Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"Protocol for academic-community collaboration in the Sweet Dreams study, a community-integrated study of time tradeoffs, sleep, and cardiometabolic health among minoritized women.","authors":"Kelly G Baron, Sara E Simonsen, Yeny B Arones, Bobbie Bonilla Bermudez, Princess Bombyck, Dorina Lee, Clarisa Medina-Poeliniz, Kiese Mpongo, Valentine Mukundente, Robin Repta, Elsie Star Prescott-Langi, Sharon Talboys, Fahina Tavake-Pasi, Kamaile Tripp-Harris, Jeanette Villalta, Cathy Wolfsfeld, Ivette A López","doi":"10.1093/sleepadvances/zpag055","DOIUrl":"10.1093/sleepadvances/zpag055","url":null,"abstract":"<p><strong>Study objectives: </strong>Women from racially and ethnically minoritized communities experience cardiometabolic health disparities. Insufficient sleep and poor sleep quality are common and potentially modifiable factors that impact cardiometabolic health; however, women face unique challenges to sleep. A bi-directional community-integrated approach is used as a foundation to learn more about sleep in under-researched populations of Utah, resulting in a study approach that is both effective and rigorous.</p><p><strong>Methods: </strong>We present the protocol for community integration and development of focus groups among female community health workers who represent the four communities participating in this study: African Immigrant, Black/African American, Native Hawaiian/Pacific Islander, and Latina. We describe establishing relationships, initiating the project, and preparing and conducting data collection, analysis, and dissemination plans.</p><p><strong>Results: </strong>We anticipate the results of this project will provide unique perspectives about sleep in the participating communities, based on the experience of community health workers as community members and trusted leaders of their communities.</p><p><strong>Conclusions: </strong>This project continues an ongoing partnership between community health workers and academic researchers focused on reducing disparities in cardiometabolic disorders. The results of this project will lead to the identification of future research questions, outreach/education efforts, and development of a plan for future interventions among diverse racial and ethnic groups in our community.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag055"},"PeriodicalIF":0.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13298869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-wide properties of slow waves across vigilance states.","authors":"Senyu Yang, Olivia Poole, Matthew C Walker, Laurent Sheybani","doi":"10.1093/sleepadvances/zpag065","DOIUrl":"10.1093/sleepadvances/zpag065","url":null,"abstract":"<p><p>Until recently, slow waves (SWs) were considered to be highly specific, if not exclusive, to sleep and non-rapid eye movement (NREM) sleep in particular. During NREM sleep, they are proposed to track and contribute to normalization of homeostatic sleep pressure. However, recent evidence has identified typical SWs during wakefulness and rapid-eye movement (REM) sleep. SWs during wakefulness have been regarded as intrusions of sleep, supported by the finding of an associated down-state of neural activity. Although this suggests that the underlying neurobiology of SWs might be shared across vigilance states, i.e. the activity of neurons is comparable, it does not address the question as to whether SWs display state-dependent differences that could reflect a homeostatic regulation. To address this question, we utilized an intracranial dataset of 106 adult patients with drug-resistant epilepsy and computed specific features of SWs-their incidence, slope, transition frequency, associated high gamma activity, multipeak morphology and overlap across brain regions. Overall, we found that changes in these features reflect a state-dependent modulation, potentially in line with expected changes in homeostatic pressure. The multipeak morphology displayed the greatest changes across states. SW differences were sufficiently specific to vigilance state that we could successfully classify these states using SW properties. Our work provides further evidence that SWs during wakefulness and REM sleep are consistent with intrusion of NREM-SW and establish normative values for future studies on SWs across vigilance states and brain regions.