Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"Bridging the gap between lab and field sleep studies: a proof-of-concept for studying wild rats in semi-captive environments.","authors":"Paul-Antoine Libourel, Sébastien Arthaud, Antoine Bergel, Fabrice Brescia, Azzedine Dib, Bertrand Massot, Eric Vidal, Wilfreid Weiss","doi":"10.1093/sleepadvances/zpaf036","DOIUrl":"10.1093/sleepadvances/zpaf036","url":null,"abstract":"<p><p>Sleep is a vital and universal behavior distinct from mere inactivity, yet its ecological role remains poorly understood due to methodological limitations in recording sleep in the wild. Using a small, low-power biologger, collecting brain activity, body movements, and physiology, we recorded key sleep parameters in wild black rats (<i>Rattus rattus</i>) under semi-captive conditions. We developed a rapid (<1 h) surgical procedure using a custom subdermal flexible electrode, providing signal quality comparable to standard cortical electrodes. Our validated semi-captive setup allowed animals to remain in their natural environment with ad libitum food and social contact while minimizing interactions. This protocol enables the study of sleep's ecological role and the influence of environmental factors on sleep expression, offering insights into its evolution. Additionally, it can help clarify sleep's central role in the context of global environmental change. By monitoring general behavior and sleep patterns in four wild rats for up to 10 days post-surgery, as well as feeding behavior for over a month, we observed no signs of pain or stress, with sleep patterns stabilizing within 2 days. This approach provides a unique tool to assess sleep variability and flexibility, demonstrating its feasibility for studying sleep in small (<200 g) wild animals.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf036"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological effects of targeting sleep spindles with closed-loop auditory stimulation.","authors":"Hugo R Jourde, Milo Sobral, Giovanni Beltrame, Emily B J Coffey","doi":"10.1093/sleepadvances/zpaf007","DOIUrl":"10.1093/sleepadvances/zpaf007","url":null,"abstract":"<p><p>Sleep spindles are neural events unique to nonrapid eye movement sleep that play key roles in memory reactivation and consolidation. However, much of the evidence for their function remains correlational rather than causal. Closed-loop brain stimulation uses real-time monitoring of neural events (often via electroencephalography; EEG) to deliver precise auditory, magnetic, or electrical stimulation for research or therapeutic purposes. Automated online algorithms to detect and stimulate sleep spindles have recently been validated, but the time- and frequency-resolved physiological responses generated by them have not yet been documented. Building on the recent findings that sleep spindles do not block the transmission of sound to cortex, the present work investigates the neurophysiological responses to closed-loop auditory stimulation of sleep spindles. EEG data were collected from 10 healthy human adults (6 nights each), whilst sleep spindles were detected and in half the nights, targeted with auditory stimulation. Spindles were successfully stimulated before their offset in 97.6% of detections and did not disturb sleep. Comparing stimulation with sham, we observed that stimulation resulted in increased sigma activity (11-16 Hz) at about 1 second poststimulation but that stimulation occurring at the beginning of the spindle also resulted in early termination of the spindle. Finally, we observed that stimulating an evoked spindle did not elicit additional sigma activity. Our results validate the use of closed-loop auditory stimulation targeting sleep spindles, and document its neural effects, as a basis for future causal investigations concerning spindles' roles in memory consolidation.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf007"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive behavioral therapy for insomnia among heavy-drinking veterans: a randomized pilot trial.","authors":"Mary Beth Miller, Ryan W Carpenter, Sydney D Shoemaker, Katie R Moskal, Brian Borsari, Eric R Pedersen, Bruce D Bartholow, Douglas Steinley, Christina S McCrae","doi":"10.1093/sleepadvances/zpaf037","DOIUrl":"10.1093/sleepadvances/zpaf037","url":null,"abstract":"<p><strong>Study objectives: </strong>Two in five Veterans report symptoms of insomnia, with higher rates among those who drink heavily. Although Cognitive Behavioral Therapy for Insomnia (CBT-I) has demonstrated efficacy among those with Alcohol Use Disorder, abstinence is often considered a prerequisite for treatment, leaving its impact unclear among those who are actively drinking. This trial tested the efficacy of CBT-I among heavy-drinking Veterans with insomnia (#NCT03804788).