Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"The CHARMS study: rationale and study protocol for an observational study of sleep and biobehavioral rhythms in older adult couples.","authors":"Wendy M Troxel, Brian R W Baucom, Matthew J Euler, Bobbie Bermudez, Kelly G Baron","doi":"10.1093/sleepadvances/zpaf043","DOIUrl":"10.1093/sleepadvances/zpaf043","url":null,"abstract":"<p><p>Individuals with mild cognitive impairment (MCI) demonstrate cognitive decline without major functional impairment and are at increased risk for developing Alzheimer's disease and related dementias (ADRD). Sleep and biobehavioral rhythm disturbances (disruptions in 24-h oscillations in physiology and behavior, including rest-activity patterns and mealtimes) are more than twice as common among patients with MCI than cognitively intact older adults. Importantly, the consequences of sleep and biobehavioral rhythm disruption in MCI extend beyond the patient, also profoundly affecting the spouse/partner. However, scant research has investigated sleep and biobehavioral rhythms that may contribute to the health and cognitive functioning of individuals with MCI and their partners. The current paper presents the rationale and methods for the Couples Healthy Aging and Rhythms (CHARMS) study, a longitudinal cohort study of sleep and biobehavioral rhythms among older couples in which one partner evidences cognitive decline but is independent in daily functioning. The targeted enrollment goal will consist of 185 couples who meet study eligibility criteria including that one partner shows evidence of cognitive decline but reports being independent in daily activities. This is a longitudinal observational study that includes a baseline assessment, a seven-day at-home naturalistic study protocol, and a two-year follow-up to examine change over time. Findings from this study will advance the understanding of the daily and longitudinal relationships between the individual and couple-level processes in sleep and biobehavioral rhythms that influence the progression of cognitive decline in a population at increased risk for developing ADRD.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf043"},"PeriodicalIF":0.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between a novel measure of sleep health and cognitive functioning in middle childhood: a crosssectional Environmental Influences on Child Health Outcomes cohort study.","authors":"Joshua Marchant, Matthew Ferrell, Yingjia Wei, Kelly Baron, Courtney K Blackwell, Anat Sigal, Sarah Geiger, Susan L Schantz, Tina Hartert, Rachel S Kelly, Hooman Mirzakhani, Amy Elliott, Jody Ganiban, Dana Dabelea, Jonika Hash, Joseph B Stanford","doi":"10.1093/sleepadvances/zpaf049","DOIUrl":"10.1093/sleepadvances/zpaf049","url":null,"abstract":"<p><strong>Study objectives: </strong>Research linking children's sleep to cognitive outcomes is inconsistent and has largely focused on one aspect of sleep, such as duration, rather than measuring multiple dimensions of sleep health. We hypothesized that children's sleep health would be positively associated with inhibitory control and cognitive functioning.</p><p><strong>Method: </strong>We cross-sectionally assessed 1595 participants (ages 7-11) from the Environmental influences on Child Health Outcomes cohort using the NIH Toolbox Cognition Battery, Environmental influences on Child Health Outcomes Sleep Health of Children and Adolescents questionnaire, and Patient Reported Outcome Measurement Information System Sleep Disturbance/Sleep-related Impairment instruments. We created a novel scale measuring sleep health using dichotomous \"good-bad\" cutoffs for sleep duration, timing, latency, satisfaction, and alertness. We used generalized estimating equations and random forest models to examine associations between sleep health and inhibitory control, working memory, processing speed, cognitive flexibility, episodic memory, reading decoding, and receptive vocabulary.</p><p><strong>Results: </strong>Sleep health did not have statistically significant associations with any aspect of cognitive functioning. Notably, over 75 per cent of our sample had good sleep health.</p><p><strong>Conclusions: </strong>This study assessed sleep health as a multi-faceted construct, distinguishing between \"good\" and \"poor\" sleep health across several domains. The absence of statistically significant associations between sleep health and cognitive functioning suggests children's cognitive functioning may not be cross-sectionally related to multidimensional sleep health measures. Experimentally manipulating key sleep domains such as duration or timing (as done in prior research) may be more robust. Future research might benefit from examining the cumulative impact of poor sleep health over time.