Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"Short sleep recovery partially restores decision-making alterations induced by total sleep deprivation.","authors":"Quentin Schlitter, Vincent Beauchamps, Michael Quiquempoix, Pierre Fabries, Anthony Vacher, Marion Trousselard, Thibaut Dondaine, Fabien Sauvet","doi":"10.1093/sleepadvances/zpag038","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag038","url":null,"abstract":"<p><p>The dynamics of recovery from impaired decision-making after total sleep deprivation (TSD) are not well understood. We investigated the impact of TSD and subsequent 3 h sleep recovery night period on decision-making. After one baseline night (8 h Time in Bed [TIB], 23:00-07:00), 40 study participants (50 per cent women) followed a sleep deprivation protocol including one night of TSD (40 h continuous awakening), followed by 3 h TIB sleep recovery period (23:00-02:00) and 8 h TIB sleep recovery period. Indices derived from reaction time (RT), Go/No-Go, and complex Go/No-Go tasks (involving perceptual components, motor responses, RT, and accuracy) were assessed daily during dual-choice decision-making tasks (MindPulse Digital Battery). Composite indices to describe executive speed, reaction to difficulty, speed/accuracy balance, and parameters from decision diffusion model analysis were recorded. Errors and RT increased after TSD and remained elevated after a 3-h sleep recovery night, particularly for Go/No-Go tasks. Anticipation and inhibition errors as well as speed/accuracy balance are not restored by 3 h sleep recovery night, whereas RT was restored. Lower decision diffusion model drift values (i.e. slower information accumulation) observed in the higher difficulty (complex Go/No-Go) after TSD, persisted after the 3-h recovery night. All parameters were restored after an 8-h TIB recovery night. No effect of sleep loss on executive speed and reaction to difficulty was observed. In conclusion, short sleep recovery partially restored decision-making alterations induced by TSD. Slower perceptual and motor processes that persist after a short recovery night may favor errors, with possible operational consequences for shift or on-call workers. <b>Clinical trial:</b> NCT05924737, https://clinicaltrials.gov/study/NCT05924737, 2023_RECOPS study, registered 2023-06-12 (Study start 2023-10-01). <b>Clinical Trial Informations:</b> Delta Waves and Cognitive Recovery (RECOPS), NCT05924737, https://clinicaltrials.gov/study/NCT05924737, study record: 2023-06-20, study start: 2023-10-01.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag038"},"PeriodicalIF":0.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian misalignment and adolescent obesity risk behaviors: physical & sedentary activity, dietary intake, and food reward.","authors":"Kara M Duraccio, Afton B Craig, Sarah Kamhout, Isabella D Wright, Gracie T Crandall, Nicholas York, Chad D Jensen","doi":"10.1093/sleepadvances/zpag036","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag036","url":null,"abstract":"<p><strong>Objectives: </strong>Sleep duration and quality frequently predict obesity-related behaviors, though less is known about how circadian misalignment relates to obesogenic behaviors. The current study evaluated the impact of experimentally induced circadian misalignment on dietary intake, food reward, and physical/sedentary activity in adolescents.</p><p><strong>Methods: </strong>Thirty-one adolescents (ages 14-18 (M = 15.5, <i>SD</i> = 0.89); 37.5 percent female) with night owl tendencies underwent a randomized cross-over experimental sleep timing manipulation. Specifically, adolescents spent both 5 nights in an aligned sleep pattern (spending from 1:00 to 10:00 am in bed) and 5 nights in a misaligned sleep pattern (spending from 9:30 pm to 6:30 am in bed), with the order of the condition randomized. All adolescents wore an Actiwatch 2 to determine adherence to study protocols and an ActiGraph GT3x + to measure physical and sedentary activity; adolescents completed dietary recalls throughout the study protocol and the Power of Food Scale after each manipulation. We ran a series of repeated-measure general linear models to test for differences in adolescent dietary intake, food reward, and physical/sedentary activity.</p><p><strong>Results: </strong>Participants consumed a moderate amount of more carbohydrates in the misaligned condition, compared to the aligned condition (t(15) = -2.14; <i>p</i> = .049; <i>g</i> = -.522). There were no other differences in dietary intake noted across conditions, nor any differences in food reward or physical activity outcomes across conditions.</p><p><strong>Conclusions: </strong>Circadian misalignment, independent of sleep loss, may play a limited role in shaping short-term obesogenic behaviors in adolescents, highlighting the need for future interventions and research to continue prioritizing sleep duration and quality while clarifying the contexts in which sleep timing may be most relevant.