Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"Pioneering in clinical pediatric sleep medicine: an interesting journey.","authors":"Richard Ferber","doi":"10.1093/sleepadvances/zpae098","DOIUrl":"10.1093/sleepadvances/zpae098","url":null,"abstract":"<p><p>In 1978, as a young pediatrician, I became interested in the developing field of clinical sleep medicine and set out on a journey into uncharted waters, namely into the previously non-existent field of pediatric sleep medicine. I describe my early training (in a specialty where no formal training programs existed), my excellent mentors, my early struggles to work with equipment that was both primitive by today's standards and not designed to work with children and infants, and various other obstacles I initially faced. I also share some of early findings in pediatric insomnia, sleepiness, parasomnias, and rhythm disorders, and I outline some of our efforts to develop new treatment approaches and techniques where scientifically based ones previously did not exist. Finally, I try to describe translating what I was learning about children and their sleep problems into a wide-ranging book to help parents, especially those who were sleep-deprived themselves.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpae098"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11854892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the efficacy of technology-enabled treatments for insomnia: study protocol for a randomized controlled trial.","authors":"Hannah Scott, Madelaine Green, Kerri Jones, Kelly A Loffler, Nicole Lovato, Barbara Toson, Darah-Bree Bensen-Boakes, Michael Perlis, Sean P A Drummond, Billingsley Kaambwa, Leon Lack","doi":"10.1093/sleepadvances/zpaf010","DOIUrl":"10.1093/sleepadvances/zpaf010","url":null,"abstract":"<p><p>Chronic insomnia is a prevalent sleep disorder where <1% of patients receive the recommended first-line treatment; Cognitive Behavioural Therapy for Insomnia. Digital technologies and self-managed therapies are scalable solutions to address this critical gap in patient care, but it is presently difficult to know which therapies are best. This study will test the comparative efficacy and cost-benefits of Intensive Sleep Retraining administered by the THIM sleep tracker, Sleep Healthy Using the Internet (SHUTi) treatment program, and their combination (THIM then SHUTi) versus a waitlist control group. This study is a 4 (treatment: +/- THIM and +/- SHUTi) × 3 (time: pretreatment, posttreatment, and 2-month follow-up) randomized controlled trial. Participants who meet the diagnostic criteria for Chronic Insomnia Disorder will be randomized to one of four groups. Sleep and daytime functioning symptoms will be assessed via self-report daily and weekly questionnaires, and objective sleep trackers during treatment and for 2 weeks at pre-treatment, post-treatment, and 2-month follow-up. The primary outcome is total wake time, with a reduction of ≥30 minutes considered a clinically meaningful difference. For the primary analysis, the interaction between the treatment group and time on total wake time will be analyzed using repeated measures analyses of variance (ANOVA). This project was approved by the Southern Adelaide Clinical Human Research Ethics Committee (2021/HRE00414) and registered in the Australian and New Zealand Clinical Trials Registry (ACTRN12622000778785). As the first study to investigate the comparative efficacy of two different technology-enabled treatments for insomnia, this study will help inform clinicians and public health policy regarding the use cases for public and private health-funded technology-enabled options for insomnia.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf010"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tonic-clonic seizures induce hypersomnia and suppress rapid eye movement sleep in mouse models of epilepsy.","authors":"Ruizhi Wang, Sasa Teng, Matt Turanchik, Fenghua Zhen, Yueqing Peng","doi":"10.1093/sleepadvances/zpaf009","DOIUrl":"10.1093/sleepadvances/zpaf009","url":null,"abstract":"<p><p>The reciprocal relationship between sleep and epilepsy has been reported by numerous clinical studies. However, the underlying neural mechanisms are poorly understood. Animal models of epilepsy are powerful tools to tackle this question. A lagging research area is the understudied sleep in epilepsy models. Here, we characterize sleep architecture and its relationship with seizures in a mouse model of sleep-related hypermotor epilepsy, caused by mutation of <i>KCNT1</i>. We demonstrated that nocturnal tonic-clonic seizures induce more non-rapid eye movement (NREM) sleep but suppress rapid eye movement (REM) sleep, resulting in altered sleep architecture in this mouse model. Importantly, the seizure number is quantitatively anticorrelated with the amount of REM sleep. Strikingly, this modulation of NREM and REM sleep states can be repeated in another mouse model of epilepsy with diurnal tonic-clonic seizures. Together, our findings provide evidence from rodent models to substantiate the close interplay between sleep and epilepsy, which lays the ground for mechanistic studies.