Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"White matter microstructure statistically mediates associations between circadian rest/activity rhythms and cognition in older adults.","authors":"Daniel D Callow, Corinne Pettigrew, Vadim Zipunnikov, Sarah K Wanigatunga, Marilyn Albert, Arnold Bakker, Anja Soldan, Adam P Spira","doi":"10.1093/sleepadvances/zpaf027","DOIUrl":"10.1093/sleepadvances/zpaf027","url":null,"abstract":"<p><p>Aging is associated with disruptions in circadian rhythms, lower brain white matter integrity, and cognitive changes. However, whether white matter integrity serves as a potential mechanism linking circadian dysfunction to age-related cognitive abilities in older adults is unclear. We investigated cross-sectional associations of actigraphic circadian rest/activity rhythms (RARs) with whole-brain white matter tract fractional anisotropy (FA) and executive function performance in 156 older adults without dementia from the BIOCARD study (mean age = 71.3 years, including 19 with mild cognitive impairment and 137 cognitively unimpaired). We studied non-parametric metrics of RAR strength (relative amplitude [RA]), day-to-day stability (interdaily stability [IS]), and fragmentation (intradaily variability [IV]). After adjusting for age, sex, education, <i>APOE</i>-e4 genotype, vascular risk, and diagnostic group, we found that greater rhythm strength (higher RA) was associated with better executive function. Additionally, higher rhythm strength (RA) and stability (IS) were associated with greater whole-brain FA, reflecting better white matter integrity, whereas greater fragmentation (IV) was associated with lower FA. Greater white matter integrity was also associated with better executive function and statistically mediated the association of higher RA with better executive function performance. Findings underscore the relationships between RAR strength and cognitive health in older adults and suggest that white matter integrity may be a key mechanism underlying these associations.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf027"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of insufficient sleep on the serial reproduction of information.","authors":"David L Dickinson, Sean P A Drummond","doi":"10.1093/sleepadvances/zpaf026","DOIUrl":"10.1093/sleepadvances/zpaf026","url":null,"abstract":"<p><p>Story retelling is an important form of communication, cultural practice, and message transmission. Insufficient sleep is known to affect relevant cognitive skill areas necessary for story retelling or transmission fidelity. We conducted a preregistered randomized cross-over study on <i>n</i> = 155 young adults with exogenously assigned nightly sleep levels experienced in their at-home environments. A serial story reproduction task was administered online, and chains of up to three retells of a given story involved varied numbers of sleep restricted (SR) versus well-rested (WR) retellers. While story content decayed with each retell, group-level analysis showed that additional SR retellers in a chain was associated with greater decay, which mostly resulted from the introduction of an initial SR reteller at the first retell. Supporting the group-level effect, individual-level analysis confirmed that the number of details and the story's key event were significantly less preserved during a participant's SR treatment week. Exploratory analysis showed an attenuation of this effect in those reporting a higher level of affective response (interest or surprise) in the story. This suggests that emotional engagement can combat the deleterious effects of SR on successful story retelling, and perhaps on other types of content recollection.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf026"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We choose to go.","authors":"Ralph Lydic","doi":"10.1093/sleepadvances/zpaf024","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpaf024","url":null,"abstract":"","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf024"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort.","authors":"Kathryn R Dalton, Vicky C Chang, Mikyeong Lee, Katherine Maki, Pedro Saint-Maurice, Vaishnavi Purandare, Xing Hua, Yunhu Wan, Casey L Dagnall, Kristine Jones, Belynda D Hicks, Amy Hutchinson, Linda M Liao, Mitchell H Gail, Jianxin Shi, Rashmi Sinha, Christian C Abnet, Stephanie J London, Emily Vogtmann","doi":"10.1093/sleepadvances/zpaf023","DOIUrl":"10.1093/sleepadvances/zpaf023","url":null,"abstract":"<p><strong>Study objectives: </strong>The microbiome is proposed as a contributor to the adverse health impacts from altered sleep. The oral microbiome is a multifaceted microbial community that influences many health functions. However, data on the relationship between sleep and the oral microbiome are limited, and no studies have incorporated lifestyle and environmental exposures.