiness) and fatigue (TIDI-fatigue) factor with divergent and convergent validity, alongside a general tiredness factor. Higher TIDI-sleepiness was associated with increased apnoea risk and shorter sleep duration, whereas TIDI-fatigue was associated with increased insomnia and reduced sleep efficiency. Controlling for TIDI-sleepiness, TIDI-fatigue was associated with increased depression, anxiety, reduced well-being, and lower physical activity. Increased TIDI-sleepiness and TIDI-fatigue were both associated with paranoia and hallucinations.</p><p><strong>Conclusions: </strong>The results indicate that the TIDI can be used as a brief scale to measure and differentiate fatigue and sleepiness, particularly in non-clinical populations and for research purposes. Assessment of its validity in discriminating fatigue and sleepiness in relevant clinical sleep, mental, and physical health populations should be a focus of future research.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag072"},"PeriodicalIF":0.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in Australian patients with central disorders of hypersomnolence.","authors":"Stephen Kinder, Sara Winter, Brett Duce, Claire M Ellender","doi":"10.1093/sleepadvances/zpag070","DOIUrl":"10.1093/sleepadvances/zpag070","url":null,"abstract":"","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag070"},"PeriodicalIF":0.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}