</p><p><strong>Methods: </strong>Veterans from across the United States were randomly assigned to CBT-I or sleep hygiene control. Participants completed retrospective surveys and 14 sleep diaries at baseline, post-treatment, and 3-month follow-up. Primary outcomes were feasibility and insomnia severity. All other outcomes are secondary/exploratory. Intent-to-treat analyses were conducted using multilevel models.</p><p><strong>Results: </strong>Recruitment spanned June 2019 to March 2023 (<i>N</i> = 71, 80% male, <i>M</i> = 38 years). On average, we recruited 4 participants per month, with retention of 86% at post-treatment and 90% at follow-up. Of 38 CBT-I participants, 33 (87%) completed all 5 treatment sessions, and most responded to treatment (based on change in outcome scores; 22/38 at post, 27/38 at follow-up). Relative to control (<i>n</i> = 33), CBT-I participants reported large improvements in insomnia severity, both post-treatment [<i>d</i> = 1.26 (95% CI: 0.74, 1.76)] and at 3-month follow-up [<i>d</i> = 1.33 (95% CI: 0.81, 1.84)]. At follow-up, results for use of alcohol as a sleep aid [<i>d</i> = 0.66 (95% CI: 0.18, 1.14)] and sleep medication [<i>d</i> = 0.44 (95% CI: -0.03, 0.91)] also favored CBT-I.</p><p><strong>Conclusions: </strong>CBT-I is feasible among heavy-drinking Veterans and has large effects on insomnia severity. Studies testing mechanistic effects on alcohol outcomes are warranted.</p><p><strong>Clinical trial information: </strong>The iTAP Study for Veterans, registered on clinicaltrials.gov (#NCT03804788) on January 11, 2019: https://clinicaltrials.gov/study/NCT03804788?term=NCT03804788&rank=1.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf037"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of nocturnal hypoxemia and white blood cell count in a multicenter cohort.","authors":"Aditi Shah, Mohammadreza Hajipour, A J Hirsch Allen, Najib Ayas, Tetyana Kendzerska, Patrick Hanly, John Kimoff, Frederic Series, Annie Lajoie, Rebecca Robillard, Rachel Jen, Andrew E Beaudin, Jill Raneri, Robert Skomro","doi":"10.1093/sleepadvances/zpaf028","DOIUrl":"10.1093/sleepadvances/zpaf028","url":null,"abstract":"<p><strong>Study objectives: </strong>There is a higher risk of cardiovascular disease (CVD) in patients with obstructive sleep apnea (OSA) and innate immunity is a potential pathophysiologic pathway. The objective of this study was to determine whether nocturnal hypoxemia is associated with circulating markers of innate immunity in OSA.</p><p><strong>Methods: </strong>This was a cross-sectional study of an observational cohort from the multicentre, clinic-based, Canadian Sleep and Circadian Network. Oxygen desaturation index 4% (ODI4%) was used to diagnose and determine the severity of OSA. The percentage of time spent below SpO₂ <90% (T90) and minimum SpO₂ we considered as other measures of nocturnal hypoxemia. Multiple linear regressions were used to assess associations between total white blood cell (WBC) and subsets and ODI and hypoxemia indices.</p><p><strong>Results: </strong>A total of 1296 patients were included in the analysis. There was a positive association between ODI4% and lymphocyte count, adjusting for confounders. For every 1-<i>SD</i> increase in ODI4%, lymphocyte counts increased by 0.08 × 10⁹ L (95% CI 0.01 to 0.15) <i>SD</i>. Patients with severe OSA (ODI4% ≥ 30 events/hour) had significantly higher total WBC and lymphocyte count than non-OSA cohort, in the adjusted model, <i>p</i>-value <.02, for both. There was a positive association between T90 and total WBC, neutrophil, lymphocyte, and monocyte count, adjusting for confounders. Minimum SpO₂ was independently associated with total WBC, neutrophil, and monocyte counts.</p><p><strong>Conclusions: </strong>In this pan-Canadian clinic-based cohort of individuals with suspected OSA, nocturnal hypoxemia indices were associated with an increase in total WBC and subset counts.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf028"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of acute trazodone administration on sleep in mice.","authors":"Mayuko Arai, Brianne A Kent","doi":"10.1093/sleepadvances/zpaf031","DOIUrl":"10.1093/sleepadvances/zpaf031","url":null,"abstract":"<p><strong>Study objectives: </strong>Trazodone is an antidepressant with robust hypnotic effects, frequently prescribed off-label to treat insomnia. Trazodone has gained recent attention in the context of neurodegenerative diseases because sleep has been proposed as a novel target for disease-modifying therapeutics. Preclinical research in rodents examining the effects of trazodone on sleep is limited, so here we aimed to develop a translationally focused protocol to study the sleep-promoting effects of trazodone in mice.</p><p><strong>Methods: </strong>We investigated the effects of voluntary oral trazodone administration at doses of 10, 40, and 60 mg/kg on sleep in C57BL/6J mice (<i>n</i> = 15; females = 6; age 10-13 months). Mice were dosed with trazodone for 6 consecutive nights, while being recorded with intracranially implanted 2-channel electroencephalogram (EEG) and electromyography (EMG). EEG/EMG recordings were analyzed for time spent in each vigilance state and power spectra.