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag036"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A polygenic risk score modifies the cardiovascular risk associated with obstructive sleep apnea.","authors":"Christian W Thorball, Adrien Waeber, Geoffroy Solelhac, Flavia Hodel, Théo Imler, Grégory Heiniger, Roxane de La Harpe, Pedro Marques-Vidal, Peter Vollenweider, Jacques Fellay, Raphaël Heinzer","doi":"10.1093/sleepadvances/zpag037","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag037","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) carries increased cardiovascular (CV) risk. However, this risk is not fully captured by the apnea-hypopnea index (AHI). We investigated whether a validated coronary artery disease polygenic risk score (CAD-PRS) refines CV risk assessment in OSA.</p><p><strong>Methods: </strong>We derived CAD-PRS using genome-wide genotyping data for 1379 participants of the CoLaus|HypnoLaus cohort who underwent polysomnography. Associations between OSA, CAD-PRS, clinical factors, and incident CV events were assessed using multivariable Cox proportional hazards models. Risk stratification improvement was assessed with reclassification analyses compared to clinical risk scores (SCORE2/SCORE2-OP).</p><p><strong>Results: </strong>During 7.2 years of median follow-up, 100 participants experienced CV events. A significant interaction between OSA and CAD-PRS was observed (p=.013). The effect of OSA on CV risk differed across PRS categories. In the intermediate genetic-risk group (CAD-PRS quintiles 2-4), OSA patients (AHI ≥15/h) had a markedly higher CV risk compared to non-OSA (HR[95% CI]: 2.68[1.54-4.66]), whereas OSA did not significantly increase CV risk in either the low or high PRS strata. The complete model with OSA, CAD-PRS and their interaction allowed a significant reclassification (Net Reclassification Index 0.171, p=.014) compared to SCORE2/SCORE2-OP and 52% of individuals at intermediate risk were reclassified as low or high CV risk.</p><p><strong>Conclusions: </strong>In this population-based cohort, a CAD-PRS was associated with CV risk stratification in individuals with OSA. The impact of OSA on CV risk was greatest in individuals with intermediate genetic risk. Adding CAD-PRS and OSA to SCORE2 was associated with improved model performance and reclassification, supporting more precise CV risk assessment in OSA.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag037"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From night-to-night and from person-to-person: dynamic phenomena of insomnia.","authors":"Mona M Klau, Jaap Lancee, Mathilde I Looman, Han L J Van Der Maas, Renée M Visser, Tessa F Blanken","doi":"10.1093/sleepadvances/zpag035","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag035","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep is complex and variable, yet insomnia research and treatment often rely on averages-either across nights or across individuals. Such approaches risk obscuring dynamic features that characterize insomnia as a disorder and its unique manifestation in individuals. In this study, we explore disorder-specific (group-level) and person-specific (individual-level) dynamic phenomena of insomnia among people with insomnia.</p><p><strong>Methods: </strong>We analyzed 8 weeks of sleep diary data from 61 participants with insomnia. Four domains of sleep dynamics were examined at group- and individual-levels: (1) night-to-night variability, (2) temporal dependency of sleep quality, (3) stability of sleep complaints, (4) weekday-weekend variability. We correlated these domains with insomnia severity, pre-sleep arousal, and sleep-related safety behavior.</p><p><strong>Results: </strong>At the group-level, insomnia was characterized by (1) night-to-night fluctuations in sleep parameters, (2) unpredictable sleep quality, (3) frequent co-occurrence and fluctuations in type of sleep complaints, and (4) different sleep patterns on weekdays and weekends. These disorder-specific dynamic phenomena showed medium-sized significant correlations with insomnia indices, ranging from <i>r</i> = -0.25 to 0.41. At the individual-level, all four domains varied markedly across individuals. While the group-level characterizations were fitting for some participants, others showed patterns clearly distinct. We developed a Shiny application which allows readers to explore individual sleep profiles (https://uvasobe.shinyapps.io/PersonalSleepExplorer/).</p><p><strong>Conclusions: </strong>Sleep in insomnia varies from night-to-night and person-to-person. Reliance on averages across nights and across individuals may obscure fluctuations of potential clinical relevance. We call for broader use of sleep diaries to capture dynamic patterns of insomnia and for investigation of their clinical utility.</p><p><strong>Clinical trial: </strong>Sleep Restriction Treatment for Insomnia.URL: https://clinicaltrials.gov/study/NCT05548907.</p><p><strong>Registration: </strong>NCT05548907.