Sleep advances : a journal of the Sleep Research Society最新文献

{"title":"Sleep dependent autonomic correlates of affect and arousal in younger and older adults.","authors":"Anjana Subramoniam, Pin-Chun Chen, Negin Sattari, Sara C Mednick, Lauren N Whitehurst","doi":"10.1093/sleepadvances/zpag083","DOIUrl":"10.1093/sleepadvances/zpag083","url":null,"abstract":"<p><strong>Study objectives: </strong>Aging alters affect, with older vs. younger adults exhibiting greater positive and reduced negative affect. Sleep and autonomic factors contribute to this change, yet it is untested whether sleep-dependent autonomic activity plays a role. The current study examined bidirectional associations between affect, arousal, sleep architecture, and cardiac autonomic activity across a daytime nap in healthy younger and older adults.</p><p><strong>Materials and methods: </strong>Polysomnography and electrocardiogram were collected during a midday nap. Sleep architecture and autonomic activity outputs (i.e. high frequency, HF-HRV, and low frequency, LF-HRV, heart rate variability) were extracted. Affect ratings (assessed <i>via</i> the Multiple Affect Adjective Checklist), captured before and after the nap, were considered along two continua: (1) positive and negative valence and (2) low and high arousal. Positivity ratings (positive - negative valence) were determined within the two arousal categories.</p><p><strong>Results: </strong>Younger adults reported stronger positivity for low- relative to high-arousal affect after the nap, whereas positivity did not differ by arousal in older adults. Wake and NREM autonomic activity was lower in older than younger adults. Higher waking and NREM LF activity were associated with stronger post-nap positivity, whereas higher HF activity was associated with diminished post-nap positivity. Pre-sleep positivity ratings were not meaningfully associated with HRV during sleep. Sleep and wake findings were broadly consistent across age cohorts.</p><p><strong>Conclusion: </strong>The current study extends previous work linking sleep-related autonomic activity and psychosocial outcomes and offers that autonomic activity during wake and sleep may work synergistically to calibrate affective experiences across the lifespan.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag083"},"PeriodicalIF":0.0,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and neurocognitive performance in middle-aged Latina women in a rural agricultural community: insights from the CHAMACOS Maternal Cognition Study.","authors":"Nadia A Rojas, Lucia Calderon, Katherine Kogut, Yesli Perez-Rocha, Jenny S Guadamuz, Mark Fleming, Marcella Warner, Brenda Eskenazi, Hector M González, Julianna Deardorff, Jacqueline M Torres","doi":"10.1093/sleepadvances/zpag085","DOIUrl":"10.1093/sleepadvances/zpag085","url":null,"abstract":"<p><strong>Study objectives: </strong>To evaluate the connection between sleep measures and neurocognitive function among middle-aged Latinas in rural settings.</p><p><strong>Materials and methods: </strong>We analyzed cross-sectional data from the 2022-2024 CHAMACOS Maternal Cognition study of middle-aged (mean age: 49) Latinas (n = 500) residing in a rural agricultural community in California. We measured nightly sleep duration, sleep quality, and weekly nap frequency via self-report. Participants completed the SOL-INCA-AD neurocognitive battery, yielding global and domain-specific (memory, executive function, verbal fluency) cognitive z-scores. We estimated associations between sleep measures and cognitive scores controlling for socio-demographic and health-related covariates.</p><p><strong>Results: </strong>Participants averaged 8.5 hours of sleep per night. Overall, 65% of participants reported no naps, 22% 1-2 naps, and 13% 3+ naps per week; 21% reported \"restless or very restless sleep.\" There was an inverted U-shaped association between sleep duration and memory z-scores (linear 𝛽: 0.45, SE: 0.20; quadratic 𝛽: -0.03, SE: 0.01), but no statistically significant associations with other cognitive scores. Reporting 1-2 weekly naps (vs. none) was associated with higher memory (𝛽: 0.21, SE: 0.10) and lower verbal fluency (𝛽: -0.18, SE: 0.09) z-scores, but no statistically significant association with executive function or global z-scores. Reporting 3+ weekly naps (vs. none) was associated with lower memory z-scores (𝛽: -0.30, SE: 0.12). We observed no statistically significant associations between sleep quality and neurocognitive scores.</p><p><strong>Conclusions: </strong>Our results suggest the importance of sleep as a modifiable factor for ADRDs risk reduction among US Latinos and provide a foundation for longitudinal research on sleep and cognitive decline.