</p><p><strong>Methods: </strong>Within a subset (N=1,139) of the NIH-AARP cohort, we examined the association between self-reported sleep duration and the oral microbiome via 16S rRNA gene amplicon sequencing. Statistical models were adjusted for demographic characteristics. Additional models examined the role of various lifestyle and neighborhood exposures on the sleep-oral microbiome association.</p><p><strong>Results: </strong>Compared to participants reporting the recommended 7-8 hours average sleep duration (n=702), those reporting short sleep (6 or fewer hours, n=284) had consistently decreased within-sample oral microbial diversity [e.g. number of observed amplicon sequence variants difference -8.681, p-value=0.009]. Several bacterial genera were more likely to be absent in the short sleep group. We found a higher relative abundance of <i>Streptococcus</i> and <i>Rothia</i>, and lower abundance of <i>Fusobacterium</i>, <i>Atopobium</i>, and <i>Campylobacter</i> in the short compared to the recommended sleep duration group. Results were consistent when controlling for lifestyle and neighborhood factors.</p><p><strong>Conclusions: </strong>Our findings provide evidence for an association of short sleep duration with oral microbial diversity and composition. This suggests that oral bacteria may play a possible mechanistic role related to sleep health. Improved understanding of physiological pathways can aid in the design of interventions that may beneficially improve overall sleep health.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf023"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and performance.","authors":"Cheryl L Spinweber","doi":"10.1093/sleepadvances/zpaf015","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpaf015","url":null,"abstract":"<p><p>I review the path of my career in sleep. My focus has been on the need for sleep and the relationship between sleep and performance. I have done sleep research in the sleep lab setting and have also taken unique opportunities to measure sleep loss effects on real-world performance. My studies have included long and short sleeper studies, evaluations of various sleep aids, sleep loss effects, jet lag effects, naps, and the consequences of being a poor sleeper. Over the course of my career in sleep, I have also taught about sleep in university and professional educational settings. I am a Board Certified Sleep Medicine Specialist with a private practice, providing diagnosis and treatment of sleep disorders in children and adults.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf015"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for a pilot hybrid type I effectiveness-implementation study to improve help-seeking for sleep disorders in the future healthcare workforce: The Sleep Check Before Shift Work trial.","authors":"Claire Dunbar, Kelly Sansom, Nicole Lovato, Andrew Vakulin, Kelly A Loffler, Katrina Nguyen, Josh Fitton, Shantha M W Rajaratnam, Tracey L Sletten, Gorica Micic, Sally A Ferguson, Sian E Wanstall, Brandon W J Brown, Gillian Harvey, Robert Adams, Amy C Reynolds","doi":"10.1093/sleepadvances/zpaf020","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpaf020","url":null,"abstract":"<p><p>Sleep disorders are prevalent in shift workers but are commonly undiagnosed and unmanaged. This poses considerable safety, productivity, and health risks. There is limited education or early intervention to encourage awareness of, and treatment for, sleep disorders in young adults who will transition into careers requiring shift work. This study aims to investigate (a) the <i>clinical effectiveness</i> of simulated shift work exposure and cognitive performance feedback for prompting help-seeking for sleep problems, and (b) the feasibility and acceptability of <i>implementing</i> this intervention for future healthcare workers. A hybrid type I effectiveness-implementation trial will be conducted from June 2024 to December 2025 with prospective healthcare workers currently enrolled in a medicine, paramedicine, or nursing degree. Ninety adults (18-39 years) who self-report sleep disturbances will be recruited and complete a combination of structured clinical interviews, screening questionnaires, remote monitoring technology, and overnight polysomnography (PSG). Participants will be randomized across three conditions, with varying exposure to a simulated transition to night shift without sleep, and cognitive performance feedback. All individuals will attend a diagnostic appointment with a sleep psychologist or sleep physician and discuss help-seeking pathways for their sleep. The primary outcomes will be help-seeking from a health professional for sleep (yes/no), time to help-seeking (days), and road safety-related events over 12 months. Process evaluation will explore the feasibility and acceptability of this approach from the participants' perspective.