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf049"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimentally inducing dreams of remote emotional memory.","authors":"Chadwick C Frost, Erin J Wamsley","doi":"10.1093/sleepadvances/zpaf054","DOIUrl":"10.1093/sleepadvances/zpaf054","url":null,"abstract":"<p><p>People frequently dream of recent experiences, which may reflect the consolidation of memories in the sleeping brain. Many studies demonstrate that experimentally introducing new learning prior to sleep can induce dreams of recently encoded memories. Here, for the first time, we tested whether activating a <i>remote</i> memory just before sleep can similarly induce participants to dream about the remote past. Participants (<i>N</i> = 34) completed an Autobiographical Emotional Memory Task (AEMT), in which they recalled and wrote about an emotionally negative remote memory prior to a daytime nap. In a control condition, participants instead wrote about designing a new college course. As hypothesized, the AEMT induced emotionally negative dreams related to the remote memory activated before sleep. Specifically, according to judge ratings, dreams incorporated content from the remote memory recalled during the AEMT to a greater degree than they incorporated content from the control task. While participants themselves did not perceive their dreams as more strongly related to the AEMT memory than the control task, they did rate their dreams as more emotionally negative following the AEMT. This shows it is possible to experimentally induce dreams of a specific remote memory by activating it before sleep. These findings are discussed in light of the hypothesis that dream content might be influenced by the reconsolidation of recently reactivated remote memory.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf054"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimentally induced sleep restriction relates to less healthy eating behaviors in some adolescents: effects of age, sex, race, weight class, and socioeconomic status.","authors":"Carson Hernandez, Chad D Jensen, Kara M Duraccio","doi":"10.1093/sleepadvances/zpaf050","DOIUrl":"10.1093/sleepadvances/zpaf050","url":null,"abstract":"<p><strong>Study objectives: </strong>This secondary data analysis study was designed to evaluate demographic and socioeconomic characteristics that may increase the magnitude of the impact of experimentally induced shortened sleep on suboptimal eating behaviors in adolescence.</p><p><strong>Methods: </strong>Sixty-four adolescents completed a two-phase crossover study comparing five nights of restricted sleep to five nights of healthy sleep with adherence determined via accelerometry and with order randomized. Participants completed a 24-h dietary recall on the final day of each condition. We conducted repeated-measure <i>t</i>-tests to examine the main effect of experimental condition on dietary outcomes and general linear models to test the moderating impact of sex, age, race, income, and weight class on these relationships.</p><p><strong>Results: </strong>There was no significant main effect of sleep condition on any dietary outcome. However, we found that males in the restricted sleep condition ate more added sugar, more carbohydrates, and fewer fruits than when in healthy sleep. Furthermore, younger adolescents consumed more carbohydrates, sugar, and added sugar when sleep restricted, compared to sleep extension. Lastly, adolescents from lower-income households consumed fewer vegetables when sleep restricted compared to when sleep was healthy, while-contrary to our hypothesis-participants from higher-income households consumed more vegetables in the restricted sleep condition relative to healthy sleep.</p><p><strong>Conclusions: </strong>While no significant main effects of sleep duration on any dietary outcome were observed, this study provides preliminary evidence that restricted sleep can increase unhealthy eating habits, especially for males, younger adolescents, and adolescents from low-income households, informing obesity prevention and intervention efforts.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf050"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding discrepancies between self-reported and objective sleep in adolescents and young adults with subacute concussion.","authors":"Caitlyn E Wong, Madison N Luther, Avery Scatena, Seiji Koike, Melissa Novak, Jonathan E Elliott, Jeffrey J Iliff, Miranda M Lim, Emily Kosderka, Juan Piantino","doi":"10.1093/sleepadvances/zpaf048","DOIUrl":"10.1093/sleepadvances/zpaf048","url":null,"abstract":"<p><strong>Study objectives: </strong>Conduct a multidimensional analysis of sleep perception, objective sleep, and neuropsychiatric wellbeing in individuals with subacute concussion compared to controls.