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag085"},"PeriodicalIF":0.0,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a contactless, self-directed, home-based dim-light melatonin onset protocol: the Circadia pilot study.","authors":"Gregory Bormes, Jessica J Love, Angus C Burns, Oluwaseun Akeju, Jakob M Cherry, Nisha Kantesaria, Lovemore Kunorozva, Salim Qadri, Shadab A Rahman, Frank A J L Scheer, Brandon Westover, John W Winkelman, Richa Saxena, Jacqueline M Lane","doi":"10.1093/sleepadvances/zpag081","DOIUrl":"10.1093/sleepadvances/zpag081","url":null,"abstract":"<p><strong>Study objectives: </strong>To test the feasibility of a self-directed, in-home, contactless salivary dim light melatonin onset (DLMO) assessment protocol to remotely measure endogenous circadian phase in participants with circadian rhythm disorders and healthy controls.</p><p><strong>Materials and methods: </strong>The 4-6-week protocol involved sleep, activity, and light tracking, sleep diaries, questionnaires, and two self-directed at-home salivary sample collections for DLMO one week apart with objective compliance measures. Individuals participated remotely using an online portal and received a mailed kit. The study population included five cases with Circadian-Rhythm Sleep-Wake Disorders and five controls ages 27-63.</p><p><strong>Results: </strong>Salivary DLMO times could be calculated for 14/20 assessments, resulting in 8/10 participants with at least 1 valid DLMO and 6/10 having valid DLMOs for both. Failures in DLMOs resulted from compliance errors (eg, bright light levels) or consistently below/above threshold melatonin levels. After completing the DLMO collections, 70% of participants felt confident after completing DLMO 1, while 90% felt confident after DLMO 2. DLMO occurred on average at 24.08 hours (SEM = 1.10 hours) for four participants with Delayed Sleep Wake Phase Disorder, and at 21.37 hours (SEM = 0.71 hours) for five controls. The first and second DLMOs were strongly correlated (<i>r</i> = 0.98, <i>p</i> < .001).</p><p><strong>Conclusions: </strong>Our results indicate that contactless, self-directed, at-home DLMO assessments are feasible, reliable, and capable of detecting clinically relevant differences in circadian timing. The current protocol may serve as a framework to reliably and scalably assess circadian phase in both clinical and general populations.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag081"},"PeriodicalIF":0.0,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of obstructive sleep apnea in Indigenous peoples worldwide.","authors":"Shannon L Edmed, Daniel P Sullivan, Michelle Olaithe, Scott Coussens, Philip Terrill, Dwayne Mann, Danielle L Wilson, Wayne Williams, Danny J Eckert, Sheethal Kalmadka, Sylistah Gadam, Yaqoot Fatima","doi":"10.1093/sleepadvances/zpag080","DOIUrl":"10.1093/sleepadvances/zpag080","url":null,"abstract":"<p><strong>Study objectives: </strong>Emerging evidence indicates that Indigenous peoples experience disproportionately high rates of obstructive sleep apnea (OSA). This systematic review aimed to examine OSA prevalence, contributing factors, and intervention or treatment outcomes among Indigenous peoples worldwide.</p><p><strong>Materials and methods: </strong>We systematically searched PubMed, Embase, CINAHL, Cochrane CENTRAL, ATSI Health, Web of Science and PsycINFO (last searched June 30, 2025), and grey literature for original research involving Indigenous peoples (≥18 years) diagnosed with OSA via self-report or laboratory-based measures (e.g. polysomnography). Data extraction focused on study characteristics and key findings. Methodological quality was assessed using NIH tools, and cultural appropriateness was evaluated using the CREATE Aboriginal and Torres Strait Islander Quality Appraisal Tool. A narrative synthesis was conducted.</p><p><strong>Results: </strong>From 599 records, 41 studies from six countries were included. OSA prevalence among Indigenous populations varied widely (community-based samples, 6.5%-69%; referred samples, 85%-95%; self-reported diagnosis, 1.2%-8.4%; hospital audit diagnoses, 0.8%-11.4%), with only one study reporting a robust population-based estimate (~6.5% among Māori). Severe cases predominated in referred samples. Factors associated with OSA included male sex, age, BMI, neck circumference, craniofacial and geographic factors, and symptoms such as snoring. Treatment evidence was limited to CPAP, with low adherence.</p><p><strong>Conclusions: </strong>Findings suggests that OSA is common among Indigenous peoples across diverse settings. However, prevalence estimates are heterogeneous and limited by differences in study design, sampling frame, and diagnostic approaches, with most evidence based on referred clinical samples. Improving awareness and culturally responsive screening and management may improve outcomes. Sleep health among Indigenous peoples warrants a higher priority in research, policy and practice.