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag065"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-AID: a cross-sectional analysis of subjective sleep quality, psychosocial measures and real-world glycemic outcomes in people with diabetes using automated insulin delivery systems.","authors":"Drew Cooper, Tebbe Ubben, Christine Knoll, Christine Blume, Wolf-Julian Neumann, Katarina Braune","doi":"10.1093/sleepadvances/zpag066","DOIUrl":"10.1093/sleepadvances/zpag066","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep disturbances are common in people with diabetes, yet their relationship to automated insulin delivery (AID) use has not been well described in large, real-world cohorts. We assessed subjective sleep quality, fear of hypoglycemia, and their associations with glycemic outcomes among adults with diabetes using open-source and commercial AID compared with non-users.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional analysis of 529 adults from the OPEN Project (2020-2023). Participants completed the Pittsburgh Sleep Quality Index (PSQI) and Hypoglycemia Fear Survey-II (HFS-II) short form. All participants self-reported glycated hemoglobin (HbA1c) levels; a subsample of 60 AID users contributed ≥25 days of continuous glucose monitoring (CGM) data. Free-text responses to PSQI item 5j were thematically coded.</p><p><strong>Results: </strong>AID users reported better sleep (median 5 [IQR 3-7] vs. 7 [IQR 5-9], <i>p</i> < .001) and lower fear of hypoglycemia (median 7 [IQR 3-11] vs. 13 [IQR 8-19], <i>p</i> < .001) than non-users. Nevertheless, 43% of AID users and 69% of non-users exceeded poor sleep thresholds. Women reported worse PSQI and HFS-II scores than men (both <i>p</i> < .001). Diabetes-related causes of sleep disruption were more common among non-users (<i>p</i> < .05). PSQI and HFS-II scores correlated with HbA1c in the subsample, but associations with CGM metrics were not significant.</p><p><strong>Conclusions: </strong>Adults using AID systems reported better sleep quality and lower fear of hypoglycemia than those managing diabetes without automation, yet a large proportion of all participants continued to experience poor sleep. Diabetes-related nocturnal disruptions remained common among non-users, suggesting that AID may alleviate-but not eliminate-the nighttime diabetes burden.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag066"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue-related factors and perceived team functioning in United States Navy Surface Forces.","authors":"Dale W Russell, Rachel R Markwald","doi":"10.1093/sleepadvances/zpag067","DOIUrl":"10.1093/sleepadvances/zpag067","url":null,"abstract":"<p><p>Operational environments such as naval vessels demand sustained coordination and precision under conditions that test both physical and psychological endurance. This study examined associations among fatigue-related factors, perceived social support, occupational context, and perceived team functioning among 26 438 active-duty US Navy personnel. Measures included self-reported sleep needed, sleep opportunity, and sleep obtained, which were used to calculate sleep deficit and sleep opportunity conversion, along with self-reported sleep disturbance, fatigue impairment (FI), perceived social support, and perceived team processes. Hierarchical regression analyses showed that FI was strongly associated with lower perceived team functioning (β = -0.35; 95% confidence interval [CI], -0.37 to -0.33; <i>p</i> < .001). Social support was positively associated with perceived team functioning (β = 0.31; 95% CI, 0.29 to 0.33; <i>p</i> < .001) and statistically attenuated the negative association between FI and perceived team functioning (β = 0.07; 95% CI, 0.05 to 0.09; <i>p</i> < .001). Quadratic analyses indicated that associations between fatigue-related factors and perceived team functioning were stronger at moderate-to-high levels of FI and calculated sleep deficit. Occupational rate accounted for additional contextual variance, with mechanical and deck rates reporting higher FI and lower perceived team functioning than administrative or medical rates. As all constructs were assessed using cross-sectional, single-source self-report data, findings should be interpreted as correlational associations with perceived team processes rather than objective performance effects or causal impacts of insufficient sleep.