</p><p><strong>Methods: </strong>Thirty-one recently concussed individuals completed the Pittsburgh Sleep Quality Index, Insomnia Severity Index, and Patient-Report Outcomes Measurement Information System measures of depression, anxiety, stress, and cognitive function. Concussion symptom severity scores (Sports Concussion Assessment Tool) were obtained from participants' health records. Sleep parameters were derived from at least 7 days of monitoring with the Emfit QS device (total sleep time [TST], time in bed, sleep onset latency, sleep efficiency, wake after sleep onset). Data were compared to 19 controls using parametric or non-parametric tests for independence (<i>α</i> = 0.05). Pearson correlations and linear mixed models assessed relationships between data modalities.</p><p><strong>Results: </strong>Concussed individuals reported worse sleep and had lower sleep efficiency, longer time in bed, and greater sleep onset latency than controls (<i>p</i> < .05). Patient-Report Outcomes Measurement Information System symptom scores moderated these relationships at significant or near-significant levels. Controls demonstrated agreement between reported and measured sleep (for TST: <i>r</i> = 0.52; <i>p</i> = .023) and a positive relationship between sleep dissatisfaction and wake after sleep onset (<i>p</i> < .05). These relationships were not observed in individuals with concussion. Moreover, individuals with greater discrepancy between reported and measured sleep scored higher on Sports Concussion Assessment Tool concussion symptom inventories (<i>β</i> _TSTdisc = 9.5/h; <i>p</i> _beta = .007; <i>p</i> _model = .022; Total <i>R</i> ² = 0.34).</p><p><strong>Conclusions: </strong>Individuals with subacute concussion exhibited worse self-reported and objective sleep than controls, but showed discrepancy between reported and measured sleep characteristics that correlated with concussion severity at diagnosis. Future assessment of sleep discrepancy may improve understanding of post-concussive sleep disturbance.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf048"},"PeriodicalIF":0.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary investigation of obstructive sleep apnea and Alzheimer's disease in down syndrome.","authors":"Dasoo M Yoon, David T Plante, Victoria Fleming, Benjamin Handen, Patrick Lao, Jamie Peven, Bradley Christian, Ozioma Okonkwo, Charles Laymon, Beau Ances, Christy Hom, Brian Helsel, Sigan L Hartley","doi":"10.1093/sleepadvances/zpaf044","DOIUrl":"10.1093/sleepadvances/zpaf044","url":null,"abstract":"<p><p>This study provided a preliminary examination of indices of obstructive sleep apsnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer's disease (AD) pathology and symptomatology. A total of 93 adults with DS (aged 25-61 years) from the Alzheimer Biomarker Consortium-DS completed cognitive assessments, MRI and positron emission tomography (PET) scans (assessing amyloid-beta [Aβ] and tau), and a one-night home sleep study using the WatchPAT-300 device. Study partners also reported on depressive symptoms and diagnoses. Correlational analyses examined relationships between sleep variables, PET biomarkers, and AD symptomatology (cognitive functioning and depressive mood), controlling for sociodemographics. A total of 81 participants (87 per cent) completed valid WatchPAT data. Of these, 60 (74 per cent) screened positive for OSA, and an additional 11 had a prior OSA diagnosis and used CPAP during the test night. Nearly half (45 per cent) of those screening positive for OSA had no prior diagnosis, indicating under-detection. Among the 22 participants using OSA treatment, 50 per cent continued to show sleep-disordered breathing, suggesting suboptimal treatment effectiveness. Higher wake percentage and shorter total sleep time were associated with greater Aβ and tau burden. Cognitive performance was negatively associated with wake percentage, total sleep time, and oxygenation indices (minimum oxygen, desaturation, and time ≤ 88 per cent oxygen). Depressive symptoms were negatively related to total sleep time. These findings add preliminary evidence linking sleep disruption and OSA with AD-related pathology and symptomatology. Larger, longitudinal studies are needed to confirm these associations and evaluate whether improving sleep quality and treating OSA may help delay AD onset in this high-risk population.