</p><p><strong>Registration: </strong>The protocol for this systematic review was registered with Prospero (CRD42024466932).</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag080"},"PeriodicalIF":0.0,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13533188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of actigraphic sleep parameters with adipokines in older adults in the Baltimore longitudinal study of aging.","authors":"Zhikui Wei, Yiwei Yue, Jill A Rabinowitz, Marc Kaizi-Lutu, Mark N Wu, Chee W Chia, Toshiko Tanaka, Eleanor M Simonsick, Luigi Ferrucci, Adam P Spira","doi":"10.1093/sleepadvances/zpag082","DOIUrl":"10.1093/sleepadvances/zpag082","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep and adipokines are important regulators of cardiometabolic health, yet their relationship in older adults remains poorly understood. We examined cross-sectional and longitudinal associations of actigraphic sleep parameters with adipokine levels among older adults and explored sex and central obesity as potential moderators.</p><p><strong>Materials and methods: </strong>We studied 350 participants aged ≥60 years (mean = 74.8 ± 8.3 years, 48.9% females, 19.4% black) from the Baltimore Longitudinal Study of Aging who completed 6.5 ± 1.1 nights of wrist actigraphy and provided fasting plasma for adipokine measurements. Predictors were total sleep time (TST), sleep onset latency, wake after sleep onset, sleep efficiency, and average wake bout length (AWBL); outcomes were adiponectin and leptin levels.</p><p><strong>Results: </strong>At baseline, longer AWBL was associated with lower adiponectin (<i>B</i> = -2.02, 95% CI [-3.61, -0.42], <i>p</i> = .013) and leptin (<i>B</i> = -3.14, [-5.25, -1.03], <i>p</i> = .004) in fully adjusted models. Longer TST, modeled continuously, predicted a greater increase in adiponectin levels over time (<i>B</i> = 0.26, [0.081, 0.44], <i>p</i> = .007), and short TST (<6 h) was linked to subsequent decline in adiponectin (<i>B</i> = -0.90, [-1.72, -0.079], <i>p</i> = .038). Sex and central obesity moderated the baseline AWBL-adiponectin associations, which were significant in females (<i>B</i> = -3.92, [-6.25, -1.59], <i>p</i> = .001) and those with lower central obesity (<i>B</i> = -6.98, [-10.43, -3.53], <i>p</i> < .001).</p><p><strong>Conclusions: </strong>Longer sleep duration and shorter wake bouts are linked to more favorable adipokine profiles in older adults, especially in females and those with lower central obesity. Sleep may exert cardiometabolic effects through adipokines in older adults.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag082"},"PeriodicalIF":0.0,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A historical overview of the cardiovascular safety of sodium oxybate: clinical trials, clinical experience.","authors":"Clete A Kushida","doi":"10.1093/sleepadvances/zpag047","DOIUrl":"10.1093/sleepadvances/zpag047","url":null,"abstract":"","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 Suppl 1","pages":"A3-A11"},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for daily sodium intake: a counterpoint to the current recommendation for low sodium intake.","authors":"Andrew Mente","doi":"10.1093/sleepadvances/zpag027","DOIUrl":"10.1093/sleepadvances/zpag027","url":null,"abstract":"<p><p>Several health organizations suggest that people should consume less sodium, aiming for an intake below 2.3 g per day on the premise that lowering sodium intake will lower blood pressure and, in turn, reduce the incidence of cardiovascular disease. However, these guidelines were created without effective means of maintaining low-sodium diets in real life, and strong evidence is lacking that shows low sodium intake leads to fewer cardiovascular events compared with average intake levels. This review evaluates whether the advice to consume less sodium is backed by solid evidence. It argues that most people consume a moderate amount of sodium (3 to 5 g per day), which is associated with the lowest risk of cardiovascular disease, and recommends a target below 5 g per day. Results from large randomized controlled trials evaluating the effect of sodium reduction on clinical events and mortality are awaited. This is particularly relevant in clinical practice, where sodium-containing medications such as sodium oxybate (SO), a mainstay in narcolepsy treatment, contribute to daily intake but are not considered by sodium guidelines. Clinicians should evaluate each patient's total sodium intake from both diet and medications and make personalized recommendations based on their cardiovascular and renal risk profile.