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag035"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory associations of sleep spindles and sleep disordered breathing indices with hippocampal and thalamic volume, and cortical thickness, and cerebrovascular biomarkers among community dwelling older adults: results from the Brain in Motion Study.","authors":"Alison M H Donald, Andrew E Beaudin, Matiram Pun, Rebecca J Williams, Brandy L Callahan, G Bruce Pike, Marc J Poulin","doi":"10.1093/sleepadvances/zpag028","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag028","url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) impacts brain structure and cerebrovascular function and is often associated with impaired sleep microstructure such as sleep spindles. Given the lack of research in sleep spindles and brain physiology in community dwelling older adults, this exploratory study hypothesized that (1) sleep disordered breathing is associated with lower cortical thickness, thalamic volume, hippocampal volume, cerebral perfusion, and higher white matter hyperintensity (WMH) volume; and (2) greater cortical thickness, thalamic and hippocampal volume predict greater sleep spindle density, frequency and percentage of fast spindles.</p><p><strong>Methods: </strong>A total of 71 participants (males/females: 24/47) underwent magnetic resonance imaging, and sleep polysomnography.</p><p><strong>Results: </strong>Apnea hypopnea index, oxygen desaturation index, and sleep fragmentation index were not related to daytime whole brain gray matter cerebral blood flow or WMH volume (all <i>p</i> > .05). Spindle frequency was associated with thalamic volume (β = 0.24, <i>p</i> = .03, 95% CI = 0.20-3.66) but this finding did not survive correction for multiple comparisons. Hippocampal volume and cortical thickness were not associated with sleep spindle characteristics (all <i>p</i> > .05).</p><p><strong>Conclusions: </strong>Our findings suggest a potential structure-function relationship between the thalamus and spindle frequency. Our results also demonstrate that cerebral perfusion and white matter hyperintensities are not associated with OSA in community-dwelling older adults, potentially reflecting an ability of the cerebrovasculature to cope with relatively mild hypoxic insults. However, future studies should confirm these findings in a larger sample and consider the length of time in which participants experienced mild to moderately severe OSA (apnea hypopnea index <30).</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag028"},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of caffeinated beverage consumption on the relationship between sleep quality and major adverse cardiovascular events: Sleep Heart Health Study.","authors":"Hesam Varpaei, Mathew Reeves, Lorraine B Robbins, Fabrice Mowbray, Pallav Deka, Stuart F Quan","doi":"10.1093/sleepadvances/zpag031","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag031","url":null,"abstract":"<p><strong>Study objectives: </strong>Evidence is limited on the role of caffeine intake in the relationship between sleep quality and the incidence of major adverse cardiovascular events (MACE) particularly in patients with sleep breathing disorders. Therefore, this study's primary aim was to determine the potential confounding effects of total caffeine consumption on the relationship between sleep quality parameters (total sleep time [TST], sleep efficiency [SE], sleep latency [SL], daytime sleepiness, and wakefulness after sleep onset [WASO]) and MACE.</p><p><strong>Methods: </strong>This study is a secondary analysis of data from the Sleep Heart Health Study (SHHS). Sleep assessments (TST, SE, SL, daytime sleepiness, and WASO) were performed objectively using in-home polysomnography. Caffeine was measured using a survey asking about the average number of cups/cans/glasses of tea, soda, and coffee consumed per regular day and during the last night before polysomnography.</p><p><strong>Results: </strong>A final sample of 5628 participants was included in SHHS Visit 1 (78 per cent White/Caucasian; 54 per cent female). Cumulative incidence rates measured over 10.9 ± 2.8 years were 15.1 per cent for MACE and 19.7 per cent for all-cause mortality. In univariate models, all sleep measures except SL were associated with MACE; but after adjustment, only TST remained a significant predictor (odds ratio [<i>OR</i>] <i>= 1.122, p = .011</i>). No confounding effect of caffeine was observed in the associations between sleep measures and MACE. Moderate-high intake attenuated MACE risk among individuals with greater daytime sleepiness (OR = 0.91, <i>p</i> = .011).</p><p><strong>Conclusions: </strong>Caffeine was not a confounding factor in the relationship between sleep measures and MACE. While exploratory analyses suggested potential modification of the association between hypersomnolence and cardiovascular outcomes, these effects were attenuated after statistical adjustment and correction for multiple testing and should be interpreted cautiously.