Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"Correction to: <i>Wearanize+</i>: a multimodal dataset for evaluating wearable technologies in sleep research.","authors":"","doi":"10.1093/sleepadvances/zpag104","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag104","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sleepadvances/zpaf094.].</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 4","pages":"zpag104"},"PeriodicalIF":0.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Napping during major depressive episodes identifies a distinct hypersomnolence phenotype.","authors":"Pierre Alexis Geoffroy, Célia Heiligenstein, Sibylle Mauries, Justin Ulm, Fériel Zehani, Chantal Henry, Michel Lejoyeux, Patrice Bourgin, Julia Maruani","doi":"10.1093/sleepadvances/zpag097","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag097","url":null,"abstract":"<p><strong>Study objectives: </strong>Prior studies have linked depression with napping, though findings remain inconsistent. Given that major depressive episodes (MDE) commonly involve sleep-wake and circadian disturbances, we hypothesized that daytime Napping during MDE reflects more pronounced sleep/circadian disruptions and a distinct clinical profile.</p><p><strong>Materials and methods: </strong>We compared MDE patients with and without napping (MDE-NAP vs MDE), as well as unipolar and bipolar subgroups, using subjective and objective biomarkers, including actigraphy.</p><p><strong>Results: </strong>The MDE-NAP group had more frequently hypersomnia (30.6% vs 8.2% <i>p</i> < .001), daytime sleepiness (73.1% vs 41.8%, <i>p</i> < .001), daytime fatigue (97.1% vs 88.5%, <i>p</i> = .042), family history of depression (68.2% vs 52.2%, <i>p</i> = .044), weight gain (42.2% vs 21.6%, <i>p</i> = .006), and feelings of guilt (75.0% vs 57.8%, <i>p</i> = .027). The unipolar napping group had greater weight gain (48.8% vs 21.4%, <i>p</i> = .004) and more hypersomnia (26.1% vs 3.4%, <i>p</i> < .001). The bipolar napping group were more frequently women (76.9% vs 52%, <i>p</i> = .046), with more suicidal ideation (65.4% vs 37.8%, <i>p</i> = .031), sad mood (73.1% vs 43.1%, <i>p</i> = .019), hypersomnia (38.5% vs 15.8%, <i>p</i> = .04), and guilt (61.9 vs 35.1, <i>p</i> = .049). Regarding sleep scales, MDE-NAP had more hypersomnolence symptoms (HSI total score, <i>p</i> < .001), with higher frequencies of sleep inertia, daytime sleep, sleepiness, daytime dysfunction, and sleep attacks; and showed longer sleep duration (PSQI sleep duration, <i>p</i> = .025), and higher sleep efficiency (PSQI sleep efficiency, <i>p</i> = .015). Actigraphy did not reveal significant between-group differences in the subsample with usable recordings (<i>N</i> = 90).</p><p><strong>Conclusions: </strong>Daytime napping during MDE appears to identify a distinct hypersomnolence phenotype with sleep-vegetative burden, supporting the systematic assessment of napping to guide personalized sleep- and circadian-based therapeutic strategies. <i>This paper is part of the Sleep and Circadian Mechanisms in Mental Health Collection</i>.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 4","pages":"zpag097"},"PeriodicalIF":0.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between social jetlag and the sleep regularity index in young adults with and without sleep disorders.","authors":"Katrina Nguyen, Nicole Lovato, Gorica Micic, Claire Dunbar, Josh Fitton, Gemma Robertson, Ashley Montero, Kelly A Loffler, Kelly Sansom, Andrew Vakulin, Robert J Adams, Andrew J K Phillips, Amy C Reynolds","doi":"10.1093/sleepadvances/zpag102","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag102","url":null,"abstract":"","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 4","pages":"zpag102"},"PeriodicalIF":0.0,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biophysical modeling of thalamocortical circuit dynamics: species-specific insights into neural synchrony, sleep spindles, and circuit mechanisms.","authors":"Basilis Zikopoulos, Natalia Matuk, Irina Romanova, Arash Yazdanbakhsh","doi":"10.1093/sleepadvances/zpag100","DOIUrl":"10.1093/sleepadvances/zpag100","url":null,"abstract":"<p><p>Thalamocortical circuits play a central role in sensory processing, attention, and sleep spindles. Here, we used a biophysically-grounded computational model with single-compartment neurons and species-inspired thalamocortical architectures to investigate how core and matrix pathways, thalamic interneurons, and open, closed, or hybrid thalamic reticular nucleus-thalamic loop configurations influence synchrony, spatiotemporal signal propagation, and spindle-like activity. The model incorporated both core versus matrix thalamocortical projections, with core pathways providing focal, driving input to middle cortical layers and matrix pathways providing more widespread, modulatory signaling across superficial layers, along with pathway-specific receptor dynamics