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf044"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological effects of targeting sleep spindles with closed-loop auditory stimulation.","authors":"Hugo R Jourde, Milo Sobral, Giovanni Beltrame, Emily B J Coffey","doi":"10.1093/sleepadvances/zpaf007","DOIUrl":"10.1093/sleepadvances/zpaf007","url":null,"abstract":"<p><p>Sleep spindles are neural events unique to nonrapid eye movement sleep that play key roles in memory reactivation and consolidation. However, much of the evidence for their function remains correlational rather than causal. Closed-loop brain stimulation uses real-time monitoring of neural events (often via electroencephalography; EEG) to deliver precise auditory, magnetic, or electrical stimulation for research or therapeutic purposes. Automated online algorithms to detect and stimulate sleep spindles have recently been validated, but the time- and frequency-resolved physiological responses generated by them have not yet been documented. Building on the recent findings that sleep spindles do not block the transmission of sound to cortex, the present work investigates the neurophysiological responses to closed-loop auditory stimulation of sleep spindles. EEG data were collected from 10 healthy human adults (6 nights each), whilst sleep spindles were detected and in half the nights, targeted with auditory stimulation. Spindles were successfully stimulated before their offset in 97.6% of detections and did not disturb sleep. Comparing stimulation with sham, we observed that stimulation resulted in increased sigma activity (11-16 Hz) at about 1 second poststimulation but that stimulation occurring at the beginning of the spindle also resulted in early termination of the spindle. Finally, we observed that stimulating an evoked spindle did not elicit additional sigma activity. Our results validate the use of closed-loop auditory stimulation targeting sleep spindles, and document its neural effects, as a basis for future causal investigations concerning spindles' roles in memory consolidation.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf007"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disordered breathing and circulating non-esterified fatty acids: the cardiovascular health study.","authors":"Peter Ahiawodzi, Russell P Tracy, Jorge R Kizer, Susan Redline, Luc Djousse, Kenneth J Mukamal","doi":"10.1093/sleepadvances/zpaf042","DOIUrl":"10.1093/sleepadvances/zpaf042","url":null,"abstract":"<p><strong>Study objectives: </strong>Circulating non-esterified fatty acids (NEFAs) have been associated with impaired glucose metabolism but their modifiable determinants remain uncertain. We sought to determine the association between objectively-measured sleep disordered breathing (SDB), which is also associated with dysglycemia, and NEFA levels among community-dwelling older adults.</p><p><strong>Methods: </strong>We analyzed 787 older adults who had total fasting and post-load NEFAs measured in 1996-1997 in the Cardiovascular Health Study and underwent polysomnography between 1995 and 1997 in the Sleep Heart Health Study. We used multivariable linear regression to model NEFAs as a function of four SDB parameters: apnea-hypopnea index, arousal index, hypoxemia, and slow-wave sleep, and tested formal mediating effects by insulin sensitivity estimated with the Gutt index.</p><p><strong>Results: </strong>The mean age of study participants was 77.5 ± 4.3 years. The proportion of females and non-Hispanic whites was 58.7 per cent and 84.2 per cent, respectively. We did not find statistically significant associations between any of the SDB parameters and fasting NEFAs, but higher amounts of slow-wave sleep were significantly associated in a linear fashion with lower total post-load NEFAs in unadjusted and adjusted models [adjusted: β = -0.004, SE = 0.001, <i>p</i> = .02]. In mediation analyzes, 10 per cent of the slow wave sleep-NEFA association was mediated by Gutt-estimated insulin sensitivity (<i>p</i> = .45 for the indirect effect).</p><p><strong>Conclusions: </strong>Among the SDB measures studied, only higher levels of objectively measured slow-wave sleep were significantly associated with lower levels of post-load NEFAs, although the underlying mechanism is uncertain. Establishing a causal link would make SDB interventions a promising target for NEFA regulation.