</p><p><strong>Results: </strong>A single dose of trazodone, administered prior to the onset of the 12-h rest phase, dose-dependently increased non-rapid eye movement (NREM) sleep and delta power during NREM sleep, at the expense of rapid eye movement (REM) sleep. These effects on sleep persisted after six consecutive days of dosing, albeit to a lesser extent.</p><p><strong>Conclusions: </strong>We have validated a novel voluntary oral administration protocol for trazodone use in mice and have shown that trazodone effectively promotes NREM in mice. Our novel protocol will be useful for future research investigating the effects of trazodone on sleep in mouse models of disease.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf031"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted memory reactivation during REM sleep may selectively enhance the late positive potential amplitude in previously encountered negative images: preliminary findings.","authors":"Kazuki Sato, Satomi Okabe, Yoko Suzuki, Takashi Abe","doi":"10.1093/sleepadvances/zpaf034","DOIUrl":"10.1093/sleepadvances/zpaf034","url":null,"abstract":"<p><p>The function of rapid eye movement (REM) sleep in consolidating emotional memories and reducing emotional charge has been studied, but evidence remains conflicting. Our study employed the targeted memory reactivation (TMR) technique, which posits that specific sleep memories can be reactivated through sensory stimuli during sleep. Additionally, the late positive potential (LPP), a component of event-related brain potentials, was measured while participants (<i>N</i> = 16, 22.5 ± 1.2 years) viewed negative, neutral, or positive images (old images) paired with an odor stimulus. During subsequent REM sleep, the same odor was presented in the TMR condition, while an odorless stimulus was presented in the control condition. Upon awakening, participants performed the same task as before sleep, with new images added to test memory. The results demonstrated that TMR increased the LPP amplitude between 500 and 800 ms after image onset following sleep for negative old images; however, no changes were observed in the LPP in the same range for negative new images and neutral or positive images. TMR during REM sleep did not influence performance on the memory task, nor did it affect levels of arousal or emotional valence immediately after viewing the emotional images. These preliminary findings from our pilot study suggest that either the presentation of phenylethyl alcohol itself or the reprocessing induced by TMR during REM sleep selectively enhances the LPP in emotional processing of previously encountered negative stimuli. Due to the small sample size of this study, further investigation is warranted to evaluate the robustness of the results.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf034"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactivation fails to offer the improvement sleep does.","authors":"Murray M Barsky, Alexandra Morgan, Robert Stickgold","doi":"10.1093/sleepadvances/zpaf035","DOIUrl":"10.1093/sleepadvances/zpaf035","url":null,"abstract":"<p><p>In a dynamic process that ultimately affords memories their persistence, memory reconsolidation can serve to strengthen associations following reactivation, particularly in sleep, where active processes may effect overnight enhancement. Reactivation can also occur in wake, where improvement would be unexpected. In an earlier study using performance on the Weather Prediction Task (WPT) as a measure of probabilistic category learning, we looked at the effect of sleep and found significant improvement after a daytime nap, where improvement correlated with the amount of REM sleep obtained. When we introduced interference training following sleep, this REM sleep benefit vanished: post-learning task memory was otherwise preserved. Here, we follow up on these results and test whether reactivation itself-wake reactivation-might be sufficient to induce the improvement found after REM sleep. Our results show that it is not: we saw no improvement on the WPT following reactivation in wake, suggesting sleep may be unique in supporting memory improvement. When we looked at interference effects, we saw unexplained differences between wake and sleep that suggest that while interference is uniformly destabilizing of WPT memories during wake, interference after REM show effects on the memory trace formed during initial learning that are distinctly different from its effects on the subsequently sleep-enhanced memory.