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag067"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden oral inflammation and biomarker misclassification in obstructive sleep apnea trials.","authors":"Solomon Olusegun Nwhator","doi":"10.1093/sleepadvances/zpag063","DOIUrl":"10.1093/sleepadvances/zpag063","url":null,"abstract":"<p><p>Inflammatory biomarkers are used as surrogate endpoints in obstructive sleep apnea trials, assuming the measured signal originates from the airway or systemic response to intermittent hypoxia. Periodontitis-a common, extrapulmonary inflammatory reservoir-elevates systemic active matrix metalloproteinase-8 independently of obstructive sleep apnea. This Perspective examines whether unmeasured oral inflammation confounds biomarker attribution in obstructive sleep apnea trials. Epidemiological and interventional evidence indicates that periodontitis is highly prevalent, is more common in individuals with obstructive sleep apnea, and substantially elevates circulating active matrix metalloproteinase-8. Moreover, non-surgical periodontal therapy reduces this signal to a degree comparable to early Continuous Positive Airway Pressure (CPAP) effects. In published CPAP trials that reported inflammatory or cardiovascular outcomes, periodontal status has not been reported or incorporated into primary analyses. We propose a heuristic conceptual model: measured circulating active matrix metalloproteinase-8 = obstructive sleep apnea-related component + periodontal-derived component + measurement noise. Without adjustment for periodontal status, observed changes cannot be uniquely attributed to obstructive sleep apnea treatment. The ORBIT heuristic framework (Oral Reservoir Bias Inflammatory Trial) is introduced as a conceptual prompt for reporting oral inflammatory burden. Inflammatory biomarker responses in obstructive sleep apnea trials are consistent with a composite signal that includes an unmeasured oral component. A testable prediction is that adjusting for periodontal status would reduce between-trial heterogeneity of matrix metalloproteinase-8effect estimates without altering within-subject respiratory outcomes. Prospective validation is warranted. The framework extends beyond active matrix metalloproteinase-8 to any circulating inflammatory marker influenced by extra-target inflammatory reservoirs.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag063"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the association between caffeine exposure and sleep duration and trouble sleeping in adults.","authors":"Patrick Viet-Quoc Nguyen, Qiaowei Lin, Shakila Meshkat, Jithin T Joseph, Reinhard Janssen, Wendy Lou, Venkat Bhat","doi":"10.1093/sleepadvances/zpag064","DOIUrl":"10.1093/sleepadvances/zpag064","url":null,"abstract":"<p><strong>Study objectives: </strong>This study examines whether caffeine is independently associated with sleep outcomes in the general population.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey from 2005 to 2018 were analyzed, including adults aged ≥18 years who completed both dietary interviews and the Sleep Disorders Questionnaire. Caffeine exposure was estimated from a 24-h dietary recall and expressed as milligrams per day, modeled both continuously and categorically (0, 1-99, 100-399, and ≥ 400 mg/day). Sleep outcomes included self-reported sleep duration (<6 h vs. ≥6 h). Survey-weighted multivariable logistic regression models were applied to examine associations, adjusting for age, sex, race/ethnicity, education, smoking status, alcohol use, income-to-poverty ratio, and depression.</p><p><strong>Results: </strong>The sample included 37 469 adults (mean age 46.4 years; 51.7 per cent female). Compared with 0 mg/day, the adjusted odds ratios (aORs) for short sleep were 1.0 (95 per cent CI, 0.9-1.2) for 1-99 mg/day, 1.1 (95 per cent CI, 0.9-1.2) for 100-399 mg/day and 1.5 (95 per cent CI, 1.2-1.8) for ≥400 mg/day. Caffeine intake of 101-400 mg taken within 8 h of bedtime was associated with short sleep. Although significant in unadjusted analyses, the association between caffeine intake and self-reported trouble sleeping was no longer significant after multivariable adjustment (low intake: aOR 1.0 [95 per cent CI, 0.9-1.1]; moderate intake: aOR 1.0 [95 per cent CI, 0.9-1.2]; high-intake: aOR 1.0 [95 per cent CI, 0.9-1.2]).</p><p><strong>Conclusions: </strong>In this U.S. cross-sectional sample, higher caffeine intake was modestly associated with shorter self-reported sleep duration particularly when taken within 8 h of bedtime.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag064"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13363248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148439021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No more counting sheep? Interoceptive not-distracting as a novel predictor of insomnia symptom severity in college students.","authors":"Lara R LoBrutto, Natalie D Dautovich, Patricia A Kinser, Bruce Rybarczyk, Joseph Dzierzewski","doi":"10.1093/sleepadvances/zpag062","DOIUrl":"10.1093/sleepadvances/zpag062","url":null,"abstract":"<p><strong>Study objectives: </strong>Emerging adults demonstrate vulnerability to pre-sleep arousal due to pervasive electronic device use, heightened rumination, and higher overall anxiety. To address this concern, this study sought to assess interoceptive awareness, a non-judgmental and trusting attitude toward body sensations that may reduce pre-sleep arousal, as a protective factor against insomnia symptoms during young adulthood.