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf009"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLEEP Advances, Phase 2.","authors":"Sean P A Drummond","doi":"10.1093/sleepadvances/zpaf005","DOIUrl":"10.1093/sleepadvances/zpaf005","url":null,"abstract":"","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf005"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"So Long, <i>SLEEP Advances</i>….","authors":"Mary A Carskadon","doi":"10.1093/sleepadvances/zpaf006","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpaf006","url":null,"abstract":"","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf006"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Layover start timing predicts layover sleep quantity and timing on long-range and ultra-long-range trips.","authors":"Michael J Rempe, Ian Rasmussen, Kevin Gregory, Cheyenne Johnson, Matthew Hsin, Erin Flynn-Evans, Amanda Lamp, Cassie J Hilditch","doi":"10.1093/sleepadvances/zpaf002","DOIUrl":"10.1093/sleepadvances/zpaf002","url":null,"abstract":"<p><strong>Study objectives: </strong>Airline transport pilot sleep during layover is an important factor for alertness on subsequent flights. Assessing pilots' sleep on layover is an important first step in helping them obtain the most recuperative sleep possible on layover. Here, we investigate the quantity and timing of sleep during layovers and determine predictors for layover sleep.</p><p><strong>Methods: </strong>Sleep was assessed in 256 pilots flying a total of 473 long-range (LR; flight time 12-16 hours) or ultra-long-range (ULR; flight time <i>></i> 16 hours) trips. Sleep was assessed using actigraphy. We employed linear mixed-effects models with layover sleep characteristics as the outcomes. The predictor variables included operational factors and sleep history.</p><p><strong>Results: </strong>Overall, pilots averaged 7.2 hours of sleep per 24 hours of layover, which was significantly less than their daily sleep before or after the trip. Layover start time (relative to home base time) was the most salient predictor of sleep timing and quantity during both shorter (∼24-hour) and the first 24 hours of longer (∼48-hour) layovers. During the last 24 hours of longer layovers, crew type predicted sleep quantity.</p><p><strong>Conclusions: </strong>Although average sleep quantity during layovers was within the margins of recommended sleep duration, it was still less than pre- and post-trip sleep duration, suggesting modest sleep loss on layovers. Layover start timing was the strongest predictor of layover sleep quantity and timing and, thus, may be a modifiable factor to protect circadian-aligned sleep opportunities during layover.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood adversity and adolescent epigenetic age acceleration: the role of adolescent sleep health.","authors":"Karissa DiMarzio, Darlynn M Rojo-Wissar, Evelyn Hernandez Valencia, Mikayla Ver Pault, Shane Denherder, Adamari Lopez, Jena Lerch, Georgette Metrailer, Sarah Merrill, April Highlander, Justin Parent","doi":"10.1093/sleepadvances/zpaf003","DOIUrl":"10.1093/sleepadvances/zpaf003","url":null,"abstract":"<p><strong>Study objectives: </strong>We investigated how a dimension of early life adversity (ELA), capturing threat in the home, relates to later epigenetic age acceleration in adolescence through sleep (duration, efficiency, and timing) to empirically test theoretical models suggesting the importance of sleep as a key mechanism linking ELA with poor health outcomes and to expand the limited literature on sleep and epigenetic aging among youth.</p><p><strong>Methods: </strong>We utilized data from 861 participants in the Future of Families and Child Wellbeing Study who participated in the actigraphy substudy at age 15. Sleep variables used were average total sleep time (TST), sleep efficiency (SE), and sleep onset timing. Home threat was determined at ages 3, 5, and 9 from parent reports on the Child Conflict Tactics Scale, and epigenetic aging was measured through DNA methylation analyses of saliva samples collected at age 15.</p><p><strong>Results: </strong>Higher levels of childhood home threat exposure were associated with less adolescent TST, lower SE, and later sleep onset timing. Adolescent SE and timing were associated with a faster pace of aging and epigenetic age acceleration. SE and timing mediated the link between childhood home threat exposure and adolescent epigenetic aging.</p><p><strong>Conclusions: </strong>Epigenetic embedding of childhood threat exposure in the home may occur through adversity-related sleep disturbances in adolescence. Findings warrant greater attention to pediatric sleep health in theoretical models of biological embedding of adversity and point to sleep health improvement as a potential way to prevent adversity-related epigenetic age acceleration. <i>This paper is part of the Genetic and other Molecular Underpinnings of Sleep, Sleep Disorders, and Circadian Rhythms Including Translational Approaches collection.