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf035"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being in the right place at the right time.","authors":"Sonia Ancoli-Israel","doi":"10.1093/sleepadvances/zpaf033","DOIUrl":"10.1093/sleepadvances/zpaf033","url":null,"abstract":"<p><p>This paper is a review of my life as a sleep researcher and clinician. I chanced into sleep by being at the right place at the right time. Over the last 45 years, I became an expert on sleep and circadian rhythms in aging, in Alzheimer's disease and Parkinson's disease and in cancer. We were one of the first to show how common sleep apnea and periodic limb movements in sleep are in the elderly. We \"moved\" into the nursing home and showed how disrupted sleep is in these patients. We used light therapy to improve sleep in the nursing home. We studied the effect of CPAP on sleep and cognition in both Alzheimer's disease and Parkinson's disease. And we were some of the first to study sleep and circadian rhythms in women with breast cancer, starting the evaluations before they started their chemotherapy. These studies were both observational and treatment studies. I am very proud of the work we did. For me, everything revolves around sleep. And that is the beginning of my story.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf033"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SleepInvestigatoR: a flexible R function for analyzing scored sleep in rodents.","authors":"Mackenzie C Gamble, Benjamin R Williams, James T McKenna, Ryan W Logan","doi":"10.1093/sleepadvances/zpaf032","DOIUrl":"10.1093/sleepadvances/zpaf032","url":null,"abstract":"<p><p>Analyzing scored sleep is a fundamental prerequisite to understanding how sleep changes between health and disease. Classically, this is accomplished by manually calculating various measures (e.g. percent of non-rapid eye movement sleep) from a collection of scored sleep files. This process can be tedious and error-prone, especially when studies include large animal numbers or involve long recording sessions. To address this issue, we present SleepInvestigatoR, a versatile tool that can quickly organize and analyze multiple scored sleep files into a single output. The function is written in the open-source statistical language R and has a total of 25 parameters that can be set to match a wide variety of experimental needs. SleepInvestigatoR delivers a total of 23 unique measures of sleep, including all measures commonly reported in the rodent literature. A simple plotting function is also provided to quickly graph and visualize the scored data. All code is designed to be implemented with little formal coding knowledge, and step-by-step instructions are provided on the corresponding GitHub page. Overall, SleepInvestigatoR provides the sleep researcher a critical tool to increase efficiency, interpretation, and reproducibility in analyzing scored rodent sleep.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf032"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrative approach prioritizes the orphan GPR61 genomic region in tissue-specific regulation of chronotype.","authors":"Cynthia Tchio, Jonathan S Williams, Herman Taylor, Hanna M Ollila, Richa Saxena","doi":"10.1093/sleepadvances/zpaf030","DOIUrl":"10.1093/sleepadvances/zpaf030","url":null,"abstract":"<p><strong>Study objectives: </strong>Chronotype, a manifestation of circadian rhythms, affects morning or evening preferences and ease of getting up. This study explores the genetic basis of morning chronotype and ease of getting up, focusing on the G-protein-coupled receptor locus, GPR61.</p><p><strong>Methods: </strong>We analyzed the genetic correlation between chronotype and ease of getting up using linkage disequilibrium score regression with summary statistics from the UK Biobank (<i>n</i> = 453,379). We prioritized shared signals between chronotype and ease of getting up using the Human Genetic Evidence (HuGE) score. We assessed the significance of GPR61 and the lead variant rs12044778 through co-localization and <i>in silico</i> analyses from ENCODE, Genotype-Tissue Expression, Hi-C, and Knockout Mouse Project databases to explore potential regulatory roles of causal genes.</p><p><strong>Results: </strong>We identified a strong genetic correlation (Rg = 0.80, <i>p</i> = 4.9 × 10³²⁴) between chronotype and ease of getting up. Twenty-three genes, including three circadian core clock components, had high HuGE scores for both traits. Lead variant rs12044778 in <i>GPR61</i> was prioritized for its high HuGE score (45) and causal pleiotropy (posterior probability = 0.98). This morningness variant influenced gene expression in key tissues: decreasing <i>GPR61</i> in tibial nerve, increasing <i>AMIGO1</i> in subcutaneous adipose, and increasing <i>ATXN7L2</i> in the cerebellum. Functional knockout models showed <i>GPR61</i> knockout increased fat mass and activity, <i>AMIGO1</i> knockout increased activity, and <i>ATXN7L2</i> knockout reduced body weight without affecting activity.</p><p><strong>Conclusions: </strong>Our findings reveal pleiotropic genetic factors influencing chronotype and ease of getting up, emphasizing <i>GPR61</i>'s rs12044778 and nearby genes like <i>AMIGO1</i> and <i>ATXN7L2</i>. These insights advance our understanding of circadian preferences and suggest potential therapeutic interventions.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf030"},"PeriodicalIF":0.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}