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf020"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of spindle-inspired transcranial alternating current stimulation during a nap on sleep-dependent motor memory consolidation in healthy older adults.","authors":"Maëva Moyne, Manon Durand-Ruel, Chang-Hyun Park, Roberto Salamanca-Giron, Virgine Sterpenich, Sophie Schwartz, Friedhelm C Hummel, Takuya Morishita","doi":"10.1093/sleepadvances/zpaf022","DOIUrl":"10.1093/sleepadvances/zpaf022","url":null,"abstract":"<p><p>With the increase in life expectancy and the rapid evolution of daily life technologies, older adults must constantly learn new skills to adapt to society. Sleep reinforces skills acquired during the day and is associated with the occurrence of specific oscillations such as spindles. However, with age, spindles deteriorate and thus likely contribute to memory impairments observed in older adults. The application of electric currents by means of transcranial alternating current stimulation (tACS) with spindle-like waveform, applied during the night, was found to enhance spindles and motor memory consolidation in young adults. Here, we tested whether tACS bursts inspired by spindles applied during daytime naps may (i) increase spindle density and (ii) foster motor memory consolidation in older adults. Twenty-six healthy older participants performed a force modulation task at 10:00, were retested at 16:30, and the day after the initial training. They had 90-minute opportunity to take a nap while verum or placebo spindle-inspired tACS bursts were applied with similar temporal parameters to those observed in young adults and independently of natural spindles, which are reduced in the elderly. We show that the density of natural spindles correlates with the magnitude of memory consolidation, thus confirming that spindles are promising physiological targets for enhancing memory consolidation in older adults. However, spindle-inspired tACS, as used in the present study, did not enhance either spindles or memory consolidation. We therefore suggest that applying tACS time-locked to natural spindles might be required to entrain them and improve their related functions.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf022"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary findings on caffeine intake, screen time, social factors, and psychological well-being: their impact on chronotype and sleep health in Hispanic adolescents.","authors":"Alexander L Wallace, Laika Aguinaldo, Michael L Thomas, Michael J McCarthy, Alejandro D Meruelo","doi":"10.1093/sleepadvances/zpaf019","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpaf019","url":null,"abstract":"<p><p>This study examined the relationships between caffeine intake, screen time, and chronotype/sleep outcomes in adolescents, with a focus on differences between Hispanic and non-Hispanic groups and the influence of peer network health, school environment, and psychological factors, including perceived stress, depression, and anxiety. Data from the Adolescent Brain Cognitive Development (ABCD) study were analyzed using <i>t</i>-tests and structural equation modeling (SEM) to assess behavioral, social, and psychological predictors of chronotype, social jet lag, and weekday sleep duration, incorporating demographic covariates. Hispanic adolescents exhibited a later chronotype (Cohen's <i>d</i> = 0.42), greater social jet lag (Cohen's <i>d</i> = 0.38), and shorter weekday sleep duration (Cohen's <i>d</i> = -0.12) compared to non-Hispanic peers. They also reported higher caffeine intake (Cohen's <i>d</i> = 0.22), though caffeine was not significantly associated with sleep outcomes. Screen time was more prevalent among Hispanic adolescents, particularly on weekday evenings (Cohen's <i>d</i> = 0.27) and weekend evenings (Cohen's <i>d</i> = 0.35), and was strongly associated with later chronotype and greater social jet lag. Higher perceived stress was linked to later chronotype and greater social jet lag, while depressive symptoms were associated with earlier chronotype and lower social jet lag. The SEM model explained 12.9% of variance in chronotype, 10.5% in social jet lag, and 6.2% in weekday sleep duration. These findings highlight disparities in adolescent sleep health but should be interpreted cautiously due to methodological limitations, including low caffeine use and assessment timing variability. Targeted interventions addressing screen time, peer relationships, and stress may improve sleep, while longitudinal research is needed to clarify causality.