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag031"},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13106951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily step-count and sleep metrics across pregnancy: an observational analysis of the LEAP cluster randomized clinical trial.","authors":"Bethany R Hallenbeck, Sylvia E Badon, Fei Xu, Charles P Quesenberry, Monique M Hedderson","doi":"10.1093/sleepadvances/zpag030","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag030","url":null,"abstract":"<p><strong>Study objectives: </strong>We investigated daily associations between step count and sleep quality across trimesters using wearable devices.</p><p><strong>Methods: </strong>Participants (<i>N</i> = 243; pre-pregnancy body mass index≥ 25 kg/m²) from a mobile health randomized clinical trial intervention arm, wore Fitbits day and night from ~8 weeks' gestation- delivery. Devices tracked daily step count (primary exposure), moderate to vigorous physical activity (MVPA) and light physical activity (LPA) (secondary exposures), and sleep measures (duration, stage length, efficiency, awakenings, midpoint and multidimensional sleep score). Covariate-adjusted mixed effects models estimated daily associations between movement and sleep outcomes, stratified by trimester.</p><p><strong>Results: </strong>Participants averaged 5795 steps/day. In trimester 1, step count (per 1000) was associated with shorter sleep duration (-23 min, odds ratio [OR] = 0.84, 95% confidence interval [CI] = -38.7 to -8.6). In the trimester 2, step count was associated with shorter sleep duration (-22 min, CI = -27.6 to -16.4), shorter light sleep (-10 min, CI = -13.3 to -6.6), longer deep (+4 min, CI = 2.7 to 6.1), and rapid eye movement (REM) sleep (+6 min, CI = 3.5 to 7.7). In trimester 3, step count was associated with lower odds of poor sleep (OR = 0.84, CI = 0.70 to 1.00), shorter light sleep (-14 min, CI = -18.4 to -9.3), longer deep (+6 min, CI = 3.3 to 7.8), and REM sleep (+8 min, CI = 5.5 to 11.4), and more awakenings (+0.9, CI = 0.4 to 1.4). Associations of MVPA and LPA with sleep were smaller in magnitude but relatively consistent with step count.</p><p><strong>Conclusions: </strong>Higher daily step count was associated with higher quality sleep in the following night during second and third trimesters. These findings highlight step count as a potential target to support prenatal sleep quality.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag030"},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep phenotypes and subjective cognitive decline in the Hispanic Community Health Study/Study of Latinos.","authors":"Kevin A González, Rachel Membreno, Wassim Tarraf, Ariana M Stickel, Charles DeCarli, Freddie Marquez, Christian Agudelo, Sanjay R Patel, Linda C Gallo, Omonigho Bubu, Martha Daviglus, Fernando D Testai, Daniela Sotres-Alvarez, Frank J Penedo, Barbara Junco, Hector M González, Alberto R Ramos","doi":"10.1093/sleepadvances/zpag032","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag032","url":null,"abstract":"<p><strong>Study objectives: </strong>Disturbed sleep and daytime sleepiness have been associated with subjective cognitive decline (SCD), which often precedes objective cognitive deficits and clinical dementia. Due to heterogeneity of sleep problems, researchers have used phenotype-based approaches to cluster individuals based on a group of sleep symptoms. These clusters have been associated with continuous positive airway pressure (CPAP) efficacy and cardiovascular incidence risk, but less work has related them to SCD. We sought to examine the relationships between sleep phenotypes and SCD among a diverse sample of Hispanic/Latino individuals.</p><p><strong>Methods: </strong>We used data from the Hispanic Community Health Study/Study of Latinos, a large dataset of Hispanic/Latino communities. We included 15 sleep symptoms and 4 cardiovascular measures in our latent class analysis model to find the optimal cluster size. SCD was assessed using the Everyday Cognition Scale. We ran survey weighted linear regression models to assess domain specific and global SCD across the groups.</p><p><strong>Results: </strong>A total of <i>N</i> = 5551 individuals were included in the analysis. The 3-class solution was the best fit, and groups were consistent with previous work. Those in the sleepiness-disturbed sleep (<i>N</i> = 943) or disturbed sleep (<i>N</i> = 1886) group had more SCD across all domains, including global, compared to those in the minimally symptomatic (<i>N</i> = 2722) group. Adjusting for social, cardiovascular factors, and obstructive sleep apnea attenuated but did not fully explain associations.</p><p><strong>Conclusions: </strong>Daytime sleepiness and disturbed sleep clusters were associated with worse SCD. These findings suggest that sleep disturbances, regardless of sleep apnea, could have significant implications for cognitive health in diverse Hispanic/Latino populations.