and rodent-like versus primate-like circuit configurations that differed primarily in the presence of thalamic interneurons, as these cells are sparse in rodents but comprise up to a third of the thalamic neurons in primates. Across the tested conditions, the rodent-like circuits were more sensitive to parameter changes in core and matrix thalamocortical connectivity strength, while primate-like circuits maintained relatively stable spatiotemporal patterns across parameter variations, exhibiting greater stability and synchrony. Spindle analyses further suggested greater variability in event structure and timing in rodent-like networks and more regular spindles in primate-like networks. These findings provide insights into how species-inspired architectural differences may shape thalamocortical dynamics, thereby affecting spindle generation and network synchronization.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag100"},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimentally manipulating dream content by reactivating a remote emotional memory.","authors":"Henderson S Holder, Erin J Wamsley","doi":"10.1093/sleepadvances/zpag101","DOIUrl":"10.1093/sleepadvances/zpag101","url":null,"abstract":"<p><p>Sleep and dreaming have long been hypothesized to serve a functional role in emotion regulation. Here, we investigated how reactivating highly emotional autobiographical memories prior to sleep affects dream content and subsequent emotional appraisal of these memories. Participants (<i>N</i> = 42) completed the Autobiographical Emotional Memory Task prior to bed for three consecutive nights, providing up to three verbal dream reports each night, with sleep monitored via wrist actigraphy. Consistent with emotion regulation theories of dreaming, we hypothesized that reactivating negative emotional memories before sleep would affect the content and emotion of dreams more than reactivating positive memories, and that participants who dreamed about negative memories would have greater overnight reductions in emotional reactivity toward them than those who did not. As hypothesized, the valence of reactivated memories strongly influenced participants' dream emotions. Contrary to our hypotheses, positive memories were descriptively more likely to be incorporated into dream content than negative memories, although this difference did not reach significance. Furthermore, overnight changes in emotional appraisal of memories were unrelated to dream emotion or content. These observations demonstrate that it is possible to experimentally manipulate dreaming by reactivating highly emotional autobiographical memories before sleep. However, we find no support for preferential incorporation of negative emotional experiences into dreams, and no evidence that dreaming about emotional memories is associated with overnight changes in reactivity toward them.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 4","pages":"zpag101"},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the sleep tunnel: effects of a single-session scarcity-informed mass psychoeducation on dysfunctional beliefs and insomnia symptoms.","authors":"Chang-Ho Yun, Saeil Nam, Hyeongsuk Ryu, Sang-Min Paik, Jae Rim Kim, Jee-Eun Yoon","doi":"10.1093/sleepadvances/zpag099","DOIUrl":"10.1093/sleepadvances/zpag099","url":null,"abstract":"<p><strong>Study objectives: </strong>Cognitive-behavioral therapy for insomnia (CBT-I) effectively targets dysfunctional sleep beliefs but remains inaccessible to most. This study examined whether a single 60-minute mass psychoeducation session, incorporating Scarcity Theory with CBT-I psychoeducation elements and Acceptance and Commitment Therapy concepts, could reduce dysfunctional beliefs and insomnia symptoms over 4 weeks.</p><p><strong>Materials and methods: </strong>This prospective, single-arm study was conducted at Seoul National University Bundang Hospital. Of 182 lecture attendees, 81 consented, 40 completed baseline and immediate post-lecture assessments, and 29 completed all four timepoints through 4 weeks. The primary outcome was the Korean Dysfunctional Beliefs and Attitudes about Sleep-6 (K-DBAS-6). Secondary outcomes included the Insomnia Severity Index-3 (ISI-3), Bandwidth Tax Visual Analogue Scale (BT-VAS), and Patient Global Impression measures. Longitudinal effects were analyzed using repeated measures ANOVA (<i>N</i> = 29).</p><p><strong>Results: </strong>K-DBAS-6 decreased significantly (<i>d</i> z = 0.63, p = .003). ISI-3 (<i>d</i> z = 0.60, p = .003), BT-VAS (<i>d</i> z = 0.62, p = .002), and PGI-S (<i>d</i> z = 0.97, p < .001) also improved. BT-VAS showed immediate post-lecture reduction (<i>d</i> z = 0.63, p < .001; <i>N</i> = 40). At 4 weeks, 72.4% reported global improvement (PGI-I ≤ 3). Anchor-based minimal clinically important differences were 1.32 (K-DBAS-6), 1.58 (ISI-3), and 1.83 (BT-VAS). All effects remained significant after adjusting for age and sex.