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf042"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep restriction impairs item memory discrimination but not general recognition in young adolescents.","authors":"Jared M Saletin, Sinéad M Moyles, Victoria O Dionisos, Taylor G Christiansen, Claire Mayew Sherman, Gina M Mason, Silvia A Bunge, Francisco Xavier Castellanos, Judith Owens, David H Barker, Daniel P Dickstein, Mary A Carskadon","doi":"10.1093/sleepadvances/zpaf038","DOIUrl":"10.1093/sleepadvances/zpaf038","url":null,"abstract":"<p><strong>Study objectives: </strong>The impact of sleep loss on memory encoding is well described in adults, yet less understood in youth, despite the prevalence and educational relevance of adolescent sleep loss. Here, we implement at-home sleep restriction in youth ages 10-14 and a well-validated hippocampus-dependent learning task to elucidate how real-world levels of sleep loss affect distinct memory encoding processes at this young age.</p><p><strong>Methods: </strong>A within-subject cross-over design involved five nights of at-home sleep restriction (7.5 h in bed) compared to sleep optimization (10 h in bed). Restriction was achieved by delaying bedtime and advancing risetime equally. All sleep was monitored with wrist actigraphy, sleep diaries, and daily calls to the laboratory. Testing involved the validated Mnemonic Similarity Task (MST), which can distinguish between two components of successful memory encoding: general memory recognition for old items and \"lure discrimination,\" a hippocampus-dependent ability to distinguish similar yet distinct items.</p><p><strong>Results: </strong>As estimated by actigraphy, our manipulation reduced sleep by 1.4 ± 0.48 h per night for five nights. This reduction resulted in a selective deficit in MST-indexed memory encoding; we observed a decrease in lure discrimination (i.e. the ability to distinguish highly similar items), but no impact on recognition of old items.</p><p><strong>Conclusions: </strong>We present evidence that low levels of sleep loss for five nights (typical of a school week) are sufficient to alter memory encoding in youth. We interpret these data in the context of classroom-based learning and speculate that reduced lure discrimination may yield memory that is less capable of distinguishing closely related facts and concepts.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf038"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbance and multimorbidity: a cross-sectional and longitudinal study in the knee pain and related health in the community cohort.","authors":"Will Thompson, Subhashisa Swain, Carol Coupland, Frances Rees, Phil Courtney, Michelle Hall, Eamonn Ferguson, David A Walsh, Ana M Valdes, Richard Morriss, Michael Doherty, Weiya Zhang","doi":"10.1093/sleepadvances/zpaf039","DOIUrl":"10.1093/sleepadvances/zpaf039","url":null,"abstract":"<p><strong>Study objectives: </strong>To examine whether there is a temporal association between sleep disturbance and multimorbidity.</p><p><strong>Methods: </strong>We performed a cross-sectional and longitudinal observational analysis in people aged 40 years or more, recruited from the knee pain and related health in the community cohort study. The primary exposure was the Sleep Problems Index II score in tertiles measured at baseline. The primary outcome was count of chronic conditions developed in 5 years. Pain, low mood, and anxiety were measured at 2 years as mediators. Poisson regression was used to calculate adjusted relative risk and 95% confidence intervals.</p><p><strong>Results: </strong>We included 4488 participants in the cross-sectional analysis at baseline and 1941 in the 5-year longitudinal analysis. At baseline, the adjusted relative risks for prevalent multimorbidity were 1 (reference) for tertile 1, 1.09 (95% confidence interval; 1.01-1.18) for tertile 2, and 1.21 (95% confidence interval; 1.11-1.32) for tertile 3 of the sleep disturbance score (p for trend <.001). Of the total association between sleep disturbance and multimorbidity, 14 per cent (95% confidence interval; 9% to 19%) were mediated by pain and 7 per cent (95% confidence interval; 2% to 13%) by low mood. In the 5 year follow-up, the adjusted relative risk for incident multimorbidity were 1 (reference) for tertile 1, 1.12 (95% confidence interval; 0.98-1.28) for tertile 2, and 1.25 (95% confidence interval; 1.06-1.47) for tertile 3 (p for trend .007). Of the total association between sleep disturbance and multimorbidity, 10 per cent (95% confidence interval; 2% to 18%) was mediated by pain.</p><p><strong>Conclusions: </strong>Sleep disturbance is associated with multimorbidity. The association is dose-dependent, temporal, and partially mediated by pain.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 3","pages":"zpaf039"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}