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf019"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A performance validation of six commercial wrist-worn wearable sleep-tracking devices for sleep stage scoring compared to polysomnography.","authors":"An-Marie Schyvens, Brent Peters, Nina Catharina Van Oost, Jean-Marie Aerts, Federica Masci, An Neven, Hélène Dirix, Geert Wets, Veerle Ross, Johan Verbraecken","doi":"10.1093/sleepadvances/zpaf021","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpaf021","url":null,"abstract":"<p><strong>Study objectives: </strong>The aim of this study is to assess the performance of six different consumer wearable sleep-tracking devices, namely the Fitbit Charge 5, Fitbit Sense, Withings Scanwatch, Garmin Vivosmart 4, Whoop 4.0, and the Apple Watch Series 8, for detecting sleep parameters compared to the gold standard, polysomnography (PSG).</p><p><strong>Methods: </strong>Sixty-two adults (52 males and 10 females, mean age ± <i>SD</i> = 46.0 ± 12.6 years) spent a single night in the sleep laboratory with PSG while simultaneously using two to four wearable devices.</p><p><strong>Results: </strong>The results indicate that most wearables displayed significant differences with PSG for total sleep time, sleep efficiency, wake after sleep onset, and light sleep (LS). Nevertheless, all wearables demonstrated a higher percentage of correctly identified epochs for deep sleep and rapid eye movement sleep compared to wake (W) and LS. All devices detected >90% of sleep epochs (ie, sensitivity), but showed lower specificity (29.39%-52.15%). The Cohen's kappa coefficients of the wearable devices ranged from 0.21 to 0.53, indicating fair to moderate agreement with PSG.</p><p><strong>Conclusions: </strong>Our results indicate that all devices can benefit from further improvement for multistate categorization. However, the devices with higher Cohen's kappa coefficients, such as the Fitbit Sense (κ = 0.42), Fitbit Charge 5 (κ = 0.41), and Apple Watch Series 8 (κ = 0.53), could be effectively used to track prolonged and significant changes in sleep architecture.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf021"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facility-measured nocturnal hypoxemia and sleep among adults with long COVID versus age- and sex-matched healthy adults: a preliminary observational study.","authors":"Haoqi Sun, Rammy Dang, Monika Haack, Kristine Hauser, Jennifer Scott-Sutherland, M Brandon Westover, Sairam Parthasarathy, Susan Redline, Robert J Thomas, Janet M Mullington","doi":"10.1093/sleepadvances/zpaf017","DOIUrl":"10.1093/sleepadvances/zpaf017","url":null,"abstract":"<p><strong>Study objectives: </strong>Persistent post-acute sequelae of SARS-CoV-2 infection, i.e. long COVID, impacts multiple organ systems. While lower blood oxygen is expected when SARS-CoV-2 infects the lungs, hypoxia without pulmonary symptoms may continue after the acute phase. Ventilation and blood oxygen are more vulnerable during sleep, but nocturnal hypoxemia hasn't been studied in people with long COVID in a facility setting using gold-standard polysomnography (PSG).</p><p><strong>Methods: </strong>We conducted an observational study with 50 participants (25 long COVID, 25 age-sex-matched healthy controls) using in-laboratory overnight PSG. We calculated the average SpO₂, average SpO₂ after removing desaturations, the respiratory rate in different sleep periods, and the hypoxic costs using all desaturations.</p><p><strong>Results: </strong>We found that average SpO₂ was lower in participants with long COVID: 1.0% lower after sleep onset (<i>p</i> = .004) and 0.7% lower during REM (<i>p</i> = .002); average SpO₂ after removing desaturations was also lower in participants with long COVID: 1.3% lower after sleep onset (<i>p</i> = .002), 0.9% lower during REM (<i>p</i> = .0004), and 1.4% lower during NREM (<i>p</i> = .003); and respiratory rate was 1.4/minute higher in participants with long COVID during REM (<i>p</i> = .005). There were no significant differences in SpO₂ and respiratory rate before sleep onset, the within-participant change from before to after sleep onset, or hypoxic costs.</p><p><strong>Conclusions: </strong>The results suggest that long COVID had a persistent lower nocturnal blood oxygen saturation, and support the need for a large-scale study of nocturnal hypoxemia in people with long COVID compared to the general population.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"6 2","pages":"zpaf017"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}