</p><p><strong>Conclusions: </strong>A single mass psychoeducation session informed by Scarcity Theory produced significant, sustained reductions in dysfunctional sleep beliefs and insomnia symptoms with medium effect sizes. This scalable approach warrants investigation as a first-step intervention for insomnia.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag099"},"PeriodicalIF":0.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral sex differences in serum serotonin modulation in habitual short sleepers: an exploratory randomized trial of encapsulated <i>Lacticaseibacillus rhamnosus</i> GG.","authors":"Gonzalo Saiz-Gonzalo, Ahmed W Al-Humadi, Seamus McSweeney, Carel W le Roux, Sinéad B Bleiel","doi":"10.1093/sleepadvances/zpag098","DOIUrl":"10.1093/sleepadvances/zpag098","url":null,"abstract":"<p><p>Sleep restriction, serotonin biology, and gut-brain signaling are interconnected, but whether habitual short sleep is associated with altered peripheral serotonin in healthy adults remains unclear. Probiotic modulation of circulating serotonin has also been insufficiently characterized. In this exploratory randomized, double-blind, placebo-controlled study, 21 healthy adults received microencapsulated <i>Lacticaseibacillus rhamnosus</i> GG or placebo for 28 days and were classified by habitual sleep duration as short sleepers (≤5 h/night) or adequate sleepers (≥6 h/night). Fasting serum serotonin was measured at baseline and day 28. Habitual short sleep was not associated with elevated serum serotonin. Female sex was associated with higher adjusted day-28 serum 5-HT in the primary winsorized log-transformed ANCOVA model (Type II ANOVA: F = 6.04, <i>p</i> = .03, partial η² = 0.29), whereas treatment and sleep group did not show evidence of association. Although no statistically detectable independent probiotic effect was identified in this small exploratory sample. Directional decreases were observed in some participants with higher baseline serotonin values. These findings suggest that sex may be an important source of variation in peripheral serotonin and support further adequately powered studies using objective sleep phenotyping and prespecified sex-stratified analyses.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag098"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study investigating the effect of serum 25-hydroxyvitamin D on device-estimated sleep metrics in young black women: a single-arm open-label clinical trial.","authors":"Michele N D'Agata, Krista M Szymanski, Freda Patterson, Mackenzie L Rattigan, Alexs A Matias, David G Edwards, Christopher R Martens, Sushant M Ranadive, Melissa A Witman","doi":"10.1093/sleepadvances/zpag096","DOIUrl":"10.1093/sleepadvances/zpag096","url":null,"abstract":"<p><strong>Study objectives: </strong>Vitamin D deficiency has been linked to poor sleep health outcomes in the general population. Black women (BLW) experience a higher prevalence of vitamin D deficiency and short and disturbed sleep compared with other races. Therefore, this study tested cross-sectional associations between serum 25-hydroxyvitamin D concentration ([25(OH)D]) and sleep health estimates in young adult BLW, followed by an 8-week vitamin D supplementation intervention.</p><p><strong>Materials and methods: </strong>Forty-three 18-30-year-old BLW underwent blood sampling for serum [25(OH)D]. Sleep metrics were derived from 14-days of wrist accelerometry. Thereafter, participants with [25(OH)D] <30 ng/ml (N = 16) completed an 8-week vitamin D3 supplementation intervention (5000 IU/day) and repeated blood sampling and sleep monitoring.</p><p><strong>Results: </strong>Linear regressions demonstrate significant cross-sectional associations for [25(OH)D] with sleep efficiency (β = 0.11, <i>p</i> = .03; %) and sleep onset standard deviation (SOSD) (β = -0.53, <i>p</i> = .04; minutes), but no associations with sleep duration or sleep duration standard deviation (<i>p</i> > .18). Among intervention participants, paired-sample <i>t-</i>tests demonstrate a significant increase in [25(OH)D] (16.8 ± 7.0 vs. 55.3 ± 10.0, ng/ml; <i>p</i> < .001), however, no changes were observed among actigraphy-derived sleep variables (all <i>p</i> > .21).</p><p><strong>Conclusions: </strong>[25(OH)D] was cross-sectionally associated with sleep efficiency and SOSD, however, intervention results from this pilot study do not demonstrate a beneficial effect of vitamin D on several device-estimated sleep metrics in young BLW.</p><p><strong>Clinical trial registration: </strong>Effects of Vitamin D on Cardiovascular Health in Black Women, https://clinicaltrials.gov/study/NCT05656742?locStr=Delaware&country=United%20States&state=Delaware&cond=Vitamin%20D%20Deficiency&term=blood%20pressure&intr=Vitamin%20D&rank=1 Registered on ClinicalTrials.gov ID NCT05656742.