</i></p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf003"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REM refines and rescues memory representations: a new theory.","authors":"Alessandra E Shuster, Allison Morehouse, Elizabeth A McDevitt, Pin-Chun Chen, Lauren N Whitehurst, Jing Zhang, Negin Sattari, Tracy Uzoigwe, Ali Ekhlasi, Denise Cai, Katherine Simon, Niels Niethard, Sara C Mednick","doi":"10.1093/sleepadvances/zpaf004","DOIUrl":"10.1093/sleepadvances/zpaf004","url":null,"abstract":"<p><p>Despite extensive evidence on the roles of nonrapid eye movement (NREM) and REM sleep in memory processing, a comprehensive model that integrates their complementary functions remains elusive due to a lack of mechanistic understanding of REM's role in offline memory processing. We present the REM Refining and Rescuing (RnR) Hypothesis, which posits that the principal function of REM sleep is to increase the signal-to-noise ratio within and across memory representations. As such, REM sleep selectively enhances essential nodes within a memory representation while inhibiting the majority (<i>Refine</i>). Additionally, REM sleep modulates weak and strong memory representations so they fall within a similar range of recallability (<i>Rescue</i>). Across multiple NREM-REM cycles, tuning functions of individual memory traces get sharpened, allowing for integration of shared features across representations. We hypothesize that REM sleep's unique cellular, neuromodulatory, and electrophysiological milieu, marked by greater inhibition and a mixed autonomic state of both sympathetic and parasympathetic activity, underpins these processes. The RnR Hypothesis offers a unified framework that explains diverse behavioral and neural outcomes associated with REM sleep, paving the way for future research and a more comprehensive model of sleep-dependent cognitive functions.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf004"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: P071 Legislative and governance pathways to psychologist prescribing of melatonin in the behavioural sleep medicine setting in Queensland.","authors":"","doi":"10.1093/sleepadvances/zpaf001","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpaf001","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sleepadvances/zpae070.153.].</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpaf001"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distressing dreams in trauma survivors: using a sleep diary mobile app to reveal distressing dream characteristics and their relationship to symptoms and suicidal ideation in trauma-exposed adults.","authors":"Anne Richards, Anthony Santistevan, Miles Kovnick, Polina Orlova, Leslie Yack, Emily Berg, Shane Pracar, Thomas Metzler, Thomas Neylan, Steven Woodward","doi":"10.1093/sleepadvances/zpae099","DOIUrl":"10.1093/sleepadvances/zpae099","url":null,"abstract":"<p><strong>Study objectives: </strong>Trauma nightmares are a core feature of PTSD, with potentially devastating implications for mental health outcomes. Treatments remain unsatisfactory and nightmares are poorly understood, both biologically and phenomenologically; measurement methods are limited. The aims of the current analyses were to (1) characterize distressing dreams in trauma survivors, (2) examine the relationships of dream features to next-day symptoms and to suicidal ideation, and (3) validate sleep diary mobile app items for the measurement of clinically relevant dream characteristics.</p><p><strong>Methods: </strong>Adult male and female veterans and nonveterans with a history of PTSD criterion trauma and at least 1 nightmare weekly were enrolled. Participants completed 3 weeks of sleep diary, including bedtime and morning surveys and weekly assessments. They also completed a Clinician-Administered PTSD Scale (CAPS)-5 PTSD assessment. Multivariable mixed models with repeated measures and standard regression were utilized to examine relationships between dream features and next-day symptoms and suicidal ideation.</p><p><strong>Results: </strong>Dream features and dream distress independently predict clinically relevant outcomes; no single feature was sufficient for predicting all outcomes of interest. In particular, the replicative quality of trauma nightmares stood out in terms of associations with next-day symptoms, CAPS severity, and suicidal ideation. Subjective dream duration, extent of postdream arousal, and subjective distress severity also independently predicted daytime symptoms.</p><p><strong>Conclusions: </strong>Results underscore the importance of examining dream characteristics to understand nightmare effects and associations with suicidal ideation. These findings also underscore the utility of mobile app technology for obtaining informative data with high temporal resolution in an appealing and user-friendly manner.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 1","pages":"zpae099"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}