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 Suppl 1","pages":"A12-A18"},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing patient outcomes and empowering the patient-clinician partnership.","authors":"Michael Thorpy","doi":"10.1093/sleepadvances/zpag034","DOIUrl":"10.1093/sleepadvances/zpag034","url":null,"abstract":"<p><p>The treatment landscape for narcolepsy is rapidly evolving with the introduction of new therapies featuring unique mechanisms of action and innovative formulations of established treatments. The recent approval of a once-nightly sodium oxybate formulation (SO-ER) has expanded the spectrum of oxybate therapies to 3, including the traditional immediate-release formulation (OXB) and a low-sodium version containing calcium, magnesium, potassium, and sodium oxybates (LXB). While the availability of diverse options allows clinicians to tailor oxybate-based treatments, it also raises challenges in selecting and fine-tuning these therapies. Involving patients in the decision-making process through shared decision-making (SDM) platforms can be an effective approach to optimizing oxybate therapy. This review article aims to provide clinicians with a comprehensive overview of the unique characteristics of available oxybate formulations and potential strategies for delivering empathetic care that incorporates SDM into the selection and optimization of oxybate-based treatment regimens.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 Suppl 1","pages":"A19-A24"},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction: sodium oxybate and cardiovascular safety: reconciling 20 years of clinical and research experience with sodium intake guidelines.","authors":"Clete A Kushida","doi":"10.1093/sleepadvances/zpag049","DOIUrl":"https://doi.org/10.1093/sleepadvances/zpag049","url":null,"abstract":"","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 Suppl 1","pages":"A1-A2"},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13388318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a nighttime medical order adjustment protocol on objective and subjective sleep quality in hospitalized adults: a randomized controlled trial.","authors":"Sofía Parra-Avila, Juan Enrique Santos-Macías, Arnulfo Garza-Silva, Dalia Gutierrez-González, Iván Francisco Fernández-Chau, Sara Jaqueline Castruita-Von Chong, Oscar Alberto Quiroga Gómez, Juan Guillermo Rodríguez Barrientos, Maria Elena Romero-Ibarguengoitia","doi":"10.1093/sleepadvances/zpag079","DOIUrl":"10.1093/sleepadvances/zpag079","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep disruption is common among hospitalized patients and is often exacerbated by non-essential nighttime medical activities. Evidence from general hospital wards in Latin America remains limited. We evaluated the effect of an adjusted nighttime medical order protocol on sleep quality in hospitalized adults.</p><p><strong>Materials and methods: </strong>In this randomized controlled trial, patients were allocated to standard care or an intervention protocol in which non-essential nocturnal procedures (routine vital sign checks, medication administration, and laboratory sampling) were rescheduled. Objective sleep parameters were monitored with Fitbit Sense over three consecutive nights. The first night served as a baseline, followed by two intervention nights. Subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) at baseline and study completion.</p><p><strong>Results: </strong>Fifty-one patients were included [mean (<i>SD</i>) age 41.2 (13.0) years; 56.9% female], with 26 (51.0%) assigned to the intervention group. Compared with controls, the intervention group had longer geometric mean [geometric standard deviation (GSD)] total sleep time [398 (1.28) vs. 301 (1.40) min; <i>p</i> = .015] and longer estimated Stage R [rapid eye movement (REM)] sleep duration [79.2 (1.36) vs. 58.0 (1.49) min; <i>p</i> = .010]. In addition, nocturnal awakenings were eliminated by the second intervention night. Subjective sleep quality also improved in the intervention group, with lower PSQI scores at study completion than in the control group [4.6 (2.5) vs. 8.7 (3.2); <i>p</i> = .040].</p><p><strong>Conclusions: </strong>Reorganizing nighttime medical routines significantly improved objective and subjective sleep quality in hospitalized patients. This low-cost, pragmatic intervention may represent a scalable strategy for implementing sleep-friendly hospital practices.</p>","PeriodicalId":74808,"journal":{"name":"Sleep advances : a journal of the Sleep Research Society","volume":"7 3","pages":"zpag079"},"PeriodicalIF":0.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}