</p><p><strong>Methods and measures: </strong>We assessed the association between interoceptive awareness, pre-sleep arousal, and insomnia symptom severity using cross-sectional data from university students (<i>N</i> = 420) in the mid-Atlantic United States. Participants completed the Multidimensional Assessment of Interoceptive Awareness-2, Pre-sleep Arousal Scale, and the Insomnia Severity Index. Data were analyzed using hierarchical linear and logistic regressions and a mediation analysis.</p><p><strong>Results: </strong>The \"not-distracting\" factor emerged as the strongest interoceptive predictor of insomnia symptoms in emerging adults. When adjusting for mood and demographic covariates, not-distracting significantly predicted pre-sleep arousal (<i>b</i>* = -0.12, <i>p</i> < .001). In the mediation model, pre-sleep arousal (95% CI: -0.25, -0.11) mediated the association between not-distracting and insomnia symptoms. Not engaging in distraction from pain and discomfort was associated with lower insomnia symptom severity via lower levels of cognitive and physiological arousal before sleep.</p><p><strong>Conclusions: </strong>Interoceptive not-distracting and pre-sleep arousal may be important factors to consider in the treatment of sleep disturbance in this age group. Findings suggest that specific training in interoceptive capacities could be a valuable addition to preventive interventions for sleep health in young adults.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag062"},"PeriodicalIF":0.0,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13387498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transoral neuromuscular electrical stimulation therapy adherence and intensity levels in veterans with mild OSA.","authors":"Carl Stepnowsky, Tania Zamora, Yzabel Velazquez, Chris N Schmickl, Cesar Cervantes-Gameros, Robert L Owens, Brian S Wojeck, Peter Colvonen, Brandon Nokes","doi":"10.1093/sleepadvances/zpag061","DOIUrl":"10.1093/sleepadvances/zpag061","url":null,"abstract":"<p><strong>Study objectives: </strong>To describe the use of transoral neuromuscular stimulation therapy in Veterans with mild obstructive sleep apnea (OSA) by looking at session-level data for both adherence and stimulation intensity.</p><p><strong>Methods: </strong>A retrospective review of session-level data of the 82 patients prescribed the eXciteOSA device at the VA San Diego Healthcare System was analyzed. The device is prescribed for use over two phases: (1) Phase 1: one daily 20-min session daily for 42 days, and (2) Phase 2: one daily 20-min session on 2 days per week.</p><p><strong>Results: </strong>Forty-one out of 76 patients (54 per cent) completed Phase 1 (42 sessions) within the first 60 days of using eXciteOSA therapy. Three (4 per cent) completed Phase 1 after the first 60 days, and 32 (42 per cent) patients never completed Phase 1. Initial Phase 1 graduates had a cumulative usage of 866 min, while those that did not complete Phase 1 had 578 min. Average stimulation intensity levels (SIL) in the initial Phase 1 graduates increased from week 1 to week 6 (from 3.2 to 11.2).</p><p><strong>Conclusions: </strong>Based on the prescription-based adherence definition, adherence is modest but is contingent on how adherence is defined. Notably however, median positive airway pressure adherence is 40 per cent for those with a recent prescription within our facility for comparison. Future research should focus on interventions to help improve both adherence and SIL of this novel daytime OSA therapy.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag061"},"PeriodicalIF":0.0,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of tonic motor activation (TOMAC) on sleep in adults with medication-refractory restless legs syndrome.","authors":"Stephanie K Rigot, Erik K St Louis, Fiona C Baker, Hussein Alawieh, Haramandeep Singh, Joseph Ojile, Jatin Tekchandani, Viktoriia Kolotovska, Bahman Adlou, Jonathan D Charlesworth","doi":"10.1093/sleepadvances/zpag060","DOIUrl":"10.1093/sleepadvances/zpag060","url":null,"abstract":"<p><strong>Study objectives: </strong>Tonic motor activation (TOMAC) delivers high-frequency electrical stimulation to the common peroneal nerve to reduce restless legs syndrome symptoms and improve subjective sleep quality. This cross-sectional analysis provides the first objective evaluation of the wake-sleep transition and an exploration of sleep parameter and leg movement changes following mid-sleep TOMAC sessions during polysomnography.