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag096"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study of restless legs syndrome in end-stage renal disease.","authors":"Noah Risse, Philip Harrer, Giorgos K Sakkas, Ioannis Stefanidis, Nathalie Schandra, Ambra Stefani, Magdalena Wildt, Yves Dauvilliers, Georgios M Hadjigeorgiou, Chen Zhao, Juliane Winkelmann, Konrad Oexle, Barbara Schormair","doi":"10.1093/sleepadvances/zpag095","DOIUrl":"10.1093/sleepadvances/zpag095","url":null,"abstract":"<p><strong>Study objectives: </strong>Restless legs syndrome (RLS) is predominantly idiopathic (iRLS), with a prevalence of 2%-10% in Europe. In end-stage renal disease patients (ESRD), uremic RLS (uRLS) is substantially more prevalent, with estimates of 24%-28%. Its pathophysiology has not been fully uncovered. Therefore, we investigated potential genetic and phenotypic risk factors for uRLS.</p><p><strong>Materials and methods: </strong>We performed case-control genome-wide association studies (GWAS) on ESRD patients with and without RLS from two German and one Greek ESRD study populations (cases/controls: 186/356, 80/176, 134/357). We applied a polygenic risk score (PRS) for iRLS to four groups: uRLS cases, uremic controls, a group of iRLS cases and European 1000G individuals. Additionally, we investigated RLS associations with phenotype data available in one German dataset.</p><p><strong>Results: </strong>No SNP reached genome-wide significance in any single dataset or meta-analyses. The mean iRLS PRS was significantly higher in uRLS cases compared to uremic controls (<i>p</i> = 9.47e-10) and European 1000G individuals (<i>p</i> = 9.93e-6) and significantly smaller compared to iRLS cases (<i>p</i> = 4.84e-5). Among 164 available lead SNPs at known RLS risk loci, rs113851554 at the MEIS1 locus, the strongest known iRLS-associated variant, was significant after Bonferroni correction (0.05/164 = 3.05e-4) in the German uremic meta-analysis (<i>p</i> = 5.73e-5). Two loci rs36127502 and rs5769388, previously not associated with RLS, show suggestive significance (<i>p</i> = 1.37e-7, <i>p</i> = 1.92e-7) in a meta-analysis combining the three GWAS datasets. Regular smoking and parathormone levels were nominally associated with RLS in ESRD.</p><p><strong>Conclusions: </strong>Our findings indicate that uRLS and iRLS share a substantial part of their genetic architecture, while also pointing to candidate signals specific to uRLS.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag095"},"PeriodicalIF":0.0,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance use to cope with trauma: the interactive effect of insomnia and neighborhood socioeconomic status.","authors":"Grace M Seymour, Anthony N Reffi, Matthew B Jennings, David A Kalmbach, Philip Cheng, David A Moore, Gregory C Mahr, Christopher L Drake","doi":"10.1093/sleepadvances/zpag094","DOIUrl":"10.1093/sleepadvances/zpag094","url":null,"abstract":"<p><strong>Study objectives: </strong>Emerging literature suggests insomnia predicts post-trauma substance use. Socioeconomic context may exacerbate this relation, such that individuals with insomnia living in more disadvantaged areas may face elevated risk of substance use after trauma. The present study is the first to test whether insomnia predicts later substance use to cope after trauma, and whether this effect is stronger for individuals from more disadvantaged areas.</p><p><strong>Materials and methods: </strong>Patients recruited from an urban Level I trauma center following traumatic injury (<i>N</i> = 88, <i>M</i> _age = 39.5 ± 14.3) were evaluated for clinically significant insomnia (Insomnia Severity Index; ISI ≥ 15) and frequency of substance use to cope with trauma (Brief-COPE) during hospitalization (Time 1 [T1]), one month post-trauma (Time 2 [T2]), and two months post-trauma (Time 3 [T3]). Participants were classified as belonging to \"more\" or \"less\" disadvantaged areas based on their residential ZIP codes using the Social Vulnerability Index (SVI).</p><p><strong>Results: </strong>The interaction between T1 insomnia and SES significantly predicted the frequency of substance use to cope one-month post-trauma (<i>p</i> = .01, <i>η² _p</i>  = .11). Surprisingly, participants with insomnia living in less disadvantaged areas reported greater substance use to cope than those in more disadvantaged areas. A similar interaction emerged between T2 insomnia and SES on substance use to cope two months post-trauma (<i>p</i> = .04, <i>η² _p</i>  = .09). No such differences were observed among participants without insomnia.</p><p><strong>Conclusions: </strong>Living in less disadvantaged areas exacerbated the prospective effect of insomnia on risk for substance use to cope after trauma. Trauma patients with insomnia may benefit from sleep-focused interventions that consider alternative coping strategies to substance use.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag094"},"PeriodicalIF":0.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}