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag032"},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of lemborexant and zolpidem on sleep electroencephalography in older adults with insomnia: a randomized trial.","authors":"Negin Sattari, Abhishek Dave, Hamid Niknazar, Ivy Y Chen, Ariel B Neikrug, Bryce A Mander, Ruth M Benca","doi":"10.1093/sleepadvances/zpag017","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag017","url":null,"abstract":"<p><p>How sleep medications affect brain physiology over time remains largely unknown. Prior pharmacodynamic work has established distinct spectral signatures of GABA-A receptor modulators vs. DORAs in younger or mixed adult samples. Here, we report how sleep EEG effects evolve from acute (days 1-2) to chronic (days 29-30) exposure in older adults with insomnia meeting DSM-5 criteria, and how within-person changes relate to Insomnia Severity Index (ISI). This analysis used data from a randomized, double-blind, placebo-controlled, active-comparator phase III trial (May 2016-January 2018). A subset of 249 participants was analyzed for EEG outcomes. Participants received 5 mg or 10 mg LEM (LEM5, LEM10), 6.25 mg extended-release zolpidem (ZOL), or placebo nightly for 30 days. Polysomnography was collected at baseline, after acute exposure, and after chronic exposure. Acute ZOL exposure produced significant increases in non-rapid eye movement (NREM) slow oscillation (SO), sigma, beta, and gamma power, with decreases in delta and theta compared to all treatment groups. These effects persisted with chronic exposure, alongside an alpha increase from acute to chronic exposure. LEM10 showed minimal acute effects but, with continued use, increased SO and decreased alpha power. The degree of SO power increase from acute to chronic exposure predicted improvements in ISI scores, driven by the LEM10 group. ZOL showed similar REM effects, whereas LEM5, but not LEM10, reduced REM sigma and beta power. These findings demonstrate that ZOL and LEM differentially modulate sleep EEG, with sustained SO enhancement under LEM10 linked to symptom improvement.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag017"},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13116325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of a sleep health intervention among adolescents in Ugandan schools: A prospective pilot intervention study.","authors":"Denis Ndekezi, Rebecca Kyomugisha, Betty Nyangoma, Prossy Namirembe, Beatrice Nanyonga, Aaron Nyaruhuma, Claudia Ateo, Calvin Robert Rutainama, Katherine A Thomas, Ratifah Batuusa, Benson Muhindo, Sheilah Kasabiiti, Connie Alezuyo, Nambusi Kyegombe, Chris Bonell, Daniel Michelson, Fiona C Baker, Faith Orchard, Femke Bannink Mbazzi, Helen A Weiss","doi":"10.1093/sleepadvances/zpag029","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag029","url":null,"abstract":"<p><strong>Study objectives: </strong>There is little research on sleep health interventions in Africa. We assessed the feasibility and acceptability of a tiered sleep health intervention among Ugandan adolescents. The intervention, delivered in two secondary schools, comprised universal components (sleep education sessions, structural changes to light, temperature and school-timings) plus targeted psychologist-delivered group cognitive behaviour therapy for insomnia (CBT-I) for students with moderate/severe insomnia (Insomnia Severity Index ≥15).</p><p><strong>Methods: </strong>Feasibility and acceptability were assessed through semi-structured interviews immediately after the intervention (T1) and 3 months later (T2) among students with baseline (T0) insomnia, teachers and dormitory matrons, along with structured implementation trackers. We conducted a quantitative survey at baseline to assess prevalence of dimensions of sleep and mental health, and for those with insomnia only, repeated this at T1 and T2.</p><p><strong>Results: </strong>The intervention was feasible and acceptable. High fidelity, dose and reach were achieved through integration of sleep education to the school schedule, structural changes to light, temperature and wake-up time for boarding students, effective small group delivery of CBT-I sessions and good retention despite fatigue due to extended sessions. Acceptability was reflected in high student engagement and positive feedback on the relevance of both universal and targeted components. Among 36 students with baseline insomnia, prevalence of moderate/severe insomnia decreased to 19.4% (7/36) post-intervention and further to 3.6% (1/28) at three months, indicating strong potential for impact.</p><p><strong>Conclusions: </strong>Multi-level, school-based sleep interventions can be successful in low-income settings. Large-scale cluster-randomized controlled trials are needed to estimate impact and cost-effectiveness.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 2","pages":"zpag029"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}