</p><p><strong>Methods: </strong>Twenty participants with medication-refractory restless legs syndrome completed two polysomnographies and activated 30-min TOMAC sessions as needed when awakening mid-sleep with restless legs syndrome symptoms. Objective sleep parameters including sleep reinitiation latency, architecture, and hourly indices of periodic leg movements during sleep (PLMS) and PLMS associated with arousal were compared between the sleep periods before and after activating mid-sleep TOMAC sessions.</p><p><strong>Results: </strong>Sleep reinitiation occurred during the 30-min TOMAC session for 24 of 29 (82.8%) mid-sleep sessions, with a median latency of 6.7 (range = 0.9-45.9) min following TOMAC activation. The latency from TOMAC activation to sleep reinitiation was shorter in participants who activated TOMAC within 10 min of awakening compared to those who waited longer (<i>p</i> = 0.016). There was a linear increase in the proportion of delta and a decrease in alpha electroencephalogram (EEG) frequency-band power after activating mid-sleep TOMAC (both <i>p</i> < 0.001), indicating the transition towards deeper sleep. Comparing sleep intervals before and after activating mid-sleep TOMAC, PLMS/hour decreased by 47.9% (<i>p</i> = 0.042) and PLMS associated with arousal/hour decreased by 70.8% (<i>p</i> = 0.004).</p><p><strong>Conclusions: </strong>TOMAC was compatible with sleep; rapid sleep reinitiation and a transition to deeper sleep were observed during TOMAC stimulation. These data also provide proof-of-concept evidence that PLMS may decrease following activation of mid-sleep TOMAC.</p><p><strong>Clinical trial details: </strong>This study was preregistered on January 31, 2022 ClinicalTrials.gov with name \"Noninvasive Peripheral Nerve Stimulation for Medication-Naive and Medication-Refractory RLS\" and number NCT05214963 at https://clinicaltrials.gov/study/NCT05214963.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag060"},"PeriodicalIF":0.0,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13390924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is sleep a mechanistic factor in the blood pressure lowering effects of low-dose aspirin taken at bedtime? A pilot study.","authors":"Michael Vazquez, Huan Yang, Michael Goldstein, Monika Haack, Janet M Mullington","doi":"10.1093/sleepadvances/zpag058","DOIUrl":"10.1093/sleepadvances/zpag058","url":null,"abstract":"<p><strong>Introduction: </strong>This was a pilot study designed to test the hypothesis that bedtime administration of acetylsalicylic acid (ASA) lowers BP through sleep improvements that impact the inflammatory, and renin-angiotensin-aldosterone system (RAAS). We predicted that ASA would enhance sleep consolidation and lower sympathetic activation, protecting against the physiological stress of fragmented sleep.</p><p><strong>Methods: </strong>Seven participants (5F, 2M, mean age 25.71 ± 4.03 years, body mass index (BMI) 22.40 ± 1.91 kg/m²) completed this within-subject, double-blind, balanced study involving 2 × 5 in-patient days. Participants were randomized to daily intake of ASA (81 mg/day) or placebo at bedtime for 2 weeks before each hospital research stay that included 1 baseline (BL) night, 2 nights of an experimental sleep disturbance (ESD) protocol and finally, 1 night of recovery sleep. The ESD protocol included 1-h delayed sleep onset, fragmentation of sleep with 5 × 20-min awakenings, and a 1-h earlier lights on time.</p><p><strong>Results: </strong>ASA did not decrease BP following the 2-week at-home ASA administration, nor during ESD. Evening renin was significantly reduced (<i>p</i> = .048), compared to placebo after 2 weeks of ASA. Mood and well-being improved after 2 weeks of ASA. There were statistical trends toward decreased 24-h average heart rate (<i>p</i> = .053), and increased heart rate variability (<i>p</i> = .080). When challenged with the ESD protocol, ASA was associated with a longer duration of individual slow waves (<i>p</i> = .013), lower 24-h average HR (<i>p</i> < .001) and a trend to greater non-rapid eye movement delta power (<i>p</i> = .061).</p><p><strong>Conclusions: </strong>This pilot study is the first investigation exploring effects of ASA on renal & hemodynamic parameters at night, implicating sleep as an important mechanistic factor.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag058"},"PeriodicalIF":0.0,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}